Clinical trials: GENE EXPRESSION
NFAT Regulated Gene Expression in Tacrolimus Treated Patients
NFAT-regulated Gene Expression After Tacrolimus
Aim of the study is measurement of NFAT-RGE (IL-2 (interleukin-2), IFN-γ (interferon-gamma), GM-CSF (granulocyte monocyte colony stimulating factor)) after tacrolimus (TAC) in de-novo immunosuppressed patients after liver…
- Trial name
- NCT03315858
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Gene Expression in Response to Acute Stress
Temporal Genomics Mechanisms Underlying Disease and Aging
Given the salient role of early-life adversity and the resulting biological embedding in disease risk, there is a critical need to understand the mechanisms operating at multiple levels of analysis in order to promote effective…
- Trial name
- NCT03637751
- Testing
- Behavioral, Control condition
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cancer, Cancer Metastatic
Real Word European Registry of NTRK Fusions and Other Rare Actionable Fusions (TRacKING)
This registry will make it possible to describe real life management of patients with rare actionable fusions and to better understand these cancers.
- Conditions
- Cancer, Cancer Metastatic, NTRK Gene Fusion Overexpression, NTRK Family Gene Mutation
- Trial name
- TRacKING (NCT04921553)
- Testing
- Data collection and quality of life questionnaire
- Where
- 41 sites in Austria, Czechia and 9 more
- Volunteers
- 500 people
- Sponsor
- Centre Leon Berard
Diabetes and Healthy Control, FTO Gene Expression
Effects of Exercise Intervention and Confounding Factors on Type II Diabetic Muscles
The aim of the first year of this three-year plan is to analyze and compare the muscle quality of lower limb muscle (microcirculation, muscle performance and mechanical characteristics) and maximal aerobic exercise capacity in…
- Conditions
- Diabetes and Healthy Control, FTO Gene Expression, Aerobic Exercise Intervention or Home Exercise, Pre-training and Post-training
- Trial name
- NCT03869411
- Testing
- supervised aerobic exercise or home-based aerobic exercise
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Kidney Cancer, Biomarkers
Identification of Predictive Gene Expression Profile of Sunitinib Response in Metastatic Clear Cell Renal Carcinomas
Renal cell carcinoma accounts for 2-3% of all cancers in western countries. Brazilian kidney cancer data show an incidence of 6,270 new cases for 2018.
- Conditions
- Kidney Cancer, Biomarkers, Gene Expression
- Trial name
- NCT04415697
- Testing
- Gene expression test using nanostring technology.
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Barretos Cancer Hospital
ALK Fusion Protein Expression, BRAF wt Allele
Capmatinib, Ceritinib, Regorafenib, or Entrectinib in Treating Patients With BRAF/NRAS Wild-Type Stage III-IV Melanoma
This phase II trial studies how well capmatinib, ceritinib, regorafenib, or entrectinib work in treating patients with BRAF/NRAS wild-type stage III-IV melanoma.
- Conditions
- ALK Fusion Protein Expression, BRAF wt Allele, Invasive Skin Melanoma, MET Fusion Gene Positive
- Trial name
- NCT02587650
- Testing
- Capmatinib, Ceritinib, Entrectinib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, San Francisco
Gene Expression Profiles in CML Non-responders
Gene Expression Profiles in CML Non-responders
Chronic myeloid leukaemia (CML) is a haematological malignancy primarily driven by the fusion oncogene BCR-ABL1, resulting in a constitutively expressed tyrosine kinase.
- Trial name
- NCT04219111
- Testing
- Clariom
- Where
- United Kingdom
- Sponsor
- Sheffield Children's NHS Foundation Trust
Ovarian Reserve, Endometrioma, PTEN-AKT-FOXO3 Gene Expression
PTEN-AKT-FOXO3 Gene Expression Relation With Low-ovarian Reserve in Endometriomas
In this study, we aimed to investigate the relationship between PTEN-AKT-FOXO3 gene expression and decrease in ovarian reserve in the presence of endometrioma and other benign ovarian pathologies.
- Trial name
- NCT04058912
- Testing
- PTEN-AKT-FOXO3 Gene Expression
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uludag University
Vitamin D Receptor Target Gene Expression, Serum 25(OH)D Concentration
Efficiency of Vitamin D3 and 25-hydroxyvitamin D3 on Transcriptomic Changes of Low Vitamin D Responders
The purpose of the study is to investigate in vivo whether a high-dose vitamin D3 oral bolus (2000 micrograms) produces marked vitamin D receptor target gene expression response and whether there is large inter-individual…
- Trial name
- VitDHiD (NCT03537027)
- Testing
- Vitamin D3
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Melanoma (Skin), Melanoma Recurrent
Expanded Access for Pembrolizumab (MK-3475)
This is an expanded access program (EAP) for patient with Melanoma and Glioblastoma who have progressed after prior Protocol therapy including Bevacizumab, Temozolomide ( TMZ ), Ipilimumab, BRAF and MEK inhibitors.
- Conditions
- Melanoma (Skin), Melanoma Recurrent, Glioblastoma Multiforme, Glioblastoma by Gene Expression Profile
- Trial name
- NCT03311542
- Testing
- pembrolizumab
- Where
- 4 sites in Belarus, Hong Kong and 2 more
- Sponsor
- Center Trials & Treatment
Acute Pain, Gene Expression
Bone Marrow Aspiration Pain Study
Background: Many people feel pain during and after bone marrow aspiration (collection). Studies suggest that pain may be related to different kinds of inflammation, or the presence of nitric oxide (a normally occurring gas) in…
- Conditions
- Acute Pain, Gene Expression, Nitric Oxide
- Trial name
- NCT01524523
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Breastcancer, Invasive Breast Carcinoma by Gene Expression Profile
The Symphony Triple A Study: Using Symphony in Treatment Decisions Concerning Adjuvant Systemic Therapy
Rationale: Prediction of prognosis in patients with breast cancer is important to determine the indication for adjuvant chemo-, endocrine- and immunotherapy.
- Trial name
- Symphony (NCT02209857)
- Where
- 34 sites in Netherlands
- Volunteers
- 660 people
- Sponsor
- Diakonessenhuis, Utrecht
Adipose Tissue Gene Expression
The Influence of Different Dietary Status on the Acute Responses to Exercise
The purpose of this study is to investigate whether dietary conditions (fed versus fasted) affects the acute responses to exercise.
- Trial name
- NCT02870075
- Testing
- Fed exercise, Fasted exercise
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Bath
Vitamin D Receptor Target Gene Expression, Serum 25(OH)D Concentration
The Effect of a High-dose Oral Vitamin D3 Bolus on Serum 25(OH)D3 and Vitamin D Receptor Target Gene Expression
The purpose of the study is to investigate whether a high-dose vitamin D3 oral bolus (2000 micrograms) produces marked vitamin D receptor target gene expression response and whether there is large inter-individual variation.
- Trial name
- VitDbol (NCT02063334)
- Testing
- Vitamin D3
- Where
- Finland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Gene Expression Profiling, Gastric Intestinal Metaplasia
Gene Expression Profiling in Human Gastric Intestinal Metaplasia Mucosa and Duodenal Mucosa
To analyze the genome pattern in human gastric Intestinal Metaplasia Mucosa and duodenal Mucosa.
- Conditions
- Gene Expression Profiling, Gastric Intestinal Metaplasia, Duodenum
- Trial name
- NCT02846688
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Shandong University
Gene Expression
Neural and Physiological Responses to Real-World Experiences
UCLA researchers looking for healthy individuals (aged 35-50) who have a home computer with internet access, are not pregnant, planning to become pregnant, or currently breastfeeding (if female), to participate in a study…
- Trial name
- NCT01723410
- Testing
- Writing about people, Writing about places, objects
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Breast Neoplasms, Neoplasm Metastasis
Gene Expression Profiling of Breast Cancer Cells Predict the Response of Malignant Pleural Effusion
The investigators want to develop a gene expression profile for the prediction of immunotherapy response of patients with metastatic breast cancer presenting malignant pleural effusion.
- Conditions
- Breast Neoplasms, Neoplasm Metastasis, Gene Expression Profiling, Immunotherapy
- Trial name
- GMPE (NCT01256801)
- Testing
- cytokine
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Peking University Cancer Hospital & Institute
Wound Healing, Cell Proliferation
Study to Assess on a Molecular Level the Influence of a 5 % Dexpanthenol Ointment in Subjects With Superficial Injuries
In previous in vitro studies it could be shown, that Dexpanthenol has an influence on the gene expression of fibroblasts. The genes which are influenced by Dexpanthenol play mainly a role during cell proliferating processes.The…
- Conditions
- Wound Healing, Cell Proliferation, Gene Expression
- Trial name
- NCT00859196
- Testing
- Dexpanthenol (BAY81-2996)
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bayer
Dehydroepiandrosterone, DHEAS
Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is one the challenge in the field of artificial reproductive technology (ART) while there is still no effective resolution of this disorder.
- Conditions
- Dehydroepiandrosterone, DHEAS, Gene Expression of Cumulus Cells., Ovarian Hyper-stimulation Protocol.
- Trial name
- NCT02150330
- Testing
- Dehydroepiandrosterone (DHEAS)
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Android Obesity, Metabolic Parameters and Adipose Tissue (AT) Gene Expression
Effect of Hula Hooping as Compared to Walking on Adipose Tissue Distribution, Metabolic Parameters and Adipose Tissue Gene Expression
o determine effects of hula-hooping on android obesity, metabolic parameters and adipose tissue (AT) gene expression.
- Trial name
- NCT01913171
- Testing
- Exercise
- Where
- Finland
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Helsinki