Clinical trials: Fungal Diseases
HIV Infections, Tuberculous Meningitis
Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis
The optimal time to initiate antiretroviral therapy (ART) in HIV-associated tuberculous meningitis (TBM) unknown. There are concerns that immediate ART may worsen rather than improve outcome, because drug interactiond and…
- Trial name
- NCT00433719
- Testing
- Combivir and efavirenz
- Where
- 2 sites in Vietnam
- Volunteers
- 253 people
- Sponsor
- University of Oxford
Anthrax
Single Dose, Weight-Based, Dose-Escalation Study With Intravenous ETI-204 in Adult Volunteers
This study will determine the safety and PK of a single IV dose of ETI-204 in subjects 18 to 65 years of age. Three cohorts will be studied with subjects receiving ETI-204.
- Trial name
- NCT01453907
- Testing
- ETI-204, "Anthim"
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Elusys Therapeutics
Coccidioidomycosis
A Multi-center Study of Spherule-Derived Coccidioidin
Adult volunteers were skin tested with 1.27 ug spherule-derived coccidioidin. The skin test antigen was evaluated in three different populations of adult volunteers to determine the safety and efficacy of the product in the…
- Trial name
- NCT00690092
- Testing
- Spherule-derived coccidioidin
- Where
- 4 sites in United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Nielsen BioSciences, Inc.
Antibiotic Enterocolitis
Effect of Antibiotics on Enteric Neurons and Glia
The interactions between bacteria and their products with the intestinal tissue are important for maintaining a healthy and balanced system.
- Trial name
- NCT05834036
- Testing
- Amoxicillin Oral Capsule
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Fatigue, Inflammatory Rheumatism
Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases
Fatigue is common and debilitating in rheumatic inflammatory diseases as for other chronical medical conditions. The purpose of this study is to develope and evaluate a cognitive behavioural intervention targeting fatigue.
- Trial name
- NCT03216616
- Testing
- Cognitive Behavioural Therapy
- Volunteers
- 40 people
- Sponsor
- Diakonhjemmet Hospital
TB
Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine
Tuberculosis (TB) kills about three million people annually. It is estimated that one third of the world's population are latently infected with Mycobacterium tuberculosis (M.tb).
- Trial name
- NCT00654316
- Testing
- BCG
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cystic Fibrosis Pulmonary Exacerbation
Markers of Pulmonary Dysbiosis Associated With Exacerbation in Patients Followed for Cystic Fibrosis
The aim objective is to identify markers of bacterial, viral and fungal pulmonary dysbiosis, associated with the occurrence of exacerbation in patients followed for cystic fibrosis.
- Trial name
- DYSBIOSE-CF (NCT03569904)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Grenoble
Tuberculosis, HIV
Evaluation Of The Performance Of The Nitrate Reductase And Resazurin Titre Assay For The Detection of Mycobacterium Tuberculosis Complex From Sputum In A High Tb and Hiv Setting
The Principle objective of this study is To evaluate the performance of NRA, NRA-p and REMA-p for the detection of M. tuberculosis complex from sputum samples from adult pulmonary TB suspects in a high TB and HIV prevalence…
- Conditions
- Tuberculosis, HIV, AIDS, HIV Infections
- Trial name
- NRA RETA (NCT01053598)
- Where
- Uganda
- Volunteers
- 600 people
- Sponsor
- Epicentre
Urinary Tract Infection
Immediate vs. Conditional Use of Antibiotics in Uncomplicated Urinary Tract Infection (UTI) - ICUTI
In this study, patients with uncomplicated urinary infection are investigated. It is investigated if treatment of only symptoms of the uncomplicated urinary infection is as effective as treatment with antibiotics with respect to…
- Trial name
- NCT01488955
- Testing
- Ibuprofen, Fosfomycin-Trometamol
- Where
- 2 sites in Germany
- Volunteers
- 494 people
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Latent Tuberculosis
Microneedles for Diagnosis of LTBI
This study will evaluate new technique, microneedle, to detect latent tuberculosis (TB) in healthy volunteers
- Trial name
- NCT04552015
- Testing
- TST vs PPD microneedle test
- Where
- Thailand
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Pharmacokinetics, Antibacterial Agents
Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients
Multidrug resistance towards Gram-negative pathogens makes essential the re-examination of older compounds. Temocillin is a penicillin originally marketed in the 1980s but then largely abandoned.
- Conditions
- Pharmacokinetics, Antibacterial Agents, Infections, Bacterial, Infection
- Trial name
- TEMODELTA (NCT03557840)
- Testing
- temocillin
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Paul M. Tulkens
Helicobacter Infection
Comparison of Sequential or Concomitant Therapy for Helicobacter Pylori Infection
Helicobacter pylori is a bacteria that infects the lining of the stomach and is associated with ulcers. Helicobacter pylori may also increase the long-term risk of developing certain forms of gastric cancer.
- Trial name
- 960025 (NCT00656968)
- Testing
- 10-day sequential treatment, 10-day concomitant therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 232 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Chronic Myeloproliferative Disorders, Leukemia
Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant
RATIONALE: Studying immune response to flu vaccine in patients who have undergone a stem cell transplant may help doctors plan the best treatment.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00964821
- Testing
- trivalent influenza vaccine, Immunoenzyme technique, Laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Tuberculosis, Pleural Effusion
Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion
Tuberculosis (TB) remains as an important public health problem worldwide. Pleural tuberculosis is the most prevalent form of extrapulmonary presentation in immunocompetent patients.
- Trial name
- NCT00560521
- Testing
- CPAP
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Tuberculous Meningitis
Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis
The genetically polymorphic N-acetyltransferase type 2 (NAT2) is responsible for isoniazid metabolism, and rapid acetylators were associated with low concentrations of isoniazid based on previous studies.
- Trial name
- NCT03787940
- Testing
- Isoniazid
- Where
- 4 sites in China
- Volunteers
- 676 people
- Sponsor
- Beijing Chest Hospital
Infection, Cross Infection
A Safety and Efficacy Study of Doripenem in Participants With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Urinary Tract Infections
The purpose of this study is to assess the safety and efficacy of doripenem in participants with nosocomial pneumonia (inflammation of the lungs in which the lungs become heavy; pneumonia occurring at least 48 hours after…
- Conditions
- Infection, Cross Infection, Bacterial Infections, Pneumonia, Ventilator-Associated
- Trial name
- NCT00965848
- Testing
- Doripenem
- Where
- 8 sites in Thailand
- Volunteers
- 270 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Lung Diseases, Obstructive, Pulmonary Rehabilitation
Respiratory Function in Patients With Post-tuberculosis Lung Impairment
Pulmonary tuberculosis (TB) is an important risk factor for chronic respiratory disease due to residual lung damage. A recent review of the literature on TB sequelae and rehabilitation has provided clear evidence that TB is…
- Conditions
- Lung Diseases, Obstructive, Pulmonary Rehabilitation, Lung TB
- Trial name
- NCT03821285
- Testing
- Pulmonary Rehabilitation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Università degli Studi dell'Insubria
Tinea Cruris
Topical Antifungal Treatment for Tinea Cruris
To determine if a topical antifungal cream is safe and effective for the treatment of tinea cruris
- Trial name
- NCT01342315
- Testing
- 33525
- Where
- 21 sites in United States, Belize and 3 more
- Volunteers
- 483 people
- Sponsor
- Medicis Global Service Corporation
Onychomycosis, Dermatophytosis
Study Evaluating the Effect of Jublia on Dermatophytomas
This study will examine how Jublia affects dermatophytomas, which are difficult to treat with other therapeutic options.
- Trial name
- NCT03098615
- Testing
- Jublia (Efinaconazole 10% Topical Solution)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Breast Cancer, Chronic Myeloproliferative Disorders
Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining chemotherapy and peripheral stem cell transplantation with biological therapy may kill more cancer…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Kidney Cancer
- Trial name
- NCT00003408
- Testing
- aldesleukin, recombinant interferon alfa, sargramostim
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cancer Treatment Centers of America
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