Clinical trials: GI Cancer, open to volunteers
Gastrointestinal Cancers
A Multicenter Prospective Observational Cohort Study for Digestive Tract Tumor Screening Using Multi-Target Blood and Fecal Biomarkers
This project aims to evaluate the sensitivity and specificity of combined blood multi-gene methylation and fecal biomarkers for pan-digestive tract cancer screening, so as to establish a novel technical system for the early…
- Trial name
- NCT07769892
- Where
- 7 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Gastrointestinal Tumors
A Study on Gastrointestinal Cancer Screening Using a Multi-Targeted Combined Detection Model
This study is a multicenter, randomized controlled trial. The plan is to enroll eligible participants and randomly assign them to two groups: one group will undergo testing using a combined model of "multi-target blood…
- Trial name
- NCT07712107
- Testing
- Multi-target blood methylation + fecal FIT + fecal calprotectin
- Where
- 6 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Digestive Health, Quality of Life
Effect of a Fermented Dairy Protein With Prebiotic Fiber on GI Complaints
A positive impact of a fermented dairy protein with prebiotic fiber supplement on self-reported GI complaints and wellbeing has been suggested (Wardenaar et al. 2024).
- Trial name
- NCT06946017
- Testing
- Fermented dairy protein with prebiotic fiber supplement
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Healthy Volunteer, Prostate Cancer
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Earlier detection of disease recurrence will enable greater treatment options and has strong potential to improve patient outcomes.
- Conditions
- Healthy Volunteer, Prostate Cancer, Head and Neck Cancer, Esophageal Cancer
- Trial name
- NCT04354064
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Breast Cancer, Gastrointestinal Cancer
Improving Comprehensive Care of Cancer Patients
Cancer survivors have unique healthcare needs, including managing serious late effects, ongoing surveillance, lifestyle modifications to reduce second cancer risk, and psychosocial support.
- Conditions
- Breast Cancer, Gastrointestinal Cancer, Hematologic Cancer
- Trial name
- NCT05323409
- Testing
- OPTIMISE
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Ampulla of Vater Carcinoma, Appendix Carcinoma
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
This clinical trial is being done to learn whether using the proactive, graduated dose modification algorithm for leucovorin, 5-fluorouracil (5-FU), and oxaliplatin (FOLFOX) (PAGODA) algorithm to guide chemotherapy dosing for the…
- Conditions
- Ampulla of Vater Carcinoma, Appendix Carcinoma, Carcinoma of Unknown Primary With Gastrointestinal Profile, Colon Carcinoma
- Trial name
- NCT07283939
- Testing
- PAGODA algorithm, Oxaliplatin, Folinic Acid
- Where
- 398 sites in United States, Guam and 1 more
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Colorectal Carcinoma
A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers
This clinical trial evaluates a clinic-wide intervention called Primary Care-Gastrointestinal (GI) Connect for improving follow-up colonoscopy rates in patients at a Federally Qualified Health Center (FQHC) who have an abnormal…
- Trial name
- NCT06568016
- Testing
- Best Practice, Communication Intervention, Coordination
- Where
- 2 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm
Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study
This study evaluates the use of extended venous thromboembolism prophylaxis (ePPx) following abdominopelvic cancer surgery within the NCI Community Oncology Research Program (NCORP) network, targeting surgeons and surgical…
- Conditions
- Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Genitourinary System Neoplasm
- Trial name
- STOP-VTE (NCT07215624)
- Testing
- Non-Interventional Study
- Where
- 104 sites in United States, Puerto Rico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Screening Compliance
A Multilevel Intervention to Improve Uptake of Gastrointestinal Cancer Screening: a Cluster Randomized Clinical Trial
This study is a cluster randomized controlled trial aimed at evaluating the effectiveness of a multi-level intervention strategy in improving adherence to gastrointestinal cancer screening.
- Trial name
- NCT06830304
- Testing
- Multi-level Education and Navigation Program for Gastrointestinal Cancer Screening, Health education
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Chongqing University Cancer Hospital
Capecitabine, Hand-foot Syndrome
Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot Syndrome
This study hypothesizes that electroacupuncture combined with self-administered acupressure plus doctor-prescribed treatment is effective in preventing Hand-Foot Syndrome (HFS) caused by capecitabine.
- Conditions
- Capecitabine, Hand-foot Syndrome, Electroacupuncture, Self-administered Acupressure
- Trial name
- NCT06602167
- Testing
- True electroacupuncture + True self-administered acupressure, Doctor-prescribed treatment
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital of Qinghai University
Gastrointestinal Cancer
Dyadic Sleep Study
The purpose of this study is to learn about sleep behaviors and test different ways to help patients with cancer and caregiver partners.
- Trial name
- NCT06569693
- Testing
- My Sleep Our Sleep (MSOS) Program, Brief Behavioral Treatment for Insomnia (BBTI)
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Miami
Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer
Gastrointestinal (GI) cancers remain a major global health burden, largely due to the lack of effective and accessible early screening strategies.
- Conditions
- Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC), Esophageal Squamous Cell Carcinoma (ESCC)
- Trial name
- MiGIC (NCT07224750)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Melanoma, Gastrointestinal Cancer
Harvesting Cells for Experimental Cancer Treatments
Background: The NCI Surgery Branch has developed experimental therapies that involve taking white blood cells from patients' tumor or from their blood, growing them in the laboratory in large numbers, and then giving the cells…
- Conditions
- Melanoma, Gastrointestinal Cancer, Metastatic Cancer, Breast Cancer
- Trial name
- NCT00068003
- Testing
- Anti-CD19 CAR PBL
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Gastrointestinal, Mobile Health
GutCheck: Optimization of a Personalized Mobile Health App for Survivors of Gastrointestinal Cancer
There are two components to the study: a patient and a clinician study. The clinician study will include one-hour semi-structured interviews with oncology specialists to identify facilitators and barriers to integrating digital…
- Conditions
- Gastrointestinal, Mobile Health, Gastrointestinal Symptoms, Gut Health
- Trial name
- NCT07661017
- Testing
- Stool Sample, App Activity
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Complication of Surgical Procedure, Infections
Pathogenesis of Postoperative Infections and Biomarkers for Early Diagnosis of it
Infections remain a prevalent complication after major abdominal surgery. The common belief that most surgical site infections (SSIs) following elective surgery with modern antiseptic techniques are due to intraoperative…
- Trial name
- NCT06513598
- Testing
- Major visceral surgery for gastrointestinal cancer
- Where
- 2 sites in Lithuania
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Breast Carcinoma, Malignant Digestive System Neoplasm
Studying the Workflow of the American College of Surgeons Geriatric Surgery Program to Improve Clinical Outcomes in Older Adults Undergoing Surgery at the James Cancer Hospital
This study examines how the American College of Surgeons Geriatric Surgery Verification Program, also called the ACS GSV Program, is implemented at the James Cancer Hospital.
- Conditions
- Breast Carcinoma, Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Genitourinary System Neoplasm
- Trial name
- NCT07606287
- Testing
- Serious Illness Conversation Program training, ACS Geriatric Surgery Verification Program Implementation
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cancer Screening, Lung Cancer
Precision Navigation to Improve Community Cancer Screening Participation
This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening.
- Conditions
- Cancer Screening, Lung Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT07676383
- Testing
- Precision Navigation Intervention, Usual Health Education
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hunan Cancer Hospital