Clinical trials: Fusion of Spine, Lumbar Region
Postoperative Pain Management
Phase 4 Study in Adult Subjects Undergoing Posterior Lumbar Spine Surgeries
Primary Objective: The primary objective of this study is to compare postsurgical opioid consumption through 72 hours postsurgery in patients receiving local infiltration analgesia (LIA) with EXPAREL and bupivacaine HCl (EXPAREL…
- Trial name
- FUSION (NCT03927911)
- Testing
- EXPAREL and Bupivacaine, Standard of Care
- Where
- 12 sites in United States
- Volunteers
- 65 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Lumbar Degenerative Disc Disease
Percutaneous Dynamic Stabilization (PDS) System Versus Fusion for Treating Degenerative Disc Disease
The objective of this study is to evaluate the safety and effectiveness of the PDS System compared to the surgical control of posterolateral fusion with autograft and pedicle screw fixation for the treatment of one or two levels…
- Trial name
- NCT00878579
- Testing
- PDS System, Fusion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Interventional Spine, Inc.
Spine Fusion, Lumbar Spondylolisthesis
Titanium vs. PEEK Fusion Devices in 1 Level TLIF
The objective of this study is to evaluate and follow the clinical and radiographic outcomes of patients undergoing 1 level TLIF randomized to either a titanium or a PEEK spacer to 24 months after surgery.
- Conditions
- Spine Fusion, Lumbar Spondylolisthesis, Lumbar Stenosis
- Trial name
- TLIF (NCT05691062)
- Testing
- Titanium Fusion Device, PEEK Fusion Device
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Twin Cities Spine Center
Degenerative Disc Disease
Natural Matrix Protein™ (NMP™) in Interbody Lumbar Fusion
The objective of this study is to evaluate the performance of Induce Biologics NMP™ when used to promote interbody fusion for degenerative disease of the lumbar spine.
- Trial name
- NCT05972616
- Testing
- Natural Matrix Protein (NMP)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Induce Biologics USA Inc.
Degeneration, Spinal Stenosis
Vertebropexy - Randomized-controlled Trial
To assess the need for additional fusion surgery versus the risk of a revision surgery in patients with degenerative lumbar spinal disease and to assess efficacy and risk of the ligamentous fixation technique (vertebropexy)
- Conditions
- Degeneration, Spinal Stenosis, Fusion of Spine
- Trial name
- VPRCT (NCT06024785)
- Testing
- Vertebropexy
- Where
- Switzerland
- Volunteers
- 164 people
- Sponsor
- Balgrist University Hospital
Vertebral Fusion
Transforaminal Lumbar Interbody Fusion in PEEK Oblique Cages With and Without Titanium Coating
Clinical outcome with regard to oswestry disability index and lumbar fusion rate after implantation of titanium coated PEEK cage and common PEEK cage
- Trial name
- NCT03063008
- Testing
- PEEK, TiPEEK
- Volunteers
- 40 people
- Sponsor
- Mohammad ARAB MOTLAGH
Complications, Postoperative
A Prospective, Randomized Comparison Of Drainage Techniques After One- Or Two-Level Open Posterior Lumbar Decompression Or Decompression And Fusion
This project is being done to understand if a drain reduces recovery problems after surgery, such as infection or the need for more surgery.
- Trial name
- NCT06820736
- Testing
- Drain
- Where
- United States
- Volunteers
- 975 people
- Sponsor
- Twin Cities Spine Center
Lumbar Spine Degeneration
INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine
This investigation will provide safety and effectiveness information on the use of INFUSE® Bone Graft with the CAPSTONE® Spinal System and CD HORIZON® Spinal System with a Transforaminal Lumbar Interbody Fusion (TLIF) surgical…
- Trial name
- TLIF (NCT01415908)
- Testing
- INFUSE Bone Graft, Iliac Crest Bone Graft
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Medtronic Spinal and Biologics
Spinal Fusion
Use of the Bone Substitute SintLife® in Vertebral Arthrodesis Procedures. A Pilot Study.
This pilot study is to evaluate the potential effectiveness of bone substitute SintLife within the spinal surgery in spinal stabilization applications for degenerative diseases.
- Trial name
- NCT03407560
- Testing
- SintLife
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Istituto Ortopedico Rizzoli
Stenosis, Fusion of Spine (Disease)
Anterior Bridging Cage With Bone Substitute Versus Localized Autobone in Transforaminal Lumbar Interbody Arthrodesis
The purpose of this study is to evaluation for the pattern of bone bridging of patients who undergo transforaminal lumbar interbody arthrodesis, the investigators hypothesize that auto local bone mixed with β-calcium phosphate +…
- Trial name
- NCT02485574
- Testing
- transforaminal lumbar interbody arthrodesis
- Where
- South Korea
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Zenoss Co, Ltd
Lumbar Spinal Stenosis, Degenerative Lumbar Spondylolisthesis
Retrospective Comparison of Tubular Decompression ± Rhizotomy Versus TLIF in Lumbar Spinal Stenosis
This retrospective observational study examines clinical outcomes in patients with lumbar spinal stenosis who underwent minimally invasive tubular decompression, with or without subsequent multisegmental percutaneous rhizotomy…
- Conditions
- Lumbar Spinal Stenosis, Degenerative Lumbar Spondylolisthesis, Neurogenic Claudication
- Trial name
- TUBE-FUSE (NCT07489508)
- Where
- 2 sites in Spain
- Volunteers
- 246 people
- Sponsor
- University of Valencia
Lumbar Spine Fusion
Early Initiation of a Strength Training Based Rehabilitation After Lumbar Spine Fusion Improves Core Muscle Strength
To analyze safety and the effects of early initiation of the rehabilitation. Including the objective measurement outcomes after lumbar spine fusion, based on the principles of strength training.
- Trial name
- NCT03349580
- Testing
- The training group
- Volunteers
- 27 people
- Sponsor
- Dejan Kernc
Fusion of Spine, Lumbar Region, Anesthesia, Local
Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery
The purpose of this study is to determine if the method for injecting local anesthesia affects patients' pain and opioid usage after surgery.
- Conditions
- Fusion of Spine, Lumbar Region, Anesthesia, Local, Pain, Postoperative, Opioid Use
- Trial name
- NCT06528288
- Testing
- Erector Spinae Plane Block, Subcutaneous Anesthesia
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Massachusetts, Worcester
Spine Disease, Spinal Fusion
Validity and Accuracy of a Machine Learning Predictive Model in the Exploitation of Patients Related Outcomes in Spine Surgery
The objective of the study is the establishment, optimization and prospective evaluation of a digital predictive platform capable of providing for each lumbar spine operated patient a clinical predictive status: Patient green…
- Conditions
- Spine Disease, Spinal Fusion, Surgery, Spine Degeneration
- Trial name
- DeepSurgery (NCT05166018)
- Testing
- SuMO Patient
- Where
- 2 sites in France
- Volunteers
- 174 people
- Sponsor
- Cortexx Medical Intelligence
Lumbar Spine Fusion Surgery
Multimodal GA for Lumbar Spine Surgery
To evaluate the effects of multimodal general anesthesia on the recovery profile of elder patients undergoing lumbar spine fusion surgery.
- Trial name
- NCT05247177
- Testing
- dexmedetomidine, ketamine co-administration with sevoflurane for general anesthesia, Conventional general anesthesia by administration of sevoflurane alone
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Degenerative Disc Disease, Spondylolisthesis
Pilot Study to Assess Safety/Prelimary Effectiveness of Prefix in Subjects With Degenerative Disc Disease (DDD) Undergoing Spine Fusion Surgery
This is a pilot study to evaulate the safety and prelimary effectiveness of Prefix as compared to autogenous bone for spinal fusion procedures in skeletally mature subjects with degenerative disc disease (DDD) at one level from…
- Trial name
- NCT00798239
- Testing
- Prefix (AMPLEX) B2A Peptide Enhanced Ceramic Granules, Iliac crest autograft
- Where
- 5 sites in Canada
- Volunteers
- 24 people
- Sponsor
- BioSurface Engineering Technologies, Inc
Spondylolisthesis, Scoliosis
A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP®
OsteoAMP is a novel allograft bone graft substitute (BGS) that has been processed to retain multiple endogenous growth factors for use in spinal fusion.
- Conditions
- Spondylolisthesis, Scoliosis, Intervertebral Disc Disease
- Trial name
- NCT02225444
- Testing
- OsteoAMP
- Where
- 9 sites in United States
- Volunteers
- 42 people
- Sponsor
- Bioventus LLC
Lumbar Facet Disease
A Post-Market Study of Transfacet Lumbar Spine Fixation and Fusion Utilizing the PERPOS™ PLS System
The purpose of this study is to utilize the PERPOS™ PLS System for transfacet lumbar spine fixation to evaluate its effect on patients' level of pain, procedural complications and functional status.
- Trial name
- NCT00887835
- Testing
- PERPOS™ PLS
- Volunteers
- healthy volunteers welcome
- Sponsor
- Interventional Spine, Inc.
Pain, Postoperative
TAP Block Efficacy After Lumbar Spine Surgery Through Anterior Approach: a Randomized, Placebo-controlled Study
Anterior Lumbar Interbody Fusion (ALIF) as well as Direct Lateral Interbody Fusion (DLIF) are established techniques for lumbar interbody fusion.
- Trial name
- TAP-LIF (NCT02778178)
- Testing
- ropivacaine plus clonidine, ultrasound
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Lumbar Spine Degeneration
Development of a Patient-reported Outcome Instrument for Patients With Lumbar Degenerative Disease After Lumbar Fusion
The commonly used scales (ODI+JOA-29+VAS) lack the assessment of lumbar stiffness, and there is no scale for evaluating lumbar stiffness in China.Based on the Delphi method and the analytic hierarchy process, this study will…
- Trial name
- DPROIPLDDALF (NCT04781517)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital