Clinical trials: GI Tract Disorders
Parkinson Disease
Effects of Resistant Starch on Bowel Habits, Fecal Short Chain Fatty Acids and Gut Microbiota in Parkinson Disease
The investigators will investigate the effects of an 8-week resistant starch (RS) supplementation (5 g twice a day) in patients with Parkinson Disease and matched controls on: 1.
- Trial name
- RESISTA-PD (NCT02784145)
- Testing
- Resistant starch, Recommendation with regard to nutrition
- Where
- Germany
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Universität des Saarlandes
HBV, HBV Coinfection
Changes in Bile Acids and Microbiota in Patients With Hepatitis D Treated With Bulvertide
HDV is an RNA virus that infects only in the presence of HBV, affecting about 13% of HBsAg carriers. In Italy, prevalence ranges from 3.2% to 9.3%.
- Conditions
- HBV, HBV Coinfection, HCV, HIV Infections
- Trial name
- Bio-Delta (NCT07429864)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Malnutrition
Mesalamine in Environmental Enteropathy
Undernutrition is one of the most important health issues in Kenya. Children who are chronically undernourished do not reach their full potential and are at increased risk of infectious disease.
- Trial name
- NCT01841099
- Testing
- Mesalamine
- Where
- Kenya
- Volunteers
- 44 people
- Sponsor
- Kelsey Jones
Malnutrition, Diarrhea
WASH Benefits Kenya
The purpose of this study is to measure the independent and combined effects of interventions that improve sanitation, water quality, handwashing, and nutrition on child health and development in the first years of life.
- Conditions
- Malnutrition, Diarrhea, Child Development
- Trial name
- WASHB-Kenya (NCT01704105)
- Testing
- Water Quality, Sanitation, Handwashing
- Where
- Kenya
- Volunteers
- 8,246 people, healthy volunteers welcome
- Sponsor
- Innovations for Poverty Action
Depression, Fatigue
Programs To Support You During Chemotherapy
This randomized pilot trial studies how well two supportive programs work for improving fatigue and depressive symptoms in patients with GI undergoing chemotherapy.
- Conditions
- Depression, Fatigue, Stage IIA Colorectal Cancer, Stage IIB Colorectal Cancer
- Trial name
- PRO-YOU (NCT02489422)
- Testing
- Laboratory Biomarker Analysis, Questionnaire Administration, Daily Survey Administration
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Wake Forest University Health Sciences
Irritable Bowel Syndrome
Fecal Amino Acids，Gut Taste Receptors and Irritable Bowel Syndromes
Clinical data, fresh feces and intestinal mucosal tissues of patients with diarrheal IBS were collected. High performance liquid chromatography, immunohistochemistry and immunofluorescence were used to study the amino acid levels…
- Trial name
- NCT06489444
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
SCI - Spinal Cord Injury
Gut-Brain Neural Coupling in Spinal Cord Injury
The purpose of this research is to determine the effects of food on brain and stomach activity in persons with and without spinal cord injury (SCI).
- Trial name
- NCT07052344
- Testing
- Preload condition, Ad-libitum control condition
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Miami
Obsessive-Compulsive Disorder
The Gut Microbiota in Obsessive-Compulsive Disorder
This study will examine the gut microbiota and serum inflammatory markers in patients with Obsessive-Compulsive Disorder vs. healthy controls.
- Trial name
- NCT02285699
- Testing
- SSRIs
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type-II Diabetes
Postbiotic MBS and Metformin Combination in Patients With T2DM
The primary objective is to evaluate the effect of MBS treatment in human subjects, and to validate its impact on intestinal flora and diabetes symptoms on diabetic patients undertaking metformin.
- Trial name
- NCT04639492
- Testing
- MBS oral solution
- Where
- Taiwan
- Volunteers
- 14 people
- Sponsor
- Microbio Co Ltd
Aging, Cognition Improvement
Westlake Aging Cohort (WeAC)
The Westlake Ageing Cohort (WeAC) is a longitudinal cohort study conducted in Hangzhou, Zhejiang Province, China. The investigators aim to enroll 2,800 participants aged 55 years and older for long-term follow-up.
- Conditions
- Aging, Cognition Improvement, Cognition Disorders, Cognition
- Trial name
- NCT07373444
- Where
- 2 sites in China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Westlake University
Low Mood
Effect of a Nutritional Supplement on Mental Wellness in Adults
Trillions of microbes reside in human gut and constitute "gut microbiota". Composition of these microbes and substances produced by them play an important role in human health and wellness.
- Trial name
- NCT06058364
- Testing
- Intervention 1 - Triglyceride
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Pharmavite LLC
Alcohol-associated Liver Disease
A Cross-sectional Study on the Association of Peptidoglycan Fragments Derived From Gut Microbiota With Alcohol Liver Disease
alcohol-associated liver disease (ALD) is a leading cause of cirrhosis, yet the role of gut microbiota-derived peptidoglycan (PG) metabolites in liver injury remains unclear.
- Trial name
- NCT07284862
- Testing
- An observational, non-interventional study design.
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Oesophageal Cancer, Gastric Cancer
Modulated Mid-frequency Whole-body Electromyostimulation and Nutritional Therapy in Gastrointestinal Cancer Patients
The purpose of this study is to assess the efficacy of modulated mid-frequency whole-body electromyostimulation (WB-EMS) combined with nutritional therapy in patients with gastrointestinal cancer.
- Conditions
- Oesophageal Cancer, Gastric Cancer, Duodenal Cancer, Colorectal Cancer
- Trial name
- MOMENT (NCT06414122)
- Testing
- mid-frequency whole-body electromyostimulation (WB-EMS), conventional exercise training, nutritional therapy
- Where
- Germany
- Volunteers
- 88 people
- Sponsor
- University of Cologne
Hepatic Encephalopathy, Cirrhosis, Liver
Oral Fecal Transplant in Cirrhosis
To evaluate the safety and tolerability of oral fecal transplant in patients with cirrhosis and hepatic encephalopathy
- Trial name
- NCT03152188
- Testing
- FMT
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Lung Cancer, Effects of Chemotherapy
Intestinal Microflora in Lung Cancer After Chemotherapy
Probiotics modulate the gut microflora and immune status in lung cancer who need chemotherapy.
- Conditions
- Lung Cancer, Effects of Chemotherapy, Tumor Immunity, Malnutrition
- Trial name
- NCT02771470
- Testing
- Probiotics
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Shandong University
B Cell Lymphoma, Multiple Mieloma
Immunomonitoring and Predictive Biomarkers After CAR-T Cell Therapy in B-Cell Lymphoma and Multiple Myeloma
CARBIOM is a single-centre, non-randomized interventional study involving additional biological sampling with minimal risks and constraints.
- Trial name
- CARBIOM (NCT07852377)
- Testing
- Biological sample collection and immunomonitoring
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Henri Becquerel
Multiple Sclerosis, Clinically Isolated Syndrome (CIS)
Prebiotic vs Probiotic in Multiple Sclerosis
This is a randomized crossover-designed study to explore the immunologic effects of Prebiotics, as opposed to direct supplementation with beneficial bacteria (Probiotics) in the immune system of patients with MS and Clinically…
- Trial name
- MS (NCT04038541)
- Testing
- Prebiotics (Prebiotin Prebiotic Fiber Stick Pac), Probiotics (Visbiome®)
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Columbia University
Obesity
Effect of a Very Low-Calorie Ketogenic Diet on Gut Microbiota and Fat Distribution
Short-term interventions that use very low-calorie ketogenic diets and meal replacements may be prescribed for selected overweight or obese patients with type 2 diabetes or prediabetes.
- Trial name
- NCT04019431
- Testing
- Whey protein, vegetable protein or animal protein
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
Dementia Alzheimers
Ageing Gut Brain Interactions
This research project will address a desperate need for evidence on how diet could be used to treat and improve symptoms of Alzheimer's disease (AD).
- Trial name
- NCT03593941
- Testing
- Standard Diet
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
DGBI, Depression/Anxiety
Feasibility and Acceptability of an Online ACT Intervention for Disorders of Gut-Brain Interaction
The goal of this clinical trial is to assess the acceptability, feasibility, and usability of the iACTforDGBI intervention among patients with Disorders of Gut-Brain Interaction (DGBI).
- Trial name
- iACTforDGBI (NCT06887751)
- Testing
- Acceptance and Commitment Therapy (ACT), Psychoeducation
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Örebro University, Sweden
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