Clinical trials: GI-bleeding
Gastrointestinal Bleeding, Delayed Bleeding
A Evaluation of the Utilisation, Effectiveness and Safety of Purastat® in the Management of Gastrointestinal Bleeding
Problem statement GI bleeding can arise from peptic ulcers, malignancy, angiodysplasia or during endoscopic resection procedures such as endoscopic mucosal resection and endoscopic submucosal dissection.
- Trial name
- POPS (NCT03983707)
- Testing
- Purastat®
- Where
- United Kingdom
- Volunteers
- 379 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Acute Coronary Syndrome, Acute Myocardial Infarction
Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease
Aspirin and clopidogrel +/- heparin or thrombolytic co-therapy is well established and effective treatment for unstable cardiac patients. However, the major complication was gastrointestinal bleeding (GIB) due to peptic ulcer.
- Trial name
- NCT00683111
- Testing
- esomeprazole 20 mg daily, famotidine 40 mg daily
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruttonjee Hospital
Gastrointestinal Hemorrhage, Portal Hypertension
Secondary Prophylaxis of Gastrointestinal Bleeding in Cirrhotic Patients Using THALIDOMIDE
The natural history of cirrhosis has a symptomatic and asymptomatic stage. The symptoms include the development of ascites, hepatic encephalopathy, or variceal bleeding.
- Trial name
- NCT00787436
- Testing
- Thalidomide
- Where
- United States
- Sponsor
- The Cleveland Clinic
Gastrointestinal Bleeding
Efficacy of a Novel Hemostatic Powder in GI Bleeding
Hemospray™ is a new endoscopic hemostatic powder. Aims of this multicenter prospective study is to determine effectiveness of Hemospray™ on short and medium term in different clinical situations, predictive factors of rebleeding…
- Trial name
- GRAPHE (NCT02595853)
- Testing
- Non interventional study
- Where
- 19 sites in France, Monaco
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital
Upper Gastrointestinal Bleeding
HemoPill Acute ® in Suspected Nonvariceal Upper Gastrointestinal Bleeding
The study examines, whether the use of the HemoPill Acute ® capsule in case of suspected nonvariceal upper gastrointestinal bleeding can identify cases in which endoscopy can be delayed to 48-96 hours without risk to the patient.
- Trial name
- NCT04472364
- Testing
- HemoPill Acute ®
- Where
- 4 sites in Germany
- Volunteers
- 73 people
- Sponsor
- Wuerzburg University Hospital
Crohn's, Ulcerative Colitis
Single-dose Linaclotide for Capsule Endoscopy Preparation
Video capsule endoscopy is an important procedure that can be used by doctors to find abnormalities in the small intestine, especially those that can cause bleeding.
- Conditions
- Crohn's, Ulcerative Colitis, Gastrointestinal Bleeding
- Trial name
- NCT02465385
- Testing
- Linaclotide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Gastrointestinal Hemorrhage (Clinically Important, Upper)
Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial
Patients who are critically ill in the in the Intensive Care Unit (ICU), especially those who need a breathing machine, can develop ulcers in the stomach that bleed.
- Trial name
- REVISE (NCT03374800)
- Testing
- Pantoprazole
- Where
- 67 sites in United States, Australia and 6 more
- Volunteers
- 4,800 people
- Sponsor
- McMaster University
Variceal Bleeding
Time Interval for Endoscopic Variceal Ligation
Patients with liver disease frequently present to the hospital with bleeding from dilated veins in their foodpipe (called esophageal varices).
- Trial name
- NCT01291277
- Testing
- Endoscopic Variceal Ligation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Southern California
Diverticular Disease
Prophylactic Elective Clipping of Colonic Diverticula
Diverticular bleeding is the most common cause of acute lower gastrointestinal bleeding (LGIB) in Western populations. Although self-limited in 85% of cases, some patients may require hospitalization with blood transfusion and…
- Trial name
- NCT02094456
- Testing
- Endoscopic clipping of diverticula, Follow-up colonoscopy
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- King's College Hospital NHS Trust
Lower Gastrointestinal Bleeding, Hemostatic Disorder
Clinical and Urgent Colonoscopy Outcomes Using the Pure-Vu® Cleansing System
The Pure-Vu® System can be effectively used as a cleansing device in patients admitted with acute LGIB to the intensive care unit and the regular nurse floor (RNF) bypassing the need to administer an oral bowel preparation for…
- Trial name
- NCT04729946
- Testing
- Pure-Vu Cleansing Device
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The Cleveland Clinic
Colorectal Cancer, Precancerous Polyp
A Study of a Urine Test to Detect Colorectal Cancer
The purpose of this study is to find out whether a urine test can detect colorectal cancer (CRC) and precancerous polyps in participants living in Ghana, Tanzania, and South Africa.
- Conditions
- Colorectal Cancer, Precancerous Polyp, Rectal Bleeding, CRC
- Trial name
- NCT07649057
- Testing
- 3-metabolite biosensor
- Where
- 4 sites in United States, Ghana and 2 more
- Volunteers
- 210 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obscure Gastrointestinal Bleeding
Preparation Regimens to Improve Capsule Endoscopy Visualization and Diagnostic Yield
Small bowel capsule endoscopy (SBCE) has become an important tool in clinical practice since its introduction in 2000. This non-invasive method allows the visualization of small bowel mucosa, being essential in the management of…
- Trial name
- PrepRICE (NCT05140057)
- Testing
- Moviprep
- Where
- Portugal
- Volunteers
- 210 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Lower Gastrointestinal Bleeding
Endoscopic Findings in Patients Presented With Lower GIT Bleeding in Assiut University Hospitals, a Single-centre Study
Lower gastrointestinal bleeding (LGIB) refers to hematochezia or bright blood passing per rectum of colorectal source distal to ileocecal valve.
- Trial name
- NCT07073300
- Testing
- Endoscopy
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assiut University
Upper Gastrointestinal Bleeding
Trial of Hemospray Plus Epinephrine Injection Versus Endoscopic Hemoclip
The non-variceal upper gastrointestinal bleeding is defined as gastrointestinal bleeding located proximal to the angle of Treitz, whose cause is not related to esophagogastric varices or gastropathy of portal hypertension.
- Trial name
- NCT02537353
- Testing
- Metal clips, Hemospray, Endoscopy Exam
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Hematemesis, Melena
Point of Care Testing of Platelet Function in Patients With Acute Upper Gastrointestinal Bleeding
Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency. In an ageing population, antiplatelet drugs are increasingly being prescribed for treatment and prophylaxis against cardiovascular thrombo-embolic…
- Conditions
- Hematemesis, Melena, Gastrointestinal Hemorrhage, Platelet Dysfunction
- Trial name
- POCGIB (NCT03028064)
- Testing
- blood taking
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Chinese University of Hong Kong
Acute Coronary Syndrome, Helicobacter Pylori Infection
The Effect of Dual Eradication Therapy vs PPI on Gastrointestinal Bleeding in ACS Patients
Patients with acute coronary syndrome (ACS) after Percutaneous Coronary Intervention (PCI) require routine treatment with dual antiplatelet (DAPT) treatment, but with the high risk of bleeding, gastrointestinal bleeding is the…
- Trial name
- NCT04728516
- Testing
- Vonoprazan-based dual eradication therapy for two weeks, amoxicillin, Pantoprazole
- Where
- 42 sites in China
- Volunteers
- 2,600 people
- Sponsor
- Qilu Hospital of Shandong University
Gastrointestinal Hemorrhage, Critical Illness
Gastrointestinal Bleeding in Critically Ill Patients
This prospective cohort study aims to determine the prevalence of gastrointestinal bleeding among critically ill patients admitted to intensive care units, identify independent risk factors, and describe clinical outcomes…
- Trial name
- NCT07822958
- Volunteers
- 310 people
- Sponsor
- Assiut University
Upper Gastrointestinal Bleeding
OTSC vs. Angiographic Embolization in Patients With Refractory Non-variceal Upper Gastrointestinal Bleeding
In the management of patients with acute upper non-variceal upper gastrointestinal bleeding, further bleeding is the most important adverse factor predictive of mortality.
- Trial name
- NCT04902248
- Testing
- The OTSC® System Set, angiographic embolization
- Where
- 5 sites in China, Hong Kong and 1 more
- Volunteers
- 236 people
- Sponsor
- Chinese University of Hong Kong
Bleeding Peptic Ulcer
The Use of OTSC in LBGDU to Standard Endoscopic Hemostatic Methods
In managing bleeding gastroduodenal ulcers, endoscopic control of bleeding is the first line treatment-further bleeding after endoscopic hemostasis is associated with a 3-fold increase in mortality.
- Trial name
- OTSC-LBGDU (NCT06196710)
- Testing
- Over-the-scope Clips, Hemo-clipping
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Hemorrhage, Clostridium Difficile Colitis
Enteral Nutrition as Stress Ulcer Prophylaxis in Critically Ill Patients.
study is to determine if proton pump inhibitors plus enteral nutrition is superior to enteral nutrition alone as a stress ulcer prophylaxis strategy in critically ill patients in terms of incidence of overt and significant GI…
- Trial name
- NCT01477320
- Testing
- Pantoprazole 40 mg IV daily and tube feed.
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Mohamed Saad