Clinical trials: GI Disorders
Crohn Disease
Contribution of a Non Medicamentous Approach by Hypnosis on Quality of Life in Crohn Disease
Evaluation of hypnosis therapy efficacy in addition to pharmacologic standard treatment of Croh disease during remission by the evaluation of quality of life;
- Trial name
- HYPNOCROHN (NCT03623932)
- Testing
- immunosuppressor/TNFalpha, Hypnosis
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Neoplasms, Carcinoma, Non-Small-Cell Lung
A Study of mRNA-5671/V941 as Monotherapy and in Combination With Pembrolizumab (V941-001)
This study will determine the safety and tolerability and establish a preliminary recommended Phase 2 dose of V941(mRNA-5671/V941) as a monotherapy and in combination with pembrolizumab infusion.
- Conditions
- Neoplasms, Carcinoma, Non-Small-Cell Lung, Pancreatic Neoplasms, Colorectal Neoplasms
- Trial name
- NCT03948763
- Testing
- V941, Pembrolizumab
- Where
- 26 sites in United States, Australia and 5 more
- Volunteers
- 70 people
- Sponsor
- Merck Sharp & Dohme LLC
Crohn's Disease
Capsule Colonoscopy in Crohn's Disease and Its Correlation With Conventional Colonoscopy and Faecal Calprotectin
Aims: To study the feasibility of capsule colonoscopy in patients with Crohn's Disease (CD). To compare the results of capsule colonoscopy with conventional colonoscopy in assessing mucosal healing.
- Trial name
- NCT02624414
- Testing
- PillCam® COLON 2 Capsule Endoscopy
- Where
- Australia
- Volunteers
- 47 people
- Sponsor
- Melbourne Health
Gastric Cancer, Gastric Neoplasms
Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers
Background: Some people have a mutation in the cadherin-1 gene (CDH1) gene that is known to lead to stomach cancer. They are advised to get regular endoscopies with biopsies even if their stomach appears normal.
- Conditions
- Gastric Cancer, Gastric Neoplasms, Gastric Adenocarcinoma
- Trial name
- NCT04535414
- Testing
- Cellvizio (Registered trademark) Real-Time In Vivo Cellular Imaging Platform with Confocal Miniprobes, Olympus Graphics Interchange Format (GIF) 190 endoscope, Gastric mucosal biopsy
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- National Cancer Institute (NCI)
Paralytic Ileus
The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section
Following all abdominal surgery, paralytic ileus commonly develops. Surgeons have traditionally withheld postoperative oral intake until the return of bowel function to prevent related complications.
- Trial name
- GUM01 (NCT01131416)
- Testing
- Gum chewing
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Pain, Postoperative, Acute Pain
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
The aim of the trial is to study the efficacy of continuous bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic colectomy.
- Conditions
- Pain, Postoperative, Acute Pain, Postoperative Complications, Pain
- Trial name
- EFFECT (NCT04879004)
- Testing
- Ropivacaine injection
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Democritus University of Thrace
Crohn Disease
Personalising Anti-TNF Therapy in Crohns Disease (PANTS)
To develop a cost-effective, individualised anti-TNF treatment strategy for patients with Crohn's disease which maximizes benefit and minimises harm.
- Trial name
- PANTS (NCT03088449)
- Where
- United Kingdom
- Volunteers
- 1,750 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Barrett's Esophagus
Effect of Dexlansoprazole 60 mg QD and 60 mg BID on Recurrence of Intestinal Metaplasia in Subjects Who Have Achieved Complete Eradication of Barrett's Esophagus With Radiofrequency Ablation
This study is designed to evaluate the effect of dexlansoprazole once daily (QD) and twice daily (BID) dosing on the recurrence of intestinal metaplasia (IM) in participants who achieved complete eradication of Barrett's…
- Trial name
- NCT02162758
- Testing
- Dexlansoprazole
- Where
- 6 sites in United States
- Volunteers
- 6 people
- Sponsor
- Takeda
Postoperative Ileus, Postoperative Complications
Coffee After Pancreatic Surgery
Postoperative ileus is a common complication after major abdominal surgery. A positive effect of coffee to bowel movement has been described after colorectal and gynecologic interventions.
- Conditions
- Postoperative Ileus, Postoperative Complications, Bowel Dysfunction, Pancreatic Diseases
- Trial name
- COPS (NCT04205058)
- Testing
- Standard coffee, Caffeine-free coffee, Drinking water
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Gastroesophageal Reflux Disease (GERD)
The EndoGastric Solutions TEMPO Trial
The purpose of this study is to assess the efficacy and safety of Transoral Incisionless Fundoplication (TIF) performed with EsophyX as compared to proton pump inhibitor (PPI) therapy for the treatment of chronic Gastroesophageal…
- Trial name
- TEMPO (NCT01647958)
- Testing
- EsophyX System with SerosaFuse fasteners, PPI
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- EndoGastric Solutions
Esophageal Cancer, Precancerous Condition
Tethered Capsule Endoscope in Screening Participants for Barrett Esophagus
RATIONALE: A tethered capsule endoscope may be as effective as standard sedated endoscopy of the esophagus, stomach, and duodenum in screening for Barrett esophagus.
- Trial name
- NCT00903136
- Testing
- questionnaire administration, comparison of screening methods, diagnostic endoscopic procedure
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Colorectal Neoplasm
The Usefulness of I-scan in Screening Colonoscopy
Image-enhanced endoscopy in screening colonoscopy 1. useful tool for detecting subtle epithelial lesions 2. useful tool for predicting real-time histology of epithelial lesions.
- Trial name
- NCT01417611
- Testing
- i-scan CE, SE, TE mode
- Where
- South Korea
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Konkuk University Hospital
Colon Tumor, Malignant, Rectum Tumor
Use of VIrtual REAlity to Reduce Postoperative Anxiety and Pain After Surgery for Colorectal Cancer
In patients operated for colorectal cancer, pain, anxiety and depression are important factors in postoperative rehabilitation. The use of new technologies, as virtual reality immersion, could further improve their postoperative…
- Conditions
- Colon Tumor, Malignant, Rectum Tumor, Pain, Postoperative
- Trial name
- VIREA (NCT05653934)
- Testing
- Pre-operative use of virtual reality headset, Standard surgery, Post-operative use of virtual reality headset
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Disease Activity, Remission of Ulcerative Colitis
Maresin-1 and Resolvin-D1 Levels and Disease Activity in Ulcerative Colitis
Specialized pro-resolving mediators (SPMs), which are typically thought to be formed via consecutive steps of oxidation of polyenoic fatty acids, have been shown to suppress inflammation and promote timely resolution of…
- Conditions
- Disease Activity, Remission of Ulcerative Colitis, Ulcerative Colitis Flare
- Trial name
- NCT06652464
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Cancer of the Rectum, Neoplasms, Rectal
Immunoscore in Rectal Cancer
This is an observational study of tumor samples and MRI imaging in patients with colorectal cancers. A tumor sample, MRI scans, and treatment outcome data will be used for research purposes to see if it is possible to predict…
- Conditions
- Cancer of the Rectum, Neoplasms, Rectal, Rectal Cancer, Rectal Tumors
- Trial name
- NCT02017509
- Testing
- Diagnostic Biopsy and Surgical Procedure, Intravoxel incoherent motion MRI (IVIM), Dynamic Contrast Enhanced MRI (DCE-MRI)
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Providence Health & Services
Panic Disorder
Psychoeducation Based on Acceptance and Commitment Therapy
The aim of this study is to manage individual psychoeducation in acceptance and commitment therapy for problems with panic disorder and to evaluate the effect of this program on rumination and self-resilience.
- Trial name
- NCT06704399
- Testing
- Acceptance and Commitment Therapy-Based Psychoeducation, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Muğla Sıtkı Koçman University
Irritable Bowel Syndrome (IBS)
Confocal Endomicroscopy Utility (p-CLE) in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. It has prevalence in general population of 5-20% and is more common in women and young adults.
- Trial name
- NCT02651532
- Testing
- Confocal Laser Endomicroscopy
- Where
- Ecuador
- Volunteers
- 74 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Esophageal Varices
Optimal Time for Follow up After Variceal Band Ligation
Optimal time for follow up after variceal band ligation in cirrhotic patients remains to be determined
- Trial name
- NCT04602663
- Testing
- Esophageal Variceal Band ligation
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Tanta University
Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer
MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
Brain metastases are the most common intracranial malignancy occurring in 20-40% of all cancers, and the presence of CNS metastases is associated with a poor prognosis.
- Conditions
- Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer, Breast Cancer, Cancer of Breast
- Trial name
- NCT02669914
- Testing
- MEDI4736
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Esophageal Cancer
Clinical Trial Evaluating TQB6411 Injection in Participant s With Esophageal Cancer
The Phase Ib stage of this study primarily aims to evaluate the tolerance and safety of TQB6411 Injection in participants with recurrent or metastatic Esophageal cancer who have previously failed treatment with PD-1/PD-L1…
- Trial name
- NCT07367516
- Testing
- TQB6411 Injection
- Where
- 30 sites in China
- Volunteers
- 105 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
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