Clinical trials: GI Tract Disorders
Crohn Disease
Bacteria & Inflammation in the Gut (BIG) Study
Exclusive Enteral Nutrition (EEN) is the liquid diet given to children with active Crohn's Disease (CD). EEN has previously been shown to induce changes in major bacterial metabolites and dominant bacterial species which are more…
- Trial name
- BIG (NCT02341248)
- Testing
- Exclusive Enteral Nutrition (EEN)
- Where
- 5 sites in United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Breast Neoplasms
Dance-Based Exercise for Cancer-Related Fatigue in Breast Cancer Patients
The goal of this clinical trial is to learn whether a 12-week dance-based exercise program can reduce cancer-related fatigue in women with newly diagnosed breast cancer who are undergoing treatment before surgery.
- Trial name
- DANCE-BC (NCT07817355)
- Testing
- Dance-Based Exercise Program
- Where
- Slovakia
- Volunteers
- 104 people
- Sponsor
- Comenius University
Psychological Stress, Sleep Disturbance
Sleep More, Stress Less: 90-Day Trial of Neuralli Mood
This decentralized, single-arm study evaluates the effects of 90 days of daily Neuralli Mood supplementation on perceived stress, sleep disturbance, mood, anxiety, depressive symptoms, happiness, and occupational burnout in…
- Conditions
- Psychological Stress, Sleep Disturbance, Anxiety Symptoms, Depressive Symptoms
- Trial name
- NM90 (NCT07717385)
- Testing
- Neuralli Mood
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Efforia, Inc
Obesity
Obeticholic Acid in Morbidly Obese Patients and Healthy Volunteers
OCAPUSH (EudraCT 2014-002313-33) is a double-blind placebo-controlled parallel-arms study of the effects of obeticholic acid on farnesoid X receptor expression in jejunum and on gut microbiota in morbidly obese patients and…
- Trial name
- OCAPUSH (NCT02532335)
- Testing
- Obeticholic acid
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Obese Patients, Obese Patients With Bariatric Surgery
Bariatric Surgery and Gut Microbiota Changes Over Time
The goal of this observational study is to learn how bariatric surgery affects gut bacteria and gut-related metabolic products over time in adults with obesity.
- Conditions
- Obese Patients, Obese Patients With Bariatric Surgery, Gut Microbiota, Healthy Participants
- Trial name
- RYGB-MICROGUT (NCT07381140)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Inflammation, Metabolic Disorder
Impact of Aronia Berry Consumption on Inflammation, Metabolites, and the Gut Microbiome
The goal of this project is to elucidate interactions between the gut microbiome, anti-inflammatory/anti-oxidant food metabolomic signatures, and human inflammation phenotypes.
- Conditions
- Inflammation, Metabolic Disorder, Hypertriglyceridemia
- Trial name
- NCT05255718
- Testing
- Aronia juice
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Montana State University
Probiotic, Gut Microbiota
The Effects of Yogurt on Gut Microbiome and Metabolism in H. Pylori.
Helicobacter pylori is a common pathogen causing upper gastrointestinal diseases including gastric ulcer and gastric cancer. Recent epidemiological findings have also shown that it is also related to colon cancer, metabolic…
- Conditions
- Probiotic, Gut Microbiota, Helicobacter Pylori Infection, Insulin Resistance
- Trial name
- NCT05374980
- Testing
- Yogurt
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Cystic Fibrosis in Children
Quality of Life and Gut Health in Pediatric Patients With Cystic Fibrosis
The aim of the present study is to investigate the effect of probiotic supplementation on GI related quality of life, through a randomised placebo-controlled clinical trial.
- Trial name
- NCT06284577
- Testing
- Multistrain Probiotic
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Mental Health Issue, Critical Illness
Gut-Brain-Axis/Lung-Brain-Axis and Mental Ill Health in Critical Illness
Survivors of critical illness commonly experience long-lasting cognitive, mental health and physical impairments. Clinically significant symptoms of anxiety, depression, and post-traumatic stress disorder (PTSD) may occur in 40%…
- Conditions
- Mental Health Issue, Critical Illness, Gut Microbiome
- Trial name
- NCT05580367
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Liver Cancer
Gut Microbiota in Liver Cancer (Treated With TKIs In Combination With ICIs)
To evaluate the additional efficacy and safety of oral enterobacterial capsules in patients with intermediate and advanced liver cancer and treated with tyrosine kinase inhibitors (TKIs) combined with immunotherapy.
- Trial name
- NCT06563934
- Testing
- Oral enterobacterium capsules, Lenvatinib + PD-1 monoclonal antibody
- Volunteers
- 70 people
- Sponsor
- Xu Yong, MD
Colorectal Cancer, Esophageal Cancer
Nutritional Status and Nutrient Supply in Hospitalised Surgical Patients
Prospective single arm, single center observational study to assess the nutritional status and the nutrient supply during hospitalization for elective gastrointestinal surgery.
- Conditions
- Colorectal Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT03787537
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- Charite University, Berlin, Germany
Ulcerative Colitis in Remission
Effect of Procyanidins in Leaky Gut Repairing in IBD
The goal of this clinical trial is to learn if the Grape Seed Extract Ecovitis, featuring low monomeric catechins content and a high concentration of oligo-polymeric procyanidins, could modulate the Gut Microbiota composition of…
- Trial name
- EcoVitis (NCT06576700)
- Testing
- Grape Seed Extracts
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Padova
Ulcerative Colitis
Prebiotics in Reducing Inflammation and Clinical Endpoints in Ulcerative Colitis (PRInCE-UC)
The community of microbes living in the gut is called the 'gut microbiome'. Changing this could be an exciting new way of treating people living with ulcerative colitis (UC). UC is a type of inflammatory bowel disease.
- Trial name
- PRInCE-UC (NCT06050811)
- Testing
- 2'-Fucosyllactose
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- Royal Berkshire NHS Foundation Trust
Pain (Visceral, Somatic, or Neuropathic), Women of Reproductive Age
Virtual Menstrual Pain Approaches in Females
This research study is testing two self-care approaches that may help prevent or reduce period pain in young females with recurrent painful menstrual cramps.
- Conditions
- Pain (Visceral, Somatic, or Neuropathic), Women of Reproductive Age, Mental Disorder, Digital Health
- Trial name
- AABQ (NCT07497711)
- Testing
- Virtual Auricular Acupressure, Virtual Baduanjin Qigong Exercise, Self Education
- Where
- Singapore
- Volunteers
- 145 people
- Sponsor
- Nanyang Technological University
Malignant Neoplasm of Breast, CNS Malignancy
Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors
This phase I trial using the EffTox design will evaluate activity and safety of alisertib, an Aurora A kinase inhibitor, when given in combination with the selective VEGFR inhibitor pazopanib in patients with advanced, previously…
- Conditions
- Malignant Neoplasm of Breast, CNS Malignancy, Malignant Neoplasm of Gastrointestinal Tract, Genitourinary Neoplasms Malignancy and Gender Unspecified
- Trial name
- NCT01639911
- Testing
- Alisertib, Pazopanib
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Illinois Chicago
Hyperuricemia, Gout
Probiotic-Uricase Complex Preparation for Improving Uric Acid Metabolism in Patients With Hyperuricemia
This single-center, open-label, two-arm interventional study aims to evaluate the efficacy and safety of a probiotic-uricase complex preparation in patients with hyperuricemia.
- Trial name
- NCT07613164
- Testing
- Probiotic-uricase complex preparation
- Volunteers
- 45 people
- Sponsor
- Maanshan Shiqiye Hospital
Acute Lymphoblastic Leukemia
The Association Between Gut Microbiome Composition Signature and Cancer-related Symptoms in Children With Acute Lymphoblastic Leukemia
This study is a prospective longitudinal investigation. Data on disease-related information, gut microbiota composition, cancer-related symptoms, dietary intake, and levels of pro-inflammatory cytokines, LPS were collected…
- Trial name
- NCT07515430
- Testing
- Questionnaires set, fecal sample collecting
- Where
- 2 sites in China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-sen University
Morbid Obesity
Efficacy and Mechanism Study of Bariatric Surgery to Treat Moderate to Severe Obesity in Han Chinese Population
This is a long-term follow-up and interventional study in individuals who have been diagnosed with moderate to severe obesity with or without diabetes.
- Trial name
- NCT02653430
- Testing
- Sleeve gastrectomy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Axial Spondyloarthritis
Efficacy of Golimumab in Early Axial Spondyloarthritis in Relation to Gut Inflammation
The hypothesis of the study is that the presence of (subclinical) gut inflammation at baseline in patients with early active axial spondyloarthritis predisposes to a more severe disease defined as more need to use anti-tumor…
- Trial name
- GO-GUT (NCT03270501)
- Testing
- Golimumab
- Where
- 3 sites in Belgium
- Volunteers
- 64 people
- Sponsor
- University Ghent
Anorexia Nervosa
Whole Gut Microbiome Sequencing in Patients With Anorexia Nervosa
Background. Anorexia nervosa (AN) still carries the highest fatality rate of any psychiatric disease, and less than half of the patients recover, completely refractory to any treatment.
- Trial name
- NCT02217384
- Where
- 3 sites in Denmark
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
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