Clinical trials: GI Tract Disorders
Functional Heartburn (FH), Reflux Hypersensitivity
Volume-Oriented Incentive Spirometry-Assisted Diaphragmatic Breathing Exercise for Functional Heartburn or Reflux Hypersensitivity
The goal of this pilot randomized controlled trial is to determine whether volume-oriented incentive spirometry-assisted diaphragmatic breathing exercise (VIS-assisted DBE) can improve reflux-related symptoms and health-related…
- Trial name
- VISDBE (NCT07706101)
- Testing
- Volume-Oriented Incentive Spirometry-Assisted Diaphragmatic Breathing Exercise, standard pharmacological treatment with lifestyle modification education
- Volunteers
- 82 people
- Sponsor
- Changhua Christian Hospital
Esophageal Cancer, Kidney Cancer
GI Organ Tracking Via Balloon Applicators
The hypothesis of this study is that an occlusion balloon catheter placed in the stomach via an oral or nasogastric route will be safe and permit tracking of the stomach during radiation therapy.
- Conditions
- Esophageal Cancer, Kidney Cancer, Larynx Cancer, Liver Cancer
- Trial name
- NCT05471401
- Testing
- Balloon-tipped catheter
- Sponsor
- Washington University School of Medicine
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Normal-weight Obesity, Obesity
Exercise-Induced Gut Permeability in Normal-weight Obesity
Exercise acutely increases gut permeability and inflammation, even in healthy populations. However, whether this response differs in groups at-risk for CVD that present with low-grade inflammation (e.g., normal-weight obesity)…
- Trial name
- NCT05889767
- Testing
- Exercise tests (VO2 max test and 45-minute exercise session at 65% VO2 max)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Inflammatory Marker, Gut Microbiome
The Effects of Jing-Si Herbal Tea Liquid Packets and Jing-Si Herbal Tang Heng Power Drink
Through empirical research evaluating the effects of "JING SI HERBAL TEA LIQUID PACKETS" and "JING SI HERBAL TANG HENG POWDER DRINK" as adjunctive treatments for various cardiovascular diseases, we aim to provide sufficient…
- Conditions
- Inflammatory Marker, Gut Microbiome, Trimethylamine N-oxide, HbA1c
- Trial name
- NCT06522412
- Testing
- JING SI HERBAL TEA LIQUID PACKETS, JING SI HERBAL TANG HENG POWDER DRINK
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Microbial Colonization, Antibiotic Side Effect
Autoflor -Lyophilized Capsulated Autological FMT to Restore Gut Microbiome After Treatment With Antibiotics
In this clinical trial, our aim is to assess the effect of auto-FMT (Fecal microbiome transplantation) on the intestinal microbiota, after a course of antibiotics. 30 healthy adults are recruited.
- Trial name
- FMT (NCT06250413)
- Testing
- FMT, Amox Clav
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Otto Helve
Droplet Spread, Covid19
COVID-19 Aerosol in EGD Using a Droplet Reduction Mouthpiece
Measurement of aerosolisation during esophagogastroduodenoscopy (EGD) to compare two types of mouthpieces, conventional versus a new and commercially available one 'the droplet reduction mouthpiece B1'.
- Trial name
- NCT04864015
- Testing
- Mouthpiece B1(Mouthpiece MPC-ST GMDN:62534 Generic name: Endoscopic bite block, basic, reusable
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endoscopic Suturing, GI Tract Disorders
Gastrointestinal Tract Disorders: A Prospective Multicenter Registry
The purpose of this prospective registry is to assess long-term data on efficacy, safety and clinical outcome of endoscopic placement of suture(s) and approximation of soft tissue within the gastrointestinal tract for various GI…
- Conditions
- Endoscopic Suturing, GI Tract Disorders, Gastrointestinal Disorders
- Trial name
- NCT05127408
- Testing
- Interventional Endoscopy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Methodist Health System
Chronic Pancreatitis, Pancreatic Cancer
Blood Biomarkers and Gut Microbiota for Pancreatic Cancer Risk in Chronic Pancreatitis
The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in…
- Trial name
- NCT07762950
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Liver Fibroses, Alcohol-Induced Disorders
Alcohol Challenge On Liver and Gut Measured by Liver Vein Catheterization. A Pathophysiological Intervention Trial
To investigate the effects of acute alcohol challenge on the gut and liver axis.
- Trial name
- NCT03018990
- Testing
- Ethanol
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Term and Preterm Neonates (24-41 Weeks Gestational Age), Hematopoietic Stem Cell Transplant Recipient Children
Ontogeny of MAIT Cells in Neonates and Hematopoietic Stem Cell Transplant Recipients
The objective of this study is 1/ to determine the rate and kinetics of MAIT cell expansion and maturation in neonates in relation with gestational age, and in HSCT recipient children in relation with the source of donor stem…
- Trial name
- NEOMAIT (NCT02403089)
- Testing
- Tubes fund recovery blood count, the rest of the blood test and stool sample
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peripheral Arterial Disease
Gut Microbiota in Patients With Peripheral Arterial Disease and Chronic Limb-threatening Ischemia
Microbiota has been associated with risk factors for cardiovascular diseases (hypertension, obesity, dyslipidemia, diabetes mellitus, heart failure).
- Trial name
- NCT05757297
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Type 1 Diabetes
Do People With Complications of Type 1 Diabetes Mellitus Have a Different Microbiome (MARVEL)
This study looks at whether people with type 1 diabetes have different gut bacteria. We also want to see if this is linked to keeping insulin production up and preventing complications like heart disease and nerve damage.
- Trial name
- MARVEL (NCT06560060)
- Testing
- No intervention
- Volunteers
- 5,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colitis, Ulcerative, Sleep Quality
Clinical Characteristics of Sleep Disorders in Patients With Ulcerative Colitis
Ulcerative colitis(UC) is one of the two main forms of inflammatory bowel disease(IBD), which seriously affects the quality of life of patients.
- Conditions
- Colitis, Ulcerative, Sleep Quality, Gastrointestinal Microbiome, Autonomic Nervous System Imbalance
- Trial name
- NCT06359808
- Where
- China
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Ulcerative Colitis, Crohn Disease
A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative Colitis
Probiotics are live microorganisms that provide health benefits when consumed in sufficient amounts. Traditional probiotics, mainly from the Lactobacillus and Bifidobacterium genera, originate from fermented foods or the human…
- Trial name
- ANEMONE (NCT07724990)
- Testing
- For a bipsies, rectal administration
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Catholic University of the Sacred Heart
Parkinson Disease
Constipation and Changes in the Gut Flora in Parkinson's Disease
The aim of this study is to investigate the link between gut health and Parkinson's disease
- Trial name
- GUT-PD (NCT05787756)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Pancreatic Cancer
Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer
A multi-institutional, single arm pilot study of antibiotics and pembrolizumab, following chemotherapy for the treatment of surgically resectable pancreatic cancer.
- Trial name
- NCT05462496
- Testing
- Biopsy, FOLFIRINOX, Ciprofloxacin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Overweight or Obesity
Modified Atkins Diet for Overweight and Obesity
The aim of the study is to investigate dynamic changes in biochemical metabolism, gut microbiome and its metabolites among overweight and obese participants while they are on a modified Atkins Diets.
- Trial name
- NCT04207879
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hebei Medical University Third Hospital
Irritable Bowel Syndrome
A Pilot Study of Cognitive-Behaviour Therapy for Irritable Bowel Syndrome and the Gut Microbiome
This study evaluates the effectiveness of a group cognitive behaviour therapy for Irritable Bowel Syndrome (IBS) in decreasing symptoms of IBS, improving quality of life, and normalizing the gut microbiome.
- Trial name
- IBS (NCT02313246)
- Testing
- Group Cognitive Behaviour Therapy
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Hamilton Health Sciences Corporation
Diet, Healthy
Red Palm Olein on Inflammation and Gut Health
A parallel intervention was conducted to test the effect of consuming diets enriched with red palm olein (RPOO), extra virgin coconut oil (EVCO) and extra virgin olive oil (EVOO; positive control) in centrally obese individuals…
- Trial name
- RPO (NCT05791370)
- Testing
- A 12-week parallel dietary intervention
- Where
- Malaysia
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
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