Clinical trials: Gamma Knife Radiosurgery
Acromegaly
Late Effects of Radiosurgery on Acromegaly Study
Transsphenoidal surgery is the first-line treatment of acromegaly. Adjunctive radiotherapy can be necessary when surgery is ineffective to avoid a prolonged medical treatment.
- Trial name
- LateRAc (NCT02296216)
- Testing
- Gamma Knife radiosurgery
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Brain Metastases
Response of Brain Metastases After Gamma-Knife Radiosurgery Using Dynamic Susceptibility-weighted Contrast-enhanced Perfusion Magnetic Resonance Imaging
This study is designed to evaluate whether advanced magnetic resonance imaging (MRI) techniques such as dynamic susceptibility-weighted contrast-enhanced perfusion MRI may be used to predict treatment response of brain metastasis…
- Trial name
- NCT02311556
- Testing
- dynamic susceptibility-weighted contrast-enhanced perfusion magnetic resonance imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Washington University School of Medicine
Cancer, Brain Metastases
Phase II Study of Gamma Knife Radiosurgery and Temozolomide for Brain Metastases
The protocol is designed to determine the efficacy of temozolomide in preventing the development of new brain metastases within the first year in patients undergoing stereotactic radiation for newly diagnosed brain metastases.
- Trial name
- RAD0102 (NCT00582075)
- Testing
- temozolomide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Lung Cancer, Brain Metastases
Clinical Evaluation of the Treatment of Intellectual Metastases by Radiosurgery Gamma Knife by Means of a Support System by Mask.
the Mask fixation isn't a new solution for the immobilization of the patient's head and has been used in current practice for long years.
- Trial name
- Mask (NCT02732769)
- Testing
- GammaKnifePerfexion®, GammaKnifeIcon®, Efficast®
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Brain Metastases
Perfexion Registration Using CBCT
Measuring precision radiation delivery through cone-beam computed tomography (CBCT) and intra-fraction motion management (IFMM) incorporated on a GammaKnife unit via the Leksell Coordinate Frame (LCF) and relocatable mask system…
- Trial name
- NCT04170777
- Where
- Canada
- Volunteers
- 1,250 people
- Sponsor
- University Health Network, Toronto
Brain Metastases
Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection
Background. Brain metastases (BM) are the most common intracranial tumor and occur in 20-40% of all oncological patients. The most common primary cancer in brain metastases is lung cancer, followed by melanoma, breast cancer…
- Trial name
- NCT04857905
- Testing
- Microsurgical resection, Gamma Knife radiosurgery
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Neoplasm Metastases
Neurocognition After Gamma Knife Radiosurgery for Multiple Brian Metastases
Cancer which spreads to the brain (brain metastases) is a common and significant problem. Historically, whole-brain radiotherapy has been used to treat these patients but has a negative effect on cognition.
- Trial name
- NCT01970644
- Testing
- Gamma knife radiosurgery
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- CancerCare Manitoba
Trigeminal Neuralgia (TN)
Ultra-Early Gamma Knife Stereotactic Radiosurgery for TN
The goal of this clinical trial is to evaluate Gamma Knife stereotactic radiosurgery (GK-SRS) as an ultra-early treatment option for trigeminal neuralgia (TN). The main questions it aims to answer are: 1.
- Trial name
- URGEnt-TN (NCT06949436)
- Testing
- GK SRS
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- University of Alberta
Glioblastoma
Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for Recurrent Glioma
The purpose of this study is to assess the efficacy, of treating patients with recurrent glioblastoma using Gamma-Knife Radiosurgery (GKS) to target a tumor volume defined by a combination of gadolinium enhancement and magnetic…
- Trial name
- GKS (NCT01011231)
- Testing
- Gamma Knife Radiosurgery
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of California, San Francisco
Melanoma, Renal Cell Carcinoma
A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI and Rational Dose Selection
The purpose of this study is to collect prospective data for use as a comparator for future subsequent studies attempting to increase the efficacy or reduce the toxicity of gamma knife radiosurgery.
- Conditions
- Melanoma, Renal Cell Carcinoma, Sarcoma, Breast Cancer
- Trial name
- NCT02005614
- Testing
- Gamma Knife Radiosurgery
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Yale University
Vestibular Schwannoma, Neurinoma, Acoustic
Evolution of Vestibular Function After Treatment of a Vestibular Schwannoma by Gamma-knife Radio-surgery
The purpose of this study is to evaluate the vestibular effects of gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.
- Conditions
- Vestibular Schwannoma, Neurinoma, Acoustic, Acoustic Neuroma
- Trial name
- EVERS (NCT06112509)
- Testing
- Vestibular exam
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon