Clinical trials: Fungal Diseases
Vulva; Candidiasis
An Efficacy and Safety Study of Miconazole and Hydrocortisone Cream in the Treatment of Vulvar Candidiasis
The purpose of this study is to evaluate the efficacy and safety of miconazole plus hydrocortisone cream in the treatment of participants with vulvar candidiasis (yeast infection of the vulva).
- Trial name
- NCT01769339
- Testing
- Miconazole plus Hydrocortisone
- Volunteers
- 115 people
- Sponsor
- Janssen Pharmaceutica
Fungal Prophylaxis, Candida Infection
Antifungal Prophylaxis in Intensive Care Unit (ICU) Patients
Purpose. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonization and infection. However, Candida prophylaxis in intensive care unit (ICU) is still a matter of debate. Methods.
- Conditions
- Fungal Prophylaxis, Candida Infection, Critical Illness, Surgery
- Trial name
- NCT01495039
- Testing
- Nystatin
- Where
- Italy
- Volunteers
- 99 people
- Sponsor
- Policlinico Hospital
Infection, Bacterial
Comparison of Sterile Gauze and Semi-permeable Film Dressing for Hemodialysis Central Venous Catheter
This prospective single center RCT aims to compare sterile gauze and tape versus Semi-permeable film dressing on the incidence of exit-site infection, CRBSIs (catheter-related bloodstream infections), skin irritation, total…
- Trial name
- NCT04800575
- Testing
- semi-permeable film, sterile gauze and tape
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Peking University People's Hospital
Cholera
Safety and Immunogenicity of the Live Oral Cholera Vaccine Candidate PXVX0200
The purpose of this study is to compare the safety and immunogenicity of a single dose of the PXVX0200 live cholera vaccine versus placebo in volunteers (Vaccinees) and whether PXVX0200, which is a live attenuated bacteria, can…
- Trial name
- NCT01585181
- Testing
- PXVX0200
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Mycosis Fungoides
Phototherapy and Mogamulizumab in Early Stage MF (PLIGHT)
This is an open label, single arm, single-center, pilot study of concurrent phototherapy and POTELIGEO (mogamulizumab-kpkc) in early-stage mycosis fungoides.
- Trial name
- PLIGHT (NCT06235281)
- Testing
- Mogamulizumab-Kpkc, Phototherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Whooping Cough
Viaskin Pertussis Vaccine Trial
The study is a Phase I, first in human, monocenter study, aiming at assessing the safety and immunogenicity of a genetically detoxified pertussis toxin (PT) when administered via the cutaneous route with Viaskin patches to…
- Trial name
- NCT03035370
- Testing
- Viaskin PT 25 mcg, Viaskin PT 50 mcg, Boostrix™
- Where
- Switzerland
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- DBV Technologies
HIV, PrEP
Same-Day PrEP Initiation and Sexual Health for Transgender Women
Transgender women (trans women; assigned male sex at birth but identify as female) are at high risk for HIV infection, and are an important, under-researched population in sub-Saharan Africa.
- Conditions
- HIV, PrEP, Transgender Women, Sexually Transmitted Diseases, Bacterial
- Trial name
- NCT04491422
- Testing
- Integrated Next Steps Counseling with Real-Time Drug Level Feedback
- Where
- Uganda
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Makerere University
Leprosy
Novel Interventions and Diagnostic Tests for Leprosy
Contact with Mycobacterium leprae (M. leprae) infected individuals is a risk factor for development of leprosy. Thus, detection of asymtomatically M.
- Trial name
- INDIGO#2 (NCT06222372)
- Testing
- Rifampin
- Where
- Bangladesh
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Annemieke Geluk
Diabetes Mellitus, Pulmonary Tuberculosis
Pulmonary Tuberculosis Patients With Diabetes Mellitus
The purpose of this study is to evaluate the effect of enhanced glycemic monitoring of diabetes upon diabetes glycaemic control during tuberculosis treatment in tuberculosis- diabetes patients.
- Trial name
- TANDEM (NCT02106039)
- Testing
- intensive monitoring
- Where
- 3 sites in Indonesia, Peru and 1 more
- Volunteers
- 350 people
- Sponsor
- Universitas Padjadjaran
Cirrhosis
Study Of Bacterial/Fungal Infections in Hospitalized Patients With Liver Cirrhosis in China
This is a national, investigator-initiated, multicenter, prospective, observational, web-based registry in hospitalized patients with cirrhosis across China.
- Trial name
- SONIC (NCT03676777)
- Where
- 23 sites in China
- Volunteers
- 1,232 people
- Sponsor
- Ruijin Hospital
Tuberculosis (TB), Tuberculosis Infection, Latent
Screening With Portable X-rays for Rapid Recognition of TB
SPOT-TB (Screening with Portable X-rays for rapid recOgniTion of TB) is a prospective study evaluating a community-based tuberculosis (TB) screening strategy for migrant populations in New York City.
- Conditions
- Tuberculosis (TB), Tuberculosis Infection, Latent, HIV (Human Immunodeficiency Virus)
- Trial name
- SPOT-TB (NCT07737275)
- Testing
- Mobile chest radiography for tuberculosis screening
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Infant, Newborn, Respiratory Insufficiency
Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure
This pilot study was a randomized, placebo-controlled, clinical trial to test the safety of using the intravenous form of Prostaglandin E1 (PGE1) in an inhaled form for treatment of hypoxemic respiratory failure in term newborns.
- Conditions
- Infant, Newborn, Respiratory Insufficiency, Pulmonary Hypertension, Respiratory Distress Syndrome, Newborn
- Trial name
- IPGE1 (NCT00598429)
- Testing
- Inhaled Prostaglandin E1
- Where
- 11 sites in United States
- Sponsor
- NICHD Neonatal Research Network
Bacteremia, Sepsis
Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care
Eurobact II will investigate the mortality and morbidity of hospital-acquired blood stream infections in patients treated in intensive care units (ICU).
- Conditions
- Bacteremia, Sepsis, Hospital Acquired Condition, Resistance Bacterial
- Trial name
- EurobactII (NCT03937245)
- Where
- 2 sites in Australia, France
- Volunteers
- 3,058 people
- Sponsor
- Outcome Rea
Pyoderma Gangrenosum, Hidradenitis Suppurativa
JAK-STAT Signaling Pathway in Pyoderma Gangrenosum
The investigators hypothese that Janus kinase/signal transduction and activator of transcription (JAK/STAT) signaling pathway play a key role in pathophysiology of pyoderma gangrenosum (PG).
- Conditions
- Pyoderma Gangrenosum, Hidradenitis Suppurativa, Psoriasis
- Trial name
- NCT04792957
- Testing
- immunohistochemical methods
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Pneumonia, Bacterial
The Effect of a Point-of-care Sputum Specimen Assay at the Emergency Department for Patients Suspected of Pneumonia
Antibiotic resistance has been identified by the WHO as one of the biggest threats to the health of the world population. In Denmark, there has been an increasing focus on optimizing antibiotic consumption in recent years, but…
- Trial name
- NCT04651712
- Testing
- POC-PCR
- Where
- Denmark
- Volunteers
- 290 people
- Sponsor
- University of Southern Denmark
Onychomycosis
Open-Label Pharmacokinetics (PK)/Safety Study of Luliconazole Solution, 10% in Distal Subungual Onychomycosis
To determine the safety, tolerability, systemic exposure and pharmacokinetics of luliconazole after repeat daily topical application of Luliconazole Solution, 10% in a maximal use setting in adults with distal subungual…
- Trial name
- NCT01044381
- Testing
- Luliconazole Solution, 10%
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Topica Pharmaceuticals
Southern Tick-Associated Rash Illness
Investigation of Southern Tick-Associated Rash Illness (STARI)
This study will evaluate blood and tissue samples for a condition called Southern Tick-Associated Rash Illness (STARI). This is a skin rash resembling erythema migrans, the rash found in people infected with Lyme disease.
- Trial name
- NCT00358761
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis, HIV
Assessing the Feasibility of Coach Mpilo for Men With TB and HIV
Men are less likely to report TB-related symptoms, get diagnosed, smear convert, or complete treatment, suggesting that outcomes along the TB cascade are worse for men.
- Trial name
- Coach Mpilo (NCT07117370)
- Testing
- Coach Mpilo
- Where
- South Africa
- Volunteers
- 240 people
- Sponsor
- Arizona State University
Bacterial Infections, Bone Diseases, Infectious
Fosfomycin I.v. for Treatment of Severely Infected Patients
The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin…
- Conditions
- Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
- Trial name
- FORTRESS (NCT02979951)
- Where
- 50 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Infectopharm Arzneimittel GmbH
Denture Stomatitis, Oral Candidosis
Efficacy of 5% Nanochitosan Paste in the Treatment of Oral Candidosis
This study is designed to survey the therapeutic effect of a low molecular weight 5% nanochitosan paste against oral candidosis (denture stomatitis) and compare its efficacy with a standard Nystatin ointment.
- Trial name
- NCT07793331
- Testing
- 5% Nanochitosan Paste, Nystatin Ointment
- Volunteers
- 30 people
- Sponsor
- Kerman University of Medical Sciences
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