Clinical trials: GERD, open to volunteers
GERD (Gastroesophageal Reflux Disease)
A Blinded Randomized Clinical Study of RefluxStop™ Compared With Nissen Fundoplication in the Treatment of GERD
This study will evaluate if the RefluxStop™ device will treat your acid reflux and improve your symptoms and how it compares to the standard surgical treatment for GERD, the Nissen fundoplication.
- Trial name
- RENEW RCT (NCT07004400)
- Testing
- RefluxStop™ implantation, Nissen fundoplication
- Where
- 4 sites in Austria, Germany and 1 more
- Volunteers
- 200 people
- Sponsor
- Implantica CE Reflux Ltd.
GERD (Gastroesophageal Reflux Disease)
Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms
The purpose of this research is to evaluate the safety and effectiveness of the eGERD device, which is a novel device for treating Gastroesophageal Reflux Disease (GERD). The main questions this research aims to answer are: 1.
- Trial name
- NCT06613438
- Testing
- eGERD device
- Where
- 5 sites in United States, Israel
- Volunteers
- 84 people
- Sponsor
- Gerd Care Medical Ltd
Gastroesophageal Reflux, Regurgitation
A Study of Breath Testing for Small Intestinal Bacterial Overgrowth
Researchers hope to determine how often small intestinal bacterial overgrowth occurs after taking proton pump inhibitors.
- Conditions
- Gastroesophageal Reflux, Regurgitation, Heartburn
- Trial name
- NCT05976165
- Testing
- Breath Testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Reflux Disease, Microbiome
Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux
A two-arm, double-blind, randomized, placebo-controlled study investigating the efficacy of a probiotic preparation developed as supportive supplementation of probiotics in patients with reflux.
- Conditions
- Reflux Disease, Microbiome, Probiotics Supplement
- Trial name
- NCT07600008
- Testing
- A probiotic dietary supplement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Olomouc
Achalasia
POEM-F for Achalasia International Study
Per-oral endoscopic myotomy (POEM) has emerged as the endoscopic treatment of choice for achalasia, offering comparable symptom relief with laparoscopic Heller's cardiomyotomy.
- Trial name
- NCT06042127
- Testing
- POEM-F, Conventional POEM
- Where
- 7 sites in United States, China and 2 more
- Volunteers
- 81 people
- Sponsor
- Chinese University of Hong Kong
Refractory GERD, NERD
Vonoprazan Test for PPI Refractory GERD
Among patients suffering from gastroesophageal reflux disease (GERD) symptoms, esophageal pH monitoring and the assessment of symptom-reflux correlation can identify two distinct subgroups characterized by normal acid exposure…
- Conditions
- Refractory GERD, NERD, PCAB
- Trial name
- NCT07437768
- Testing
- Patients received a 4-week treatment of vonoprazan 20 mg once daily (VOCINTI®)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital
Fundoplication, GERD
Transoral Incisional Fundoplication (TIF) for Patients Suffering From Gastroesophageal Reflux Disease in an Asian Population
Transoral incisionless fundoplication (TIF) has become a widely used intervention to restore the valve at the gastroesophageal junction in selected patients suffering from gastroesophageal reflux disease (GERD).
- Trial name
- NCT07556289
- Testing
- Transoral incisional fundoplication
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Heart Valve Disease, Mitral Valve (MV) Regurgitation
Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease
The objective of this study is to evaluate and predict the progression of moderate cardiac valve stenosis and regurgitation using clinical, biological, echocardiographic, computed tomography (CT), and magnetic resonance imaging…
- Conditions
- Heart Valve Disease, Mitral Valve (MV) Regurgitation, Mitral Valve Disease, Mitral Valve Stenosis
- Trial name
- VALVE-COMPASS (NCT07267117)
- Where
- 15 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Barrett Esophagus, Gastroesophageal Reflux
Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test.
- Conditions
- Barrett Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
- Trial name
- NCT06687603
- Testing
- EsoCheck, EsoGuard
- Where
- 5 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Bronchopulmonary Dysplasia, Gastroesophageal Reflux
Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia
The goal of this clinical trial is to learn if transpyloric tube feeding (feeding directly into the small intestine) versus gastric tube feeding tolerably and effectively reduces gastroesophageal reflux in infants born premature…
- Trial name
- NCT06534359
- Testing
- Transpyloric tube feeding, Gastric tube feeding
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Philadelphia
Incentive Spirometer, Diaphragmatic Breathing
Effect of Breathing Training on Symptoms of Gastroesophageal Reflux Disease
The goal of this clinical trial is to evaluate whether two types of breathing training can improve symptoms of gastroesophageal reflux disease (GERD) in adults.
- Conditions
- Incentive Spirometer, Diaphragmatic Breathing, Gastroesophageal Reflux Disease (GERD), Breath Exercise
- Trial name
- NCT07179250
- Testing
- Volume-Oriented Incentive Spirometer, Diaphragmatic Breathing Exercise (DBE), Usual Care and Education
- Volunteers
- 51 people
- Sponsor
- Changhua Christian Hospital
Perioperative Pain Management, Gastreoesophageal Reflux Disease
Intrathecal Analgesia in Laparoscopic Nissen Fundoplication.
Patients planned for laparoscopic Nissen fundoplication or robotic- assisted laparoscopic surgery will receive either intrathecal morphine, intrathecal fentanyl or iv morphine (control).
- Trial name
- NCT07629323
- Testing
- Fentanyl Intrathecal 20ug, NOL-guided intravenous morphine analgesia, Intrathecal Morphine 100ug
- Where
- Sweden
- Volunteers
- 63 people
- Sponsor
- Karlstad Central Hospital
Gastroesophageal Reflux Disease, Emotional Distress
Mindfulness Intervention for Emotional Distress (MIED) in Patients With GERD
The goal of this multicenter randomized waitlist-controlled clinical trial is to evaluate whether an online Mindfulness-Based Intervention for Emotional Distress (MIED) can reduce emotional distress and reflux-related symptoms in…
- Trial name
- NCT07667894
- Testing
- TAU, MIED
- Where
- 15 sites in China
- Volunteers
- 500 people
- Sponsor
- Xinghua Liu
Gastroesophageal Reflux Disease
A Retrospective Analysis of Patients With Gastroesophageal Reflux Disease Based on a Prospective Clinical Dataset
This retrospective, observational cohort study aimed to establish a comprehensive research cohort utilizing a large-scale prospective clinical registry.
- Trial name
- NCT07749989
- Testing
- Clinical Data Collection
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Friendship Hospital
GERD - PPI Non-responders
Effect of Baclofen in Management of Patients With Gastroesophageal Reflux Disease Symptoms
The goal of this clinical trial is to assess the effect of using baclofen along with conventional treatment in improving GERD symptoms.
- Trial name
- NCT07063576
- Testing
- Baclofen 10mg
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- Adnan Imtiaj Rahul
Non-erosive Reflux Disease (NERD)
Clinical Efficacy Evaluation of Chaizhi Hewei Decoction in the Treatment of Non-Erosive Reflux Disease With Liver-Stomach Disharmony Syndrome
This study focuses on patients with NERD (gastroesophageal reflux disease) and liver-gallbladder disharmony syndrome as its research subjects.
- Trial name
- NCT07518420
- Testing
- Chaizhi Hewei Decoction
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Gastroesophageal Reflux, Sleeve Gastrectomy
Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction
Researchers are trying to identify predictors for gastroesophageal reflux disease after sleeve gastrectomy.
- Conditions
- Gastroesophageal Reflux, Sleeve Gastrectomy, Bariatric Surgery Complication
- Trial name
- NCT04411823
- Testing
- EndoFLIP measurement
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Gastro Esophageal Reflux
Prevalence of Symptomatic Gastroesophageal Reflux Disease in Czech Children (Czech GERDKids)
This study aims to determine the prevalence of symptomatic gastroesophageal reflux disease (GERD) in children aged 8-9 years and 12-13 years in the Czech Republic.
- Trial name
- Czech GERDKids (NCT07482969)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol
Barrett's Esophagus, Gastroesophageal Reflux Disease
Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry
The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer.
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux Disease, Esophageal Adenocarcinoma
- Trial name
- NCT00574327
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Non-erosive Reflux Disease (NERD)
Effect of Inspiratory Muscle Training on Symptom Severity and Quality of Life in Non-Erosive Reflux Disease
The goal of this clinical trial is to learn if inspiratory muscle training (IMT) works to treat on clinical symptom severity and quality of life in patients with Non-erosive reflux disease (NERD).
- Trial name
- NCT07584096
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Izmir University of Economics