Clinical trials: Functional Iron Deficiency
Cognitive Function and Mood, Non-anaemic Iron Deficiency
Efficacy Evaluation of 16 Weeks' Dietary Supplementation With Iron Bis-glycinate Plus Vitamin C on Cognitive Function, Subjective Mood, Fatigue, Health and Well-being
Iron deficiency is the most prevalent nutritional deficiency worldwide with one in four estimated to be affected by iron deficiency anaemia.
- Trial name
- NCT04469010
- Testing
- Iron Bis-Glycinate Chelate and Vitamin C, Iron Bis-Glycinate Chelate
- Where
- United Kingdom
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Functional Iron Deficiency, Trauma
RCT of Goal-directed Iron Supplementation of Anemic, Critically Ill Trauma Patients, With and Without Oxandrolone
The purpose of this trial is to determine if the combination of goal directed iron supplementation and hepcidin mitigation can safely eliminate both the serum and bone marrow iron debt of anemic, critically ill trauma patients…
- Conditions
- Functional Iron Deficiency, Trauma, Anemia
- Trial name
- NCT02047552
- Testing
- Iron sucrose, Oxandrolone
- Where
- United States
- Sponsor
- Denver Health and Hospital Authority
Rare Iron Overloads Except C282Y Homozygosity
Rare Iron Overloads Except C282Y Homozygosity : Description and Characterization.
Chronic iron overload is responsible for morbidity and mortality. There are many genetic and acquired causes. One of them is an hepcidin deficiency. Hepcidin is the regulating hormone for iron.
- Trial name
- HEPCIDEF (NCT01541813)
- Where
- 10 sites in France
- Volunteers
- 62 people
- Sponsor
- Rennes University Hospital
Heart Failure With Preserved Ejection Fraction, Iron Deficiency
IV Iron Therapy for Older Adults With Heart Failure With Preserved Ejection Fraction and Iron Deficiency
This randomized, double-blind, placebo-controlled clinical trial evaluates intravenous ferric derisomaltose in older adults with HFpEF and iron deficiency.
- Trial name
- INFUSE-HFpEF (NCT07686692)
- Testing
- Ferric derisomaltose
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Iron Deficiency Anemia
Impact of Intravenous Iron on Musculoskeletal Function in Older Adults
Anaemia is a risk factor for functional decline and frailty in older adults including decreased physical performance and muscle strength, increased hospitalisation risk and mortality, falls, and poorer recovery from activities of…
- Trial name
- FERIDA (NCT05708170)
- Testing
- Ferinject, Ferrous Sulfate 200 MG
- Volunteers
- 100 people
- Sponsor
- Liverpool Hope University
Solid Cancer Metastatic Disease, Lymphoid Disease
Randomized Study Evaluating Agents Stimulants Erythropoiesis (ASE) Associated With Ferric Carboxymaltose (Ferinject ®) in Concomitant or Sequential Patients Treated for Cancer and With Anemia Associated With Functional Iron Deficiency
Anemia in patients with cancer is a common problem associated with an impaired quality of life. Treatment with erythropoiesis stimulating agents (ESA) allows an increase in hemoglobin levels in 40-70% of patients and decreased…
- Trial name
- NCT02213653
- Testing
- ARM A : IV iron + epoietin zeta, ARM B: IV iron + epoietin zeta sequence, ARM C : single epoietin zeta
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Centre Francois Baclesse
Anemia, Iron-Deficiency
A Two-part Single- and Repeat-dose Study of CSJ137 in Anemic Chronic Hemodialysis Patients
The study will assess the safety, tolerability and efficacy of CSJ137 in chronic hemodialysis patients. It is hypothesized that treatment with CSJ137 may improve the level of hemoglobin in patients on chronic hemodialysis with…
- Trial name
- NCT02570854
- Testing
- CSJ137
- Where
- 13 sites in United States, Czechia and 2 more
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Myocardial Infarction, Iron-deficiency
An Open Study on the Efficacy of Iron Therapy Using iv Iron Relative to Oral Iron for Increasing LV Systolic Function
The OPERA-MI trial evaluates the effect of i.v. ferric carboxymaltose compared to the effect of oral iron, on left ventricular systolic function.
- Trial name
- OPERA-MI (NCT05309499)
- Testing
- ferric carboxymaltose, ferrous sulphate
- Where
- Russia
- Volunteers
- 298 people
- Sponsor
- Kazan State Medical University
Iron-deficiency, Iron Deficiency Anemia
Fatigue, Quality of Life, Cognitive Function and Physical Ability in Patients Suspected of Colorectal Malignancy
The aim is to investigate if iron deficiency at the time of colorectal cancer diagnosis has an influence on fatigue, quality of life, cognition and physical ability.
- Conditions
- Iron-deficiency, Iron Deficiency Anemia, Colorectal Cancer, Fatigue
- Trial name
- NCT04749589
- Testing
- iron deficiency
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Iron Deficiency, Anaemia in Children
Effect of a Dietary Iron Program on Iron Status and IQ in Children in Phatthalung Province, Thailand
Iron deficiency (ID) continues to be one of the most prevalent disorders, which can adversely affect cognitive ability in childhood.
- Trial name
- NCT05878379
- Testing
- Dietary Iron Program
- Where
- Thailand
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Iron-deficiency, Ventricular Function
Iron Status and Cardiopulmonary Physiology
This study involved human volunteers undertaking a high-altitude expedition. It assessed changes in physiological parameters of relevance to high-altitude cardiopulmonary physiology.
- Conditions
- Iron-deficiency, Ventricular Function, Pulmonary Vascular Resistance Abnormality, Altitude Hypoxia
- Trial name
- NCT03707249
- Testing
- Ferric Carboxymaltose Injectable Product, Normal Saline 0.9% Infusion Solution Bag
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Royal Centre for Defence Medicine
Iron Deficiency
Iron-fortified Flavoured Skimmed Milk With or Without Vitamin D in Iron Deficient Women
Iron deficiency and vitamin D deficiencies are common in menstruating women. The present assay studied the influence of the consumption of a flavoured skimmed milk with iron (iron pyrophosphate) or with iron and vitamin D3 in…
- Trial name
- NCT01739907
- Testing
- Iron fortified flavoured skimmed milk with or without vitamin D in iron deficient women
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
The goal of this clinical trial is to learn which iron treatment works better for adults with congestive heart failure and low iron levels: intravenous (IV) iron given through a vein or oral (PO) iron taken by mouth.
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Iron Deficiency
- Trial name
- IRONICA (NCT07053475)
- Testing
- Ferric Carboxymaltose, Ferrous Sulfate
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Syed Hamza Mufarrih
Aortic Valve Stenosis, Iron Deficiency
Iron Infusion in Patients Undergoing Transcatheter Aortic Valve Implantation
The aim of the open-label, randomized controlled superiority IRON TAVI trial is to investigate whether intravenous iron therapy (ferric carboxymaltose) improves Health-Related Quality of Life (HRQOL) in patients with severe…
- Conditions
- Aortic Valve Stenosis, Iron Deficiency, TAVI(Transcatheter Aortic Valve Implantation), Cardiovascular Diseases
- Trial name
- IRON TAVI (NCT07370688)
- Testing
- Intravenous ferric carboxymaltose
- Where
- Netherlands
- Volunteers
- 402 people
- Sponsor
- Erasmus Medical Center
Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis
A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Participants (MOMENTUM)
MOMENTUM is a randomized, double-blind, active control Phase 3 trial intended to confirm the differentiated clinical benefits of the investigational drug momelotinib (MMB) versus danazol (DAN) in symptomatic and anemic…
- Conditions
- Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
- Trial name
- NCT04173494
- Testing
- Momelotinib, Danazol
- Where
- 167 sites in United States, Australia and 20 more
- Volunteers
- 195 people
- Sponsor
- Sierra Oncology LLC - a GSK company
Heart Failure, Congestive
A Study of Iron Oligosaccharide in CHF Patients
The purpose of this study is to determine the safety profile of iron oligosaccharide in patients with congestive heart failure with a need for parenteral iron.
- Trial name
- NCT00537186
- Testing
- Iron oligosaccharide
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Pharmacosmos A/S
Iron-Deficiency Anemia
Ferric Carboxymaltose in Subjects With Functional Iron Deficiency Undergoing Chemotherapy
Anaemia and functional iron deficiency are common conditions in patients with lymphoid malignancies, conditions which reduce significantly the quality of life and increase morbidity and mortality.
- Trial name
- FID-CHEMO (NCT01101399)
- Testing
- Ferric carboxymaltose
- Where
- 2 sites in Germany, Sweden
- Volunteers
- 19 people
- Sponsor
- Vifor Pharma
Iron Deficiency, Anemia
The Effects of Iron and Omega-3 Fatty Acid Supplementation on Cognition and Immune Function in Iron Deficient Children
The aim of this study is to determine if providing iron and a mixture of DHA and EPA, alone and in combination, to children with iron deficiency and poor n-3 fatty acid intake will improve their cognitive performance, activity…
- Trial name
- FeFA (NCT01092377)
- Testing
- DHA and EPA Fish Oil capsule, Iron tablet
- Where
- South Africa
- Volunteers
- 320 people
- Sponsor
- North-West University, South Africa
Heart Transplant Recipients
Intravenous Iron Supplement for Iron Deficiency in Cardiac Transplant Recipients
Iron deficiency is prevalent in heart transplant recipients, and may be associated with reduced functional capacity. The IronIC trial is designed to assess the effect of intravenous iron isomaltoside on exercise capacity, muscle…
- Trial name
- IronIC (NCT03662789)
- Testing
- Iron Isomaltoside 1000
- Where
- Norway
- Volunteers
- 102 people
- Sponsor
- Oslo University Hospital
Iron Deficiency Anemia
A Study to Evaluate the Safety and Preliminary Efficacy of a Response-guided Dose Titration of KER-047 in the Treatment of Functional IDA (Iron Deficiency Anemia).
This study aims to explore the safety and preliminary efficacy of a response-guided dose titration of KER-047 in the treatment of functional IDA (Iron deficiency anemia) in MDS (Myelodysplastic syndrome), MF(Myelofibrosis), and…
- Trial name
- NCT05927012
- Testing
- KER-047
- Where
- 5 sites in Australia, Israel
- Sponsor
- Keros Therapeutics, Inc.