Clinical trials: Fungal Infections
Bacterial Vaginosis
Safety Study of Lactobacillus Administered Vaginally to Healthy Women
The purpose of this study is to compare the safety, tolerability, and acceptability of LACTIN-V (Active Ingredient: Lactobacillus crispatus CTV-05) with a matching placebo at three doses using pre-filled vaginal applicators in…
- Trial name
- NCT00537576
- Testing
- Low dose LACTIN-V applicator, Medium dose LACTIN-V applicator, High dose LACTIN-V applicator
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Osel, Inc.
Lymphoma, T-Cell, Mycosis Fungoides
Phase II Study Of Roferon and Accutane For Patients With T-Cell Malignancies
The purpose of this study is to determine the response rate of patients with T-cell malignancies to combination therapy using interferon-alpha (Roferon) and Isotretinoin (Accutane).
- Conditions
- Lymphoma, T-Cell, Mycosis Fungoides, Hematologic Neoplasms
- Trial name
- NCT00038376
- Testing
- Isotretinoin (Accutane), Interferon Alpha
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- M.D. Anderson Cancer Center
Aspergillosis, Invasive Fungal Infections
Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi
The purpose of this study is to investigate the efficacy and safety of isavuconazole in the treatment of renally impaired participants with invasive fungal infections caused by Aspergillus and participants with invasive fungal…
- Trial name
- VITAL (NCT00634049)
- Testing
- isavuconazole
- Where
- 96 sites in United States, Argentina and 17 more
- Volunteers
- 149 people
- Sponsor
- Astellas Pharma Inc
Distal Lateral Subungual Onychomycosis, Onychomycosis
Evaluation of the Effectiveness of Nail Genesis DLSO Product for Onychomycosis
This is a Pre-IDE, prospective, multicenter, randomized, parallel-group, double-blind, vehicle- controlled study to evaluate safety and effectiveness of Nail Genesis DLSO Product for the treatment of DLSO compared with vehicle in…
- Trial name
- NCT06074315
- Testing
- Nail Genesis DLSO Product, Nail Genesis DLSO Product (vehicle only)
- Where
- 10 sites in United States
- Volunteers
- 338 people
- Sponsor
- Nail Genesis LLC
Meningococcal Disease
Persistence Of Antibody Responses Among Children Who Previously Received Novartis MenACWY Conjugate Vaccine or Meningococcal C Conjugate Vaccine
The primary purpose of this study is to evaluate the persistence of bactericidal antibodies in children of approximately 22 to 45 months of age previously enrolled in the V59P22 study (NCT00667602) who received Novartis MenACWY…
- Trial name
- NCT01345721
- Testing
- MenACWY-CRM
- Where
- 11 sites in Germany
- Volunteers
- 205 people
- Sponsor
- Novartis Vaccines
TB
Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine
Tuberculosis (TB) kills about three million people annually. It is estimated that one third of the world's population are latently infected with Mycobacterium tuberculosis (M.tb).
- Trial name
- NCT00654316
- Testing
- BCG
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Mycoplasma Pneumoniae Pneumonia
Development and Validation of an Early Prediction Model for Severe Mycoplasma Pneumoniae Pneumonia in Children
Pneumonia is a major threat to the health of children. Mycoplasma pneumoniae infection is a core cause of pediatric pneumonia, and the incidence of severe mycoplasma pneumoniae pneumonia (SMPP) has increased in recent years.
- Trial name
- NCT07333833
- Testing
- medical history taking, blood test, pulmonary ultrasound
- Where
- China
- Volunteers
- 964 people
- Sponsor
- Beijing Friendship Hospital
Tuberculosis
TB PCR in BAL and EBUS-TBNA
This prospective observational multi-centre UK study will evaluate Xpert MTB/RIF Ultra for the detection of Mycobacterium tuberculosis (MTB) in bronchoalveolar lavage (BAL) samples for pulmonary TB and endobronchial ultrasound…
- Trial name
- TRiBE (NCT04909385)
- Where
- United Kingdom
- Volunteers
- 394 people
- Sponsor
- Imperial College Healthcare NHS Trust
Hidradenitis Suppurativa
A National Registry For Patients With Hidradenitis Suppurativa
The goal of this study is to get a better understanding of the skin condition, Hidradenitis Suppurativa, and to find out how the disease affects quality of life.
- Trial name
- NCT03289585
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Montefiore Medical Center
Mansonella Perstans Infection, Buruli Ulcer
Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana
This study will determine the influence of doxycycline treatment against Wolbachia/M. perstans on immunity against concomitant mycobacterial infections in healthy M. perstans infected individuals.
- Conditions
- Mansonella Perstans Infection, Buruli Ulcer, Tuberculosis, Co-infection
- Trial name
- Map2Co (NCT02281643)
- Testing
- Doxycycline
- Where
- Ghana
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kwame Nkrumah University of Science and Technology
Onychomycosis, Dermatophytosis
Study Evaluating the Effect of Jublia on Dermatophytomas
This study will examine how Jublia affects dermatophytomas, which are difficult to treat with other therapeutic options.
- Trial name
- NCT03098615
- Testing
- Jublia (Efinaconazole 10% Topical Solution)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Tuberculosis
Reactogenicity, Safety and Immunogenicity of a TB/FLU-01L Tuberculosis Vaccine
The study is a single centre, phase I, open, randomized, by intranasal and sublingual application trial that explored the safety and immunogenicity of 2 doses (Day 1 and Day 21) TB/FLU-01L tuberculosis vaccine in BCG-vaccinated…
- Trial name
- NCT03017378
- Testing
- TB/FLU-01L
- Where
- Kazakhstan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Research Institute for Biological Safety Problems
Urinary Tract Infection, Acute Pyelonephritis
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
This is an open-label, randomized, multi-center, interventional, active-controlled Phase 4 study to evaluate the efficacy and safety of CAZ-AVI versus BAT in the treatment of infected participants with selected infection types…
- Conditions
- Urinary Tract Infection, Acute Pyelonephritis, Hospital Acquired Pneumonia, Ventilator-associated Pneumonia
- Trial name
- NCT04882085
- Testing
- Zavicefta, Ceftazidime-Avibactam, Best Available Treatment
- Where
- 37 sites in China
- Volunteers
- 60 people
- Sponsor
- Pfizer
Tuberculosis, Latent Tuberculosis
The Epidemiology of TST Change in Korea
TST will be analyzed in young general population in Korea. Young adults undertake TST as CDC recommendation. Participants with chest radiograph showing active TB lesion are excluded from this study.
- Trial name
- NCT01850043
- Where
- South Korea
- Volunteers
- 5,552 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Onychomycosis of Toenails, Onychomycosis of Fingernail
Exploring Different Dose-frequency Home Photodynamic Therapy Protocols Using a Novel Home-targeted LED Device for Onychomycosis
This randomized feasibility trial aims to determine the optimal light energy dose and treatment frequency for home-based photodynamic therapy (hPDT) using a novel LED device (L-Home PhoD) for the treatment of onychomycosis.
- Trial name
- HomePDT_Nails (NCT07012343)
- Testing
- Photodynamic Therapy with Conventional Methylene Blue, urea 40% cream
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chulalongkorn University
Mycobacterium Avium-Intracellulare Infection, HIV Infections
A Study to Examine the Effects of Stopping Preventive Therapy for Disseminated Mycobacterium Avium Complex (DMAC) in HIV-Positive Patients
The purpose of this study is to evaluate the effects of stopping preventive therapy for DMAC in HIV-positive patients who (1) have been treated for DMAC for at least 12 months and are now free of any signs of DMAC for at least 16…
- Trial name
- NCT00000907
- Where
- 24 sites in United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sexually Transmitted Diseases, Bacterial
Mycoplasma Species and the Genitourinary System
The purpose of this study is to determine if the presence of Mycoplasma hominis bacteria is associated with Bacterial vaginosis (BV), non-gonococcal urethritis (NGU) or vaginitis in patients attending sexual health clinic.
- Trial name
- NCT05186792
- Testing
- Test:mycoplasma
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cwm Taf University Health Board (NHS)
Voriconazole, Fungal Infection
The Study of Voriconazole Trough Level in the First Two Weeks After Administration in King Chulalongkorn Memorial Hospital.
Invasive fungal infections are a significant cause of morbidity and mortality in immunocompromised host such as prolong neutropenic patients , post transplantation patients, malignancies or advanced AIDS .
- Trial name
- NCT03260634
- Testing
- Voriconazole
- Where
- Thailand
- Volunteers
- 92 people
- Sponsor
- Chulalongkorn University
Clostridium Difficile Infection
Gut Microbiota Changes After Fecal Microbiota Transplantation
This study aims to document early changes in the distal gut microbiota (both fecal and mucosa-associated) post FMT. Furthermore, whole blood and urine samples will facilitate collaborative immunologic and metabolomic analyses.
- Trial name
- NCT02557685
- Testing
- Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The Miriam Hospital
Pneumonia, Bronchopneumonia
Duration of Antibiotic Therapy in Community - Acquired Pneumonia
The purpose of the study is to assess the efficacy of an individualized approach to duration of antibiotic therapy based on each subject's clinical response compared to a local standard approach in patients coming from the…
- Conditions
- Pneumonia, Bronchopneumonia, Pleuropneumonia, Pneumonia, Bacterial
- Trial name
- DURATION (NCT01492387)
- Testing
- Discontinuation of antibiotic therapy
- Where
- 15 sites in Italy
- Volunteers
- 892 people
- Sponsor
- University of Milan
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