Clinical trials: Fungal Infection Lungs
Invasive Pulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis
Voriconazole Inhalation Powder for the Treatment of Pulmonary Aspergillosis
Voriconazole Inhalation Powder is available on an expanded access basis to patients with pulmonary aspergillosis for up to 12 weeks.
- Conditions
- Invasive Pulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis, Chronic Pulmonary Aspergillosis, Aspergillus Tracheobronchitis
- Trial name
- NCT05897294
- Testing
- Voriconazole Inhalation Powder
- Sponsor
- TFF Pharmaceuticals, Inc.
Pneumocystis Pneumonia
Pneumocystis Jirovecii Genotyping
We share our lives with microorganisms, and these generally do not pose a problem if an individual is healthy with a normal immune system.
- Trial name
- NCT06442345
- Volunteers
- 70 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Pneumocystis
Pneumocystis in Patients Over 75 Year
Pneumocystis pneumonia is an infectious disease caused by Pneumocystis jirovecii that affects the lung parenchyma preferentially. Historically described in an immunocompromised population through HIV.
- Trial name
- C_PAPY (NCT07004127)
- Where
- France
- Volunteers
- 162 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mycoses, Fungemia
Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients
The purpose of this study is to compare the efficacy of anidulafungin versus fluconazole for the prevention of fungal diseases in liver transplant recipients
- Conditions
- Mycoses, Fungemia, Central Nervous System Fungal Infections, Lung Diseases, Fungal
- Trial name
- NCT00841971
- Testing
- Anidulafungin, Fluconazole
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Allergic Bronchopulmonary Aspergilloses
A Study Evaluating Vitamin D in Allergic Bronchopulmonary Aspergillosis Complicating Asthma
Allergic bronchopulmonary aspergillosis (ABPA) is a immunological pulmonary disorder caused by hypersensitive reaction to spores of Aspergillus fumigatus.
- Trial name
- NCT03133299
- Testing
- Glucocorticoids, Vitamin D
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Cryptococcal Infection, Cryptococcal Pneumonia
Fungal Infection Susceptibility
The protocol will be carried out in accordance with International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Good Clinical Practice (GCP) and the following United States Code of…
- Conditions
- Cryptococcal Infection, Cryptococcal Pneumonia, Pulmonary Cryptococcosis, Cryptococcal Meningitis
- Trial name
- NCT00001352
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pulmonary Invasive Fungal Infections, Pulmonary Invasive Aspergillosis
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
This study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (PIFI).
- Trial name
- DOMINIC (NCT03827694)
- Testing
- Non-Invasive Testing for PIFI
- Where
- 33 sites in United States, Canada
- Volunteers
- 400 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Pulmonary Candidiasis, Invasive Candidiasis
Candida Spp. in the Lower Respiratory Tract: Harmless Residents or Pathogen?
In critically ill patients Candida spp. are frequently isolated from respiratory tract secretions such as endotracheal aspirates and bronchoalveolar lavages (BAL) and are most often considered as colonizers of the respiratory…
- Trial name
- NCT00786903
- Where
- Austria
- Volunteers
- 202 people
- Sponsor
- Robert Krause, MD
Pneumonia, Pneumocystis Carinii, HIV Infections
Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
To compare the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium) with that of conventional therapy (sulfamethoxazole-trimethoprim) in the treatment of moderately severe…
- Trial name
- NCT00001013
- Testing
- Trimetrexate glucuronate, Pentamidine isethionate, Sulfamethoxazole-Trimethoprim
- Where
- 23 sites in United States
- Volunteers
- 364 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumocystis Pneumonia
Trimethoprim/Sulfamethoxazole Combined With Caspofungin as First-line Therapy in PCP
This is a prospective, randomized clinical trial. During the study, non-HIV patients who are admitted to ICU due to Pneumocystic pneumonia (PCP) and have not received anti-PCP therapy or have received therapy less than 48hrs will…
- Trial name
- NCT03978559
- Testing
- caspofungin, TMP/SMZ(trimethoprim/sulfisoxazole), Methylprednisolone
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Bin Du
Pneumonia, Pneumocystis Carinii, HIV Infections
A Treatment IND for 566C80 Therapy of Pneumocystis Carinii Pneumonia
To facilitate provision of atovaquone (566C80) to patients who have mild to moderate Pneumocystis carinii pneumonia (PCP) and are intolerant and/or unresponsive to trimethoprim / sulfamethoxazole (TMP / SMX ); to monitor serious…
- Trial name
- NCT00001991
- Testing
- Atovaquone
- Where
- United States
- Sponsor
- Glaxo Wellcome
Pneumocystis Jiroveci Pneumonia, Intensive Care Unit
Prospective Registration of Severe Pneumocystis Jiroveci Pneumonia Requiring ICU Admission
the investigators aim to set up a multicenter registry study for severe PJP requiring ICU admission. The purpose of this study is 1.
- Trial name
- NCT03201497
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Pneumonia, Pneumocystis Carinii, HIV Infections
An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies
To determine the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium (TMTX / LCV)) in the treatment of Pneumocystis carinii pneumonia (PCP) in patients who have AIDS, are HIV…
- Trial name
- NCT00000714
- Testing
- Trimetrexate glucuronate, Leucovorin calcium
- Where
- 21 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS)
Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray
Background: Allergic fungal rhinosinusitis (AFRS) is a severe type of sinus infection. People with AFRS develop heavy mucus and growths called polyps that apply pressure to the sinuses and block their breathing.
- Conditions
- Allergic Fungal Rhinosinusitis (AFRS), Chronic Rhinosinusitis (CRS), Asthma, Nasal Polyps
- Trial name
- NCT06461949
- Testing
- Dupilumab
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Invasive Pulmonary Aspergillosis
PCR for Aspergillus Fumigatus in Blood and Bronchoalveolar Lavage Fluid for Monitoring Cases of Invasive Aspergillosis: What is Its Prognostic Value
Aspergillus fumigatus PCR is currently used in conjunction with serum galactomannan to support the diagnosis of invasive aspergillosis or for monitoring at-risk patients not receiving antifungal prophylaxis.
- Trial name
- ASP (NCT07313527)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Pneumonia, Pneumocystis, Coronavirus
Efficacy and Safety of Darunavir and Cobicistat for Treatment of COVID-19
The study aims to evaluate the efficacy and safety of darunavir and cobistastat in the treatment of COVID-19 pneumonia
- Trial name
- DC-COVID-19 (NCT04252274)
- Testing
- Darunavir and Cobicistat
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Shanghai Public Health Clinical Center
ABPA, Severe Asthma
Benralizumab in the Treatment of Patients With Severe Asthma With ABPA
Phase IV, open-label study will evaluate effects of Benralizumab in the treatment of severe asthma in patients with allergic bronchopulmonary aspergillosis
- Conditions
- ABPA, Severe Asthma, Allergic Bronchopulmonary Aspergillosis
- Trial name
- NCT04108962
- Testing
- Fasenra, 30 Mg/mL Subcutaneous Solution
- Where
- United States
- Sponsor
- Baylor Research Institute
Cystic Fibrosis, Allergic Bronchopulmonary Aspergillosis
Open-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis
The purpose of this study is to see if giving people with CF and ABPA enough vitamin D to make their blood levels of the vitamin higher, will reduce the allergic response in their body and make the symptoms caused by ABPA better.
- Trial name
- NCT01222273
- Testing
- cholecalciferol (Vitamin D3)
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Pittsburgh
HIV
Occurrence of Pneumocystis Pneumonia in HIV-Infected Patients and the Interference of the HAART
From the beginning of the AIDS epidemic, pulmonary pneumocystosis (PCP) has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality.
- Trial name
- NCT00516581
- Where
- Brazil
- Volunteers
- 376 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Invasive Fungal Infections, Liposomal Amphotericin B
Population Pharmacokinetics of L-AmB in Chinese Patients Assisted by Extracorporeal Membrane Pulmonary Oxygenation (ECMO)
The goal of this study is to investigate the effects of ECMO-assisted therapy on L-AmB PK parameters in patients with critically ill patients of invasive fungal infections, and to determine the in vivo pharmacokinetic changes of…
- Trial name
- NCT06754436
- Testing
- Determination of blood drug concentration
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Anzhen Hospital