Clinical trials: Gait Disorder
Stroke, Stroke, Acute
A Multisite Exploration of Balance Perturbations With and Without Body Weight Support
ZeroG is an FDA-listed robotic body weight support system (BWSS). Mounted on an overhead track, patients are fitted in a harness system tethered to said track, and are able to practice gait and balance activities without the risk…
- Conditions
- Stroke, Stroke, Acute, Balance; Distorted, Balance; Impairment
- Trial name
- NCT05110300
- Testing
- Body weight support system control group, Body weight support system with balance perturbations
- Where
- 4 sites in United States
- Volunteers
- 114 people
- Sponsor
- Gaylord Hospital, Inc
Stroke
Comparison of Two High-intensity Gait Training Interventions on Contraversive Pushing Behaviors in Individuals Poststroke
The purpose of this study is to investigate the effect of two high-intensity gait training interventions on contraversive pushing behaviors in individuals poststroke in the acute inpatient rehabilitation setting.
- Trial name
- NCT04550039
- Testing
- Body-weight-supported treadmill, Ekso Bionics EksoNR exoskeleton
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Foot Drop
Ankle Robot to Reduce Foot Drop in Stroke
Deficits in ankle control after stroke can lead to foot drop, resulting in inefficient, aberrant gait and an elevated falls risk.
- Trial name
- NCT02483676
- Testing
- Treadmill plus anklebot, Treadmill only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Peripheral Arterial Disease
Exoskeleton Variability Optimization
Exoskeletons, wearable devices that assist with walking, can improve mobility in clinical populations. With exoskeletons, it is crucial to optimize the assistance profile.
- Trial name
- NCT04338815
- Testing
- Exoskeleton Optimization, Endurance Evaluation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Parkinson Disease
Optimizing Vibrational Therapy to Improve Gait and Balance in Parkinson's Disease
The purpose of this research study is to test the safety, tolerability, and the effect of vibration (delivered by an experimental device called PDVibe2) on freezing of gait (FOG) in persons with Parkinson's disease (PD).
- Trial name
- NCT03883217
- Testing
- Vibration Session, No vibration session
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Paraplegia, Quadriplegia
Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI)
This proposal investigates the hypothesis that progressive aerobic exercise with Lokomat is feasible in people with motor incomplete spinal cord injury, and three months of training will improve cardiovascular fitness and gait…
- Conditions
- Paraplegia, Quadriplegia, Spinal Cord Injury, Tetraplegia
- Trial name
- NCT00385918
- Testing
- Lokomat Training, Home stretching then Lokomat training
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease
Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait Using Neural and Kinematic Feedback
Deep Brain Stimulation of the subthalamic nucleus (STN) has become a standard of care, FDA-approved treatment for Parkinson's disease, with stimulation delivered at a constant amplitude and voltage, operating in an open-loop…
- Trial name
- NCT04043403
- Testing
- Open Loop DBS, Adaptive (Closed Loop) DBS, Intermittent Open Loop DBS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Parkinson Disease
Safety and Efficacy of State-of-the-Art Exoskeleton Technology to Improve Mobility in Parkinson's Disease
The purpose of this study is to test the safety and efficacy of using of a portable exoskeleton for walking training in persons with Parkinson's disease that have gait mobility problems and/or postural instability.
- Trial name
- NCT04587193
- Testing
- Robotic-assist gait training device
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Virginia Commonwealth University
Acute Stroke
Metabolic Costs of Walking Post Stroke
This will be a randomized, matched-group study to compare the cardiopulmonary / metabolic benefits for persons post stroke that learn to walk utilizing early treadmill training post-acute stroke to persons post stroke that learn…
- Trial name
- NCT02108912
- Testing
- ESTT, Traditional outpatient
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Texas Southwestern Medical Center
Foot Injuries and Disorders
Ankle Foot Orthosis Comparative Effect
The proposed effort is designed to support evidence-based practice and optimal care by evaluating how the form, fit and function of two commercially available carbon fiber custom fit braces (Orthoses) influences outcomes…
- Trial name
- AFOCE (NCT03901053)
- Testing
- Reaktiv AFO, PhatBrace AFO
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- Jason Wilken
Stroke, Gait Impairment
Transcranial Direct Current Stimulation for Post-stroke Gait Rehab
Stroke affects upwards of 800,000 Americans every year and has an enormous impact on the well-being of the American Veteran population with 6,000 new stroke admissions every year.
- Trial name
- NCT03666533
- Testing
- Active transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Diabetic Neuropathies, Peripheral Nerve Diseases
Effect of Exercise on Gait and Balance in Peripheral Neuropathy
The purpose of this study is to find out if participation in one of the study groups: functional balance training, Tai Chi, or education, results in better outcomes overall.
- Conditions
- Diabetic Neuropathies, Peripheral Nerve Diseases, Peripheral Nervous System Diseases
- Trial name
- NCT00270842
- Testing
- Tai Chi, Functional Balance, Education Control group
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- US Department of Veterans Affairs
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Plus Finasteride Treatment After Spinal Cord Injury
The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injuries
- Trial name
- NCT02248701
- Testing
- Testosterone Enanthate, Finasteride
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Hereditary Spastic Paraplegia, Adrenomyeloneuropathy
Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneuropathy
Hereditary spastic paraplegia (HSP) is the group of inherited disorders, characterized by progressive gait disturbance. There is no established therapy. Adrenoleukodystrophy (AMN) is an x-linked hereditary disease.
- Trial name
- NCT03627416
- Testing
- rTMS
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- Jakub Antczak
Cerebral Palsy
Short-Burst Interval Treadmill Training Cerebral Palsy
Ambulatory children with cerebral palsy (CP) walk predominately in low intensity stride rates with little variability, thus limiting their walking activity and ability to participate in daily life.
- Trial name
- NCT04026295
- Testing
- Short Burst Interval Treadmill Training (SBLTT), Traditional Locomotor Treadmill Training (TLTT)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kristie Bjornson
Multiple Sclerosis
An Open Label, Proof of Concept Study to Evaluate the Effects of Dalfampridine Withdrawal on Gait and Balance Parameters in Subjects With Multiple Sclerosis (MS)
The purpose of this study is to determine changes on overall gait as well as in multiple gait and balance parameters after withdrawal of dalfampridine-ER 10mg in MS subjects who are receiving the medication consistently for at…
- Trial name
- NCT01535664
- Testing
- Withdrawal of dalfampridine-ER 10mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Acorda Therapeutics
Parkinson's Disease
Long-term Effect of Low Frequency Stimulation on Aspiration and Freezing of Gait in PD With STN DBS
Our recent study (Xie et al, Neurology 2015; 84: 415-420) found that bilateral STN DBS of 60Hz, compared to the traditional 130Hz, decreased the aspiration frequency and swallowing difficulty, freezing of gait (FOG), and other…
- Trial name
- NCT02549859
- Testing
- Deep Brain Stimulation (DBS) at 60 Hz, Deep Brain Stimulation (DBS) at 130 Hz
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Chicago
Parkinson's Disease
A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease
The purpose of this study is to evaluate the effect of AMPYRA on a number of symptoms in Parkinson's disease. AMPYRA is a medication approved by FDA for gait dysfunction in multiple sclerosis.
- Trial name
- NCT01491022
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Miami
Cerebellar Ataxia
Effects of High Intensity Stepping Training on Gait in Patients With Ataxia
The purpose of this study is to examine the effects of high intensity stepping training on gait recovery, including walking speed and endurance, in patients with cerebellar ataxia.
- Trial name
- NCT06450457
- Testing
- Polar H10 heart rate monitor, Therastride Treadmill System, VECTOR Bioness
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
Down Syndrome
Treadmill Training and Orthotic Use in Infants With Down Syndrome
This study determines the effect of orthotic use in combination with treadmill training on the development of gross motor skills and walking onset in infants with Down syndrome.
- Trial name
- NCT00825175
- Testing
- Treadmill Training, Supramalleolar Orthoses
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan