Clinical trials: Fungal Diseases
Haemophilus Influenzae Type b, Diphtheria
Safety of DTPa-IPV/Hib & DTPa-HBV-IPV/Hib, Followed by DTPa-IPV/Hib Vaccine in Infants Who Received Hepatitis B Vaccine
To assess the safety and reactogenicity of the DTPa-HBV-IPV/Hib vaccine and DTPa-IPV/Hib vaccine. This DTPa-IPV/Hib vaccine given at 3 and 4 months of age is co-administered with GSK Biologicals' rotavirus vaccine or Placebo.
- Conditions
- Haemophilus Influenzae Type b, Diphtheria, Tetanus, Poliomyelitis
- Trial name
- NCT00325143
- Testing
- DTPa-HBV-IPV/Hib, DTPa-IPV/Hib vaccine
- Where
- 3 sites in Singapore
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Onychomycosis of Toenails, Onychomycosis of Fingernail
Exploring Different Dose-frequency Home Photodynamic Therapy Protocols Using a Novel Home-targeted LED Device for Onychomycosis
This randomized feasibility trial aims to determine the optimal light energy dose and treatment frequency for home-based photodynamic therapy (hPDT) using a novel LED device (L-Home PhoD) for the treatment of onychomycosis.
- Trial name
- HomePDT_Nails (NCT07012343)
- Testing
- Photodynamic Therapy with Conventional Methylene Blue, urea 40% cream
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chulalongkorn University
Cutaneous T-Cell Lymphoma
Study of Oral LBH589 in Adult Participants With Refractory/Resistant Cutaneous T-Cell Lymphoma (CTCL)
This study evaluated the safety and efficacy of LBH589B in adult participants with refractory/resistant Cutaneous T-Cell Lymphoma and prior Histone Deacetylase (HDAC) inhibitor therapy.
- Trial name
- NCT00490776
- Testing
- Panobinostat
- Where
- 18 sites in United States
- Volunteers
- 9 people
- Sponsor
- Novartis Pharmaceuticals
Tuberculosis (TB)
Usability mTBScreen
Building on recent developments in the sphere of digital health and data science, as well as the principles of usability engineering, we propose to assess the usability of a digital tool called mTBscreen for tuberculosis (TB)…
- Trial name
- mTBscreen (NCT07840989)
- Testing
- mTBscreen Application, Mobile phone Application
- Where
- 4 sites in Zambia
- Volunteers
- 30 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
Tuberculosis
Pharmacokinetics and Pharmacodynamics of High Versus Standard Dose Rifampicin in Patients With Pulmonary Tuberculosis
In this phase II clinical trial, the pharmacokinetics, safety and (short-term) efficacy of higher than standard doses rifampicin will be studied during the intensive phase of tuberculosis (TB) treatment.
- Trial name
- High RIF (NCT00760149)
- Testing
- Rifampicin in higher doses
- Where
- Tanzania
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Infection, Cross Infection
A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections
The purpose of this study is to assess the safety and efficacy of doripenem in participants with nosocomial pneumonia (inflammation of the lungs in which the lungs become heavy; pneumonia occurring at least 48 hours after…
- Conditions
- Infection, Cross Infection, Bacterial Infections, Pneumonia, Ventilator-Associated
- Trial name
- NCT00965848
- Testing
- Doripenem
- Where
- 8 sites in Thailand
- Volunteers
- 270 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Pertussis
2-year Follow-up After a Single Dose Acellular Pertussis Vaccination
In July 2015-November 2016, a phase II/III randomized, observer-blind,controlled study of two acellular Pertussis vaccines (aP standalone and TdaP combined vaccined) manufactured by BioNet-Asia Co., Ltd.
- Trial name
- NCT04113655
- Testing
- Pertagen (aP BioNet), Boostagen (TdaP BioNet), Adacel
- Where
- 2 sites in Thailand
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Meningitis, Meningococcal
A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Infants
This study will evaluate the safety and immune response of the Novartis Meningococcal ACWY conjugate vaccine when administered with routine infant vaccinations to healthy infants.
- Trial name
- NCT00474526
- Testing
- Meningococcal ACWY Conjugate Vaccine, DTaP-IPV-HBV, Hib
- Where
- 63 sites in United States, Argentina and 1 more
- Volunteers
- 4,545 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Rheumatic Heart Disease in Children, Latent Rheumatic Heart Disease
Determining the Impact of Penicillin in Latent RHD: The GOAL Trial
Rheumatic heart disease (RHD) affects at least 32.9 million people, mostly children living in low-resource settings. Long-term intramuscular benzathine penicillin G (BPG) prophylaxis is proven to prevent progression of chronic…
- Conditions
- Rheumatic Heart Disease in Children, Latent Rheumatic Heart Disease, Rheumatic Heart Disease, Heart Diseases
- Trial name
- GOAL (NCT03346525)
- Testing
- intramuscular benzathine penicillin G (BPG) prophylaxis
- Where
- Uganda
- Volunteers
- 807 people
- Sponsor
- Children's National Research Institute
Yaws, Cutaneous Ulcer
Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws)
The goal of this clinical trial is to test the non inferiority of linezolid compared with azithromycin as a treatment for yaws .
- Trial name
- Trep-AByaws (NCT05764876)
- Testing
- Linezolid Oral Tablet, Azithromycin Oral Tablet
- Where
- Papua New Guinea
- Volunteers
- 383 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Vaginal Health
Garden of Life Once Daily Women's Probiotic: Vaginal pH and Quality of Life Study
This decentralized observational study is designed to understand the effects of daily consumption of once daily woman's probiotic (ODWP) on vaginal pH levels in healthy female populations ages 19-70 years of age across the United…
- Trial name
- NCT05330091
- Testing
- Once Daily Women's Probiotic
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Garden of Life, LLC
Onychomycosis
The Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis
The purpose of this study is to evaluate the safety and efficacy of topical application of IDP-108 versus vehicle in treating patients with onychomycosis.
- Trial name
- NCT01007708
- Testing
- IDP-108, Vehicle
- Where
- 44 sites in United States, Canada
- Volunteers
- 780 people
- Sponsor
- Dow Pharmaceutical Sciences
Anthrax
BARDA Securing Anthrax Immunity For the Elderly
This study is designed to assess the safety and ability of BioThrax and AV7909 anthrax vaccines to generate an immune response in adults ≥ 66 years of age in stable health in comparison to adults 18-50 years of age in stable…
- Trial name
- B-SAFE (NCT03518125)
- Testing
- BioThrax, AV7909
- Where
- 4 sites in United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Biomedical Advanced Research and Development Authority
Fungal Invasive Disease
Predictive Factors of Mortality in Invasive Fungal Disease in Post-surgical Critical Care Unit
Invasive fungal disease in the critically ill patient is a serious complication that increases hospitalization times, morbidity and mortality, and healthcare costs.
- Trial name
- FPR-IIS (NCT04484376)
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- Hospital Universitario La Fe
Listeriosis, Pregnancy Complications
National Study on Listeriosis and Listeria
Listeriosis is a foodborne infection responsible for severe disease. Three main forms are described: septicaemia, central nervous system infections and maternal-fetal infections.
- Conditions
- Listeriosis, Pregnancy Complications, Infectious, Central Nervous System Infections
- Trial name
- MONALISA (NCT01520597)
- Where
- France
- Volunteers
- 2,132 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumococcal Disease
A Study to Assess the Safety, Tolerability, and Immunogenicity of 3 Lots of a Multivalent Pneumococcal Conjugate Vaccine Administered to Adults
The purpose of this study is to provide safety data and demonstrate lot consistency with the PG4 vaccine by evaluating the immunogenicity of 3 different lots of this vaccine.
- Trial name
- NCT07794748
- Testing
- PG4 Multivalent Vaccine, 20 Valent Pneumococcal Conjugate Vaccine (20vPnC)
- Where
- 37 sites in United States
- Volunteers
- 4,670 people, healthy volunteers welcome
- Sponsor
- Pfizer
Invasive Fungal Infections
A Russian Prospective Observational Study of Invasive Fungal Infections in Patients With Acute Leukemia and Hematopoietic Stem Cell Transplantation
Estimate the rate of occurrence of Invasive Fungal Infections (IFIs) in patients with acute leukemia for the first 6 months of chemotherapy (that usually correspond to four courses of chemotherapy), and hematopoietic stem cells…
- Trial name
- NCT01519648
- Where
- Russia
- Volunteers
- 808 people
- Sponsor
- National Hematological Society, Russia
HIV-1-infection, Bacterial Vaginoses
Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women
This study will enrol African, Caribbean and Black (ACB) women who are known to have a more diverse vaginal microbiome, higher rates of bacterial vaginosis with lower numbers of protective lactobacilli, and are at increased risk…
- Trial name
- NCT03837015
- Testing
- Estring Vaginal Ring, RepHresh Pro-B
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cutaneous T Cell Lymphoma, Mycosis Fungoides
A Phase 1, Open-label Study of the Absorption, Metabolism, Excretion of [14C]-Resminostat
Resminostat is a potent, orally available inhibitor of Class I, IIb and IV histone deacetylases (HDACs), including a pronounced activity against HDAC6.
- Conditions
- Cutaneous T Cell Lymphoma, Mycosis Fungoides, Sezary Syndrome
- Trial name
- NCT04955340
- Testing
- [14C]-resminostat
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- 4SC AG
Bacterial Vaginosis, HIV
Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity
The investigators propose to explore the hypothesis-supported by limited data-that a contraceptive vaginal ring (CVR) that is commonly used in the United States, the NuvaRing, will enhance women's genital and reproductive health.
- Trial name
- NCT02445989
- Testing
- NuvaRing
- Where
- Kenya
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Washington
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.