Clinical trials: Fungal Infection
Gram-Positive Bacterial Infections, Soft Tissue Infections
Dalbavancin Outpatient Pilot
The purpose of this research is to determine if a new antibiotic called dalbavancin will work to treat and cure certain infections while reducing the need for daily antibiotics by vein.
- Trial name
- NCT03982030
- Testing
- Dalbavancin
- Sponsor
- Wake Forest University Health Sciences
Post Pulmonary Tuberculosis, Post-Tuberculous Bronchiectasis
The Feasibility and Acceptability of a Post-tuberculosis Lung Disease Diagnostic Algorithm in Uganda.
The goal of this clinical trial is to determine whether a structured diagnostic algorithm improves the identification and referral of people with post-tuberculosis lung disease (PTLD) in primary healthcare facilities in Uganda.
- Trial name
- IMPULSE (NCT07067528)
- Testing
- A novel PTLD clinical diagnostic algorithm
- Where
- Uganda
- Volunteers
- 80 people
- Sponsor
- Mbarara University of Science and Technology
Haemophilus Influenzae Type b
Safety and Reactogenicity of a Monovalent Conjugated Vaccine Against Haemophilus Influenzae Type b
This study will investigate safety and reactogenicity of a monovalent conjugated vaccine against Haemophilus influenzae type b in healthy children
- Trial name
- NCT00734565
- Testing
- Haemophilus influenzae type b
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Clostridium Difficile Infection
Fecal Microbiota Transplant for Recurrent Clostridium Difficile Infection
The purpose of this research is to investigate the efficacy of transplanting screened donor fecal material in treating patients with recurrent Clostridium difficile infection.
- Trial name
- FMT (NCT02326636)
- Testing
- Fecal Microbial Transplantation
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of California, Irvine
Hidradenitis Suppurativa
Study to Collect in a Real-world populatIon Data on the Treatment Pattern of Secukinumab in Adult Patients With Moderate to Severe Hidradenitis Suppurativa (HS) in Routine Clinical Practice in the Russian Federation
ANIMA-R is an observational, prospective, non-interventional, multicenter study to assess real-world effectiveness of secukinumab in the treatment of Hidradenitis Suppurativa (HS).
- Trial name
- ANIMA-R (NCT06517732)
- Testing
- Secukinumab
- Where
- 19 sites in Russia
- Volunteers
- 107 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Foot, Staphylococcus Aureus
Evaluation of the Antibiofilmogramme® Test During Diabetic Foot Infections
This is an observational study that does not change routine care. The primary objective of this study is to investigate the role of antibiogramme-antibiofilmogramme concordance (in terms of S.
- Trial name
- BioFilm PieDia (NCT02378493)
- Testing
- Antibiofilmogramme
- Where
- 6 sites in France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Tuberculosis, HIV
Evaluation of the Effect of 3HP vs Periodic 3HP vs 6H in HIV-Positive Individuals
This study is a parallel, two part, open label, individually randomized, pragmatic trial among HIV-positive individuals. Part A compares a single round of weekly high dose rifapentine plus isoniazid for three months (3HP) to six…
- Trial name
- WHIP3TB (NCT02980016)
- Testing
- rifapentine + isoniazid, Isoniazid
- Where
- South Africa
- Volunteers
- 4,027 people, healthy volunteers welcome
- Sponsor
- The Aurum Institute NPC
Lymphomatoid Papulosis, Mycosis Fungoides
Long-term Outcomes Associated With Juvenile-onset Mycosis Fungoides and Lymphomatoid Papulosis
To follow up with all our participants with juvenile-onset mycosis fungoides, check on their status, and ask them or their parents about long term outcomes associated with their condition.
- Trial name
- NCT06207812
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Tetanus
A Phase Ⅲ Clinical Study of SNA02-48 Injection
The primary objective of this clinical trial is to compare the efficacy and safety of SNA02-48 injection with Human Tetanus Immunoglobulin (HTIG) for tetanus prophylaxis.
- Trial name
- NCT07633119
- Testing
- SNA02-48, Human tetanus immunoglobulin (HTIG)
- Where
- 30 sites in China
- Volunteers
- 600 people
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Clostridium Difficile Infection
Does Fidaxomicin Therapy Reduce Spread of Clostridium Difficile?
This study evaluates whether patients with Clostridium difficile infection (CDI) who are treated with fidaxomicin have less contamination of their skin and surrounding environment with spores of C.
- Trial name
- NCT02461901
- Testing
- Environmental sampling, Skin swab sampling, Fecal sampling
- Where
- 3 sites in United Kingdom
- Volunteers
- 203 people
- Sponsor
- Professor Mark Wilcox
Diarrhoea
A Study on the Immune Response and Safety of a Multicomponent Shigella Vaccine in Preventing Shigellosis in Infants
This study evaluates the immune response and safety of a multicomponent, 2-dose Shigella vaccine in preventing shigellosis in African infants.
- Trial name
- NCT06663436
- Testing
- altSonflex1-2-3 Dose A, altSonflex1-2-3 Dose B, altSonflex1-2-3 Dose C
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hidradenitis Suppurativa
Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS
The primary objective of this randomized controlled clinical trial in a real life setting is to evaluate the cost-utility of limumab monotherapy compared with the combination of adalimumab and a maximum of three surgeries after…
- Trial name
- HS-COST (NCT03221621)
- Testing
- Wide Excision, Adalimumab Injection
- Where
- Netherlands
- Volunteers
- 128 people
- Sponsor
- Erasmus Medical Center
Tuberculosis, Pulmonary
Integrated Discovery and Development of Innovative TB Diagnostics
The long term goal of this project is to provide information critical to the development and use of a low-cost, point-of-care, rapid, simple, and highly accurate diagnostic tool that can help clinicians make a microbiological…
- Trial name
- (CETR) (NCT06624501)
- Testing
- Observational cohort study
- Volunteers
- 1,450 people, healthy volunteers welcome
- Sponsor
- Harvard University Faculty of Medicine
Mycobacterium Avium-intracellulare Infection, HIV Infections
The Safety and Effectiveness of Clarithromycin Plus Zidovudine or Dideoxyinosine in the Treatment of Mycobacterium Avium Complex (MAC) Infections in Children With AIDS
To evaluate three doses of clarithromycin in children with AIDS and Mycobacterium avium complex (MAC) infection who are receiving concurrent antiretroviral therapy.
- Trial name
- NCT00000971
- Testing
- Clarithromycin, Zidovudine, Didanosine
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Abbott
Rheumatic Heart Disease
Rheumatic Heart Disease Study in Lusaka
This study will determine the prevalence of rheumatic heart disease (RHD) in Lusaka, Zambia through school-based screening methodology using ultraportable echocardiography and a recently validated, abridged screening protocol…
- Trial name
- NCT02661763
- Where
- Zambia
- Volunteers
- 1,024 people
- Sponsor
- University of Zambia
Quality of Life, Infection, Bacterial
Retrospective Chart Review of Treataprost Added to Antibiotic Treatment in Patients With Chronic Prostatitis
Multicenter, Retrospectivecohort study in patients with Chronic Prostatitis, Chronic Bacterial Prostatitis (Category II) and Chronic Pelvic Pain Syndrome (Category IIIA, IIIB) and 140 patients without other significant…
- Conditions
- Quality of Life, Infection, Bacterial, PSA, Prostatitis
- Trial name
- Treataprost (NCT05306314)
- Testing
- TREATAPROST
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- GMG Grand Medical
Chalazion, Hordeolum
Pediatric Zylet Safety and Efficacy Study
A multicenter study to evaluate the safety and efficacy of Zylet compared to vehicle in children aged 0-6 for the management of lid inflammation (chalazion/hordeolum)
- Trial name
- NCT00420628
- Testing
- loteprednol etabonate/tobramycin opthalmic suspension, vehicle
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Bausch & Lomb Incorporated
Meningitis, Meningococcal, Serogroup C
Safety and Immunogenicity Study in Young Adults the Meningococcal Serogroup C Vaccine Produced by Bio-Manguinhos
Clinical trial phase I, randomized, double blind, where 30 individuals will receive the experimental vaccine while 30 other volunteers will receive a meningococcal C conjugate vaccine already licensed in Brazil and available in…
- Trial name
- NCT01889836
- Testing
- 'MenCC-Bio', MENJUGATE
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Bacterial Vaginosis
A Study of the New Medical Device Polybactum®
The POLARIS trial is designed as a multicenter, open label, non-comparative, 3 months, clinical study. Interventional, non-controlled, multicenter trial with a prospective design on one cohort of patients
- Trial name
- POLARIS (NCT02863536)
- Testing
- Polybactum®
- Where
- Romania
- Volunteers
- 56 people
- Sponsor
- Effik Italia S.p.A.
Anthrax
Velocity 2: An Anthrax Vaccine and Antibiotics Clinical Study
This study is designed to evaluate the pharmacokinetic (PK) profiles of ciprofloxacin or doxycycline when administered orally, prior to, and following, the intramuscular (IM) administration of a two-dose schedule of AV7909…
- Trial name
- NCT04067011
- Testing
- Ciprofloxacin 500Mg Tablet, Doxycycline 100Mg Tablet, AV7909
- Where
- 4 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions