Clinical trials: GI Symptoms
Gastrointestinal Cancers, Frailty at Older Adults
FRAIL and FiND for Chemotherapy Toxicity in GI Cancer
Older adults with gastrointestinal cancer may experience serious side effects during chemotherapy, particularly when they have reduced physical strength, functional limitations, or other health conditions.
- Conditions
- Gastrointestinal Cancers, Frailty at Older Adults, Chemotherapy
- Trial name
- FRAIL-GI (NCT07272538)
- Testing
- No Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Ankara Etlik City Hospital
Functional Dyspepsia, Epigastric Pain Syndrome
Cognitive Behavioral Therapy for Functional Dyspepsia (Epigastric Pain Syndrome and Postprandial Distress Syndrome Subtypes)
The goal of this clinical trial is to learn whether adding Cognitive Behavioral Therapy (CBT) to standard medical treatment can improve symptoms in adults with Functional Dyspepsia.
- Conditions
- Functional Dyspepsia, Epigastric Pain Syndrome, Postprandial Distress Syndrome
- Trial name
- FD-CBT (NCT07577089)
- Testing
- Optimized Standard Treatment (OPT), Cognitive Behavioral Therapy + Optimized Standard Treatment (CBT + OPT)
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Cystic Fibrosis, Digestive System Disease
A Comprehensive Approach To Relief Of Digestive Symptoms In Cystic Fibrosis: CARDS-CF
Development of a new patient reported outcome measure (PROM) that will measure the daily burden of gastrointestinal symptoms over the previous 24 hour period for people with cystic fibrosis.
- Conditions
- Cystic Fibrosis, Digestive System Disease, Genetic Disease, Respiratory Tract Diseases
- Trial name
- CARDS-CF (NCT05251467)
- Testing
- Focus group, Patient interview (n = approximately 10), Questionnaire (n = 180)
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Gastrointestinal Stromal Tumors
Symptom Inventory for Gastrointestinal Stromal Tumors
The goal of this research study is to better understand the symptoms experienced by patients with GIST. There are 3 parts to this study.
- Trial name
- NCT01178307
- Testing
- Questionnaires, Interview, MDASI-GIST Questionnaire
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Obesity, Childhood
GI Tract Biomarkers in Infants With Different Diets
Childhood obesity is increasing with more than one-third of adolescents currently overweight and one in five with obesity. The lifelong incidence of obesity-related morbidities is also increasing with childhood obesity.
- Trial name
- NCT03751137
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Infant Nutrition Disorders, Gastrointestinal Dysfunction
Post-market Surveillance Study of an Infant Formula Containing Moderately Hydrolyzed Protein and Low Lactose
The study is a before-after trial to evaluate whether the study formula containing moderately hydrolyzed protein and low lactose will be able to improve mild gastrointestinal disorders (MGDs) in infants.
- Trial name
- NCT04112056
- Testing
- Drink the study formula (NAN Comfort producted by Nestle Deutschland AG)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Peking University
Hepatic and Hepatobiliary Disorders
Essentiale® Paste in Patients With Gastrointestinal Symptoms in Acute or Chronic Liver Diseases
Primary Objective: To assess safety of Phosphatidylcholine paste 600 mg (ESSENTIALE® paste) oral 3 times a day for 12 weeks in patients with gastrointestinal symptoms in acute and chronic liver diseases.
- Trial name
- EPLID (NCT02517385)
- Testing
- Phosphatidylcholine
- Where
- Russia
- Volunteers
- 147 people
- Sponsor
- Sanofi
Gastrointestinal, Mobile Health
GutCheck: Optimization of a Personalized Mobile Health App for Survivors of Gastrointestinal Cancer
There are two components to the study: a patient and a clinician study. The clinician study will include one-hour semi-structured interviews with oncology specialists to identify facilitators and barriers to integrating digital…
- Conditions
- Gastrointestinal, Mobile Health, Gastrointestinal Symptoms, Gut Health
- Trial name
- NCT07661017
- Testing
- Stool Sample, App Activity
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Ventral Hernia
Gastrointestinal Tract Recovery in Patients Undergoing Open Ventral Hernia Repair
The purpose of this study is to determine whether Alvimopan (Entereg) in ventral hernia surgery patients is associated with accelerated gastrointestinal recovery and reduced length of hospital stay compared to placebo controls.
- Trial name
- NCT02379858
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical College of Wisconsin
Reccurent/Metastatic Solid Tumor Disease, Prostate Cancer (Post Prostatectomy)
Non-inferiority Study Comparing Salvage Pelvic Radiotherapy in 25 Fractions (62.5 Gy/25) Versus 20 Fractions (52.5 Gy/20) for Recurrent Prostate Cancer After Surgery.
Study Overview This research compares two types of post-operative salvage radiotherapy (SRT) for men with prostate cancer who have had surgery but show signs of recurrence (detectable PSA).
- Conditions
- Reccurent/Metastatic Solid Tumor Disease, Prostate Cancer (Post Prostatectomy), Prostate Cancer, Prostatic Neoplasms
- Trial name
- HYP-OP-RT (NCT07483658)
- Testing
- Standard Fractionation Post-Operative Salvage Radiotherapy (25 fractions), Hypofractionated Post-Operative Salvage Radiotherapy (20 fractions), Androgen Deprivation Therapy (ADT)
- Where
- 4 sites in Canada
- Volunteers
- 434 people
- Sponsor
- CHU de Quebec-Universite Laval
Non-Coeliac Wheat Sensitivity (NCWS)
Effects of Different Bread Types in NCWS
Although wheat and gluten containing food products are generally considered to be healthy, a large number of individuals in the general population reduces or limits their intake and/or replaces wheat by other grains because of…
- Trial name
- BREAD (NCT04084470)
- Testing
- Different types of bread
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University
Irritable Bowel Syndrome
Impact of A2 Milk Versus Conventional Milk on Intestinal Health: a Proof-of-concept Study in IBS-patients
This aim of this study is to evaluate the acute and mid-term effects of A2 milk versus conventional milk on gastrointestinal symptoms in patients with constipation-predominant IBS and in patients with diarrhea-predominant IBS.
- Trial name
- NCT04598529
- Testing
- A2 milk, Conventional milk
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Gastrointestinal Hemorrhage, Diabetes Complications
Therapeutic Conflicts and Multimorbidity
Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or…
- Conditions
- Gastrointestinal Hemorrhage, Diabetes Complications, Multimorbidity
- Trial name
- NCT02928939
- Testing
- drug-drug or drug-disease interaction
- Where
- Switzerland
- Volunteers
- 1,101 people
- Sponsor
- University of Zurich
Fecal Microbiota Transplantation
The Safety and Efficacy of Fecal Microbiota Transplantation in the Treatment of Digestive Diseases and Non-digestive System Diseases Associated With Gastrointestinal Symptoms in the Gastrointestinal Tract.
The exploration of the safety and efficacy of fecal microbiota transplantation in the treatment of non-digestive system diseases associated with gastrointestinal symptoms in the gastrointestinal tract, while also investigating…
- Trial name
- NCT06208930
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shanghai 10th People's Hospital
Healthy
Efficacy of Dietary Supplement in Subjects With Acid Reflux and/or Abdominal Bloating/Distention and GI Symptoms
This study was a prospective randomized clinical study. There was interventional treatment for a total of 8 weeks including a 2-week washout period.
- Trial name
- NCT06808867
- Testing
- Dietary Supplement with Active Ingredient Blend
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Olly, PBC
Esophageal and Gastric Varices
Validation of Esophageal Variceal Grading: A Comparative Study of Upper Gastrointestinal (GI) Endoscopy and Capsule Endoscopy
The purpose of this study is to develop a grading system for esophageal varices using capsule endoscopy in patients with portal hypertension and cirrhosis.
- Trial name
- NCT00475592
- Testing
- Esophageal Capsule Endoscopy, Upper Gastrointestinal Endoscopy
- Where
- United States
- Sponsor
- Johns Hopkins University
Adenomyosis, Uterine Leiomyoma
The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms
The aim of this study is to assess the relationship between adenomyosis/myoma and lower urinary tract symptoms, sexual function and gastrointestinal symptoms.
- Trial name
- NCT02495311
- Testing
- myomectomy or adenomyomectomy
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Gastroesophageal Reflux
ASTERIX: Low Dose ASA and Nexium
The purpose of the study is to evaluate the effect of esomeprazole 20 mg od versus placebo for the prevention of gastric and/or duodenal ulcers in patients taking low-dose ASA.
- Trial name
- NCT00251966
- Testing
- Esomeprazole
- Where
- 94 sites in Australia, Bulgaria and 9 more
- Volunteers
- 960 people
- Sponsor
- AstraZeneca
Esophageal Motility Disorders
Prevalence of IEM Among Upper GIT Symptoms
detect the prevalence of IEM among upper git symptom . clarify the role of HRM in diagnosis of refractory upper GIT symptoms.
- Trial name
- NCT05913011
- Volunteers
- 50 people
- Sponsor
- Assiut University
Malignant Neoplasm of Gastrointestinal Tract
Acupuncture for Unintentional Weight Loss and Anorexia With GI Cancer
Patients with cancer often experience appetite loss and weight loss unintentionally. Rapid weight loss negatively impact on physical functioning, quality of life, and overall survival.
- Trial name
- NCT02148159
- Testing
- Cachexia Acupuncture-A (Peace Classic Needles® ), General Acupuncture-B (Peace Classic Needles®)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Florida