Clinical trials: Functional Insufficiency
Chronic Kidney Disease (Stages 4 and 5), Chronic Kidney Disease 5D
The Practicality and Utility of Measured vs Estimated GFR in adCKD
The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately…
- Trial name
- NCT07450534
- Testing
- Iohexol Inj 300 MG/ML Diagnostic aid/agent used to measure glomerular filtration rate (GFR)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Manchester University NHS Foundation Trust
Kidney Impairment
A Study of RAY1225 in Participants With Impaired Kidney Function
The purpose of this study is to assess how fast RAY1225 gets into the blood stream and how long it takes the body to remove it in participants with impaired kidney function compared to healthy participants.
- Trial name
- NCT06613763
- Testing
- RAY1225
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Secondary Hypothyroidism
Thyroid Function in Critically Ill Patients With Acute Kidney Injury
The objective of this study was to assess the changes in thyroid hormones and its activity during CRRT in patients with Acute Kidney Injury.
- Trial name
- NCT04767763
- Testing
- Assessment of TSH, fT3, fT4,TRH, TT3, TT4, rT3 in patients with CVVHDF
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- Medical University of Gdansk
Dyslipidemia
Pharmacokinetics of Anacetrapib (MK0859) in Subjects With Impaired Renal Function (MK-0859-038)
This study will evaluate the Area Under the Curve (AUC(0 to infinity)) of anacetrapib in subjects with impaired renal function and healthy matched control subjects.
- Trial name
- NCT01122667
- Testing
- anacetrapib
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
End Stage Renal Disease
Goal Directed Fluid Administration for Kidney Transplantation
The goal of the proposed study is to evaluate the efficacy of a goal-directed fluid administration algorithm on early graft function in patients undergoing kidney transplantation.
- Trial name
- NCT02192086
- Testing
- goal directed fluid therapy, Control Group
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Swallowing Disorder, Respiratory Insufficiency
The Impact of High-Flow Nasal Cannula on Swallow Function
Background: High-flow nasal cannula (HFNC) is a non-invasive heated and humidified oxygen delivery device that is capable of delivering high-flow rates.
- Trial name
- NCT03590457
- Testing
- Airvo 2; High-Flow nasal cannula system
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Chronic Kidney Diseases
Dapagliflozin on Renal Morphology and Renal Perfusion in Patients One Year After Kidney Transplantation
The aim of this study is to observe the mechanisms of dapagliflozin on the renal interstitial tissue and renal perfusion. For this purpose, renal transplanted patients as an excellent model of CKD and high cardiovascular risk…
- Trial name
- NCT06560801
- Testing
- Dapagliflozin 10mg Tab
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Kidney Failure, Chronic, Cardiovascular Diseases
Effects of Phosphate Binding With Sevelamer in Stage 3 Chronic Kidney Disease
The purpose of this study is to determine whether lowering phosphate in patients with early chronic kidney disease with the phosphate binder sevelamer has beneficial effects on cardiovascular structure and function.
- Trial name
- NCT00806481
- Testing
- Sevelamer carbonate
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Bone Marrow Transplant Infection, Bronchiolitis Obliterans
Prospective Study of Belated Pulmonary Complications Occurring in Children Treated With Allogeneic Hematopoietic Stem Cells.
Hematopoietic stem cell transplantation (HSCT) is used to treat an expanding array of malignant and non-malignant disorders. This is a prospective multicenter study, in pediatric allo-BMT recipients to analyze the spectrum of…
- Conditions
- Bone Marrow Transplant Infection, Bronchiolitis Obliterans, Chronic Respiratory Insufficiency, Organizing Pneumonia
- Trial name
- RESPPEDHEM (NCT02032381)
- Testing
- late pulmonary complications occurring in children treated with allogeneic hematopoietic stem cells.
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Chronic Obstructive, Exercise
Change of Lung Function After Exercise in Patients With Chronic Obstructive Pulmonary Disease
The purpose of this study is to evaluate the changes of lung function before and after the exercise in patients with chronic obstructive pulmonary disease.The assessment of quality of life is also carried out through…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Exercise, Lung Function Decreased, Quality of Life
- Trial name
- NCT03551197
- Testing
- Budesonide and formoterol bid
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhujiang Hospital
Liver Diseases, Liver Cirrhosis
Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study)
The purpose of the study is to determine the role of new biomarkers in the diagnosis of sepsis in critically-ill patients with liver failure and to correlate the prognosis of these patients with parameters of endothelial function…
- Conditions
- Liver Diseases, Liver Cirrhosis, Sepsis, Critical Illness
- Trial name
- SELLIFA (NCT00488917)
- Where
- Belgium
- Volunteers
- 167 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hepatic Insufficiency
Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic Impairment Compared to Healthy Subjects
This is an open-label study to evaluate the pharmacokinetics, safety and tolerability of single oral doses of Alisporivir in subjects with mild and moderate hepatic impairment compared to matched healthy subjects with normal…
- Trial name
- NCT01860326
- Testing
- Alisporivir
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Debiopharm International SA
Alzheimer's Disease, Huntington's Disease
A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function
This study is to compare the pharmacokinetics of Dimebon in subjects with severe renal impairment to subjects with normal renal function after oral administration of a single oral 20-mg dose of Dimebon.
- Trial name
- NCT00824590
- Testing
- Dimebon
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Kidney Disease on Hemodialysis, Thyroid Gland Disease
Interleukin-6 and Thyroid Dysfunction in Hemodialysis Patients
Chronic kidney disease (CKD) is often associated with multiorgan complications, including thyroid hormone dysfunction. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been proposed as a marker of inflammation that may…
- Trial name
- NCT07328113
- Testing
- Thyroid hormone
- Where
- Indonesia
- Volunteers
- 65 people
- Sponsor
- Dr. Soetomo General Hospital
Chronic Kidney Disease, Proteinuria
Endothelin Receptor Antagonism in Proteinuric Nephropathy
The number of people with kidney problems is increasing rapidly, related in part to the increasing prevalence of diabetes. Patients with kidney problems tend to have protein leaking into the urine (proteinuria).
- Trial name
- NCT00722215
- Testing
- BQ-123 (selective endothelin A receptor antagonist), 0.9 % saline, Nifedipine
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Cardiorenal Syndrome
Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery
Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow.
- Trial name
- DECONGEST (NCT03684876)
- Testing
- diuretic use
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
COPD, COPD (Chronic Obstructive Pulmonary Disease)
How Nocturnal Hypoventilation Predicts Long-term Response to Non-invasive Ventilation in Hypercapnic COPD Patients
The study is an observational, single-center, prospective cohort study aiming to evaluate respiratory mechanics data, as well as clinical and functional parameters commonly used in clinical practice in patients with COPD and…
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Hypercapnia, Hypercapnic Respiratory Failure, COPD
- Trial name
- HYPONIV (NCT07414108)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Kidney Disease
Functional Electrical Stimulation in Chronic Kidney Disease
Chronic kidney disease is a renal injury and progressive and irreversible loss of kidney function and in its most advanced stage is called chronic renal failure.
- Trial name
- NCT02336776
- Testing
- Functional electrical stimulation
- Volunteers
- 21 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Renal Impairment, Healthy
Study to Evaluate Sotagliflozin in Subjects With Varying Degrees of Renal Function
The purpose of this study is to evaluate the effect of mild, moderate, or severe renal impairment, or end-stage renal disease (ESRD) requiring hemodialysis (HD), on the safety and tolerability of 1 or 2 single doses of…
- Trial name
- NCT02647918
- Testing
- Sotagliflozin
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lexicon Pharmaceuticals
Renal Impairment
Study of PK/PD, Safety and Tolerability of LIK066 in Patients With Decreased Renal Function.
The purpose of this trial was to evaluate whether the study drug, LIK066, causes glucose excretion in urine in patients with varying degrees of decreased kidney function and in subjects with normal kidney function.
- Trial name
- NCT03131479
- Testing
- LIK066
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Novartis Pharmaceuticals
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