Clinical trials: GI Bleed
Acute Myocardial Infarction (AMI), Gastrointestinal Bleeding
Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute Myocardial Infarction
This study aims to compare the clinical outcomes between routine use of potassium competitive acid blocker (P-CAB) and guideline-directed gastrointestinal (GI) protection strategy in patients with acute myocardial infarction…
- Trial name
- PCAB-AMI (NCT07467213)
- Testing
- Zastaprazan, Proton Pump Inhibitors (PPI)
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Samsung Medical Center
Crohn's, Ulcerative Colitis
Single-dose Linaclotide for Capsule Endoscopy Preparation
Video capsule endoscopy is an important procedure that can be used by doctors to find abnormalities in the small intestine, especially those that can cause bleeding.
- Conditions
- Crohn's, Ulcerative Colitis, Gastrointestinal Bleeding
- Trial name
- NCT02465385
- Testing
- Linaclotide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Warfarin for the first time…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947998
- Testing
- Rivaroxaban (Xarelto, Bay59-7939), Warfarin, Antiplatelet drugs
- Where
- United Kingdom
- Volunteers
- 50,299 people
- Sponsor
- Bayer
Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage
Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
We prepare this study to compare the efficacy of intermittent intravenous PPI infusion (relatively low dose PPI therapy) than continous PPI infusion method.
- Conditions
- Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage, Peptic Ulcer, Proton Pump Inhibitor Overdose
- Trial name
- NCT03814421
- Testing
- intermittent (40mg as a bolus injection daily for 72hours)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Changwon Hospital
Gastrointestinal Bleeding, Gastrointestinal Neoplasms
A Disposable Endoscopic Closing Device Used for the Closure of Gastrointestinal Tissue
This clinical trial employs a prospective, multicenter, randomized, single-blind, parallel-controlled, non-inferiority design with a positive comparator device.
- Trial name
- NCT07727564
- Testing
- disposable endoscopic closing device, metal clips, or metal clips in combination with nylon loops
- Volunteers
- 60 people
- Sponsor
- Jiangsu Vedkang Medical Science and Technology Co., Ltd
Gastrointestinal Diseases
An Observer Blinded Comparison of MACE and Conventional Upper Gastrointestinal Endoscopy in Upper GI Bleeding
Gastroscopy (OGD) is a useful test for investigating a variety of suspected upper GI disorders. But it is uncomfortable for patients and incurs the risk of intubation and sedation, plus a large proportion of procedures reveal…
- Trial name
- MACE (NCT02690376)
- Testing
- Magnetic Assisted Capsule Endoscopy
- Where
- 2 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Gastro Intestinal Bleeding
Management of Digestive Haemorrhaging In CHRU of Brest During 2009 and 2014
Gastro intestinal (GI) bleeding is relatively frequent and may lead to intensive care unit admission. Although a restrictive strategy for red blood cell transfusion is supported by a large randomized controlled trial literature…
- Trial name
- HDréa (NCT03379285)
- Where
- France
- Volunteers
- 272 people
- Sponsor
- University Hospital, Brest
Obscure Gastrointestinal Bleeding
Cap Assisted Balloon Enteroscopy Versus Conventional Balloon Enteroscopy In The Evaluation Of Obscure Gastrointestinal Bleeding: A Randomized Controlled Trial
Gastrointestinal bleeding originating from the small bowel is difficult to diagnose and treat because the small bowel is difficult to see and reach.
- Trial name
- NCT02315404
- Testing
- CAP
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Washington University School of Medicine
Venous Thromboembolism, Deep Venous Thrombosis
A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE
This is a Phase 3, multicenter, open-label, blinded endpoint study to evaluate the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal…
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism
- Trial name
- MAGNOLIA (NCT05171075)
- Testing
- Abelacimab, Dalteparin
- Where
- 117 sites in United States, Australia and 18 more
- Volunteers
- 417 people
- Sponsor
- Anthos Therapeutics, Inc.
Hemorrhage, Trauma
RE-BLEED: A Digital Platform for Identifying Bleeding Patients - a Feasibility Study
The RE-BLEED feasibility study aims to develop and test a real-time digital platform, whereby bleeding patients in-hospital can be identified and approached for their consent to participate in future research studies.
- Conditions
- Hemorrhage, Trauma, Gastro Intestinal Bleeding
- Trial name
- RE-BLEED (NCT05608577)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Early Gastric Adenocarcinoma, Adenocarcinoma, Tubular
Effects of Oral Rabeprazole on the Prevention of Ulcer Bleeding Following Endoscopic Mucosal Resection
The purpose of this study is: To examine if oral administration of Pariet (proton pump inhibitor, 20mg tablets, twice daily for 5 days) before Endoscopic mucosal resection(EMR) exhibits preventive effects of ulcer bleeding…
- Trial name
- NCT00844675
- Testing
- rabeprazole
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- The Catholic University of Korea
Radiotherapy, Radiation Proctitis
Dietary Supplements to Treat Radiation-Induced Rectal Injury
This clinical study is a prospective, single-arm, single-center trial aimed at assessing the safety and efficacy of tributyrin (TB) as dietary supplements in the treatment of chronic radiation-induced rectal injury (RRI).
- Trial name
- NCT06776016
- Testing
- Butyrate
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Bowel Cancer, Bowel Diseases, Inflammatory
LuCID - Investigating the Use of a Novel Digital Rectoscope for Community Examinations During COVID-19
The LumenEye scope and CHiP platform will be piloted in a number of clinical settings including remote colorectal clinics. The rationale is to perform an initial pilot study to determine the clinical utility of the LumenEye…
- Conditions
- Bowel Cancer, Bowel Diseases, Inflammatory, Rectal Bleeding
- Trial name
- LuCID (NCT05043363)
- Testing
- LumenEye X1 digital rectoscope
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- Imperial College London
Aspirin, GastroIntestinal Bleeding
When Should Low-dose Aspirin be Resumed After Peptic Ulcer Bleeding?
Acute upper gastrointestinal (GI) bleeding associated with the use of low-dose aspirin (ASA) is a major cause of peptic ulcer bleeding worldwide.
- Trial name
- NCT03785015
- Testing
- Resume Aspirin within 12 hours, Resume Aspirin 72 - 84 hours
- Where
- Hong Kong
- Volunteers
- 436 people
- Sponsor
- Chinese University of Hong Kong
Upper Gastrointestinal Bleeding
Patients With Upper Gastrointestinal Bleeding in Emergency Department
More than 80% of patients with upper gastrointestinal bleeding (UGIB) are hospitalized after their visit to the emergency department (ED). However, some of these hospitalizations do not seem justified.
- Trial name
- UGIB-ED (NCT05927493)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Occlusion/Thrombosis, Peptic Ulcer Hemorrhage
Systematic Screening for Risk-factors for Ulcer Bleeding Before Anti-thrombotic Treatment
In a prospective randomised study design to investigate, if a systematic risk factor screening for bleeding ulcer in patients, who following percutaneous coronary intervention (PCI) commence a one year combination treatment with…
- Trial name
- NCT01447498
- Testing
- Screening for risk factors for ulcer bleeding
- Where
- Denmark
- Volunteers
- 2,024 people
- Sponsor
- Odense University Hospital
Bleeding Anal, Pain
Topical Vitamin E Ovules for the Treatment of Hemorrhoids
Patients with hemorrohoids grade II and III were included. Patients were randomized into 2 groups: Experimental group: Patients will receive a treatment with vitamin E ovules, which must be placed inside the annus Control group…
- Conditions
- Bleeding Anal, Pain, Stings
- Trial name
- NCT04362384
- Testing
- Vitamin E ovules, Prednisolone ointment
- Volunteers
- 120 people
- Sponsor
- Hospital General Universitario Elche
Cirrhosis, Liver, Upper Gastrointestinal Bleeding
Terlipression Prevent Developing of Acute Kidney Injury During Upper-gastroentestinal Bleeding
The investigators studied the renal function index level in terlipressin treated cirrhotic patients with upper-gastrointestinal bleeding at different time point.
- Trial name
- NCT04358016
- Testing
- Terlipressin, Somatostatin
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Changhai Hospital
Peptic Ulcer Bleeding
Study to Evaluate Efficacy and Safety of Wound Dressing Solution Containing EGF in Patients With Peptic Ulcers Bleeding
This is a prospective, single-blinded, randomized study to evaluate the efficacy and safety of CEGP003 in patients with acute peptic ulcers bleeding, compared to endoscopic epinephrine injection therapy.
- Trial name
- CEGP003 (NCT03469167)
- Testing
- CEGP003, Injection Tx
- Volunteers
- 76 people
- Sponsor
- CGBio Inc.
Peptic Ulcer Hemorrhage
Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding
A large dose of PPI is effective in preventing peptic ulcer rebleeding. The investigators hypothesize that 40 mg/q6h pantoloc is equivalent to 8mg/h pantoloc in preventing rebleeding.
- Trial name
- PPI (NCT00731601)
- Testing
- pantoprazole
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Lotung Poh-Ai Hospital