Clinical trials: GI Disorders
Gastrointestinal Neoplasms
Clinical Trial on Ganoderma Spore Lipids Combined With Chemo in Patients With G.I. Cancers
A phase III double-blind randomized clinical trial on the effects of ganoderma spore lipids to the immunological response in patients with G.I. Cancers. The trial is randomized, double-blind.
- Trial name
- NCT02785523
- Testing
- Ganoderma Spore Lipids, Chemotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaonan Cui
Gastric Cancer (GC), Stomach Neoplasms
TEAS Timing for Gastrectomy Recovery (TEAS-TIME Trial)
The goal of this clinical trial is to learn if transcutaneous electrical acupoint stimulation (TEAS) works to help people recover faster after laparoscopic surgery for stomach cancer.
- Trial name
- NCT07714980
- Testing
- Transcutaneous Electrical Acupoint Stimulation
- Where
- 13 sites in China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Crohn Disease
Post-operative CRP Trend After Ileocolic Resection in Crohn's Disease Patients.
Our aim is to analyze C-Reactive Protein trends during the post-operative course in Crohn's Disease patients having undergone ileocolic resection and primary anastomosis, for the purpose of anastomotic leak early diagnosis.
- Trial name
- NCT04739579
- Testing
- C-Reactive Protein
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Central Hospital, Nancy, France
Appendicitis
Antibiotic Therapy Versus Appendectomy for Acute Appendicitis
The purpose of the study is to demonstrate that antibiotic therapy is as safe and effective as appendectomy for the treatment of acute non complicated appendicitis.
- Trial name
- NCT00135603
- Testing
- amoxicillin/clavulanate potassium, appendectomy
- Where
- 5 sites in France
- Volunteers
- 243 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Solid Cancer, Gastric (Cardia, Body) Cancer
Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients
In this study, the drug capecitabine is investigated. Capecitabine is commonly used to treat breast, colon, and stomach cancers. Capecitabine is taken in tablet form.
- Conditions
- Solid Cancer, Gastric (Cardia, Body) Cancer, Esophageal Cancer, Colorectal Cancer (CRC)
- Trial name
- ESCAPE (NCT07114627)
- Testing
- Blood sampling for pharmacokinetics
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Erasmus Medical Center
Colon Cancer
Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related Pharmacodynamic Markers
Metformin is drug that is normally used to treat people with diabetes. New research has discovered that metformin may also kill cancer stem cells.
- Trial name
- NCT01440127
- Testing
- Metformin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Tufts Medical Center
Locally Advanced Rectal Cancer (LARC)
AI-Based Prediction of Pathological Response in Rectal Cancer Patients Receiving Total Neoadjuvant Therapy
This study aims to better understand how body composition, inflammation, and nutrition affect how rectal cancer responds to treatment.
- Trial name
- CINR-AI (NCT07049627)
- Testing
- Total Neoadjuvant Therapy (TNT)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Ankara Etlik City Hospital
Irritable Bowel Syndrome
Effectiveness of Internet Delivered Cognitive Behavior Therapy (CBT) for Irritable Bowel Syndrome (IBS)
The study will recruit 80 out-patients diagnosed with Irritable Bowel Syndrome from a gastroenterological clinic. The recruitment will be consecutive with all patients receiving the diagnosis being offered to participate.
- Trial name
- NCT00844961
- Testing
- Internet delivered cognitive behavior therapy
- Where
- Sweden
- Volunteers
- 61 people
- Sponsor
- Karolinska Institutet
Metastatic Colorectal Cancer
A Real-World Study to Learn More About the Order of Different Treatments and Their Effects in People With Metastatic Colorectal Cancer Receiving Their Third and Fourth Line of Treatment
This is an observational study in which data already collected from people with metastatic colorectal cancer will be studied. Metastatic colorectal cancer (mCRC) is a cancer of the colon (large bowel) or the rectum (lowest part…
- Trial name
- RegoSeq (NCT06137170)
- Testing
- Regorafenib (Stivarga, BAY73-4506)
- Where
- 3 sites in France, Italy and 1 more
- Volunteers
- 121 people
- Sponsor
- Bayer
Metastatic Colorectal Cancer
A Study of Trifluridine/ Tipiracil in Chemorefractory mCRC in Greece
Collection of real world data on the clinical efficacy of trifluridine/ tipiracil (FTD/TPI) in the Greek population.
- Trial name
- RETRO-TAS (NCT04965870)
- Testing
- Trifluridine/Tipiracil
- Where
- 8 sites in Greece
- Volunteers
- 200 people
- Sponsor
- Hellenic Study Group of Psychoneuroimmunology in Cancer
Inflammatory Bowel Diseases, Crohn Disease
PIBD-SETQuality: the Inception Cohort and Safety Registry
The purpose of this study is to analyse effectiveness and safety signals of current treatment strategies in routine practice for patients with pediatric-onset inflammatory bowel disease (PIBD) and to correlate this to their…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PIBD-SETQ (NCT03571373)
- Testing
- No intervention
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Ulcerative Colitis
Comparison of PillCamCOLON (C2) Capsule and Standard Endoscopy for the Evaluation of Patients With Ulcerative Colitis
Ulcerative colitis (UC) is an inflammatory bowel disease progressing through flare-ups. The therapeutic objective, which was originally based on clinical remission, is currently evolving with the development of biotherapies…
- Trial name
- VCC2-RCH (NCT02610569)
- Testing
- standard endoscopy, PillCamCOLON (C2)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Dr. Arnaud Bourreille
Colorectal Cancer
Effect of Preoperative ERAS Education on Recovery After Colorectal Surgery
This randomized controlled trial describes the design and conduct of ERAS-based preoperative education in patients with colorectal cancer undergoing colorectal surgery.
- Trial name
- NCT07324369
- Testing
- ERAS-Based Preoperative Education, Standard Preoperative Education
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Izmir Katip Celebi University
Gastric Cancer
Predictive Biomarkers in Stage II/III Gastric Cancer for Adjuvant Chemotherapy
Adjuvant chemotherapy followed by curative gastrectomy for Stage II/III gastric cancer has improved disease free time and survival.
- Trial name
- NJBMR (NCT01905969)
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Iwate Medical University
Colorectal Neoplasms
Colonoscopic Removal of Aberrant Crypt Foci: a Prospective, Randomized, Blinded Trial
We hypothesized that aberrant crypt foci (ACF) are precursors of colon cancer; their prevention would correlate with cancer risk and their elimination would reduce that risk.
- Trial name
- NCT00623883
- Testing
- Surgical removal of ACF, Colonoscopic evaluation only
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- National Naval Medical Center
Digestive Tract Diseases, Liver Diseases
Tongue Image Database and Diagnostic Model for Digestive Tract Disease Diagnosis
The tongue images of patients with gastrointestinal diseases and healthy people will be collected and the tongue image database will be established.
- Conditions
- Digestive Tract Diseases, Liver Diseases, Colorectal Disease, Gastric Diseases
- Trial name
- NCT05182983
- Testing
- Tongue images，coating on the tongue and clinical data
- Where
- China
- Volunteers
- 10,690 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Crohn's Disease
Azithromycin Based Therapy for Induction of Remission in Active Pediatric Crohn's Disease
The purpose of this study is to evaluate effectiveness of 2 months antibiotic course of Azithromycin combined with Metronidazole compared with 2 months antibiotic course of Metronidazole alone.
- Trial name
- NCT01596894
- Testing
- Azithromycin + Metronidazole, Metronidazole
- Where
- Israel
- Volunteers
- 73 people
- Sponsor
- Prof. Arie Levine
Breast Cancer, Melanoma
Immunological Variables Associated to ICI Toxicity in Cancer Patients
This is a monocentric, prospective, pilot study that will enrol 435 subjects with solid tumours that are treated with immune checkpoint inhibitor(s) (ICI) alone or in combination with chemotherapy or targeted therapy.
- Conditions
- Breast Cancer, Melanoma, Non Small Cell Lung Cancer, Non-melanoma Skin Cancer
- Trial name
- NCT05429866
- Testing
- Checkpoint Blockade, Immune
- Where
- Belgium
- Volunteers
- 441 people
- Sponsor
- Jules Bordet Institute
Mild to Moderate Ulcerative Colitis
Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis
The purpose of this study is to evaluate effectiveness of once daily dosing of Pentasa compared with twice daily in children with mild to moderate active ulcerative colitis.
- Trial name
- MUPPIT (NCT01201122)
- Testing
- Mesalamine
- Where
- Israel
- Volunteers
- 86 people
- Sponsor
- Wolfson Medical Center
Inflammatory Bowel Diseases, Ulcerative Colitis
Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease
Specific Aim 1: Characterize the effects of vitamin D treatment on expression of α4β7 on B cells in patients with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT04828031
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stanford University
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