Clinical trials: GFAP
Fallers Aged 60 Years and Older, Biomarkers / Blood
Contribution of GFAP and UCH-L1 Assays in Whole Blood to Optimizing Personalized Care for "Repeated Fallers" Hospitalized in Geriatric Wards
The BACHUS study focuses on a population of patients aged 75 years and older who are hospitalized after recurrent falls. The objective is to evaluate the performance of an innovative, personalized biological screening strategy to…
- Conditions
- Fallers Aged 60 Years and Older, Biomarkers / Blood, Intracranial Bleeding
- Trial name
- BACHUS (NCT07342023)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 770 people
- Sponsor
- University Hospital, Clermont-Ferrand
Schizophrenia
Evaluation of the Role of Neurodegeneration in Schizophrenia
Schizophrenia is a progressive psychiatric disorder with a lifetime prevalence of 1%, its etiology is not fully understood, and it progresses with relapses.
- Trial name
- NCT05257720
- Testing
- GFAP, S100B
- Where
- Turkey (Türkiye)
- Volunteers
- 178 people
- Sponsor
- Istanbul Saglik Bilimleri University
Kidney Transplant; Complications, Neurologic Manifestations
Evaluation of s100β, NSE and GFAP Levels in Renal Transplantation
Uremic encephalopathy is an organic brain disorder may be frequently seen in patients with acute or chronic renal failure. Certain neurological symptoms can be found under clinical glomerular filtration rate of 15 ml/minutes.
- Conditions
- Kidney Transplant; Complications, Neurologic Manifestations, Uremic Encephalopathy
- Trial name
- NCT04042272
- Testing
- S100β, Neuron specific enolase (NSE) and Glial fibrillary acidic protein (GFAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Traumatic Brain INjury
Prognostic Potential of Prehospital Biomarkers in TBI Patients
The PreTBI III study aims to investigate the prognostic potential of prehospital and repeated in-hospital S100B, NSE and GFAP measurements as predictors of neurological outcome in patients suffering severe TBI.
- Trial name
- PreTBI III (NCT03062566)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- University of Aarhus
Traumatic Brain Injury
Biomarkers in Prehospital Rule-out of Intracranial Lesions in TBI Patients
The PreTBI I study will investigate whether prehospital blood samples drawn already in the ambulance can rule-out intracranial lesions in patients suffering head trauma.
- Trial name
- PreTBI I (NCT02867137)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 595 people
- Sponsor
- University of Aarhus
Amyotrophic Lateral Sclerosis (ALS), Neurodegenerative Disorders
Serum Neurofilaments in the Diagnosis of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease, often difficult to diagnose due to symptoms similar to other neurological pathologies.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Neurodegenerative Disorders, Motor Neuron Diseases
- Trial name
- DIAGONALS (NCT07706270)
- Testing
- Serum Neurofilament Serum NfL Measurement
- Volunteers
- 138 people
- Sponsor
- University Hospital, Montpellier
Traumatic Brain Injury
Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries
The goal of this observational study is to evaluate the performance of UCH-L1 and GFAP combined in patients with a mild traumatic brain injury.
- Trial name
- GUEST (NCT05885529)
- Testing
- UCH-L1 GFAP
- Where
- 15 sites in France, Monaco
- Volunteers
- 1,500 people
- Sponsor
- Centre Hospitalier Princesse Grace
Subjective Cognitive Decline (SCD), Functional Cognitive Disorder
Lombard Cohort of Brain Health Services
The goal of this multicenter prospective observational cohort study is to better understand the clinical, neuropsychological, and biological characteristics of individuals attending Brain Health Services (BHS) in the Lombardy…
- Conditions
- Subjective Cognitive Decline (SCD), Functional Cognitive Disorder, Alzheimer's Disease, Brain Health
- Trial name
- LoBHeS (NCT07457138)
- Where
- 5 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Milano Bicocca
Brain Damage, Postoperative
Evaluation of Neuronal Damage in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy With Biomarkers
Robotic assisted laparoscopic surgery has become an alternative to open or laparoscopic technique in various surgical fields. Robot assisted laparoscopic surgery is preferred by surgeons and patients due to easy accessibility…
- Conditions
- Brain Damage, Postoperative, Surgery-Complications
- Trial name
- NCT05692804
- Testing
- Mini Mental State Examination(MMSE),Montreal Cognitive Assessment ( MoCA),S100B ( protein S100 subunit beta) ,GFAP ( glial fibrillary acidic protein ),NSE ( neuron-specific enolase )
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Astrogliosis, Postoperative Cognitive Dysfunction
Association Between Changes of GFAP After Surgery and Postoperative Delayed Cognitive Recovery
Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day.
- Conditions
- Astrogliosis, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- NCT03683537
- Testing
- Glial fibrillary acidic protein
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Moscow Clinical Scientific Center
Concussion, Mild
Rapid, Accurate, Cost-effective Assessment of Blood Biomarkers for Diagnosis of Concussion
The goal of this observational study is to test if a biosensor can accurately measure a blood biomarker in adult patients presenting to the emergency department with concussion.
- Trial name
- RACE (NCT05588115)
- Where
- Canada
- Volunteers
- 225 people
- Sponsor
- University of Calgary
NMOSD
Clinical Study to Evaluate the Effects of the Complement C5 Inhibitor Ravulizumab on Serum Neurofilament Light Chain (sNfL) and Glial Fibrillary Acidic Protein (sGFAP) Levels in Patients With Aquaporin-4-Positive (AQP4-Ab+) Neuromyelitis Optica Spectrum Disorder (NMOSD)
This is a nationwide observational study looking at how ravulizumab, a complement C5 inhibitor, affects blood biomarkers o sNfL and sGFAP in people with AQP4-antibody positive NMOSD.
- Trial name
- NCT06903130
- Testing
- Blood samples for sNfL and sGFAP levels
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- National and Kapodistrian University of Athens
Stroke Code, Large Vessel Occlusion
Evaluation of a Point-of-care Lateral Flow Assay in Glial Fibrillary Acidic Protein (GFAP) and D-dimer in Diagnosis of Large Vessel Occlusion Acute Ischemic Stroke in a Pediatric Hospital
The goal of this study is to test the efficacy of a rapid bedside blood test in determining if a stroke is happening in children who present to the emergency department with stroke symptoms.
- Conditions
- Stroke Code, Large Vessel Occlusion, Acute Ischemic Stroke
- Trial name
- NCT07474675
- Testing
- Point of Care Rapid Assay
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Children's Hospital
Neurofilament Light Chain, Glial Fibrillary Acidic Protein
Analysis of NfL and GFAP in Different Dietary Patterns
This observational study aims to investigate the impact of different dietary patterns on brain tissue biomarkers in healthy young adults by measuring blood levels of NfL and GFAP.
- Conditions
- Neurofilament Light Chain, Glial Fibrillary Acidic Protein, GFAP, Vegan Diet
- Trial name
- NCT07312994
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Multiple Sclerosis, Exercise
Impact of Exercise Training on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis
This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period.
- Conditions
- Multiple Sclerosis, Exercise, Function
- Trial name
- NCT07521995
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Firat University
Primary Progressive Multiple Sclerosis, Primary Progressive MS
A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
The goal of this Phase 2 clinical trial is to investigate the safety and tolerability of SUN-627 in men and women aged 18-70 years old with a diagnosis of non-active SPMS/PPMS.
- Conditions
- Primary Progressive Multiple Sclerosis, Primary Progressive MS, Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive MS (SPMS)
- Trial name
- NCT07840326
- Testing
- SUN-627
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sundance Biosciences, Inc.
Delirium, Dementia, Amnestic, Cognitive Disorders, Arthroplasty, Hip Replacement
Cerebral Regional Oxygen Saturation and Markers of Brain Damage During Primary Hip Arthroplasty
Postoperative Cognitive Disorders (POCD) are common in hospitalized people > 60 year old, especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still remains unclear.
- Trial name
- NCT02342236
- Testing
- cemented or cementless type of hip prothesis
- Where
- Poland
- Volunteers
- 18 people
- Sponsor
- Military Institute od Medicine National Research Institute
Autoimmune GFAP Astrocytopathy
GFAP Auto-immunity : a French Cohort Study
Glial fibrillary acidic protein (GFAP)-Immunoglobulin G (IgG) have recently been described as a biomarker of a novel inflammatory central nervous system (CNS) disorder, termed autoimmune GFAP astrocytopathy.
- Trial name
- GFAP (NCT04463550)
- Testing
- Description and analysis
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Alzheimer Disease, Mild Cognitive Impairment
Blood Tests for Alzheimer's Disease: Can Plasma Biomarkers Diagnose and Predict Disease Progression
BLAD is a prospective, monocentric, observational epidemiological study with an additional procedure (annual blood draw) evaluating the diagnostic and prognostic performance of plasma biomarkers for Alzheimer's disease (AD) in a…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Subjective Cognitive Decline, Dementia
- Trial name
- BLAD (NCT07717567)
- Testing
- Annual blood draw for plasma biomarker measurement
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS San Raffaele