Clinical trials: GI Tract Disorders
Type 2 Diabetes
Assessing Gut Microbiome Changes Before and After an Oral Nutritional Supplement Intake Using the SIMBA Capsule in Diabetic Participants
This is a single-arm interventional clinical study, the primary objective is to assess the changes in the small intestinal (SI) metagenomic profile of in diabetic participants from baseline to midpoint and endpoint in response to…
- Trial name
- NCT06704022
- Testing
- Oral nutritional supplement
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nimble Science Ltd.
Ulcerative Colitis (UC)
TD-1473 Long-Term Safety (LTS) Ulcerative Colitis (UC) Study
A 3-Year Multi-Center, Long-Term Safety (LTS) Study to Evaluate the Safety and Tolerability of TD-1473 in Subjects with Ulcerative Colitis who have participated in the Maintenance Study of Protocol 0157
- Trial name
- NCT03920254
- Testing
- TD-1473 Dose A, TD-1473 Dose B, TD-1473 Dose C
- Where
- 184 sites in United States, Australia and 20 more
- Volunteers
- 46 people
- Sponsor
- Theravance Biopharma
End Stage Renal Disease, Gut Microbiome Dysbiosis
Prebiotics in Peritoneal Dialysis
The Prebiotics in Peritoneal Dialysis trial is a non-randomized, open-label, crossover study of p-inulin for patients with end-stage renal disease treated with peritoneal dialysis.
- Trial name
- NCT03265639
- Testing
- P-inulin
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Ali Ramezani
Cognitive Function and Mood, Cerebral Blood Flow
The Effects of Resveratrol Supplementation on Cognition, Cerebral Blood Flow, Microbiota and Systemic Inflammation.
Previous research shows that a diet high in fat has harmful effects on gut health. This increases the chance of developing obesity-related diseases (such as type 2 diabetes) and disrupts cognition and mood.
- Conditions
- Cognitive Function and Mood, Cerebral Blood Flow, Systemic Inflammation, Gut Microbiota
- Trial name
- NCT03448094
- Testing
- Resveratrol
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Collection of Real-world Data in a Single Institute
Outcome of GI Cancer in NCKUH
Alimentary tract cancer patients treated at National Cheng Kung University Hospital during 2013/01/01 to 2020/12/31 were reviewed.
- Trial name
- NCT05700188
- Where
- 2 sites in Taiwan
- Volunteers
- 730 people
- Sponsor
- National Health Research Institutes, Taiwan
Obesity, Insulin Resistance
Probiotics on Body Composition and Insulin Resistance in Patients With Obesity and Its Association With Gut Microbiota
This study aims to evaluate the modifications in body composition and insulin resistance state in patients with grade II and III obesity included in an interventional lifestyle changes program and treated with probiotics (1 x…
- Conditions
- Obesity, Insulin Resistance, Microbial Colonization
- Trial name
- NCT04086173
- Testing
- Probiotics
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Prebiotic, IBS (Irritable Bowel Syndrome)
Psyllium Husk in Pediatric IBS
Children aged 6 to 17 years with IBS will be randomly assigned to either receive psyllium husk supplementation in addition to usual care or receive usual care alone.
- Conditions
- Prebiotic, IBS (Irritable Bowel Syndrome), Psyllium, Quality of Life (QOL)
- Trial name
- NCT07880327
- Testing
- Psyllium Husk, Conventional therapy group
- Volunteers
- 70 people
- Sponsor
- Eman ElHaddad
Endoscopy, Colonoscopy
Retrospective Review of Gastrointestinal System Endoscopy Procedures
The aim of the study is retrospectively evaluating all features of endoscopic and pathological diagnoses of cases who underwent upper and lower gastrointestinal endoscopy.
- Conditions
- Endoscopy, Colonoscopy, Gastroscopy, Colonic Polyps
- Trial name
- RRGIE (NCT05012527)
- Where
- Turkey (Türkiye)
- Volunteers
- 15,448 people
- Sponsor
- Istanbul Sultanbeyli State Hospital
Irritable Bowel Syndrome
Exploring the Mechanism of a Probiotic Combination VSL#3 in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a very common chronic gastrointestinal disorder. Existing therapies for IBS are still far from satisfactory and new therapies are being constantly sought.
- Trial name
- NCT00786123
- Testing
- VSL#3
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National University Hospital, Singapore
Intestinal Obstruction
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects
The purpose of this study is to describe the effects of methylnaltrexone in preventing loperamide-induced delay of the oro-cecal and whole-gut transit time and measure pharmacokinetics of methylnaltrexone after subcutaneous and…
- Trial name
- LOP-MNTX-2009 (NCT01596777)
- Testing
- Loperamide, Methylnaltrexone 12 mg sc., Methylnaltrexone IR capsule
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Long COVID
Effect of Red Beetroot Juice Intake in Adults With Long COVID-19
Red beetroot juice may have positive effects on multiple pathways involved in long COVID. The aim of this pilot study was to explore the impact of beetroot juice supplementation on physical function, gut microbiota, and systemic…
- Trial name
- NCT06535165
- Testing
- Red Beetroot Juice
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Catholic University of the Sacred Heart
Common Variable Immunodeficiency
STA-5326 Meslylate to Treat Gut Inflammation Associated With Common Variable Immunodeficiency
This study will determine whether an experimental medicine, STA-5326 mesylate, is safe to use in patients with common variable immunodeficiency (CVID) who have inflammation of the gut.
- Trial name
- NCT00263237
- Testing
- STA-5326
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Appetitive Behavior, Obesity
Impact of Slowly Digestible Carbohydrates on the Gut-brain Axis
Our laboratory is investigating the physiological outcomes and health benefits of the consumption of high-quality carbohydrates.
- Conditions
- Appetitive Behavior, Obesity, Diabetes Mellitus, Type 2
- Trial name
- NCT05349903
- Testing
- Rice flour, Alternanoligosaccharide 15, Inulin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Esophageal Cancer, Gastric Cancer
Irinotecan and Paclitaxel in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus or Stomach
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00020761
- Testing
- irinotecan hydrochloride, paclitaxel
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5
Healthy Diet Rich in Potassium to Chronic Kidney Disease With Sodium Zirconium Cyclosilicate: A Feasibility Study
This is a descriptive single arm open-label interventional trial lasting 6 weeks aiming to test if a low protein healthy K-rich diet with fruits, vegetables, whole grains, and nuts with concomitant use of new potassium binder…
- Conditions
- Chronic Kidney Disease stage4, Chronic Kidney Disease Stage 5, Hyperkalemia
- Trial name
- HELPFUL (NCT04207203)
- Testing
- sodium zirconium cyclosilicate and healthy diet
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Karolinska Institutet
Healthy, Colorectal Adenoma
IMPACT OF SEDENTARY BEHAVIOR IN THE HOMEOSTASIS OF THE DIGESTIVE ECOSYSTEM
This study seeks to determine the relationship between sedentary behavior, gut transit, gut microbiota and polyps development. Will be conducted an evaluation which includes assessments of physical activity behaviors (through…
- Trial name
- NCT07398820
- Testing
- Initial assessment
- Where
- Chile
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Clínica Universidad de los Andes
Overweight, Postmenopausal Women
HIIT + RT on Body Composition and Gut Microbiota in Postmenopausal Women (PACWOMan)
Postmenopausal women, as men, are more prone to central or android obesity than premenopausal women. Recently, some studies have shown that obesity is associated with gut microbiota dysbiosis and gut microbiota could be…
- Trial name
- PACWOMan (NCT03940924)
- Testing
- Training program
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Respiration Disorders, Respiratory Disease
The Gut-Lung Axis and Respiratory Illness in Children
The goal of this single-centre observational study conducted at the Royal Hospital for Children in Glasgow, Scotland, is to employ a multi-omics approach to investigate the "gut-lung axis" in health and disease.
- Conditions
- Respiration Disorders, Respiratory Disease, Asthma in Children, Wheezing
- Trial name
- NCT06271213
- Testing
- observational only - no interventions as part of study
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Type 1 Diabetes
Evaluation of Main Determinants of Postprandial Glucose Response in Type 1 Diabetes
The goal of this observational study is to explore inter- and intra-individual determinants of postprandial glucose response in patients with type 1 diabetes using continous glucose monitoring (CGM).
- Trial name
- IN-DEEP (NCT05936242)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Depression, Treatment Resistant Depression
The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder
The primary goals of this proof of concept clinical trial are to determine the effectiveness, safety and tolerability of oral FMT in adults with Treatment Resistant Depression (TRD).
- Trial name
- NCT04805879
- Testing
- FMT oral Capsules
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Calgary
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