Clinical trials: GI Disorders
Rectal Cancer
Oral Steroids for Regorafenib-induced Fatigue/Malaise in Unresectable mCRC (KSCC1402/HGCSG1402)
The objective of this randomized placebo-controlled Phase 2 study is to evaluate prophylactic effects of dexamethasone for fatigue and malaise (weakness, lethargy, malaise) resulting from regorafenib treatment, as well as to…
- Trial name
- NCT02288078
- Testing
- General condition, Blood pressure, Patient Reported Outcome
- Where
- Japan
- Volunteers
- 74 people
- Sponsor
- Clinical Research Support Center Kyush
Rectal Cancer, Cervical Cancer
Irradiation Modulates the Pharmacokinetics of Anticancer Drugs
Radiation therapy (RT) is used as an effective local treatment modality to inhibit cell proliferation, induce cell death and suppress tumor growth.
- Trial name
- NCT01755585
- Volunteers
- 40 people
- Sponsor
- Far Eastern Memorial Hospital
IBS - Irritable Bowel Syndrome
Online, Gut-directed Hypnotherapy for Patients With Irritable Bowel Syndrome (IBS)
Adult IBS patients with symptoms refractory to standard medical treatment will receive online nurse-administered, gut-directed hypnotherapy in groups. The primary outcome measure was change in gastro-intestinal symptom severity.
- Trial name
- NCT06297785
- Testing
- Gut-directed hypnotherapy
- Where
- 2 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Cough
Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of AG1321001 in Chronic Cougher
This study is for therapeutic confirmation of AG1321001 to evaluate the safety and efficacy as an anti-tussive agent in cough patients.
- Trial name
- NCT00380315
- Testing
- AG1321001(drug)
- Where
- South Korea
- Volunteers
- 396 people
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Post-operative Ileus
Nicotine Gum Recovery After Colorectal Surgery
The purpose of this study is to evaluate whether the use of nicotine gum in the postoperative period influences surgical outcome in patients undergoing colorectal surgery.
- Trial name
- NCT01662115
- Testing
- Nicotine gum, Regular chewing gum
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The Cleveland Clinic
Ulcerative Colitis
Prospective, Longitudinal Multicentric Survey in the Therapeutic Care of Mild to Moderate Ulcerative Colitis
The primary objective of this study is to confirm the long-term efficacy (remission and maintenance in remission) of current validated treatments. Each patient will be followed during 3 years in this non-interventional trial.
- Trial name
- OPTIMUM (NCT01387698)
- Where
- 158 sites in France
- Volunteers
- 812 people
- Sponsor
- Ferring Pharmaceuticals
CRC (Colorectal Cancer), Lung Cancer (Diagnosis)
Validation of High-Throughput Large-Format Tissue Preprocessing for Lung and Colorectal Cancer
This project aims to employ a sample preprocessing system in conjunction with three-dimensional imaging techniques to generate morphologically more complete, high-resolution datasets for lung and colorectal cancers.
- Trial name
- NCT07239063
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Gastroesophageal Reflux Disease
Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis
The purpose of this study is to investigate whether dexlansoprazole can be as effective as double dose PPI to achieve SSR in high BMI cases with reflux esophagitis in Los Angeles grades A \& B.
- Trial name
- NCT02759393
- Testing
- Dexlansoprazole, Lansoprazole
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
Metastatic Colorectal Cancer
Folfoxiri Plus Bev Followed by Reintroduction of Folfoxiri Plus Bev at Progression Versus Folfox Plus Bev Followed by Folfiri Plus Bev in mCRC
Bev improves the efficacy of first-line chemotherapy in unresectable mCRC. In the phase III TRIBE trial upfront FOLFOXIRI plus bev provided a significant advantage in terms of PFS and RR compared to FOLFIRI plus bev.
- Trial name
- TRIBE2 (NCT02339116)
- Testing
- fluoruracil, Oxaliplatin, Irinotecan
- Where
- Italy
- Volunteers
- 654 people
- Sponsor
- Gruppo Oncologico del Nord-Ovest
Gastric Cancer
Combination Chemotherapy, Cetuximab and Radiation for Patients With Localized Gastric Cancer
RATIONALE: Radiotherapy is currently the most efficient way to induce pathologic responses, which are associated with a favorable prognosis in localized tumors.
- Trial name
- NCT01611506
- Testing
- Cetuximab, Capecitabine, Cisplatin
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Dr Anna Dorothea Wagner
Metastatic Colorectal Cancer
Panitumumab Plus FOLFIRI in First-line Treatment of Metastatic Colorectal Cancer
To estimate the effect of KRAS mutation status (Wild-type versus Mutant) on objective response rate and other measures of efficacy for patients treated with panitumumab in combination with a chemotherapy regimen of irinotecan…
- Trial name
- NCT00508404
- Testing
- Panitumumab, FOLFIRI
- Volunteers
- 154 people
- Sponsor
- Amgen
Stroke, Dysphagia
Transcranial Direct Current Stimulation for Dysphagia Therapy in Acute Stroke Patients
The purpose of this study is to evaluate whether transcranial direct current stimulation of the cerebral swallow motor cortex in addition to standard care can enhance recovery of swallow function in acute dysphagic stroke…
- Trial name
- NCT01970384
- Testing
- Transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Muenster
Colorectal Adenocarcinoma, Colorectal Carcinoma Metastatic in the Lung
Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases
This phase II trial studies how well chemotherapy and/or metastasectomy work in treating patients with colorectal adenocarcinoma that has spread to the lungs (metastases).
- Conditions
- Colorectal Adenocarcinoma, Colorectal Carcinoma Metastatic in the Lung, Stage IV Colorectal Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8
- Trial name
- NCT03599752
- Testing
- Chemotherapy, Metastasectomy
- Where
- 6 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Adenoma, Colorectal Cancer
Early Screening of Colorectal Cancer Based on Plasma Multi-omics Combining With Artificial Intelligence
To evaluate the accuracy and effectiveness of a novel screening method based on plasma multi-omics combining with artificial intelligence in a large prospective cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- RECOMMEND (NCT05587452)
- Testing
- Colonoscopy, Test of ctDNA methylation, Test of characteristics of ctDNA fragment
- Where
- 5 sites in China
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Cancer
ReAL Trial (Rectal Anastomotic seaL)
The problem of anastomotic leak is particularly relevant in rectal surgery. Many risk factors have been recognized in the onset of this complication.
- Trial name
- ReAL (NCT03941938)
- Testing
- Cyanoacrylate reinforcement, No reinforcement
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Gastrointestinal Cancer
Frailty in Patients With Gastrointestinal Cancer Who Are Undergoing Major Surgery
This research is for patients who have gastrointestinal cancer and have a planned major surgery. The purpose of this research is to identify cancer patients who may be at risk for frailty.
- Trial name
- NCT05694338
- Testing
- Frailty survey
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- The Guthrie Clinic
Gastric Cancer
Identification of Complete Lymph Node Removal by Application of Near Infrared Fluorescence Imaging in Laparoscopic and Robotic Gastrectomy
Lymph node dissection in gastric cancer surgery is a very important factor not only for exact acquisition of stage but also proper treatment.
- Trial name
- NCT01926743
- Testing
- Near infrared fluorescence imaging during laparoscopic or robotic gastrectomy
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Crohn's Disease, Ulcerative Colitis
Assessing the Drug Exposure Risk of Infants Breastfed by Women With Inflammatory Bowel Disease
Breastfeeding is beneficial to both mother and baby. However, many breastfeeding women are affected by long-term health conditions and need to take medications.
- Conditions
- Crohn's Disease, Ulcerative Colitis, Healthy Controls
- Trial name
- NCT03397108
- Testing
- The IBD group was divided into 2 subgroups: with or without anti-TNF antibody use
- Where
- 2 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Nasogastric Feeding, Training Family Caregivers
Effectiveness of an Web Application in Enhancing Informal Caregivers' Nasogastric Tube Feeding Competency
The goal of this trial is to determine whether adding a nasogastric tube web application to standard face-to-face caregiver training helps informal caregivers learn nasogastric tube feeding more quickly than standard training…
- Conditions
- Nasogastric Feeding, Training Family Caregivers, Family Caregivers, Informal Caregiver
- Trial name
- NCT07414563
- Testing
- Nasogastric tube web application
- Where
- Singapore
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Lung Disease, Brain Injury
Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology
This research seeks to establish a neonatal DNA Tissue Bank to find out if differences in small segments of DNA predispose babies to Chronic Lung Disease (CLD), Periventricular Brain Injury (PVI), Necrotizing Enterocolitis (NEC)…
- Conditions
- Lung Disease, Brain Injury, Necrotizing Enterocolitis, Respiratory Failure
- Trial name
- NCT00315263
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Children's Mercy Hospital Kansas City
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