Clinical trials: GI Disorders
Barrett's Esophagus, Overweight and Obesity
CAlorie and Protein REstriction PROgram in Barrett's Esophagus Patients (CARE-PRO).
The increasing incidence of Esophageal Adenocarcinoma (EAC) in several Western countries can be primarily ascribed to risk factors such as obesity, chronic gastroesophageal reflux, dietary habits and alcohol intake.
- Trial name
- CARE-PRO (NCT03813381)
- Testing
- Calorie and protein restriction diet
- Volunteers
- 160 people
- Sponsor
- Istituto Oncologico Veneto IRCCS
Advanced Solid Tumors, Glioblastoma
Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors
Prospective, open-label, dose-ranging, uncontrolled phase I/II study of Lurbinectedin in combination with irinotecan. The study will be divided into two stages: a Phase I dose escalation stage and a Phase II expansion stage.
- Conditions
- Advanced Solid Tumors, Glioblastoma, Soft Tissue Sarcoma (Excluding GIST), Endometrial Carcinoma
- Trial name
- NCT02611024
- Testing
- Lurbinectedin, Irinotecan
- Where
- 23 sites in United States, France and 4 more
- Volunteers
- 316 people
- Sponsor
- PharmaMar
Colon Cancer, Fragility
Prehabilitation in Frail Colon Cancer
Objectives To investigate the impact of tele-supervised prehabilitation on functional capacity in frail colon cancer patients undergoing colorectal resection and to evaluate the effects of prehabilitation on muscle strength and…
- Trial name
- NCT03097224
- Testing
- Prehabilitation
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Gastric Cancer Stage IV, Peritoneal Carcinomatosis
Intraperitoneal Paclitaxel Plus Systemic mFOLFOX6
Treatment for stage 4 gastric cancer with peritoneal carcinomatosis has been unchanged for decades. The median survival for stage 4 gastric cancer is 9-14 months with systemic chemotherapy.
- Conditions
- Gastric Cancer Stage IV, Peritoneal Carcinomatosis, Intraperitoneal Paclitaxel, mFOLFOX6
- Trial name
- IPLUS (NCT03618758)
- Testing
- Paclitaxel, mFOLFOX6 regimen
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Bundang Hospital
Gastroparesis, Idiopathic Gastric Motility Disorder
Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms
The overall objective of this study is to determine if there are pyloric sphincter abnormalities in patients with gastroparesis symptoms and determine how prevalent these abnormalities are using tests to assess the pyloric…
- Conditions
- Gastroparesis, Idiopathic Gastric Motility Disorder, Diabetic Gastroparesis
- Trial name
- PSAGS (NCT04661215)
- Where
- 5 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Colorectal Cancer
Educate, Assess Risk and Overcoming Barriers to Colorectal Screening Among African Americans
The burden of colorectal cancer (CRC) is unequal among various populations within the United States. This inequality is most notable among African Americans, who exhibit the highest CRC mortality of all US populations.
- Trial name
- NCT03640208
- Testing
- Education presented by trained caregiver
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Oral Mucositis
Study of Dentoxol® Mouthrinse for Oral Mucositis
The primary objective of this study is to determine the efficacy of Dentoxol® mouthrinse in reducing the severity of oral mucositis secondary to radiation therapy for head and neck cancer.
- Trial name
- NCT02885376
- Testing
- Dentoxol
- Where
- 3 sites in Chile
- Volunteers
- 108 people
- Sponsor
- Ingalfarma SpA
Gastric Cancer, Colon Cancer
Assessing How the Viscosity of Submucosal Gel Injections Helps With Endoscopic Mucosal Resections
This is a study to determine how the viscosity (thickness) of an FDA approved gel affects the ease in which endoscopic mucosal resections (EMR) can be performed.
- Trial name
- NCT02519140
- Testing
- Cook Medical EMR Gel
- Where
- United States
- Sponsor
- Antonios Likourezos
Colorectal Cancer, Stoma
Construction and Evaluation of a Flipped Discharge Model for Stomates With Colorectal Cancer
This multicenter randomized controlled trial aims to develop and evaluate the effectiveness of a "Flipped Discharge" intervention for colorectal cancer patients with a new intestinal stoma.
- Trial name
- NCT07463690
- Testing
- Response to Transition Theory-based Flipped Discharge Model
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer
CRC Post-surgical Assessment and Recurrence Monitoring
The surgical therapeutic effect of stage II-IV CRC patients will be assessed by the plasma mSEPT9 assay, and patients will be followed up by the same assay for recurrence monitoring.
- Trial name
- NCT03334890
- Testing
- plasma mSEPT9 level
- Where
- 4 sites in China
- Volunteers
- 50 people
- Sponsor
- BioChain (Beijing) Science and Technology, Inc.
Gastric Cancer, Chemoradiation
Feasibility Trial of Neoadjuvant Chemoradiotherapy for Locally Advanced Gastric Cancer
Because locally far-advanced gastric cancer combined with adjacent tissue invasion has a poor prognosis, some phase 2 and 3 clinical trials of neoadjuvant chemotherapy (NAC) are performed in Japan.
- Trial name
- NCT01381913
- Where
- Japan
- Volunteers
- 12 people
- Sponsor
- Kagawa University
Irritable Bowel Syndrome
The Efficacy of Sodium Butyrate and Probiotics in Patients With Irritable Bowel Syndrome
According to current IBS management guidelines, probiotic administration reduces IBS-associated symptoms and improves the quality of life.
- Trial name
- IBS-Plus (NCT05013060)
- Testing
- Probiotics and microcapsulated sodium butyrate, Maltodextrin
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Irritable Bowel Syndrome
Dietary Interventions for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by recurrent abdominal pain and altered bowel habits.
- Trial name
- IBS-DIET (NCT07774923)
- Testing
- Low-FODMAP Diet, Gluten-Free and Lactose-Free Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Gelisim University
Functional Constipation, Gastrointestinal Disorders
A Randomized, Open-label, Three-arm Study of MZRW on Tolerability, Exposure and Pharmacokinetics
This is a randomized open-label, three-arm, phase 1 clinical study. The investigators aim to investigate a Chinese Proprietary Medicine, MZRW on its tolerability, system exposure and pharmacokinetics profile.
- Trial name
- NCT02359396
- Testing
- MZRW
- Where
- China
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Hemorrhoids, Postoperative Pain
Ultrasound-guided Pudendal Nerve Block for Pain After Hemorrhoidectomy
The goal of this clinical trial is to investigate the effects of ultrasound-guided pudendal nerve block on postoperative pain, opioid consumption, and quality of recovery in patients receiving Ferguson hemorrhoidectomy.
- Trial name
- NCT05889962
- Testing
- Pudendal nerve block
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University Hospital
Colorectal Neoplasms
Levocetirizine + Capecitabine + Bevacizumab for Patients With Refractory Colorectal Cancer
This randomized phase II trial studies how giving a drug called levocetirizine to patients with colorectal cancer affects their tumor response to capecitabine and bevacizumab.
- Trial name
- NCT01722162
- Testing
- Bevacizumab, Capecitabine, Levocetirizine
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Washington University School of Medicine
Esophageal Stricture
Balloon Dilation Methods for Benign Esophageal Stricture
This is the first head to head, prospective, randomized, double-blind clinical trial comparing two different approaches of balloon dilation (standard versus progressive dilation) for benign esophageal strictures.
- Trial name
- NCT04730076
- Testing
- Standard Balloon Dilation, Progressive Balloon Dilation
- Where
- United States
- Sponsor
- Samuel H Mardini
Gastric Cancer
Comparison of Surgical,Clinical and Oncological Outcomes Between Robotic-assisted and Laparoscopic-assisted Gastrectomy
The study aims to compare the clinical outcomes between robotic-assisted and laparoscopic-assisted gastrectomy for gastric cancer,and evaluate the the feasibility and safety of robotic gastrectomy.
- Trial name
- NCT02413476
- Testing
- Robotic-assisted Gastrectomy(RAG), Laparoscopic-assisted Gastrectomy(LAG)
- Volunteers
- 120 people
- Sponsor
- wei bo
Colorectal Cancer
Metronomic Versus Conventional Chemotherapy in as Maintenance Treatment in mCRC
The optimum regimen of maintenance treatment after first-line chemotherapy in patients with metastatic colorectal cancer (mCRC) is unknown.
- Trial name
- NCT02893540
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Ruijin Hospital
Esophageal Cancer, Non-small Cell Lung Cancer
Early Prediction of Pathology Response of Chemoradiotherapy With FLT PET
The goal of this research study is to learn if a new type of PET scan (18F-FLT) can help to better detect changes of tumor growth rate (or how active) in esophagus cancer and lung cancer Researchers will study at what time during…
- Trial name
- NCT01065818
- Testing
- Fluoro-L-Thymidine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
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