Clinical trials: GI Symptoms
Breast Cancer, Gastrointestinal Cancer
Capecitabine in Metastatic Breast and GI Cancers
The purpose of this study is compare different doses of capecitabine to see if one is better than the other in terms of efficacy and toxicity.
- Trial name
- X7-7 (NCT02595320)
- Testing
- Capecitabine
- Where
- 15 sites in United States
- Volunteers
- 200 people
- Sponsor
- Qamar Khan
Osteoarthritis, Rheumatoid Arthritis
Observational Study on Non-steroid Anti-inflammatory Drugs (NSAIDs) Treated Patients With Arthritic Disorder
The aim of this study is to find out how patients with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis receiving NSAID-therapy are treated and managed by their doctor in usual clinical practice, how patients…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- EVIDENCE (NCT01176682)
- Where
- 244 sites in Belgium, France and 10 more
- Volunteers
- 1,149 people
- Sponsor
- AstraZeneca
Autism Spectrum Disorder, Gastrointestinal Symptoms
Fecal Microbiota Transplantation in Children With Autism Spectrum Disorder and Gastrointestinal Symptoms
The aim of the study is to evaluate the effectiveness and safety of fecal microbiota transplantation (FMT) in reducing gastrointestinal (GI) and behavioral symptoms in children with autism spectrum disorder (ASD).
- Trial name
- FMT-ASD-GI (NCT07371013)
- Testing
- MBiotix® HBI Caps
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Institute of Mother and Child, Warsaw, Poland
Occult Gastrointestinal Bleeding, Upper Gastrointestinal Bleeding (UGIB)
PillSense Use in Anemia and Hemoccult
In this study, participants will be offered a PillSense™ capsule, a small capsule to swallow, which can detect the presence of blood in the upper digestive tract within about 10 minutes.
- Trial name
- PillSense™ (NCT06951490)
- Testing
- PillSense™
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AdventHealth
GI Bleeding
High Dose Oral Omeprazole in High Risk UGIB
Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding.
- Trial name
- NCT04394663
- Testing
- High-dose oral omeprazole, Standard IV PPI
- Where
- 2 sites in Thailand
- Volunteers
- 128 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastrointestinal Symptoms
Foot Reflexology and Acupressure on Gastrointestinal Symptoms
This research was planned to evaluate the effects of foot reflexology and acupressure applications on gastrointestinal symptoms in women going through menopause.
- Trial name
- Menopausal (NCT07528534)
- Testing
- Foot Reflexology, Acupressure
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Osmaniye Korkut Ata University
Unidentified Gastrointestinal Discomfort Following Dairy Consumption
The Effect of Pasteurized; Pasteurized and Homogenized and UHT Treated Homogenized Cow's Milk on Gastrointestinal Symptoms in Sensitive Adults
This study aims to investigate differences in digestion rates and gastrointestinal problems caused by pasteurized; pasturized and homogenized as well as UHT-treated homogenized cow's milks in healthy adults by diary of symptoms…
- Trial name
- NCT03010904
- Testing
- Dietary intervention
- Where
- 2 sites in Finland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Turku
Gastrointestinal Symptoms
Gastrointestinal Health Survey of Dalian College Students
This is a cross-sectional study aimed to investigate the current status of gastrointestinal health among full-time undergraduate students aged 18-25 years in Dalian, and to clarify the influences of factors such as diet, sleep…
- Trial name
- NCT07634887
- Testing
- Self-Administered Questionnaire Survey
- Volunteers
- 1,020 people
- Sponsor
- DiproBio (Shanghai) Co., Ltd.
Esophageal Cancer, Gastrointestinal Dysfunction
The Effects of Acupressure on Improving Postoperative Gastrointestinal Symptom Distress in Esophageal Cancer Patients
This study is a quasi-experimental design clinical trial with the primary objective of comparing the health status of patients with esophageal cancer. Participants were divided into an experimental group and a control group.
- Trial name
- NCT06275165
- Testing
- acupressure
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- CHEN, CHIA-CHEN
Metastatic Tumors
Safety Study of Cancer Specific Epitope Peptides Cocktail for Cervical, GI, and Lung Tumors
The purpose of this study is to evaluate the clinical safety and efficacies of cyclophosphamide combined cancer specific epitope peptides cocktail for advanced/relapsed solid tumors including GI/lung/cervical cancers
- Trial name
- peptidevac (NCT00676949)
- Testing
- 5 peptide vaccines of KOC1, TTK, CO16, DEPDC1, MPHOSPH1
- Where
- Japan
- Volunteers
- 18 people
- Sponsor
- Kyushu University
Fistula, Regenerative Medicine
RESTOREGI Study: Regenerative Endoscopic Stromal Therapy: Outcomes and Risk Factor Evaluation in GI Fistulas
RESTOREGI Study Benign gastrointestinal fistulas are abnormal communications between the gastrointestinal tract and adjacent organs or the skin.
- Conditions
- Fistula, Regenerative Medicine, Stromal Vascular Fraction
- Trial name
- RESTORE-GI (NCT07661043)
- Testing
- Endoscopic tSVF-EM Therapy
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Chronic Pancreatitis
Palatable Elemental Diet for Gastrointestinal Symptoms in Chronic Pancreatitis
The goal of this clinical trial is to learn whether a 2-week exclusive palatable elemental diet is feasible, tolerable, and acceptable for adults with chronic pancreatitis and bothersome gastrointestinal symptoms.
- Trial name
- PEACE-CP (NCT07559448)
- Testing
- Palatable Elemental Diet
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Bloating, Gastrointestinal Symptoms
A Clinical Trial to Investigate the Safety and Efficacy of Bloat on Postprandial Bloating and Its Effects Over Time in Healthy Women
The goal of this clinical trial is to investigate the safety and efficacy of Bloat on postprandial bloating in healthy women. The main question it aims to answer is what is the difference in change in bloating from pre-dose…
- Conditions
- Bloating, Gastrointestinal Symptoms, Intestinal Gas
- Trial name
- NCT07370740
- Testing
- Bloat
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Arrae
Non-celiac Gluten Sensitivity
Gluten and (Extra-)Intestinal Symptoms in NCGS
The goal of this randomized, double-blind, placebo-controlled study is to investigate the effect of expectancy related to gluten consumption versus actual gluten intake on overall GI symptoms in individuals with non-coeliac…
- Trial name
- WoW (NCT05779358)
- Testing
- Expectancy and gluten
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 84 people
- Sponsor
- Maastricht University
Gastro Intestinal Bleeding, Ischaemic Heart Diseases
Gastrointestinal Bleeding is Blood Loss in the Digestive Tract, Classified as Upper or Lower. Ischemic Heart Disease is Due to Blocked Heart Arteries. Antiplatelet Drugs Help Prevent Heart Attacks But Increase GI Bleeding Risk, Especially When Used Together as Dual Therapy.
Gastrointestinal bleeding is blood loss in the digestive tract, classified as upper or lower. Ischemic heart disease is due to blocked heart arteries.
- Conditions
- Gastro Intestinal Bleeding, Ischaemic Heart Diseases, Antiplatelet Drugs, Antiplatelet Drug-related Gastrointestinal Injury
- Trial name
- NCT07125651
- Volunteers
- 112 people
- Sponsor
- Assiut University
Surgery, Infection
Efficacy of Bifidobacterium Lactis CCT 7858 in Adults Using Antibiotics
To evaluate the effectiveness of the probiotic Bifidobacterium lactis CCT 7858 in preventing and / or improving gastrointestinal symptoms in adults using antibiotics.
- Trial name
- NCT04742322
- Testing
- Bifidobacterium Lactis CCT7858, Maltodextrin
- Where
- Brazil
- Volunteers
- 116 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Bacterial Infections
Effect of Bifidobacterium Breve PRL2020 (an Amoxicillin-clavulanate-resistant Strain) on Gastrointestinal Symptoms and Gut Microbiota Composition in Children Treated With Amoxicillin or Amoxicillin/Clavulanate
Amoxicillin or Amoxicillin/Clavulanic acid antibiotic therapy has been shown to be associated with disrupting the microbiota population particularly Bifidobacterium, which may have further GI clinical implications.
- Trial name
- NCT05840588
- Testing
- Antibiotic Treatment, Probiotic Bifidobacterium breve PRL2020 (Brevicillin®) treatment
- Where
- Italy
- Volunteers
- 121 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Upper Gastrointestinal Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -A Pilot Study
This is a multi-center, prospective, non-randomized, open-label, exploratory clinical investigation performed to evaluate safety and effectiveness of the PillSense System when used for detection of blood in the stomach of…
- Trial name
- NCT05631639
- Testing
- PillSense System
- Where
- 3 sites in Czechia
- Volunteers
- 30 people
- Sponsor
- EnteraSense Limited
Capnography as an Adjunct to Standard Monitoring During Midazolam and Propofol Sedation for Interventional Upper GI Endoscopy
Capnography During Upper GI Endoscopy
In this randomized controlled trial the utility of capnography and IPI gets evaluated. Hypoxemia may occur during sedation with midazolam and propofol.
- Trial name
- NCT01242345
- Testing
- Capnography
- Where
- 3 sites in Germany
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Spinal Bupivacaine/Morphine in Laparoscopic Surgery
Spinal Bupivacaine/Morphine in Laparoscopic Gastro-intestinal Surgery
The objective of this study is to determine if a single spinal shot of morphine can decrease post-operative opioid-use, and thereby decrease opioid side-effects and lead to a quicker recovery after surgery.
- Trial name
- Salmon (NCT02284282)
- Testing
- Spinal injection bupivacaine/morphine, subcutaneum injection lidocaine
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Maasstad Hospital