Clinical trials: Fungal Disease
Sexual Assault and Rape, Sexually Transmitted Diseases
Prevalence of Sexually Transmitted Infections Among People Attending the Sexual Assault Centre in Oslo, Norway.
In this study the investigators seek to register the prevalence of sexually transmitted infections (STI) among people attending the Sexual Assault Centre in Oslo, Norway.
- Trial name
- NCT03132389
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 640 people
- Sponsor
- University of Oslo
Post-Treatment Lyme Disease Syndrome
Effect of Auricular Vagal Nerve Electrical Stimulation on Post-Treatment Lyme Disease Syndrome
This study is to assess if respiratory-gated auricular vagal nerve stimulation (RAVANS) can improve symptoms of post-treatment Lyme disease syndrome
- Trial name
- RavLyme (NCT04938687)
- Testing
- respiratory-gated auricular vagal afferent nerve stimulation (RAVANS)
- Volunteers
- 15 people
- Sponsor
- Spaulding Rehabilitation Hospital
Tuberculosis Infection
Immunization With BCG Vaccine to Prevent Tuberculosis Infection
The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG can lessen tuberculosis (TB) infection by producing an immune response when given to adults traveling to countries with a high or…
- Trial name
- TIPI (NCT04453293)
- Testing
- BCG (Tokyo 172) vaccine
- Where
- 7 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Burns, Infection Wound
The Study on Bacterial Load Following Open-to-air Management in Burn Patients.
Burns are one of the common forms of trauma and are a cause of unintentional death and injury. Management of burns becomes complex due to multiple associated complications, for instance, secondary infection of burn wounds is the…
- Conditions
- Burns, Infection Wound, Bacterial Infections
- Trial name
- NCT04502914
- Testing
- Open-to-air strategy, Traditional closed-wound management
- Where
- United States
- Sponsor
- Texas Tech University Health Sciences Center
Typhoid Fever
The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial)
Typhoid and paratyphoid (enteric) fever affects more than 11 million children and adults globally each year including 7 million in South Asia.
- Trial name
- ACT-South Asia (NCT04349826)
- Testing
- Azithromycin, Cefixime
- Where
- Nepal
- Volunteers
- 2,150 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Invasive Fungal Infection
An Individualized Administration Research of Voriconazole Based on CYP2C19 Gene Polymorphism and TDM
This was a prospective clinical study that all voriconazole-treated adult Chinese patients with invasive pulmonary infection admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University from March 2018 to April 2020.
- Trial name
- NCT04004078
- Testing
- other antifungal agents,breathing machine
- Where
- China
- Volunteers
- 314 people
- Sponsor
- People's Hospital of Zhengzhou University
Gonorrhea, Chlamydia
Pay-it-forward Gonorrhea and Chlamydia Testing Among Men in China
PIONEER is a three-arm, programmatic cluster randomized controlled trial (RCT) to compare effectiveness of three implementation strategies, followed by a mixed-methods implementation evaluation study
- Trial name
- NCT05723263
- Testing
- Standard Pay-it-forward, Community Engaged Pay-it-forward, Control arm
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Bacterial Infections
A Phase 1 TP-271 Oral PK Multiple Ascending Dose Study
This is a phase 1, single-center, randomized, placebo-controlled, double-blind, multiple ascending-dose study to assess the safety, tolerability, and PK of oral TP-271 in healthy adult subjects.
- Trial name
- NCT03450187
- Testing
- TP-271
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tetraphase Pharmaceuticals, Inc
Splenectomy; Status
Meningococcal B Vaccine in Patients with Asplenia
Patients without a spleen (asplenia) experience an increased risk for septicaemia from encapsulated bacteria, which is associated with a high mortality rate.
- Trial name
- NCT06025487
- Testing
- Bexsero
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pneumonia, Pneumocystis Carinii, HIV Infections
An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies
To determine the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium (TMTX / LCV)) in the treatment of Pneumocystis carinii pneumonia (PCP) in patients who have AIDS, are HIV…
- Trial name
- NCT00000714
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- 21 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bacterial Vaginosis, Vulvovaginal Candidiases
Light Treatment of Vaginal Infections in Reproductive Age Women
Antimicrobials have helped in managing vaginal dysbiotic conditions such as bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC).
- Trial name
- NCT06985433
- Testing
- Vaginal light therapy - Once, Vaginal Light Therapy - Twice
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- UVISA Health ApS
Glioblastoma, Glioblastoma Multiforme
Neuro-pharmacological Properties of Repurposed Ketoconazole in Glioblastomas
This research is being done to find out if the study drug (ketoconazole) can enter brain tumors at a high enough amount to stop the tumor cells from dividing.
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, Glioblastoma Multiforme, Adult
- Trial name
- NCT04869449
- Testing
- Ketoconazole
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Onychomycosis of Toenail
Safety and Tolerability Study of SKX-16 in Subjects With Moderate to Severe Distal Subungual Onychomycosis
This study is being conducted to determine the pharmacokinetics, systemic exposure, safety and tolerability after daily topical application of SKX-16 (Luliconazole 10% Solution) for duration of 29 days in a maximal use setting in…
- Trial name
- NCT05110638
- Testing
- SKX-16 (Luliconazole 10% Solution)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- SATO Pharmaceutical Co., Ltd.
Gonococcal Infection
Experimental Human Infection With Neisseria Gonorrhoeae (LptA Trial)
This is a Phase 1, interventional, non-randomized, experimental infection model study in healthy adult males (N=up to 25) between the ages of 18-35 at study enrollment.
- Trial name
- NCT04870138
- Testing
- Azithromycin, Ceftriaxone, Ciprofloxacin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Study to Investigate the Safety and Efficacy of GC3107 (BCG Vaccine) in Healthy Adults
Healthy adults will be once administered GC3107(BCG Vaccine) Intradermally.
- Trial name
- NCT03363178
- Testing
- GC3107
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Green Cross Corporation
Distal Lateral Subungual Onychomycosis, Onychomycosis
Evaluation of the Effectiveness of Nail Genesis DLSO Product for Onychomycosis
This is a Pre-IDE, prospective, multicenter, randomized, parallel-group, double-blind, vehicle- controlled study to evaluate safety and effectiveness of Nail Genesis DLSO Product for the treatment of DLSO compared with vehicle in…
- Trial name
- NCT06074315
- Testing
- Nail Genesis DLSO Product, Nail Genesis DLSO Product (vehicle only)
- Where
- 10 sites in United States
- Volunteers
- 338 people
- Sponsor
- Nail Genesis LLC
Cystic Fibrosis
Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients
This study is designed to assess the safety, tolerability, pharmacokinetics and preliminary pharmacodynamics (proof of concept) of QBW251 in healthy subjects and cystic fibrosis patients following single and multiple doses.
- Trial name
- NCT02190604
- Testing
- QBW251
- Where
- 23 sites in United States, Belgium and 5 more
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Tuberculosis
Study to Assess Efficacy and Safety of M72/AS01E-4 Mycobacterium Tuberculosis (Mtb) Vaccine in Adolescents and Adults
The study is a randomized, double-blind, placebo-controlled, multicenter, clinical trial to assess the prophylactic efficacy, safety, and immunogenicity of the investigational M72/AS01E-4 Mtb vaccine when administered…
- Trial name
- NCT06062238
- Testing
- M72/AS01E-4 Mycobacterium tuberculosis investigational vaccine
- Where
- 54 sites in Indonesia, Kenya and 3 more
- Volunteers
- 20,080 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute
CTCL/ Mycosis Fungoides
Diagnostic Classifier for Cutaneous T-cell Lymphomas
Primary cutaneous T-cell lymphomas (CTCL) are a form of skin cancer that is derived from immune cells. The most common form of CTCL is mycosis fungoides (MF).
- Trial name
- NCT04491825
- Testing
- Skin suction blistering and skin biopsies
- Where
- Austria
- Volunteers
- 160 people
- Sponsor
- Medical University of Vienna
Lyme Disease
Peripheral Facial Paralysis Sequelae in Lyme Disease Among Children
Neuroborreliosis (NB) is the second most frequent manifestation of Lyme disease. Painful meningoradiculitis is the most common neurologic manifestation in adults while facial nerve palsy (FP) and lymphocytic meningitis is…
- Trial name
- LYMEPED (NCT03981874)
- Testing
- telephonic interview
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
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