Clinical trials: GI Tract Disorders
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Lercanidipine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03497156
- Testing
- Lercanidipine
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Non-alcoholic Fatty Liver Disease
Dietary Allowance of Methyl Donor Nutrients to Minimize Risks of Non-alcoholic Fatty Liver Progression
Investigate the methyl donors requirement of NAFLD patients to correct the malnutrition, lipid-toxicity, microbiota dysfunction, and metabolomics biomarkers.
- Trial name
- NCT05291104
- Testing
- Folic acid, choline chloride
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- Fu Jen Catholic University Hospital
Irritable Bowel Syndrome, Functional Gastrointestinal Disorders
Brain-Gut-Microbiota Interaction in IBS
Are you what you eat? How can dietary components influence microbial composition of the gut and function of the peripheral and central nervous system? The gut and brain is linked through complex mechanisms of sensorimotor…
- Trial name
- NCT04296552
- Testing
- Dietary lowFODMAP intervention
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Microbiota
Intestinal Microbiota and Treatment of GD
Graves' disease is an organ-specific autoimmune disease in which both genetic predisposition and environmental factors serve as disease triggers.
- Trial name
- NCT03433352
- Testing
- Methimazole Pill, Propylthiouracil Pill
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Alzheimer Disease, Gut Microbiota
Design of Personalised SupplemenTs Based on the Gut MicRobiota Through Artificial Intelligence for Alzheimer's Patients
Studies indicate that the intestinal microbiota could have an implication in Alzheimer's disease; recently, a positive relationship has been established between levels of bacterial lipopolysaccharide (LPS) and cerebral…
- Trial name
- TREAT (NCT06199193)
- Testing
- Personalized diet, Dietary counseling
- Where
- 2 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Gastrointestinal Cancer, Pancreatic Cancer
Intestinal Microbiome, Oral Microbiome, and Whole Blood Transcriptome Analyses in Gastrointestinal Malignancies
The primary objective of this prospective observational study is to characterize the gut and oral microbiome as well as the whole blood transcriptome in gastrointestinal cancer patients and correlate these findings with cancer…
- Conditions
- Gastrointestinal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT05462314
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Viome
Autism Spectrum Disorder
Effect of Probiotic Compound K11T e K11TMax in ASD
The research is characterized as a randomized, double-blind clinical trial (phase III) in which administered the probiotic K11-T (with and without added amino acids, fatty acids and vitamins) to children between 3 and 11 years…
- Trial name
- ASD (NCT06382909)
- Testing
- Inflammatory level, Cognitive assessment, Pedagogical assessment
- Where
- 2 sites in Brazil
- Volunteers
- 505 people
- Sponsor
- Deivis de Oliveira guimaraes
Graft Versus Host Disease
Phase II Trial of Natalizumab + Prednisone for Initial Therapy of Acute GI GVHD
This research study is a Phase II clinical trial, which tests the safety and effectiveness of an investigational drug Natalizumab in treating Acute Graft-Versus-Host Disease (GVHD) in the Gastrointestinal (GI) Tract.
- Trial name
- NCT02176031
- Testing
- Natalizumab, Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Dana-Farber Cancer Institute
Irritable Bowel Syndrome
SH-DS01 on Fecal Metagenomic Stability
This is a randomized, double blind, Phase 1 study. There will be a 12-week comparison of the safety of DS-01 versus placebo with a secondary outcome measure of the efficacy in a cohort of 100 men or women with IBS with…
- Trial name
- NCT04598295
- Testing
- DS-01
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Beth Israel Deaconess Medical Center
End Stage Renal Disease (ESRD)
Food Preparation Effects on Gut Bacteria in Patients on Peritoneal Dialysis
This is an intervention study of the effects of food preparation on the gut bacteria in patients with end stage renal disease on peritoneal dialysis.
- Trial name
- NCT02467530
- Testing
- AGE
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
GI Tract Disorders, Pancreatic Disorders
EUS for Gastrointestinal Disorders: a Registry
The aim of the EUS registry is to record information about Endoscopic Ultrasound (EUS) on the management of gastrointestinal disease.
- Conditions
- GI Tract Disorders, Pancreatic Disorders, EUS
- Trial name
- NCT02855151
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Istituto Clinico Humanitas
Urea Cycle Disorders
Clinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle Disorders
This clinical food study aims to explore the effect of KB195, a novel mixture of oligosaccharides, on the metabolism of nitrogen by the microbiome in patients with urea cycle disorders (UCDs).
- Trial name
- NCT03797131
- Testing
- KB195 (a novel mixture of oligosaccharides)
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Kaleido Biosciences
Metabolic Syndrome, Insulin Resistance
An Antiinflammatory Diet as Modulator of Cardiometabolic Risk and Body Weight in Healthy Subjects
Main scientific question: A previous intervention with an anti-inflammatory multifunctional dietary portfolio (MFD) showed remarkable reductions in cardiometabolic (CM) risk markers compared with a well-designed control diet.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Overweight
- Trial name
- NCT02148653
- Testing
- Multifunctional diet (MFD), Control diet
- Where
- Sweden
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Lund University
Allergic Rhinitis
Probiotic Ameliorates Adult Allergic Rhinitis and Modulates Gut Microbiota
Assessing the clinical efficacy of weizmannia coagulans BC99 in alleviating allergic rhinitis symptoms, improving gut microbiota, and reducing adverse reactions in patients.
- Trial name
- NCT06680102
- Testing
- Probiotic, Maltodextrin
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Attention-Deficit Hyperactivity Disorder, Unspecified Type, Autism Spectrum Disorder
A Multi-dimensional Prospective Study to Discover Gene-microenvironment Interactions in Neurodevelopmental Disorders
This project is the first involving the two most common neurodevelopmental disorders, ASD and ADHD, as well as TDC to establish a multi-dimensional database (clinic, behavior, neurocognitive function, brain imaging, metabolomics…
- Trial name
- NCT04878575
- Testing
- ASD diagnosis, Psychiatric diagnosis
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- National Taiwan University Hospital
Allergic Disease, Obesity
Pre-, Peri- and Postnatal Programming and Origins of Disease: Early Targeting the Epidemics of Allergy and Overweight
Combined programme: Nutrition, Allergy, Mucosal immunology and Intestinal microbiota (NAMI) was created with the objective to reverse the rising trend of chronic inflammatory diseases, such as allergic disease and obesity, by…
- Conditions
- Allergic Disease, Obesity, Immunology
- Trial name
- NAMI (NCT00167700)
- Testing
- Dietary counselling and probiotics, Probiotics, Prebiotics
- Where
- Finland
- Volunteers
- 800 people
- Sponsor
- University of Turku
Diabetic Kidney Disease
Gut Microbiota and Serum Metabolites as Predictors of Glycemic Variability and Outcomes in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is one of the main complications of diabetes and a leading cause of end-stage kidney disease. Blood glucose variability is closely associated with disease progression in individuals with DKD.
- Trial name
- NCT07352436
- Volunteers
- 270 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Healthy
Chronic Cardiovascular and Gut-bacteria Effects of Phenolic Rich Oats in Adults With Above Average Blood Pressure
In this proposed human trial, the investigators aim to establish whether 4 weeks of daily consumption of beta-glucan matched meals providing either a high dose or a moderate dose of oat avenanthramides and phenolic acids leads to…
- Trial name
- NCT02847312
- Testing
- High avenanthramide, phenolic acid, Low avenanthramide, medium phenolic acid, Control
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Reading
AML (Acute Myelogenous Leukemia, HLH
Gut Health in Children With Cancer
The purpose of this study is to observe the impact leukaemia treatment has on gut health (microbiomes) and how quickly the gut health recovers after leukamia treatment.
- Conditions
- AML (Acute Myelogenous Leukemia, HLH, Burkitt Lymphoma/Leukemia
- Trial name
- NCT06899581
- Testing
- Enteral nutrition Food Derived Ingredient
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Type 1 Diabetes
The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
The primary aim of this pilot study is to test whether gluten-free diet (GFD) instituted in children shortly after onset of Type 1 Diabetes (T1D) can decelerate the decline in beta cell function as compared to age matched…
- Trial name
- NCT02867436
- Testing
- Gluten-free diet
- Where
- 2 sites in Czechia
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
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