Clinical trials: Fungal Diseases
Major Cutaneous Abscess, Cellulitis
A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study
Characterization of the safety profile of TR-701 Free Acid (FA) in patients with major cutaneous abscess or cellulitis/erysipelas.
- Conditions
- Major Cutaneous Abscess, Cellulitis, Erysipelas
- Trial name
- NCT01519778
- Testing
- TR701 FA
- Where
- 10 sites in United States
- Volunteers
- 200 people
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Staphylococcus Aureus
Evaluation of a Diagnostic Device for Detection of Nasal Staphylococcus Aureus
To establish the clinical test performance characteristics of sensitivity, specificity and predictive values for direct detection of nasal Staphylococcus aureus colonization against clinical microbiology laboratory culture…
- Trial name
- NCT00406549
- Where
- 11 sites in United States, France and 2 more
- Volunteers
- 2,000 people
- Sponsor
- Solventum US LLC
Enterobacteriaceae Infections
Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae
The continuous increase in the bacterial resistance rate and the slow arrival of new therapeutic options have turned into an antibiotic crisis.
- Trial name
- SIMPLIFY (NCT02795949)
- Testing
- Antipseudomonal beta-lactam antibiotic, De-escalation(short-spectrum antibiotic)
- Where
- 21 sites in Spain
- Volunteers
- 344 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Phase II Safety and Efficacy Study of Clarithromycin in the Treatment of Disseminated M. Avium Complex (MAC) Infections in Patients With AIDS
This study is designed to evaluate the efficacy and safety of clarithromycin given orally at 1 of 3 doses to treat disseminated Mycobacterium avium complex infections (MAC) in patients with AIDS.
- Trial name
- NCT00000644
- Testing
- Clarithromycin
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neisseria Gonorrheae Infection
Performance, Acceptability, and Usability of a Novel Rapid Lateral Flow Test for Detecting Neisseria Gonorrhoeae in Pregnant and Symptomatic Women Attending Clinics in South Africa.
Previous studies of the Neisseria gonorrhoeae (NG) lateral flow assay (LFA) have shown promising results. In East London, South Africa, the LFA demonstrated a sensitivity of 80% in asymptomatic women.
- Trial name
- GO-SA (NCT07530406)
- Testing
- Novel Lateral Flow Assay for Neisseria gonorrhoeae
- Where
- South Africa
- Volunteers
- 1,239 people, healthy volunteers welcome
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Bacterial Meningitis, Neonatal Infection
Neonatal Bacterial Meningitis Cohort
Neonatal bacterial meningitis (BM) is a devastating infection that occurs more commonly in neonates than in any other age group, and is associated with significant morbidity and mortality, especially in developing countries.
- Trial name
- NCT03499652
- Testing
- neonatal bacterial meningitis risk score
- Where
- 2 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Anthrax
A Study to Assess Dose-Response, Efficacy (Immunogenicity) and the Safety of GC1109
The purpose of this study is to Assess Dose-Response, Efficacy (Immunogenicity) and the Safety of GC1109 Administered in Multi Intramuscular Doses to Healthy Subjects.
- Trial name
- GC1109 (NCT01624532)
- Where
- South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Green Cross Corporation
Aspergillosis
A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA).
The combination of Anidulafungin plus AmBisome® may offer an improved outcome for patients treated for Invasive Aspergillosis (IA).
- Trial name
- NCT00037206
- Testing
- Anidulafungin, VER002
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Pfizer
Invasive Pulmonary Aspergillosis, Chronic Obstructive Pulmonary Disease
Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease
The investigators propose to study the efficacy and safety of three-week antifungal therapy with caspofungin in hospitalized patients with proven or probable IPA underlying chronic obstructive pulmonary disease.
- Trial name
- NCT01499433
- Testing
- caspofungin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Diseases, Tuberculosis
Promoting Adherence to TB Regimens in Latino Adolescents
To test a public health model of screening, preventive isoniazid treatment, and adherence counseling plus medical education of primary care clinicians to enhance their skills and attention to TB control.
- Trial name
- NCT00005738
- Sponsor
- San Diego State University
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Tuberculosis
Efficacy, Safety and Immunogenicity Evaluation of MTBVAC in Newborns in Sub-Saharan Africa
The objective of this project is to demonstrate safety, immunogenicity and improved efficacy of the new live attenuated M. tuberculosis vaccine called MTBVAC in a Phase 3 efficacy trial in HIV-uninfected infants born to…
- Trial name
- MTBVACN3 (NCT04975178)
- Testing
- MTBVAC, BCG
- Where
- South Africa
- Volunteers
- 7,120 people, healthy volunteers welcome
- Sponsor
- Biofabri, S.L
Cryptococcal Meningitis
Clinical Effectiveness and Safety of Amphotericin B With Flucytosine-Fluconazole Therapy for Cryptococcal Meningitis
To study the clinical effectiveness and safety of amphotericin B with flucytosine-fluconazole therapy for cryptococcal meningitis in patients with HIV infection.
- Trial name
- NCT04532463
- Testing
- Amphotericin B 1 mg/kg 1 week & Flucytosine 100 mg/kg 1 week followed by Fluconazole 1200 mg/day 1 week
- Where
- Burma
- Volunteers
- 30 people
- Sponsor
- University of Pharmacy, Yangon
Rifampicin-resistant Tuberculosis
French National Cohort of Patients With Rifampicin-Resistant Tuberculosis
A major obstacle in the fight against multidrug-resistant tuberculosis is its treatment. In 2021, only 60% of patients with MDR/RR tuberculosis who received treatment globally were successfully cured, while 12% succumbed to the…
- Trial name
- CONTRol-TB (NCT06565806)
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tuberculosis
Multicenter Trial for the Evaluation of a Fixed Dose Combined Tablet for the Treatment of Pulmonary Tuberculosis
The use of fixed-dose combined (FDC) drugs in the treatment of tuberculosis by National Tuberculosis Programmes has been recommended by both the International Union Against Tuberculosis and Lung Disease (The Union) and the World…
- Trial name
- NCT00216333
- Testing
- combined fixed dose combination
- Where
- 9 sites in Algeria, Bolivia and 7 more
- Volunteers
- 1,500 people
- Sponsor
- International Union Against Tuberculosis and Lung Diseases
Spondyloarthritis, Ankylosing Spondylitis
Effect of a Low Starch Diet in Patients With Ankylosing Spondylitis
The aim of this study is to explore the effect of a low starch diet (reduction of at least 40%) in the gut bacteria modulation, especially Klebsiella pneumoniae, and its relation to disease activity, functional impairment and…
- Trial name
- NCT04386538
- Testing
- Low Starch Diet (LSD), General healthy eating
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Universidade do Porto
Surgical Site Infections, Infections
Light-Activated Antimicrobial Therapy to Prevent Surgical Site Infections - Canada
This is a Phase 4 multi-center, group-randomized, crossover trial to compare nasal antimicrobial photodisinfection therapy (aPDT) with standard of care for prevention of surgical site infections in patients undergoing major…
- Conditions
- Surgical Site Infections, Infections, Surgical Wound Infections, Anti-Infective Agents
- Trial name
- LANTERN (NCT07189858)
- Testing
- Nasal antimicrobial photodisinfection therapy
- Where
- 4 sites in Canada
- Volunteers
- 401 people
- Sponsor
- Ondine Biomedical Inc.
Tick Borne Encephalitis, Lyme Disease
Tick-borne Encephalitis and Possible Borrelial Serology
In Europe, tick-borne encephalitis (TBE) virus causing TBE is transmitted by the bite of Ixodes ricinus tick, which can also transmit Lyme borreliae , the causative agent of Lyme borreliosis (LB).
- Trial name
- NCT03958058
- Testing
- Anti-borrelial antibiotic therapy, No antibiotic.
- Where
- Slovenia
- Volunteers
- 690 people
- Sponsor
- University Medical Centre Ljubljana
Healthy
Safety and Efficacy of Two Tetanus-Diphtheria Vaccines for a Donor Hyper Immunization Program
Many plasma donation centers have Tetanus immunization programs that are implemented in order to collect plasma with high levels of tetanus antibodies.
- Trial name
- NCT02673255
- Testing
- Tetanus and Diphtheria (Td) Vaccine
- Where
- 4 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Biomat USA, Inc.
Immune Modulation, Tuberculosis
CD8 Reactivity to Microorganisms in Blood and Breast Milk
Background: When a person is exposed to something that causes an infection, the body sends a type of cell called CD8 T cells to attack it. Those cells are also found in breast milk.
- Conditions
- Immune Modulation, Tuberculosis, Leprosy, Pertussis
- Trial name
- NCT03084614
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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