Clinical trials: GI Tract Disorders
Metabolic Syndrome X
Effect of Meat and Egg on TMAO in Plasma and Urine in Subjects with and Metabolic Subjects
The purpose of this clinical trial is to investigate in subjects with and without metabolic syndrome how meals of choline- and carnitine-rich foods (eggs and meat) affect the trimethylamine-N-oxide (TMAO) concentration in blood…
- Trial name
- NCT06660251
- Testing
- Egg intervention, Meatball intervention
- Where
- Sweden
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Linnaeus University
Nonalcoholic Fatty Liver Disease, NAFLD
Rifaximin in Fatty Liver Disease
TITLE Rifaximin in Fatty Liver Disease (RiFL) DESIGN Open-label pilot study HYPOTHESIS Reduction in gut flora by the antibiotic Rifaximin reduces hepatic inflammation in Non-Alcoholic Steatohepatitis (NASH).
- Conditions
- Nonalcoholic Fatty Liver Disease, NAFLD, Nonalcoholic Steatohepatitis
- Trial name
- RiFL (NCT01355575)
- Testing
- Rifaximin
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Imperial College London
Irritable Bowel Syndrome
Frequency of Sleep Abnormalities in Patients With Irritable Bowel Syndrome and Effect of Pharmacological Intervention
Irritable bowel syndrome (IBS), a common gastrointestinal (GI) disorder in India and in the rest of the World, is enigmatic in its pathogenesis.
- Trial name
- NCT04193501
- Testing
- Melatonin 3 mg
- Where
- 2 sites in India
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Type 2 Diabetes Mellitus (T2DM)
Study of AI-based Prediction Models for Exercise-Induced Gut Microbiota Alterations in Patients With Type 2 Diabetes
This study is a randomized controlled clinical trial. The participants will be randomized into two groups in a 1:1 ratio: exercise intervention and sedentary control group.
- Trial name
- NCT06931210
- Testing
- Sedentary behavior, Exercise intervention
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Shanghai 6th People's Hospital
Healthy
Study of Acute Effects of Sn-1 and Sn-3 Palmitic Acid-rich or Stearic Acid-rich Fats on Metabolic Markers
To determine the effect of degree of fat saturation on postprandial lipemia, haemostatic and inflammatory markers, gut hormone concentrations, satiety perceptions, and insulinemic responses in healthy adult subjects.
- Trial name
- NCT01428960
- Testing
- Palm Mid Fraction, Shea Butter, High Oleic Sunflower Oil
- Where
- Malaysia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Diabetes Mellitus, Type 2
The Role of Gut Hormones and Hepcidin in Type 2 Diabetes Mellitus
This study aims to investigate the potential of the gut hormones GLP-1, PP, PYY and the iron regulatory hormone hepcidin as biomarkers for progression to complications in diabetes mellitus.
- Trial name
- NCT02413762
- Testing
- No intervention
- Where
- United Arab Emirates
- Volunteers
- 1,512 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Mild Cognitive Impairment, Subjective Memory Impairment
The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial
There is a dearth of research which takes a multi-compound approach to dietary interventions, in humans, aimed at improving outcome measures of cognition.
- Trial name
- CANN (NCT02525198)
- Testing
- fatty acid/flavonoid blend
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
HIV Infections
Pilot Study on the Effect of Adding Raltegravir +/- a Second Drug on HIV Levels in the Gut
The "PLUS" study is a pilot study to measure the effect of therapy intensification (with raltegravir and optional second agent) on HIV levels in the gut and blood in patients on antiretroviral therapy (ART) with viral load < 50…
- Trial name
- PLUS (NCT00884793)
- Testing
- raltegravir, Study NNRTI, Study PI
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
Meconium Obstruction of Prematurity
Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.
The goal of this clinical trial is to study the effect of twice-daily saline enema (SE) in the treatment obstruction of prematurity (MOP) in infants with the birth weight ≤1.25kg.
- Trial name
- NCT06048614
- Testing
- Saline Enema (SE), Glycerin Suppository
- Where
- 2 sites in Singapore
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Patients With Upper Gastro-intestinal Symptoms
Prevalence of Gastroesophageal Reflux Disease (GERD) in Patients With Upper Gastrointestinal Tract Symptoms in Egypt
The purpose of this study is to calculate the prevalence of gastroesophageal reflux disease (GERD) by mean of GERD-Q questionnaire in patients with upper gastrointestinal tract symptoms in Egypt.
- Trial name
- GERD Q NIS (NCT01635959)
- Where
- 21 sites in Egypt
- Volunteers
- 3,170 people
- Sponsor
- AstraZeneca
Mild Cognitive Impairment (MCI)
Relationship Between Gut Microbiome, Probiotics, and Mild Cognitive Impairment
This study is to evaluate whether the consumption of probiotics can improve the symptoms of patients with mild cognitive impairment; also evaluate the effects of probiotics on patients' blood, oxidation and stress related…
- Trial name
- NCT04971096
- Testing
- PS23 live, PS23 heat-treated
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Neuroendocrine Tumors, Surgery
Prophylactic Cholecystectomy is Not Mandatory in Patients Candidate to the Resection for Small Intestine Neuroendocrine Neoplasms: a Propensity Score-matched and Cost-minimization Analysis
To evaluate two competitive strategies in patients undergoing resection of Small-intestine Neuroendocrine neoplasms (Si-NEN): Prophylactic Cholecystectomy (PC) versus On-demand delayed cholecystectomy
- Conditions
- Neuroendocrine Tumors, Surgery, Gut Tumor
- Trial name
- NCT04780737
- Testing
- Cholecystectomy
- Volunteers
- 230 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
X-ray Examinations of the Gastrointestinal Tract
Study Phase III Comparison of Superiority, Open With Blind Appraiser, to Evaluate the Efficacy and Safety of Barium Sulphate 66.7% With V (OPTI-BAR) Compared to Proceedings in Inert Radiological Examinations for the Diagnosis of Diseases for Image the Tratogastrointstinal
Phase III clinical study, two samples, with assessor blind for the purpose of evaluating the efficacy and safety of the superiority of the use of barium sulphate 66.7% w/v (Opti-bar) as a contrast X-ray (X-ray).
- Trial name
- NCT01629719
- Volunteers
- 73 people
- Sponsor
- Alko Do Brasil Industria e Comercio Ltda
Autism Spectrum Disorder, Functional Gastrointestinal Disorders
Low-FODMAP Diet and Probiotics: Effects on Gut, Behavior, and Microbiota in Children With Autism Spectrum Disorder
The goal of this clinical trial was to evaluate whether a low-FODMAP diet and probiotic supplements could reduce gastrointestinal (GI) symptoms and behavior problems in children with autism spectrum disorder (ASD) who also…
- Trial name
- NCT07086157
- Testing
- Probiotic, Low-FODMAP Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Colitis, Ulcerative, Crohn Disease
Unraveling a Potential Connection Between Bilirubin Metabolism, Gut Microbiota and Inflammatory Bowel Diseases
Inflammatory Bowel Diseases (IBDs) are a set of recurrent inflammatory conditions that include the colon and small intestine. The two principal conditions include Crohn's disease (CD) and ulcerative colitis (UC).
- Trial name
- NCT03841045
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Crohn Disease, Pediatric Crohns Disease
FMT in Pediatric Crohn's Disease
The goal of this study is to evaluate the safety of Fecal Microbiota Transplantation (FMT) in children with Crohn's disease who are in remission. Safety will be the primary endpoint and Pediatric Crohn's Disease.
- Trial name
- FMTPCD (NCT03194529)
- Testing
- FMT
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Children's Hospital Los Angeles
Hypertension, Gut Microbiota
Metagenomic Analysis of Gut Microbiota in Untreated and Uncontrolled Hypertensive Patients
This observational study aims to explore the relationship between gut microbiota composition and blood pressure regulation in patients with hypertension.
- Trial name
- HyGut (NCT06284928)
- Testing
- Fecal Sample Collection
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Xinjiang Medical University
Carotid Artery Plaque
TMAO and Atherosclerosis in HIV
In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery…
- Trial name
- NCT03416257
- Testing
- No intervention
- Volunteers
- 737 people
- Sponsor
- Albert Einstein College of Medicine
Gastrointestinal Neoplasms
Bone Marrow-derived Cells' Contribution to Tumor Formation and Inflammation
The purpose of this study is to clarify the relationship bone marrow-derived cells and the formation of the tumors, and the role of these cells in regeneration of epithelial cells in the gastrointestinal tract.
- Trial name
- NCT00452205
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Komagome Hospital
Bariatric Surgery Candidate, Cardiovascular Diseases
Gut Microbiota in Metabolic Surgery
Metabolic surgery is an emerging option to treat obesity-related metabolic diseases (e.g., type 2 diabetes) and prevent cardiovascular disease (CVD).
- Conditions
- Bariatric Surgery Candidate, Cardiovascular Diseases, Type 2 Diabetes, Dyslipidemias
- Trial name
- NCT05000996
- Testing
- Bariatric Surgery
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University Medical Center
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