Clinical trials: GI Disorders
Cryptosporidiosis, HIV Infections
A 28-Day Study of Diclazuril in the Treatment of Cryptosporidiosis in Patients With AIDS
To evaluate the safety and efficacy of diclazuril capsules as a treatment for cryptosporidial related diarrhea in AIDS patients who have been treated in the double-blind study # JRD 64,433/1101 and have relapsed, or de-novo…
- Trial name
- NCT00002278
- Testing
- Diclazuril
- Where
- 3 sites in United States
- Sponsor
- Janssen, LP
Colorectal Cancer, KRAS Wildtype
A Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Advanced Colorectal Cancer
This is a phase 2 study (the second phase in testing a new drug or drug combination) to see how useful the combination of two drugs, panitumumab and trametinib, are in patients with advanced colorectal cancer with KRAS, NRAS, or…
- Conditions
- Colorectal Cancer, KRAS Wildtype, NRAS Wildtype, BRAF Wildtype
- Trial name
- NCT02399943
- Testing
- Trametinib, Panitumumab
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University Health Network, Toronto
Mullerian Anomaly of Uterus, Nec
Congenital Uterine Anomalies & Pregnancy in Polycystic Ovarian Syndrome
Prospective research in which patients who applied to UUTF Gynecology and Obstetrics ART center for the treatment of infertility (inability to conceive despite one year of unprotected sexual intercourse), who will undergo IVF due…
- Trial name
- CONUTA&PPCOS (NCT04776915)
- Testing
- Ultrasound and Hysterosalpingography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Uludag University
Brain Cancer, Brain Metastases
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
The purpose of this study is to determine whether AGuIX (Activation and Guidance of Irradiation by X-ray) gadolinium-based nanoparticles make radiation work more effectively in the treatment of patients with brain metastases that…
- Conditions
- Brain Cancer, Brain Metastases, Melanoma, Lung Cancer
- Trial name
- NCT04899908
- Testing
- Stereotactic Radiation, AGuIX gadolinium-based nanoparticles
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Brigham and Women's Hospital
Computed Tomography, Carcinogenesis
CT Carcinogenic Risk in Patients With Appendicitis
The purpose of this study is to compare the incidence rate of leukemia between CT-exposed and CT-unexposed group in patients who underwent appendectomy in South Korea.
- Conditions
- Computed Tomography, Carcinogenesis, Radiation Exposure, Appendicitis
- Trial name
- NCT03776435
- Testing
- Abdomen CT
- Where
- South Korea
- Volunteers
- 1,000,000 people
- Sponsor
- Seoul National University Bundang Hospital
Ulcerative Colitis, Pouchitis
Adalimumab in the Treatment of Chronic Pouchitis
This study wants to investigate the efficiency of biological treatment for chronic pouchitis. Chronic pouchitis is inflammation in a reconstruction after removal of the colon, a pouch.
- Trial name
- ADAP (NCT01670240)
- Testing
- Adalimumab
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Odense University Hospital
Colorectal Cancer
RCT of Air Insufflation Versus Water Infusion Colonoscopy
Compared with the conventional (air) method, patients examined by the study (water) method have lower pain scores and require less medication but have similar cecal intubation rate and willingness to repeat future colonoscopy.
- Trial name
- NCT00785889
- Testing
- water infusion colonoscopy
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- East Bay Institute for Research and Education
Massive Transfusion, Trauma
Australian and New Zealand Massive Transfusion Registry
Severe and un-stopped blood loss can occur for a number of different reasons including after a serious injury, delivery of a baby and following other medical and surgical emergencies.
- Conditions
- Massive Transfusion, Trauma, Cardiothoracic Surgery, Gastrointestinal Bleeding
- Trial name
- ANZ-MTR (NCT02863250)
- Where
- Australia
- Volunteers
- 50,000 people
- Sponsor
- Monash University
Ulcerative Colitis
Clinical Outcome After Escalation and De-escalation of Adalimumab in Real Life in Ulcerative Colitis
This retrospective multi-centric Belgian observational trial will involve all patients who have initiated adalimumab for moderate-to-severe ulcerative colitis prior to September 1st 2015 in a Belgian centre maintaining a…
- Trial name
- CEDAR UC (NCT03142113)
- Where
- Belgium
- Volunteers
- 231 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroparesis
Safety, PK and Efficacy of PCS12852 on Gastric Emptying Rate in Patients With Moderate to Severe Gastroparesis
This is a randomized, double-blind, placebo-controlled study that will compare the effect of 2 different dosage regimens of PCS12852 on gastric emptying time to placebo in both idiopathic gastroparesis (IG) and diabetic…
- Trial name
- MOMENTUM (NCT05270460)
- Testing
- PCS12852
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- Processa Pharmaceuticals
Surgical Training, Residency
Laparoscopic Elective Colorectal Procedures Performed by Supervised Residents Are Safe and Sufficient.
The ability to perform laparoscopic colorectal surgery is an essential attribute of a general surgeon. Data on the participation of residents and the outcomes of colorectal procedures performed by surgeons in training are in…
- Trial name
- NCT06622720
- Testing
- surgery
- Where
- Poland
- Volunteers
- 498 people
- Sponsor
- Jagiellonian University
Peritoneal Carcinomatosis, Gastric Cancer
Neo-adjuvant Chemo + Peritonectomy + Hyperthermic Intraperitoneal Chemo in Peritoneal Carcinomatosis From Gastric Cancer
The aims of this study are to investigate whether multimodal treatment of peritoneal carcinomatosis from gastric cancer is feasible and to evaluate the clinical outcomes and clinical effectiveness of neoadjuvant systemic…
- Trial name
- NCT01379482
- Testing
- Multimodal treatment
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Uppsala University
Primary Sclerosing Cholangitis (PSC), Inflammatory Bowel Disease (IBD)
Fecal Microbiota Transplantation for Primary Sclerosing Cholangitis - Randomized Study Versus Sham Transplantation
Primary Sclerosing Cholangitis (PSC) is a rare cholestatic liver disease, commonly associated with inflammatory bowel disease (IBD) The aim of the present trial is to assess the efficacy of fecal microbiota transplantation (FMT)…
- Trial name
- FMT-SCLER (NCT07477782)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dysphagia
Study of Tongue Strengthening for Swallowing Problems
This study is a multisite, randomized clinical trial to determine the effectiveness of an 8-week rehabilitative exercise regime performed by patients with swallowing problems, termed dysphagia, compared to a control group of…
- Trial name
- NCT01570023
- Testing
- Isometric Progressive Resistance Oropharyngeal Therapy
- Where
- 9 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Wisconsin, Madison
Ileus
Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus
Patients undergoing major abdominal surgery are at highest risk for developing postoperative ileus (POI), occurring in nearly all cases.
- Trial name
- NCT00388401
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Acute Appendicitis, Perforated Gastroduodenal Ulcer
Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures
Aim of prospective randomized a placebo controlled study is to prove that in case of acute surgical procedure due to appendicitis, ileus of small bowel and perforation of small bowel and stomach appropriately administered…
- Conditions
- Acute Appendicitis, Perforated Gastroduodenal Ulcer, Small Bowel Obstruction
- Trial name
- NCT01524081
- Testing
- Metronidazole, Cefuroxime, Amoxicillin (+ clavulanic acid) and Fluconazole
- Where
- Czechia
- Volunteers
- 187 people
- Sponsor
- The Faculty Hospital Na Bulovce
Colorectal Neoplasms, Confocal Laser Endomicroscopy
Clinical Validation of Multimodal Digestive Endoscopy
According to the latest global cancer epidemiological data published by the International Agency for Research on Cancer, colorectal cancer (CRC) ranks 3rd in total incidence and 2nd in total mortality among all malignancies…
- Conditions
- Colorectal Neoplasms, Confocal Laser Endomicroscopy, Endoscopy, Digestive System, Molecular Imaging
- Trial name
- NCT05575765
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Colitis, Ulcerative, Cholangitis, Sclerosing
Compare Conventional Colonosocpy to Endoscopic AFI, NBI for Dysplasia Detection for Ulcerative Colitis & Cholangitis
This study is being done to: To attempt to increase the detection of precancerous colon tissue in patients with chronic ulcerative colitis and primary sclerosing cholangitis; To determine if an investigational scope that can look…
- Trial name
- NCT00587236
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Mayo Clinic
Metastatic Gastric Cancer, Locally Advanced Gastric Adenocarcinoma
Conversion Effects of PD-1 Antibody Camrelizumab Combined With Nab-POF Regimen Chemotherpy in Patients With Initially Unresectable Locally Advanced or Limited Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma：FDZL-GC001 Trial
This study is to evaluate the efficacy and safety of domestic programmed death 1（ PD-1） antibody (Camrelizumab for injection) combined with fluorouracil plus leucovorin, oxaliplatin, and albumin bound paclitaxel (Nab-POF) regimen…
- Conditions
- Metastatic Gastric Cancer, Locally Advanced Gastric Adenocarcinoma, Gastric Cancer Adenocarcinoma Metastatic
- Trial name
- NCT04510064
- Testing
- Camrelizumab plus mFLOT regimen, R0 surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fudan University
Breast Cancer, Colon Cancer
The PAI Trial for Breast and Colon Cancer Survivors
The purpose of the study is to determine if a Physical Activity Index (PAI) tool that collects measures on physical activity, strength training and sedentary behavior can be used in a clinical setting to monitor patient behavior…
- Trial name
- NCT05156463
- Testing
- PAI Tool and Exercise Coaching
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
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