Clinical trials: GI Disorders
Colorectal Neoplasms, Anastomotic Leak
Anastomotic Leakage and Enhanced Recovery Pathways After Colorectal Surgery
Prospective observational multicenter study on the influence of adherence to enhanced recovery pathways on early outcomes (anastomotic leakage, morbidity, mortality, readmission, reoperation rates and length of postoperative…
- Conditions
- Colorectal Neoplasms, Anastomotic Leak, Surgery--Complications
- Trial name
- iCral2 (NCT03771456)
- Testing
- Colorectal resections
- Where
- 41 sites in Italy
- Volunteers
- 1,748 people
- Sponsor
- Ospedale C & G Mazzoni
Crohn Disease
Therapeutic Optimization Study Based on MR Enterocolonography in Patients With Crohn's Disease
This randomized, controlled study aims to evaluate the impact of therapeutic intervention (step up) for the patients who are clinical remission with Magnetic Resonance Enterocolonography (MREC) active.
- Trial name
- NCT02332356
- Testing
- azathioprine or adalimumab and infliximab
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Tokyo Medical and Dental University
Irritable Bowel Syndrome
Edible Insects: Good for the Gut and the Globe
Edible insects have been eaten by people throughout human history and are consumed today across the globe. Insects are also currently being incorporated into a number of food products in the United States, Canada, and Europe due…
- Trial name
- GGG (NCT06397924)
- Testing
- Chitin Fiber
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Colorado State University
Neoplasms, Colorectal Neoplasms
Study of MK-1697 in Participants With Advanced Solid Tumors (MK-1697-001)
The purpose of this study is to evaluate the safety and preliminary efficacy of MK-1697. There are 2 parts in this study: dose escalation to determine the recommended phase 2 dose (RP2D) and confirm the RP2D (Part A) and cohort…
- Conditions
- Neoplasms, Colorectal Neoplasms, Head and Neck Neoplasms
- Trial name
- NCT03515824
- Testing
- MK-1697
- Where
- 2 sites in Australia, Hong Kong
- Volunteers
- 22 people
- Sponsor
- Merck Sharp & Dohme LLC
Irritable Bowel Syndrome (IBS), Children, Only
Butyrate in Children With IBS: Double Blind Placebo Controlled Randomized Clinical Trial
We will perform a randomized, double-blind, placebo-controlled trial to establish whether calcium butyrate relieves symptoms in children with irritable bowel syndrome (IBS).
- Trial name
- BUZIR (NCT04566679)
- Testing
- Dibuzin
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Bari
Gastroesophageal Reflux Disease
Treatment of Gastroesophageal Reflux Disease in 12-16 Year Old Patients With Rabeprazole
The primary objective of this study is to collect safety information on rabeprazole 10 mg and 20 mg in the treatment of gastroesophageal reflux disease (GERD) in children aged 12 to 16 years.
- Trial name
- NCT00132496
- Testing
- rabeprazole sodium
- Where
- 25 sites in United States
- Volunteers
- 111 people
- Sponsor
- Eisai Inc.
Colorectal Cancer
Outcome of Transanal Specimen Extraction Surgery for Elderly Colorectal Cancer Patients
Retrospective analysis of a cohort of elderly CRC patients (aged ≥ 65 years) underwent transanal-NOSES between August 2008 and February 2022 was constructed. Data were obtained from China NOSES Database (CNDB).
- Trial name
- NCT05744362
- Where
- China
- Volunteers
- 1,395 people
- Sponsor
- The Second Affiliated Hospital of Harbin Medical University
Colon Cancer
Laparoscopic Versus Open Right Colectomy for Right Colon Cancer
The purpose of this research protocol is to compare open versus laparoscopic right colectomy (according to the CME technique of complete mesocolic excision) for right colon cancer.
- Trial name
- NCT05713903
- Testing
- Laparoscopic right colectomy, Open right colectomy
- Where
- Greece
- Volunteers
- 114 people
- Sponsor
- Larissa University Hospital
Gastric Cancer, Gastric Adenocarcinoma
Stomach Cancer Exosome-based Detection
Gastric cancer continues to have a poor prognosis primarily due to the inability to detect it in its early stages. This study will develop and validate a blood assay to facilitate the non-invasive detection of gastric cancer.
- Conditions
- Gastric Cancer, Gastric Adenocarcinoma, Gastric Cancer Stage, Gastric Neoplasm
- Trial name
- DESTINEX (NCT06342427)
- Testing
- DESTINEX
- Where
- 3 sites in United States, Japan
- Volunteers
- 809 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Hemorrhoid Bleeding, Hemorrhoids Prolapse
Topical Nifedipine 0.3% Plus Lidocaine 1.5% for Uncomplicated Hemorrhoidal Disease
The goal of this observational study is to evaluate the effectiveness of topical nifedipine 0.3% plus lidocaine 1.5% for uncomplicated hemorrhoidal disease.
- Conditions
- Hemorrhoid Bleeding, Hemorrhoids Prolapse, Hemorrhoid Pain, Hemorrhoid
- Trial name
- NILOS (NCT07295886)
- Testing
- topical nifedipine 0.3% plus lidocaine 1.5%
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Cardarelli Hospital
Gastroesophageal Reflux Disease
The Proton Pump Inhibitor (PPI) Test for the Extraesophageal Manifestation of GERD
PPI test;empirical trial with high-dose proton-pump inhibitors (PPIs) has been shown to be a sensitive tool for diagnosing patients with GERD.
- Trial name
- NCT00539786
- Testing
- Proton pump inhibitor (rabeprazole)
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Eosinophilic Esophagitis, EoE
Dupilumab for Eosinophilic Esophagitis With Severe Strictures
The purpose of this research study is to determine how well an FDA-approved drug, dupilumab, works to treat patients with severe strictures and active Eosinophilic Esophagitis (EoE).
- Trial name
- DESTRICT (NCT06352073)
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Colorectal Cancer, Neoadjuvant Chemotherapy
Neoadjuvant Chemotherapy Verse Surgery Alone After Stent Placement for Obstructive Colonic Cancer
Colorectal cancer is the fourth most common cancer in China. Up to 30% of patients with colorectal cancer present with an emergency obstruction of the large bowel at the time of diagnosis, and 70% of all malignant obstruction…
- Conditions
- Colorectal Cancer, Neoadjuvant Chemotherapy, Stent, Obstruction
- Trial name
- NACSOC (NCT02972541)
- Testing
- Stenting with neoadjuvant chemotherapy, Stenting with immediate Surgery
- Where
- 32 sites in China
- Volunteers
- 248 people
- Sponsor
- Beijing Chao Yang Hospital
Fecal Incontinence
Study of the Efficacy of 4 Treatments for Fecal Incontinence in Community-dwelling Women
This is a RCT aimed to assessing efficacy of kegel exercises,biofeedback, electrostimulation and transcutaneous neuromodulation on women with fecal incontinence, measuring its impact on anorectal physiology, cortical plasticity…
- Trial name
- NCT03394794
- Testing
- Pelvic floor rehabilitation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Crohn Disease
Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease
To evaluate the effects of infusion of a Fish oil-based lipid emulsion on TNF-α production and other relevant immune functions. A soybean oil emulsion, rich in the omega-6 polyunsaturated fatty acid linoleic acid, will serve as…
- Trial name
- NCT02349594
- Testing
- Omegaven 10%, Intralipid 20%
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Unresectable/Metastatic Colorectal Cancer
Fruquintinib Plus Camrelizumab and Capecitabine as Salvage Therapy After Progression on FOLFOXIRI-based First-line Treatment in Patients With Unresectable/Metastatic Colorectal Cancer
FOLFOXIRI-based regimen is more used as a first-line therapeutic approach for patients diagnosed with unresectable or metastatic colorectal cancer for its superior efficacy.
- Trial name
- NCT06148402
- Testing
- Fruquintinib plus camrelizumab and capecitabine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Barrett Oesophagitis With Dysplasia
Itraconazole to Prevent Recurrent Barrett's Esophagus
Recurrent Barrett's esophagus (BE) that occurs at the rate of 12.4%/year is the Achilles heel of the endoscopic treatment of high-risk BE.
- Trial name
- NCT05609253
- Testing
- Itraconazole in capsule form, Itraconazole in solution form
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Rectal Neoplasms, Fecal Incontinence
The Role of Biofeedback in Improving Continence After Anterior Resection
The purpose of this study is to determine whether biofeedback exercises improve anal continence after anterior resection for rectal cancer.
- Conditions
- Rectal Neoplasms, Fecal Incontinence, Aged
- Trial name
- NCT00515853
- Testing
- Biofeedback
- Where
- United Kingdom
- Volunteers
- 121 people
- Sponsor
- University of Southampton
GERD, Apnea Neonatal
Effects of Vented Base Feeding Bottle in Preterm Infants With GERD Symptoms.
Aim of the study is to evaluate the effects of vented base bottles on respiration-swallow patterns and on gastroesophageal refluxes in preterm infants with clinical suspect of gastroesophageal reflux disease (GERD).
- Trial name
- FeedGERD (NCT03031288)
- Testing
- A, B
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Metastatic Gastric Adenocarcinoma
S1+ Paclitaxel (IV&IP) + Bevacizumab (IP) Versus S1+Oxaliplatin as First-line Treatment in Gastric Cancer With Malignant Ascites
The purpose of this study is to compare the efficacy of S1 plus paclitaxel (intravenous injection \& intraperitoneal injection) plus bevacizumab (intraperitoneal injection) vs.
- Trial name
- NCT03990103
- Testing
- S1, Paclitaxel, Bevacizumab
- Where
- China
- Volunteers
- 66 people
- Sponsor
- China Medical University, China
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