Clinical trials: Gallstones
Bile Duct; Obstruction, With Calculus, Choledocholithiasis
Clinical Trial Comparing ERCP vs ERCP and Transmural Gall Bladder Drainage
Cholelithiasis occurs in 10-20% of the general population. Up to 18% of these subjects will present symptoms. In patients with symptomatic choledocholithiasis who are not candidates for surgery with indication for ERCP…
- Trial name
- PECAS (NCT03921502)
- Testing
- Gall bladder transmural drainage with LAMS
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital del Rio Hortega
Gall Stones
Intraperitoneal Techniques of Local Anaesthesia During Laparoscopic Cholecystectomy
Pain following laparoscopic cholecystectomy (LC) results in morbidity and is a barrier to same day discharge. In several trials local anaesthetic (LA) washed over the liver and gall bladder decreases pain.
- Trial name
- NCT01090882
- Testing
- Bupivocaine, 0.9% normal saline solution
- Where
- United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Regional Anesthesia Morbidity, Gallbladder Stone
LaGRA Trial in Laparoscopic Cholecystectomy
This study investigated the effectiveness of a surgeon administered, laparoscopic guided, regional anaesthesia technique.
- Conditions
- Regional Anesthesia Morbidity, Gallbladder Stone, Pain
- Trial name
- LaGRA (NCT03394807)
- Testing
- Levobupivacaine
- Volunteers
- 76 people
- Sponsor
- Health Service Executive, Ireland
Cholelithiasis
Electrosurgical Patterns and Learning Curve in Elective Laparoscopic Cholecystectomy
This prospective observational study will examine how electrosurgical activation patterns during elective laparoscopic cholecystectomy are associated with surgeon experience and intraoperative difficulty.
- Trial name
- ELECTRO-LC (NCT07888491)
- Testing
- Elective laparoscopic cholecystectomy
- Where
- Croatia
- Volunteers
- 165 people
- Sponsor
- University Hospital of Split
Cholelithiasis
The Effect of Preoxygenation on Gastric Decompression in Laparoscopic Cholecystectomies
Aim: Gastric insufflation caused by mask ventilation during laparoscopic surgeries may affect the surgical field, lead to regurgitation of gastric contents, and consequently cause aspiration pneumonia.
- Trial name
- NCT07274488
- Testing
- Preoxygenation, Mask Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Ankara City Hospital Bilkent
Cholelithiasis
Single Incision Laparoscopic Cholecystectomy
The investigators aim to investigate the safety, feasibility and short-term outcomes of Single Incision Laparoscopic Cholecystectomy.
- Trial name
- SILC (NCT00678873)
- Testing
- Single Incision Laparoscopic Cholecystectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Choledocholithiasis
Treatment of Choledocolithiasis by Laparoscopic Exploration
There are three treatment options for choledocholithiasis: endoscopic retrograde cholangiopancreatography (ERCP) followed by laparoscopic cholecystectomy; laparoscopic exploration of the main bile duct with concomitant…
- Trial name
- NCT04690101
- Testing
- none, this is an observational study
- Volunteers
- 75 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Gallstone
Post-Cholecystectomy Quality of Life
The study aims to identify factors associated with no increase in gastrointestinal quality of life after elective cholecystectomy for gallstones.
- Trial name
- NCT03326154
- Testing
- No intervention, observational
- Where
- 2 sites in Finland
- Volunteers
- 1,000 people
- Sponsor
- Helsinki University Central Hospital
Choledocholithiasis
"Endoscopy First" or "Laparoscopic Cholecystectomy First" for Patients With Intermediate Risk of Choledocholithiasis
The study compares two different methods to evaluate extrahepatic bile ducts for possible stones for patients with cholecystolithiasis and intermediate risk for choledocholithiasis when laparoscopic cholecystectomy is indicated.
- Trial name
- NCT03658863
- Testing
- endoscopic ultrasound, intraoperative cholangiography, ERCP
- Where
- Lithuania
- Volunteers
- 106 people
- Sponsor
- Vilnius University
Calculus; Gallbladder, With Cholecystitis
Two Institutes Experience in Laparo-Endoscopic Rendezvous Technique for Gallbladder and Bile Duct Stones
The management of gallbladder stones (lithiasis) concomitant with bile duct stones is controversial. The management of CBD stones has evolved considerably since the advent of laparoscopic surgery.
- Trial name
- NCT05734144
- Testing
- The intraoperative ERCP has been performed immediately before LC, POES followed by LC
- Volunteers
- 432 people
- Sponsor
- Zagazig University
Biliary Stones
Spyglass DS Peroral Cholangioscope Guided LL or EHL Versus BML for Endoscopic Removal of Complicated Bile Duct Stones
This study aims to compare the overall rate of endoscopic clearance of complicated bile duct stones by Spyglass DS peroral cholangioscopy guided holmium:YAG laser/electrohydraulic lithotripsy versus conventional BML.
- Trial name
- NCT03244163
- Testing
- Spyglass DS cholangioscope, BML
- Where
- Hong Kong
- Volunteers
- 86 people
- Sponsor
- Chinese University of Hong Kong
Cholecystitis, Acute, Acute Cholangitis
Visualization of the Extrahepatic biliaRy Tree Trial
This study is a prospective randomized controlled trial evaluating the use of a fluorescent dye, indocyanine green (ICG), in the identification of important bile duct anatomy during emergent same-admission cholecystectomy.
- Conditions
- Cholecystitis, Acute, Acute Cholangitis, Gallstone Pancreatitis, Choledocholithiasis
- Trial name
- VERT (NCT04922528)
- Testing
- Laparoscopic Cholecystectomy with Fluorescent Cholangiography, Laparoscopic Cholecystectomy with White Light Imaging
- Where
- Canada
- Volunteers
- 340 people
- Sponsor
- University of British Columbia
Gallstone Disease
Radiological Investigation of Bile Duct Obstruction
Patients with gallstone disease should be checked whether a common bile duct (CBD) stone could be present. In case of a certain suspicion for CBD stones further investigations should be performed.
- Trial name
- RIBO (NCT02351492)
- Testing
- Cholecystectomy and intraoperative cholangiography, Magnet resonance cholangio-pancreaticography, magnet resonance imaging
- Where
- Switzerland
- Volunteers
- 122 people
- Sponsor
- University Hospital, Basel, Switzerland
Laparoscopic Cholecystectomy, Post Operative Analgesia
Postoperative Pain After Instillation Of Bupivacaine During Laparoscopic Cholecystectomy
This study aims to compare the level of postoperative pain experienced by patients undergoing laparoscopic cholecystectomy with and without the use of intraperitoneal bupivacaine.
- Conditions
- Laparoscopic Cholecystectomy, Post Operative Analgesia, Bupivacaine
- Trial name
- BUPA-LC (NCT07098429)
- Testing
- Bupivacain (Postoperative), Normal (0.9%) saline
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh
Cholecystectomy, Laparoscopic, Choledocholithiasis
ChOlecystectomy aFter successFul Endoscopic Common Bile Duct Stone Extraction in Elderly
The goal of this study is to compare safety and efficacy of laparoscopic cholecystectomy versus wait-and-see policy after endoscopic removal of common bile duct stones in elderly.
- Conditions
- Cholecystectomy, Laparoscopic, Choledocholithiasis, Cholelithiasis
- Trial name
- COFFEE (NCT07001423)
- Testing
- Laparoscopic cholecystectomy
- Where
- 12 sites in Finland
- Volunteers
- 400 people
- Sponsor
- Helsinki University Central Hospital
Gallstones
A Clinical Trial of Electro-acupuncture for Treating Gallstone Diseases
Background: Electro-acupuncture (EA) is commonly used as an alternative treatment for gallstone disease. This study aimed to investigate the effectiveness of EA.
- Trial name
- NCT03891147
- Testing
- Electro-acupuncture
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Chinese University of Hong Kong
Acute Cholecystitis
EUS-guided Gallbladder Drainage Instead of Laparoscopic Cholecystectomy for Acute Cholecystitis. A Feasibility Study.
To evaluate the feasibility of performing EGBD as a treatment of acute calculous cholecystitis in patients that are indicated for laparoscopic cholecystectomy.
- Trial name
- EGDB (NCT04197908)
- Testing
- EUS-guided gallbladder drainage (EGBD)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Cholesterol Gallstone Dissolution
Synergistic Effects of Natural Oils and Herbal Extracts on Cholesterol Gallstone Dissolution: In Vitro Comparison With Rowachol®
Objective: This study aims to evaluate the effectiveness of a natural mixture (sesame oil, extra virgin olive oil, psyllium extract, and dandelion extract) in dissolving cholesterol gallstones compared to the standard medication…
- Trial name
- NCT06972134
- Testing
- Sesame Oil (SO) at 100 mg/mL in dissolving fluid., Extra Virgin Olive Oil (EVOO) at 100 mg/mL in dissolving fluid., 50% Sesame Oil (SO) + 50% Extra Virgin Olive Oil (EVOO).
- Where
- Syria
- Volunteers
- 55 people
- Sponsor
- University of Duhok
Cholelithiasis
Lithotripsy for the Treatment of Gallstones
The purpose of this study is to determine the effectiveness and safety of using the Medstone lithotripter to treat single non-calcified gallstones from 4 to 20 mm in diameter.
- Trial name
- NCT00042549
- Testing
- Extracorporeal Shock Wave Lithotripsy, ursodiol
- Where
- 2 sites in United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Medstone International
Biliary Pancreatitis
Impact on Outcome of Early Endoscopic Extraction of Bile Duct Stones in Biliary Pancreatitis
Impact on outcome of early endoscopic extraction of bile duct stones in biliary pancreatitis: a prospective multicenter randomized controlled study.
- Trial name
- EEPAB (NCT00505128)
- Testing
- Endoscopic sphincterotomy
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris