Clinical trials: Fungal Diseases
Pneumonia, Bacterial
Blinded Efficacy and Safety Study of CAL02 IV Plus SOC in Subjects With Severe Community-Acquired Bacterial Pneumonia
This is a placebo-controlled study to evaluate the addition of CAL02 to standard of care in treating hospitalized subjects diagnosed with severe community acquired bacterial pneumonia (SCABP) requiring critical care measures
- Trial name
- NCT05776004
- Testing
- CAL02
- Where
- 90 sites in United States, Argentina and 17 more
- Volunteers
- 276 people
- Sponsor
- Eagle Pharmaceuticals, Inc.
Pneumocystis Jirovecii Infection
Pneumocystis Jirovecii Pneumonia in Non-HIV-infected Immunocompromised Patients
Pneumocystis jirovecii pneumonia (PjP) is a rare infectiouse disease with a high level of mortality. PjP is a classical opportunistic infection which concern HIV infected and immunocompromised patients.
- Trial name
- PnP-HIV-Free (NCT05458752)
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Central Hospital, Nancy, France
Brucellosis
A Multicentre, Retrospective Study of Clinical Characteristics and Long-term Outcomes of Patients With Brucellosis
This is a multicenter, retrospective clinical study, in patients with brucellosis, to analyze the clinical characteristics, complications, and the impact of different treatment options on long-term prognosis of patients with…
- Trial name
- NCT06007326
- Where
- 8 sites in China
- Volunteers
- 200 people
- Sponsor
- Qin Ning
Fungal Allergy, Allergy
Mold Allergy in Austria: Clinical Relevance of Alternaria Alternata and Related Species
Mold allergies are becoming increasingly important among the population. Increasing amounts of fungal spores are analyzed in air-samples because of urbanization, industrialization of food products and climate change.
- Trial name
- NCT05101733
- Testing
- Nasal provocation, Skin-Prick Test, Blood draw
- Where
- Austria
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Tuberculosis
Evaluating the EBA of Meropenem With Amoxicillin/Clavulanate and Pyrazinamide or Bedaquiline in Adults With PTB
A single-center, open-label clinical trial to determine the early bactericidal activity (EBA) and safety of the combination of meropenem and amoxicillin/clavulanate plus pyrazinamide vs.
- Trial name
- TB_COMBO_01 (NCT04629378)
- Testing
- Meropenem Injection, Amoxicillin Clavulanate, Pyrazinamide
- Where
- South Africa
- Volunteers
- 22 people
- Sponsor
- TASK Applied Science
Syphilis
Finding the Latent Treponema Pallidum
Some syphilitic patients remain in a serologically positive state after the recommended therapy. Whether a serofast state could represent a persistent low-level infection by Treponema pallidum is still unknown.
- Trial name
- NCT03754517
- Testing
- RPR Titer
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Cancer, Bacteremia
Procalcitonin Levels as a Predictor of Bacteremia in Febrile Pediatric Oncology Patients-Pilot Study
Fevers raise the concern for serious bacterial infections in pediatric oncology patients receiving chemotherapy. The gold standard for diagnosing bacteremia (bacterial infection of the blood) is a blood culture.
- Trial name
- NCT02417168
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- CAMC Health System
Tick Borne Encephalitis, Lyme Disease
Tick-borne Encephalitis and Possible Borrelial Serology
In Europe, tick-borne encephalitis (TBE) virus causing TBE is transmitted by the bite of Ixodes ricinus tick, which can also transmit Lyme borreliae , the causative agent of Lyme borreliosis (LB).
- Trial name
- NCT03958058
- Testing
- Anti-borrelial antibiotic therapy, No antibiotic.
- Where
- Slovenia
- Volunteers
- 690 people
- Sponsor
- University Medical Centre Ljubljana
Tuberculosis
Innovative Approach in Tuberculosis Care in Armenia
Randomized trial tests effectiveness of self-administered drug intake by empowered TB patients - supervised by a trained family member and supported by medical counseling and reminders - to improve treatment adherence and…
- Trial name
- NCT02082340
- Testing
- TB knowledge and socio-psychological counseling session, SMS text messages, phone calls
- Where
- Armenia
- Volunteers
- 392 people
- Sponsor
- Varduhi Petrosyan
Haemophilus Influenzae Type b, Neisseria Meningitidis
3 Formulations of Hib-MenCY-TT Vaccine & 1 Formulation of Hib-MenC-TT Vaccine Compared to Licensed Meningococcal Serogroup C Conjugate Vaccine, Each Administered at 2,3,4 Mths of Age
This study evaluated the safety and immunogenicity of 3 formulations of Hib-MenCY-TT vaccine and 1 formulation of Hib-MenC-TT vaccine compared to a control group receiving licensed meningococcal serogroup C conjugate vaccine…
- Trial name
- NCT00129116
- Testing
- Hib-MenCY-TT vaccine, Hib-MenC-TT vaccine, Menjugate ®
- Where
- 26 sites in Belgium, Germany
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pneumococcal Disease
A Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 With Influenza Vaccine in Adults ≥ 50 Years of Age
This is a Phase 3, randomized, double-blind study to evaluate the safety and immunogenicity of VAX-31 and seasonal influenza vaccine in pneumococcal-naïve adults ≥ 50 years when the two vaccines are administered at the same visit…
- Trial name
- NCT07365826
- Testing
- 31-valent pneumococcal conjugate vaccine, Seasonal Influenza Vaccine (SIV) (Flublok)
- Where
- 25 sites in United States
- Volunteers
- 1,390 people, healthy volunteers welcome
- Sponsor
- Vaxcyte, Inc.
Fungal Infection, Acute Myelogenous Leukemia
Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)
The purpose of this study is: to explore the potential for different dosing strategies of posaconazole oral suspension (POS) to increase plasma levels and to profile the pharmacokinetics of these dosing strategies in patients…
- Conditions
- Fungal Infection, Acute Myelogenous Leukemia, Neutropenia
- Trial name
- NCT00686543
- Testing
- Posaconazole
- Volunteers
- 75 people
- Sponsor
- Merck Sharp & Dohme LLC
Bacterial Vaginoses
Treatment of BV With Donaxyl and a Molecular Test of Cure
. Treatment with dequalinium chloride vaginal tablets for 6 days had a cure rate lower than expected; only 37% of patients were considered cured one month after treatment.
- Trial name
- NCT04057482
- Testing
- D
- Volunteers
- 58 people
- Sponsor
- Skaraborg Hospital
Atopic Dermatitis, Atopic Dermatitis Eczema
Staphylococcus Aureus and The Skin Microbiome During Flare And Resolution Of Atopic Dermatitis
The goal of this clinical trial is to compare and evaluate in patients with atopic dermatitis. The main questions it aims to answer are: Does the addition of systemic dicloxacillin to TCS treatment result in a more rapid and…
- Conditions
- Atopic Dermatitis, Atopic Dermatitis Eczema, Atopic Dermatitis Flare
- Trial name
- NCT05578482
- Testing
- Dicloxacillin Oral Capsule, Elocon 0.1 % Topical Cream
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Jacob Pontoppidan Thyssen
Tuberculosis, Tuberculosis, Pulmonary
Pharmacokinetics of Anti-tuberculosis Drugs in Gastrectomized Patients
The purpose of this study is to evaluate the effect of gastrectomy on pharmacokinetic profile of first-line anti-tuberculosis drugs in patients with pulmonary tuberculosis (TB).
- Conditions
- Tuberculosis, Tuberculosis, Pulmonary, Early Gastric Cancer
- Trial name
- NCT01364324
- Testing
- standard first line anti-TB drugs
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- National Cancer Center, Korea
Acellular Pertussis, Diphtheria
Assessment of GSK Biologicals' Tdap Candidate Vaccine Administered as a Booster (6th Dose) in Terms of Immunogenicity and Safety to Children and Adolescents Previously Vaccinated With Five Doses of an Acellular Pertussis-containing Vaccine.
The aims of this study are to evaluate the safety and immunogenicity of a booster dose of GSK Biological's candidate Tdap vaccine containing 0.3 mg Al when administered to healthy school children and adolescents (9-13 years of…
- Conditions
- Acellular Pertussis, Diphtheria, Tetanus
- Trial name
- NCT00263679
- Testing
- Prophylaxis: Diphtheria, tetanus and pertussis
- Where
- 13 sites in Germany
- Volunteers
- 321 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Plasma Administration, Invasive Fungal Infection
Association of Plasma Transfusions and Invasive Fungal Infection
Although lacking strong evidences, plasma transfusions are commonly used in critically ill neonates. To date, the relationships between plasma transfusions and nosocomial infection remain controversial and no study has reported…
- Conditions
- Plasma Administration, Invasive Fungal Infection, Neonatal Infection
- Trial name
- PT (NCT03149562)
- Testing
- plasma transfusions, non-plasma transfusions
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Legionnaires' Disease
Legionnaires' Effect on Smell
The goal of this study is to determine whether survivors of Legionnaires' disease suffer smell loss. A quantitative olfactory test will be performed by the participants.
- Trial name
- NCT03321786
- Testing
- The University of Pennsylvania Smell Identification Test (UPSIT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania
Bacillus Anthracis (Anthrax)
Safety, Tolerability and Immunogenicity of Recombinant Anthrax Vaccine Compared With Anthrax Vaccine Adsorbed
This is a dose ranging study comparing different vaccine schedules of rPA vaccine, for Anthrax, to the licensed dose of AVA, another Anthrax vaccine. Safety and the capability to induce an immune response will be evaluated.
- Trial name
- NCT00170469
- Testing
- AVA, rPA vaccine containing alhydrogel
- Where
- 16 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- PharmAthene UK Limited
Cancer
Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation
RATIONALE: Giving itraconazole or fluconazole may be effective in preventing infections in patients undergoing peripheral stem cell or bone marrow transplantation.
- Trial name
- NCT00003883
- Testing
- fluconazole, itraconazole
- Where
- 2 sites in United States
- Volunteers
- 578 people
- Sponsor
- Fred Hutchinson Cancer Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.