Clinical trials: GI Symptoms
Gastrointestinal Health
The Impact of Postbiotic Supplementation on Tolerability and Physiological/Metabolic Parameters
This study aimed to evaluate whether daily postbiotic supplementation could improve gastrointestinal well-being and influence physiological and metabolic parameters in healthy young adults.
- Trial name
- PIProBaTo-II (NCT07893301)
- Testing
- Postbiotic Supplement
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Gastrointestinal Hemorrhage
Effect of Tranexamic Acid in Upper Gastrointestinal Bleeding
The investigators hypothesize that addition of Tranexamic acid, an antifibrinolytic agent, to conventional therapy will lead to an improved outcome characterized by lower transfusion requirements.
- Trial name
- NCT01005147
- Testing
- tranexamic acid
- Sponsor
- University of Oklahoma
Healthy
Synbiotic Dietary Supplement and Gut Microbiota
To test the feasibility and safety of our designer synbiotic on gastrointestinal symptoms and gut microbiota and fecal metabolomics.
- Trial name
- NCT04097106
- Testing
- Synbiotic
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Myocardial Infarction, Coronary Artery Disease
Emulation of Randomized Clinical Trial in Cardiovascular Disease
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- RCT-BigData (NCT06241833)
- Testing
- PPI
- Where
- South Korea
- Volunteers
- 118,420 people
- Sponsor
- Samsung Medical Center
Digestive Health, Gastrointestinal Health
Microbial Enzyme Impact on Postprandial Nutrient Levels and Gastrointestinal Symptoms in Healthy Adults
The primary objective of this study is to investigate the acute effects of a microbial multi-enzyme mixture ("BC-006") on postprandial nutrient levels in healthy, middle-aged to older adults during a mixed meal tolerance test.
- Trial name
- BIO-3003 (NCT05211440)
- Testing
- BC-006 + Meal
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Esophagitis, Inflammation
Comparison of Acid Reflux at Two Levels in the Esophagus Using the BRAVO Capsule
The purpose of this research is to study the level of acid exposure above the gastroesophageal junction and the distal esophagus in patients with reflux symptoms using a capsule type acid measurement system.
- Conditions
- Esophagitis, Inflammation, Gastritis, Abdominal Pain
- Trial name
- NCT00579410
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obesity & Overweight, Gut Microbiota
Effects of Daily Kefir Consumption During Medical Nutrition Therapy on Body Composition and Psychological Well-Being in Women With Obesity
This randomized controlled study evaluated the effects of daily kefir consumption as an adjunct to medical nutrition therapy on body composition, biochemical parameters, gastrointestinal symptoms, bowel habits, and psychological…
- Conditions
- Obesity & Overweight, Gut Microbiota, Body Composition
- Trial name
- NCT07840274
- Testing
- Plain Kefir, Individualized Medical Nutrition Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Pınar Göbel
Chronic Gastrointestinal Graft vs Host Disease
Study of orBec® as Monotherapy in the Treatment of Patients With Upper GI Symptoms Caused by Chronic Graft Versus Host Disease (GVHD)
Use of an oral topically-active glucocorticoid with limited side effects may control the gastrointestinal inflammatory process of GVHD and minimize glucocorticoid exposure.
- Trial name
- NCT01925950
- Testing
- orBec
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Soligenix
Endometriosis, Microbiome Dysbiosis
Trial Evaluating Nutritional Fiber in Digestive Symptoms of Endometriosis
This study is a double-blind, randomized, placebo-controlled study that evaluates the safety and tolerability of a fiber-based dietary supplement and the mechanistic and structure-function effects of that supplement on the gut…
- Conditions
- Endometriosis, Microbiome Dysbiosis, Gastrointestinal Symptoms
- Trial name
- TEND (NCT07875062)
- Testing
- Fiber
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Gastrointestinal Symptoms, Skin Quality
Phage-based Control and Limitation of Pathobionts for Microbiome Equilibrium and Resilience
Bacteriophages are viruses that can selectively infect specific species and strains of bacteria. Some bacterial species in the human gut have been negatively associated with gut health and skin health.
- Trial name
- Phage-CLEAR (NCT07816809)
- Testing
- Bacteriophages - MuniPhage, Bacteriophages - RenuPhage
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Gastrointestinal Symptom
The Effect of Lamina-G on Gastrointestinal Symptom After Gastric Biopsy
Sometimes, subjects complain about gastrointestinal symptoms after esophagogastroduodenoscopy and biopsy. The aim of this study is to investigate the effect of sodium alginate (Lamina-G®) on biopsy-related gastrointestinal…
- Trial name
- NCT04134364
- Testing
- Sodium alginate
- Where
- South Korea
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Kyungpook National University Hospital
Gut Microbiota, Gastrointestinal Symptoms
Mother-Infant Cohort Study in Malaysia and China
This mother-infant cohort study aims to determine the geographic differences in the microbial profiles in breast milk from mothers living in Malaysia and China that are potentially important determinants of infant development.
- Conditions
- Gut Microbiota, Gastrointestinal Symptoms, Temperament, Eczema
- Trial name
- NCT04919265
- Testing
- No intervention - mother-infant cohort study
- Where
- Malaysia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Inflammatory Bowel Diseases, Neuropathic Pain
GI Medical Cannabis Study on IBD
Create a registry that will described the natural history and landscape of medical cannabis product use in patients with chronic abdominal pain or inflammatory bowel disease.
- Trial name
- GIMEDCAN (NCT03886532)
- Testing
- Medical Marijuana
- Sponsor
- Children's Hospital of Philadelphia
Autism Spectrum Disorder, Gastrointestinal Symptoms
Combination Probiotic: BB-12 With LGG (Different Doses) in Treating Children With Autism Spectrum Disorder
This protocol is a blinded randomized controlled study of the effects of BB-12 with LGG at different doses in 70 healthy children with autism spectrum disorders at lower and higher doses over an 56-day period and a 28- day…
- Trial name
- NCT03514784
- Testing
- BB-12 with LGG (Higher Dose), BB-12 with LGG (Lower Dose)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Esophageal Stricture, Eosinophilic Esophagitis
EndoFLIP Use in Upper GI Tract Stenosis
The purpose of this study is to investigate the use of a functional luminal imaging probe to characterize benign esophageal luminal strictures before and after dilation and identify predictors of response to therapy.
- Conditions
- Esophageal Stricture, Eosinophilic Esophagitis, Zenkers Diverticulum, Schatzki Ring
- Trial name
- EndoFLIP (NCT02354716)
- Testing
- EndoFLIP
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Pennsylvania
Surgical Wound Infection
NPWT in Patients Undergoing Surgical Procedures for Management of GI Malignancies
This randomized trial will use a Negative Pressure Wound Therapy device or standard wound closure, in participants with gastrointestinal neoplasms, to measure the rate of surgical site infections
- Trial name
- NCT04955730
- Testing
- Negative Pressure Wound Therapy
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gastrointestinal Disease, Signs and Symptoms, Digestive
Nexium Dyspepsia/AST
The aim is to evaluate if the resolution of upper abdominal symptoms (pain or burning) during an acid suppressive test trial of esomprazole given daily for 7 days predicts symptoms resolution at the end of a subsequent treatment…
- Conditions
- Gastrointestinal Disease, Signs and Symptoms, Digestive, Dyspepsia
- Trial name
- NCT00251914
- Testing
- Esomeprazole
- Where
- 215 sites in Argentina, Belgium and 15 more
- Volunteers
- 1,500 people
- Sponsor
- AstraZeneca
Gastric Residue, Preoperative Fasting
Preoperative Fasting Duration and Gastric Residue in Pediatric Upper Gastrointestinal Endoscopy
This retrospective observational study aims to evaluate the relationship between preoperative fasting duration and gastric residue in pediatric patients undergoing upper gastrointestinal endoscopy for gastrointestinal symptoms or…
- Conditions
- Gastric Residue, Preoperative Fasting, Upper Gastrointestinal Endoscopy
- Trial name
- NCT07614919
- Testing
- Upper Gastrointestinal Endoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Obesity &Amp; Overweight
The Impact of Probiotics on Bariatric Treatment Outcomes
The planned study aims to assess whether probiotics improve the quality of life in patients during the early postoperative period following sleeve gastrectomy, and whether they influence the absorption of micro- and…
- Trial name
- PROBE (NCT07258732)
- Testing
- Probiotic, Diet
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- University of Warmia and Mazury in Olsztyn
Type 2 Diabetes, Obesity
Study for Pre-Surgical Weight Loss in Type II Diabetes Patients
The purpose of this study is to determine whether the GI Sleeve is safe and effective in treating Type II diabetes patients
- Trial name
- NCT00791128
- Testing
- GI Liner
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- Morphic Medical Inc.