Clinical trials: Functional Magnetic Resonance Imaging (fMRI)
Tourette Syndrome
Dopaminergic Effects on Cortical Function in Tourette's (Levodopa Protocol)
Dr. Kevin J. Black at Washington University is conducting a study to learn whether we can use MRI scans to test dopamine function in the brain and to determine whether the brain performs memory tasks differently in Tourette…
- Trial name
- TSfMRI (NCT00634556)
- Testing
- levodopa solution 2mg/ml for i.v. use
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Fibromyalgia
Effect of tDCS in Intrinsic Functional Brain Connectivity Assessed by Functional Magnetic Resonance in Fibromyalgia
Considering the central component of fibromyalgia (FM), the focus of research on current therapeutic approaches has been techniques that may modify the dysfunctional neuroplasticity process, such as transcranial direct current…
- Trial name
- NCT03841227
- Testing
- Active-tDCS
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder (PTSD) and Seroquel
This 8 weeks study will investigate therapeutic responses to Seroquel pharmacotherapy in PTSD.
- Trial name
- NCT01066156
- Testing
- Seroquel
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Cambridge Health Alliance
Nicotine Dependency, Smoking
A Fmri Study on the Effects of a Conjugate Vaccine and Placebo on CNS Activation and Behavior Following a Nicotine Challenge
In this study the effects of a nicotine challenge on brain activity, behavior and mood will be evaluated in two groups of healthy volunteers who have a smoking habbit: The first group will undergo a series of treatments with…
- Trial name
- EPU057 (NCT01318668)
- Testing
- vaccination with Nicvax
- Where
- Netherlands
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Major Depressive Disorder and Irritability
Brexpiprazole (OPC 34712) Trial in the Treatment of Adults With Major Depressive Disorder and Irritability
The purpose of this study is to explore the effects of fixed-dosed brexpiprazole adjunctive treatment in subjects with Major Depressive Disorder with irritability
- Trial name
- NCT02212613
- Testing
- Brexpiprazole
- Where
- United States
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Type 2 Diabetes Mellitus, Mild Cognitive Impairment
Effects of Henagliflozin on the Brain Function in T2DM Patients With Mild Cognitive Impairment: a Randomized, Parallel Controlled Clinical Trial
This is a prospective, randomized, open label, parallel, 16-week study to explore and evaluate the therapeutic effects of Henagliflozin on the cognitive function, olfactory function, and odor-induced brain activation in T2DM…
- Trial name
- NCT06085703
- Testing
- Henagliflozin, Gliclazide
- Where
- China
- Volunteers
- 24 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Focus: Effects of Nicotine and Alcohol on Brain Circuits
Neural Mechanisms Underlying Nicotine and Alcohol Combinations
Nicotine and alcohol are frequently used together and their combined use contributes to more than half a million deaths each year, with more alcoholics dying from smoking-related diseases than from alcohol-related diseases.
- Trial name
- QfMRI (NCT02049268)
- Testing
- Nicotine + Alcohol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depression
Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetine
The purpose of this study is to find out what parts of the brain have increased or decreased activity when people are depressed and how antidepressant medicine changes this activity in depressed patients.
- Trial name
- NCT00532480
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Obesity
Diet, Imaging and Energy Balance Trial (DIET)
To evaluate whether changes in macronutrient consumption (i.e., switching to a diet low in carbohydrates) can change brain responses to cues depicting foods representing that macronutrient.
- Trial name
- DIET (NCT00787280)
- Testing
- Low Carbohydrate Ketogenic Diet (LCKD), Low Fat Diet (LFD)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Duke University
Tinnitus, Subjective
MRI Study of Noninvasive Transcranial Electrical Stimulation in Tinnitus
The purpose of this research is to understand how a neuromodulation technique, transcranial electrical stimulation (tES), affects brain function in adults with chronic tinnitus measured with functional magnetic resonance imaging…
- Trial name
- NCT03544359
- Testing
- Transcranial electrical stimulation (tES)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive
Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia.
The goal of this clinical trial is to investigate the clinical efficacy of repetitive transcranial magnetic stimulation in the treatment of achalasia in patients diagnosed with achalasia by comprehensive evaluation of clinical…
- Conditions
- Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive, Vagus Nerve Motor Disorder, Functional Magnetic Resonance Imaging
- Trial name
- NCT06027190
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhang Nina
Schizophrenia, Smoking Cessation
Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia
Purpose of the study: Evaluate the effect of deep repetitive transcranial magnetic stimulation (deep rTMS; hereafter abbreviated as "dTMS") on synaptic density measured with positron emission tomography (PET) and the radiotracer…
- Conditions
- Schizophrenia, Smoking Cessation, Tobacco Use
- Trial name
- NCT05724810
- Testing
- Active deep transcranial magnetic stimulation (dTMS)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stony Brook University
Nicotine Dependence
Brain Reaction to Treatment of Nicotine Dependence
The purpose of the study was to determine how the treatments for cigarette craving work. Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before…
- Trial name
- NCT00108173
- Testing
- Zyban
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- US Department of Veterans Affairs
Nicotine Dependence
The Impact of Real-time Functional Magnetic Resonance Imaging (fMRI) Feedback on Response to Nicotine Cues
The purpose of this study is to develop a technique to provide feedback of brain activity and to use this technique to reduce levels of craving in nicotine dependent smokers.
- Trial name
- RTSmoking (NCT01411007)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine Addiction, Cocaine Abuse
Psychology of Reward and Punishment: Functional and Molecular Brain Imaging and Monoaminergic Correlates
Background: Brain imaging studies, genetic research, and investigations of stress have provided more information about the role of dopamine in processing reward and punishment, and in vulnerability to substance dependence.
- Trial name
- NCT00865332
- Where
- 2 sites in United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcoholism
Alcohol Addiction: A Systems-oriented Approach
The goal of the multicenter subproject (SP) 10 of the eMED Alcohol Addiction Consortium - A Systems-Oriented Approach is to study neuroimaging x genetics predictions in an existing sample (NGFNplus) of tightly endophenotyped and…
- Trial name
- eMedAlcohol (NCT02910193)
- Where
- Germany
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Heart Rate, Magnetic Resonance Imaging
Investigating Neuronal and Peripheral Markers of Brain Heart Interaction in Healthy Participants Under Stress
This study seeks to investigate which regions of the brain are relevant in the regulation of cardiac control and how the interplay between HRV and those regions change during different physiological states (stress versus…
- Conditions
- Heart Rate, Magnetic Resonance Imaging, Stress, Physiological
- Trial name
- HRV_DB (NCT05358314)
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Schizophrenia Negative Type
tDCS Combined With rTMS for Negative Symptoms of Schizophrenia
Despite major advances in the field of psychopharmacology in recent years, the majority of treated schizophrenia patients retain disabling symptoms, most commonly a variety of negative symptoms.
- Trial name
- NIBSNeS (NCT05695144)
- Testing
- tDCS active stimulation combined with rTMS active stimulation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Anding Hospital
Depression, Anxiety and Fear
Frontal Stimulation to Modulate Threat Sensitivity in Anxious Depression
Over 50% of patients with major depressive disorder (MDD) do not respond to initial treatment and relapse is common. In particular, comorbid depression and anxiety disorders are associated with more treatment resistance.
- Trial name
- NCT04948944
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Fallopian Tube Cancer, Ovarian Cancer
Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer
The purpose of this study is to learn about possible changes in brain anatomy and function, and in thinking abilities, such as memory skills, in patients with ovarian cancer who receive treatment with chemotherapy.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer
- Trial name
- NCT01591772
- Testing
- Neuroimaging & Neuropsychological Evaluation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center