Clinical trials: GI Symptoms
Amyotrophic Lateral Sclerosis, Gastrointestinal Intolerance
Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in pALS
The main objective of the proposed study is to evaluate if oral intake of EN formula preceding Gtube placement will impact tolerance upon placement and feeding via Gtube in pALS.
- Conditions
- Amyotrophic Lateral Sclerosis, Gastrointestinal Intolerance, Enteral Nutrition Therapy
- Trial name
- NCT06609213
- Testing
- Medical Food
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Andrea Charvet
Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction
Personalized GI Motility Responses to Diet
The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3)…
- Conditions
- Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction, Cardiovascular Diseases, Dysbiosis
- Trial name
- NCT06386471
- Testing
- Whole grain rye bread, Refined grain rye bread
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Cystic Fibrosis
Multicenter Study of Patient-reported Gastrointestinal Symptoms in People With Cystic Fibrosis
This is a prospective, multicenter, observational study designed to collect gastrointestinal related data in patients with Cystic Fibrosis (CF).
- Trial name
- GALAXY (NCT03801993)
- Where
- 26 sites in United States
- Volunteers
- 402 people
- Sponsor
- Chris Goss
Helicobacter Pylori Infection, Dyspepsia
Effect of H. Pylori Eradication on The Improvement of Gastrointestinal Symptoms
This study aims to evaluate the effect of Helicobacter pylori eradication on gastrointestinal symptoms in adult patients. H. pylori infection is a common cause of dyspepsia and other upper gastrointestinal complaints.
- Conditions
- Helicobacter Pylori Infection, Dyspepsia, Gastrointestinal Symptoms
- Trial name
- HPE-GI (NCT07272681)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amany Usama Ahmed Arafa
NSAIDs, Upper GI Symptoms
Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
This study was a randomised, double-blind, parallel-group and placebo controlled study comparing the efficacy of esomeprazole 40 mg orally qd vs placebo and esomeprazole 20 mg orally qd vs placebo when given to patients on…
- Trial name
- NCT00241527
- Testing
- Esomeprazole
- Where
- 130 sites in United States, Australia and 9 more
- Volunteers
- 556 people
- Sponsor
- AstraZeneca
Colorectal Cancer, Colorectal Adenoma
FIT and Fecal Calprotectin in Patients With Chronic Lower GI Symptoms
Chronic lower gastrointestinal (GI) symptoms, including lower abdominal pain, bowel habit change, bleeding per rectum, and abdominal bloating, are caused by functional gastrointestinal disorders (FGID) and organic intestinal…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colitis
- Trial name
- NCT05514561
- Testing
- Fecal calprotectin, Fecal immunochemical test
- Where
- Thailand
- Volunteers
- 1,007 people
- Sponsor
- Mahidol University
Gastroesophageal Reflux Disease
Prevalence and Impact in Work Productivity of Gastroesophageal Reflux Disease (GERD) in Primary Care Patients With Upper Gastrointestinal (GI) Symptoms Using GerdQ
The purpose of the study is to provide data on the GERD prevalence as percentage of patients with upper GI symptoms that are identified with GERD using the GerdQ Questionnaire.
- Trial name
- GerdQ-Greece (NCT00914342)
- Where
- 54 sites in Greece
- Volunteers
- 889 people
- Sponsor
- AstraZeneca
Gastrointestinal Disorder, Functional
Impact of Diet on Functional Gastrointestinal Symptoms
This cross-sectional survey study is to determine the prevalence of functional gastrointestinal (GI) disorders in the general population and to describe common triggers for food-related GI symptoms.
- Trial name
- NCT03102411
- Where
- United States
- Volunteers
- 1,881 people, healthy volunteers welcome
- Sponsor
- TriHealth Inc.
Tolerance, Healthy Population
Evaluating the Impact of Different Sugar Replacer Combinations on Gastrointestinal Tolerance
This study is a randomized, double-blind, crossover trial aiming at evaluating the gastrointestinal tolerance of 3 sugar replacers mixes at 3 different doses.
- Trial name
- NCT05794100
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
IBS - Irritable Bowel Syndrome, Functional Gastrointestinal Disorders
Effect of a Diet Without Non-caloric Sweeteners on Gastrointestinal Symptoms in Patients With IBS and Dyspepsia
Digestive Functional Disorders (DFD), represent 50% of medical check ups, the symptoms interfere with patients quality of life and generate high health costs.
- Trial name
- IBS (NCT04129762)
- Testing
- Diet without NCS, Diet with NCS
- Where
- Mexico
- Volunteers
- 140 people
- Sponsor
- Hospital General de Mexico
Small Intestinal Bacterial Overgrowth, Lactose Intolerance
Clinical Utility of Breath Tests in GI
Bloating, gas, pain and diarrhea are common complaints. Routine investigations are negative; these patients are labeled as IBS. In these patients, whether testing for carbohydrate malabsorption or small intestinal bacterial…
- Conditions
- Small Intestinal Bacterial Overgrowth, Lactose Intolerance, Fructose Intolerance, Glucose Intolerance
- Trial name
- NCT03261856
- Where
- United States
- Volunteers
- 1,080 people
- Sponsor
- Augusta University
Kidney Transplant
Patient Reported Outcomes in Renal Transplant Patients Tolerating Gastrointestinal (GI) Symptoms Converted to Myfortic (EC-MPS)
Hypothesis: Presently, some patients' mycophenolate mofetil (MMF.,Cellcept) related gastrointestinal (GI) symptoms are not being spontaneously reported.
- Trial name
- NCT00676221
- Testing
- Myfortic
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Foothills Medical Centre
Colorectal Polyps
Confocal Endomicroscopy for GI Neoplasia Study
The purpose of this study is to enhance probe stabilization using a 4mm clear cap attached to endoscope in comparison to standard "free-hand" image acquisition.
- Trial name
- NCT01515514
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
HIV Infections
Acupuncture and Relaxation Response for GI Symptoms and HIV Medication Adherence
The aims of the study are to investigate individual, combined and added effects of acupuncture and the relaxation response in reducing gastrointestinal symptoms, improving medication adherence and quality of life among people…
- Trial name
- NCT00545623
- Testing
- Acupuncture, Relaxation Response
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Boston University
Healthy, Gastrointestinal Dysfunction
Heat-treated Postbiotic Consumption in Healthy People With Mild to Moderate Gastrointestinal Symptoms
The use of probiotics is a widespread clinical practice to improve the composition of the microbiota in healthy and pathological patients.
- Trial name
- BIOPOLIS (NCT05367427)
- Testing
- Heat treated postbiotic Bifidobacterium Longum consumption
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Irritable Bowel Syndrome (IBS)
Effects of HMOs on Faecal Microbiota, Gastrointestinal Symptoms, Mucosal Immunity and Barrier Function in IBS Patients
The study is a randomised, placebo-controlled, double-blind parallel study in IBS patients. A total of 60 adult patients diagnosed with IBS-C, -D or -A/M according to Rome IV criteria will be included.
- Trial name
- NCT02875847
- Testing
- HMO1, HMO2, Dextropur
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Glycom A/S
Obesity
Multi-Center Pre-Bariatric Weight Loss Study
The purpose of the study is to evaluate the safety and efficacy of the GI Sleeve in patients who require weight loss prior to their Bariatric surgery.
- Trial name
- NCT00469391
- Testing
- GI Sleeve Implantable weight loss device (EndoBarrier)
- Where
- 4 sites in United States
- Volunteers
- 56 people
- Sponsor
- Morphic Medical Inc.
Digital Education Interventions, Knowledge Types (Mechanistic Versus Procedural)
Digital Delivery of Patient Education: A Case Study of Symptom Self-Management During Cancer Treatment
The increasing shift from face-to-face to online patient-clinician encounters in the healthcare system requires patients to be more involved in their medical care.
- Trial name
- NCT06187610
- Testing
- Digital education
- Where
- Israel
- Volunteers
- 110 people
- Sponsor
- Tel Aviv University
Critical Illness, Oncology
Giving Information Systematically and Transparently in Lung and GI Cancer Phase 1
When advanced disease progresses, there comes a time when an oncologists must explain to their patients that they only have months left to live.
- Conditions
- Critical Illness, Oncology, Communication
- Trial name
- Oncolo-GIST (NCT04158908)
- Testing
- Oncolo-GIST
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Inflammation, Gastrointestinal Symptoms
Evaluating the Ability of a Multi-Strain Postbiotic to Impact Inflammation, Immune Components, Gastrointestinal Symptoms, Recovery, Anxiety, and Intestinal Permeability
This study will evaluate the effects of a multi-strain postbiotic supplement on markers of inflammation, immune function, gastrointestinal symptoms, psychological well-being, and intestinal permeability in healthy adults.
- Trial name
- BIO (NCT07387991)
- Testing
- Multi-Strain Postbiotic
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lindenwood University