Clinical trials: Gait
Parkinson Disease
Modulation of GABA-A Receptors in Parkinson Disease-Flumazenil Arm
This arm is a positron emission tomography (PET) biomechanistic GABA-A receptor target engagement study that includes detailed clinical and motor assessments before and after the i.v.
- Trial name
- NCT03462641
- Testing
- Flumazenil
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Michigan
Parkinson Disease, Physical Activity
Neuroplasticity in Parkinson´s Disease After Training
This project aims to determine the effects of the HiBalance program on neuroplastic changes in people with mild to moderate Parkinson´s disease.
- Conditions
- Parkinson Disease, Physical Activity, Gait Disorders, Neurologic, Neural Degeneration
- Trial name
- BETA-PD (NCT03213873)
- Testing
- HiBalance, Speech and communication therapy
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Karolinska Institutet
Stroke
NewGait: A Low-Cost Rehabilitation System to Improve Post-Stroke Gait (Biomechanical Adaptations)
An affordable and easy to use gait-assistive device for stroke survivors to use at home is yet to be developed. This study is intended to modify the current design of the NewGait device to specifically work for stroke survivors…
- Trial name
- NCT06269367
- Testing
- NewGait, Control wearable limb orthotic device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Knee Osteoarthritis
Mobility Optimization Through Velocity Exercise
Knee Osteoarthritis (OA) accounts for a significant proportion of mobility limitations and is one of the most disabling problems facing the growing population of older adults.
- Trial name
- MOVE (NCT00844558)
- Testing
- Gait Training, Control
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Iowa
Sarcopenia
A 24-week Off-drug Extension Study in Sarcopenic Elderly Who Completed Treatment in the 6-month Core Study
This extension study was a 24-week off-drug follow-up of the core CBYM338E2202 (NCT ) study and the main objective was to determine the long-term durability of bimagrumab (BYM338) effect after a 6-month treatment period.
- Trial name
- NCT02468674
- Testing
- bimagrumab
- Where
- 30 sites in United States, Australia and 10 more
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Stroke
Clinical Reasoning Process of Physiotherapists When Observing Hemiplegic Gait
The goal of this study is to find out what clinical reasoning process physiotherapists undergo when observing hemiplegic patients gait.
- Trial name
- NCT02504073
- Testing
- No intervention
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Technical University of Bern
Multiple Sclerosis
The Effects of Ankle Foot Orthoses (AFOs) on Mobility in Persons With Multiple Sclerosis (MS)
The purpose of this study is to investigate the impact of ankle foot orthoses (AFOs) on the spatial and temporal gait parameters, electromyography (EMG), walking endurance, and quality of life in select individuals living with…
- Trial name
- NCT01947582
- Testing
- Ankle foot orthosis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Stroke, Gait Impairment
Transcranial Direct Current Stimulation for Post-stroke Gait Rehab
Stroke affects upwards of 800,000 Americans every year and has an enormous impact on the well-being of the American Veteran population with 6,000 new stroke admissions every year.
- Trial name
- NCT03666533
- Testing
- Active transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Optimizing Vibrational Therapy to Improve Gait and Balance in Parkinson's Disease
The purpose of this research study is to test the safety, tolerability, and the effect of vibration (delivered by an experimental device called PDVibe2) on freezing of gait (FOG) in persons with Parkinson's disease (PD).
- Trial name
- NCT03883217
- Testing
- Vibration Session, No vibration session
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Cerebral Palsy, Gait Disorders, Neurologic
Precision Gait Retraining for Children With Cerebral Palsy
This project will develop the first sensor-based mobile Pelvic Assist Device (mPAD) that can deliver precise, adaptable, pelvic control to restore natural coordination of upper- and lower-limb movements during gait in children…
- Trial name
- NCT04717323
- Testing
- mPAD (or TPAD) Pelvic Assist Device, No Intervention
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Altec Inc.
Multiple Sclerosis
The Therapeutic Effects of Forced Aerobic Exercise in Multiple Sclerosis
This project will investigate the feasibility and initial efficacy of two aerobic exercise training approaches, forced and voluntary, to improve motor function in persons with multiple sclerosis (MS).
- Trial name
- NCT04906057
- Testing
- Forced Aerobic Exercise (FE), Voluntary Aerobic Exercise (VE)
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- The Cleveland Clinic
Ambulation Difficulty, Gait, Unsteady
The Sensorimotor Locus of Balance Control in Elderly Gait
The aging population is at an exceptionally high risk of debilitating falls, contributing significantly to reduced independence and quality of life.
- Conditions
- Ambulation Difficulty, Gait, Unsteady, Fall, Position Sense Disorders
- Trial name
- NCT03341728
- Testing
- Optical flow perturbations, Normal walking
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Parkinson's Disease
rTMS for the Treatment of Freezing of Gait in Parkinson's Disease
This study is a double blind comparative study examining the effectiveness of the rTMS treatment on Freezing of Gait (FOG) in patients with Parkinson's disease (PD).
- Trial name
- NCT03219892
- Testing
- High-frequency rTMS
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuanwu Hospital, Beijing
Autism Spectrum Disorder
Effect of Virtual Reality-based Training on Balance and Walking in Youth With Autism Spectrum Disorder
The goal of this clinical trial is to assess the effect of short-term (3 days/week for 2 weeks) Virtual Reality (VR) active video gaming intervention on static and dynamic balance, versus traditional balance training exercises…
- Trial name
- NCT06023563
- Testing
- Virtual reality active video gaming using Nintendo switch sports, Standard physical therapy balance exercises
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Indiana University
Sarcopenia
Dose Range Finding Study of Bimagrumab in Sarcopenia
The purpose of this study was to determine the efficacy of repeat dosing with multiple dose levels of bimagrumab on patient physical function, skeletal muscle mass and strength in older adults with sarcopenia.
- Trial name
- NCT02333331
- Testing
- bimagrumab
- Where
- 58 sites in United States, Australia and 11 more
- Volunteers
- 217 people
- Sponsor
- Novartis Pharmaceuticals
Brain Injuries, Traumatic
Noninvasive Neuromodulation for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury
The investigators hypothesis is that electrical stimulation to the tongue that directly stimulates two cranial nerve nuclei (Trigeminal and Facial Nerve Nuclei), will excite neural impulses to the brainstem and cerebellum.
- Trial name
- NCT02158494
- Testing
- Balance and Gait Training using neurostimulation modulation.
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Wisconsin, Madison
Knee Osteoarthritis
Wearable Sensors in Knee OA
This is a single-arm clinical trial to investigate the outcome of exercise-based physical therapy in people with knee osteoarthritis through the use of wearable sensors.
- Trial name
- WESENS-OA (NCT04243096)
- Testing
- Exercise-based Physical Therapy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Boston University Charles River Campus
Multiple Sclerosis
The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis
Majority of people with multiple sclerosis experience difficulty with balance and mobility, leading to an increased risk of falls.
- Trial name
- NCT05878873
- Testing
- Split-belt Treadmill, Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Dementia, Accidental Falls
Exploring the Use of Transdermal Methylphenidate to Reduce Fall Risk in Patients With Dementia.
Falls in the elderly are a very common and serious health problem with devastating consequences. Those with dementia are 5 times more likely to experience falls than older people without significant cognitive impairment.
- Conditions
- Dementia, Accidental Falls, Apathy
- Trial name
- NCT01825577
- Testing
- Transdermal Methylphenidate
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- St. Louis University
Stroke
Effect of Mirror Therapy on Lower Extremity Motor Control and Gait in Patients With Stroke
Mirror therapy may be an effective intervention in increasing motor control and gait performance in patients with stroke.
- Trial name
- NCT01574079
- Testing
- Traditional Physical Therapy, Physical Therapy plus Mirror Therapy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Mississippi Medical Center