Clinical trials: GI Tract Disorders
Severe Acute Respiratory Syndrome (SARS) Pneumonia, COVID-19 Pneumonia
GM-CSF Inhalation to Prevent ARDS in COVID-19 Pneumonia
To assess the safety and tolerability of inhaled molgramostim nebuliser solution in patients with COVID-19 pneumonia.
- Trial name
- GI-COVID (NCT04569877)
- Testing
- Molgramostim nebuliser solution
- Where
- 9 sites in Germany
- Volunteers
- 63 people
- Sponsor
- University of Giessen
Autism Spectrum Disorder
Gut to Brain Interaction in Autism. Role of Probiotics on Clinical, Biochemical and Neurophysiological Parameters
The purpose of this study is to assess the effects of a 6-months supplementation with probiotic Vivomixx® on inflammatory and gastrointestinal (GI) biomarkers, gastrointestinal disturbances, behavioral and developmental profiles…
- Trial name
- NCT02708901
- Testing
- Vivomixx®
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- IRCCS Fondazione Stella Maris
IBS - Irritable Bowel Syndrome
The Effect of Dietary Intervention on Symptoms, Epigenetics, and Gut Microbiota in IBS
The aim of the present study is to research whether subjects with irritable bowel syndrome (IBS) display epigenetic/genetic changes or altered microbiota compared to a non-IBS control group.
- Trial name
- NCT03306381
- Testing
- Dietary intervention
- Where
- Sweden
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Region Skane
HIV - Human Immunodeficiency Virus
Effect of Extra Virgin Olive Oil Consumption on the Occurrence of Cardiovascular Events in Population Living With HIV
Study Summary: OLEUM VIHTAEGeneral Information Sponsor: Fundación SEIMC - GESIDA Study Title: Effect of Extra Virgin Olive Oil (EVOO) consumption on the occurrence of cardiovascular events in people living with HIV.
- Trial name
- OLEUM VIHTAE (NCT07761819)
- Testing
- The patients must ingest 50 mL of extra virgin olive oil daily
- Where
- Spain
- Volunteers
- 1,324 people
- Sponsor
- Fundacion SEIMC-GESIDA
Metabolic Syndrome
Does Oral Lactate Affect Gut Hormone Secretion in a Dose-response Relationship?
To investigate whether there is a linear dose-response relationship between oral lactate and its effects on gut hormone secretion, motility, and appetite.
- Trial name
- NCT06589856
- Testing
- LAC5, LAC10, LAC20
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Non Small Cell Lung Cancer, Melanoma (Skin Cancer)
Gut Microbiome in Patients With Lung and Melanoma Cancer and Intestinal Microbiota in Gynecologic Cancers
This study aims to investigate the role of the gut microbiota and its derived factors, including bacterial-associated antigens that mimic tumor-associated antigens, in predicting response to immune checkpoint inhibitor…
- Conditions
- Non Small Cell Lung Cancer, Melanoma (Skin Cancer), Endometrial Cancer, Cervical Cancer
- Trial name
- CERBERO (NCT07815873)
- Testing
- sample collection
- Where
- Italy
- Volunteers
- 360 people
- Sponsor
- European Institute of Oncology
Obesity
Gut Microbiota as a Therapeutic Target for CVD
Background: The Mediterranean Diet (MD) is considered an healthy diet useful in the prevention of cardiovascular disease (CVD). High quality extra virgin olive oil (HQ-EVOO, [1]), an essential component of this diet, exerts a…
- Trial name
- oliomicroFDG (NCT03441802)
- Testing
- High quality extra virgin olive oil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Gastrointestinal Symptoms, Bloating
A Clinical Trial to Evaluate the Effects of Super Liver Liquid Drops on Gut Health, Digestive Comfort, and Daily Energy Levels
This is a decentralized (fully virtual), single-group, open-label, prospective clinical trial evaluating the effects of Super Liver Liquid Drops, a liquid botanical dietary supplement, on gut health, digestive comfort, energy…
- Conditions
- Gastrointestinal Symptoms, Bloating, Digestive Discomfort, Low Energy Levels
- Trial name
- NCT07742657
- Testing
- Super Liver
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- SuperBonsai Inc.
Obesity (Disorder), Systemic Inflammation Markers
Understanding How Gut and Brain Barriers Are Linked to Inflammation in Obesity
The goal of this observational study is to understand how obesity affects the function of the gut and blood-brain barriers in adults.
- Conditions
- Obesity (Disorder), Systemic Inflammation Markers, Intestinal Barrier Dysfunction, Blood Brain Barrier
- Trial name
- GUTBBB (NCT06787001)
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Resilience, Cognitive Function and Well-Being
Aging Resilience Through Microbiota Optimization and Regulation
Sarcopenia, characterized by the progressive loss of muscle mass and strength in older adults, is a key factor in health deterioration.
- Conditions
- Resilience, Cognitive Function and Well-Being, Muscle Function, Handgrip Strength Test, Insulin Sensitivity
- Trial name
- ARMOR (NCT06649981)
- Testing
- FMT capsule
- Where
- 2 sites in Chile
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gonzalo Jorquera, PhD
Metastatic Testicular Cancer
Impact of a Physical Activity Program to Reduce Long-term Cancer-related Fatigue in Metastatic Testicular Germ Cell Tumor Patients
Testicular germ cell tumor (TGCT) is the most common malignancy in men between 15 and 40 years. Although TCGT survivors have a good survival prognosis, they suffer from short- and long-term sequelae such as chronic fatigue…
- Trial name
- STARTER (NCT05588700)
- Testing
- Physical activity recommendations, Connected activity tracker, Physical Activity (PA) Intervention
- Where
- 12 sites in France
- Volunteers
- 236 people
- Sponsor
- Centre Leon Berard
Colorectal Cancer, Inflammatory Bowel Disease
Changes of Muramyl Dipeptide in Intestinal and Extra-intestinal Diseases
Nucleotide-binding oligomerization domain 2 (Nod2) signaling is critical for human health.To figure out the clinical relevance of NOD2 ligands, the investigators plan to evaluate the change of NOD2 ligands in inflammatory bowel…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Disease, Atherosclerotic Cardiovascular Disease, Type2 Diabetes Mellitus
- Trial name
- NCT04924686
- Testing
- Observational studies, no intervention
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Stroke, Complication
Safety and Efficacy of the Tong-Fu-Xing-Shen Herbal Formula for Stroke-Associated Pneumonia
Stroke-associated pneumonia (SAP) is the major complication of acute intracerebral haemorrhage (AICH), leads to poor clinical outcomes and increases the financial burden on the medical system.
- Trial name
- TFXSHF (NCT04275219)
- Testing
- Tongfu capsules
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Composition and Function of the Gut Microbiota Post Intervention, Metabolic and Inflammatory Variables Post Intervention
Intermittent Fasting and Exercise: Effects on Gut Microbiota, Body Composition and Inflammation.
Obesity and overweight affect around 2 billion people worldwide. Despite the growing prevalence, the treatment of obesity is still an obscure field and the impacts of this disease on the clinical and public health perspective are…
- Trial name
- NCT05237154
- Testing
- Intervention with intermittent fasting., Intervention with high-intensity interval training.
- Where
- 2 sites in Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obesity, Metabolic Disease
Xla1 Christensenella Minuta, Phase I, Randomized, Partially Placebo-controlled Double-blind Protocol, Evaluating Safety, Tolerability and Impact on the Gut Microbiota in Healthy Volunteers, Overweight and Obese Adults
Xla1 Christensenella minuta, phase I, randomized, placebo-controlled double-blind protocol, evaluating safety, tolerability and impact on the gut microbiota in healthy volunteers, overweight and obese adults.
- Trial name
- CAUSALITY (NCT04663139)
- Testing
- Xla1
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- YSOPIA Bioscience
HIV Infection
Study of Recovery of Intestinal CD4+ and Th17 T Cells in HIV-infected Individuals on Short-term Antiretroviral Therapy
HIV infection is associated with a state of chronic, generalized immune activation that has been shown in many studies to be a key predictor of progression to AIDS.
- Trial name
- NCT02097381
- Testing
- Tenofovir-Emtricitabine plus Lopinavir/Ritonavir or Darunavir/Ritonavir
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Roma La Sapienza
Feeding Patterns, Microbial Colonization
Prephage - Faecal Bacteriophage Transfer for Enhanced Gastrointestinal Tract Maturation in Preterm Infants - Donor Study
PrePhage - Fecal bacteriophage transfer for enhanced gastrointestinal tract maturation in preterm infants This pilot triol has the primary goal of demonstrating the safety of transferring viruses and proteins from healthy term…
- Trial name
- NCT05272566
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Gastrointestinal Cancer, Biliary Tract Cancer
Study of D07001-Softgel Capsules in Subjects With Gastrointestinal Cancer in Dose-Escalation Phase and in Subjects With Biliary Tract Cancer in Dose-Expansion Phase
Part 1: Dose-Escalation Phase (Phase 1b) The primary objective is to assess the safety and tolerability of increasing doses of D07001 softgel in patients with unresectable locally advanced or metastatic gastrointestinal (GI)…
- Trial name
- NCT03531320
- Testing
- D07001-softgel capsules
- Where
- 4 sites in Taiwan
- Volunteers
- 19 people
- Sponsor
- InnoPharmax Inc.
Autism Spectrum Disorder
Application of Esketamine in Anesthesia of Autism Children
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. Autistic children appear with significant frequency for medical services, lots of which requiring procedural sedation or anaesthesia.
- Trial name
- NCT05960942
- Testing
- propofol combined with esketamine, propofol-sufentanil
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second Hospital of Nanjing Medical University
IBS (Irritable Bowel Syndrome)
Study Evaluating the Effect of UCB8600 on Mast Cell Activation in the Human Gut
Study evaluating the effect of UCB8600 on mast cell activation in the human gut: IBS is a disease characterized by abdominal pain and a change in stool.
- Trial name
- MASTGUT (NCT07655375)
- Testing
- Sample collection
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Guy Boeckxstaens
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