Clinical trials: Gas Exchange
Acute Lung Injury, ARDS
The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients
The investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.
- Trial name
- NCT00143468
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Chronic Obstructive Pulmonary Disease
The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients
The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.
- Trial name
- NCT00141440
- Testing
- mechanical ventilation
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Policlinico Hospital
Acute Decompensated Heart Failure
Gas Exchange for Predicting Hospital Heart Failure Readmissions
To determine whether, and if so, which gas exchange parameters measured on the Shape-HF Cardiopulmonary Exercise Testing System predict 30 and 180 day re-hospitalization in subjects discharged from hospitalization for an episode…
- Trial name
- NCT01960218
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Shape Medical Systems, Inc.
Respiratory Failure
Comparison of Gas Exchange Between Two Invasive Mechanical Ventilation Modes in Children
This study assesses the feasibility of digital data collection for a randomized controlled trial in a quaternary pediatric intensive care unit and the effect of two commonly used mechanical ventilation modes on gas exchange (CO2)…
- Trial name
- CoCO2 (NCT05843123)
- Testing
- Respiratory support a, Respiratory support b
- Where
- Switzerland
- Volunteers
- 59 people
- Sponsor
- University Children's Hospital, Zurich
Pulmonary Disease, Chronic Obstructive
Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD
The goal of this clinical trial was to compare the action of long-acting ß2-agonists (LABA-olodaterol) and muscarinic antagonists (LAMA-tiotropium) on tissue oxygenation in COPD considering their impact on proximal and peripheral…
- Trial name
- NCT05927155
- Testing
- LABA, LAMA
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Erasme University Hospital
Respiratory Failure
PEEP Influence on Gas Exchange During Early Weaning
The purpose of this study is to determine the differences in oxygenation and decarboxylation between two weaning processes.
- Trial name
- MHOPEEP (NCT02281695)
- Testing
- PEEP adjusment during the Weaning process
- Where
- Germany
- Sponsor
- Marienhospital Osnabrück
Pleural Effusion, Exudative Pleuritis
Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis
Research project objectives. The project includes eight research hypotheses and eight corresponding study objectives. The most relevant objectives are: Analysis of lung function and gas exchange parameters in relation to the…
- Trial name
- NCT02192138
- Testing
- Therapeutic thoracentesis, Pleural catheter, Pleural manometer
- Where
- Poland
- Volunteers
- 61 people
- Sponsor
- Medical University of Warsaw
Chronic Obstructive Pulmonary Disease
Effects of Nasal High-flow Oxygen in Patients With an Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
The investigators are looking at the effect of humidified nasal high-flow with oxygen (HNHF-O2) on air exchange during exacerbations of COPD.
- Trial name
- NCT03214458
- Testing
- Nasal high flow
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Temple University
Cardiorespiratory Fitness, Metabolic Health
Validation of a Novel Incremental Step Test for Assessment of Cardiopulmonary Fitness and Ventilatory Thresholds in Adults
The purpose of this single-group diagnostic validation and test-retest reliability study is to determine whether a novel Incremental Step Test (IST) can accurately assess cardiorespiratory fitness and ventilatory thresholds in…
- Conditions
- Cardiorespiratory Fitness, Metabolic Health, Cardiac Function, Pulmonary Function
- Trial name
- VALID-IST (NCT07829003)
- Testing
- Cardiopulmonary Exercise Test, Incremental Step Test
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Heriot-Watt University
COPD Exacerbation Acute
Tolerance and Acute Effects of a New HFNT Nasal Cannula
In the care of patients experiencing an acute exacerbation of COPD, supplemental oxygen therapy is often required. Oxygen is typically administered at flow rates between 1 and 4 liters per minute.
- Trial name
- NCT05182294
- Testing
- AIRVO 2, the new asymmetric nasal cannula
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Temple University
Hypoxia
Effects of Dihydropyridine Calcium Channel Inhibitors on Respiratory Gas Exchanges in the Intensive Care Unit: a Pharmacovigilance Study in VigiBase® and a Comparison With Urapidil
Due to their effects on hypoxic pulmonary vasoconstriction (HPV), dihydropyridine calcium channel inhibitors (CCI) could lead to hypoxia in patients with a pulmonary shunt.
- Trial name
- NCT05537194
- Testing
- dihydropyridine calcium channel inhibitors use
- Where
- France
- Volunteers
- 32,000,000 people
- Sponsor
- University Hospital, Caen
Respiratory Failure
The Effects of Vertical Position on Gas Exchange in Patients With Respiratory Failure
The purpose of this study is to investigate how changing from a supine to upright position affects gas exchange for patients with hypoxemic respiratory failure.
- Trial name
- NCT01705119
- Testing
- Standing
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Chicago
Video Assisted Thoracic Surgery (VATS), Postoperative Complications
Clinical Effects of Intraoperative Heat and Moisture Exchange Systems During Thoracic Surgery: A Prospective Observational Cohort Study
General anesthesia with endotracheal intubation bypasses the physiological warming and humidification functions of the upper airway, allowing cold and dry gases to reach the lower respiratory tract.
- Conditions
- Video Assisted Thoracic Surgery (VATS), Postoperative Complications, Pulmonary Complications in Surgical Patients, Humidification
- Trial name
- NCT07729319
- Testing
- Active Heated Humidification, Heat and Moisture Exchanger
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Marmara University
Chronic Obstructive Pulmonary Disease
The Effect of Inhaled Nitric Oxide on Pulmonary Gas-exchange in COPD
Chronic Obstructive Pulmonary Disease (COPD) is a lung disorder commonly caused by smoking, which makes breathing more difficult.
- Trial name
- iNO (NCT04231760)
- Testing
- Inhaled Nitric Oxide
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Chronic Respiratory Disease, Hypoxia, Altitude
Validation of a Predictive Score for HAST
Patients with chronic lung diseases travelling by plane often suffer with symptoms related to lower oxygen levels they are exposed to while flying.
- Conditions
- Chronic Respiratory Disease, Hypoxia, Altitude, COPD, ILD
- Trial name
- NCT03728595
- Testing
- Venepuncture, Spirometry, Hypoxic altitude simulation test (HAST)
- Where
- United Kingdom
- Volunteers
- 96 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Acute Respiratory Distress Syndrome, Acute Lung Injury
Iloprost Effects on Gas Exchange and Pulmonary Mechanics
This study will examine the hypothesis that iloprost maintains and improves ventilation perfusion matching in patients with pulmonary hypertension and ARDS/ALI as reflected by 1) an improved PaO2/FIO2 ratio as calculated from the…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Pulmonary Hypertension
- Trial name
- NCT01274481
- Testing
- Iloprost
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
COPD
Study to Evaluate the Effects of Tiotropium Bromide on Chronic Obstructive Pulmonary Disease (COPD) During Exercise
The purpose of this study is to determine the effect of treatment with tiotropium bromide on efficiency of gas exchange and exercise performance in COPD subjects during exercise.
- Trial name
- NCT00412204
- Testing
- tiotropium bromide
- Volunteers
- 20 people
- Sponsor
- McMaster University
Obesity
Impact of Increased Tidal Volumes on Oxygenation and Cardiac Output
General anaesthesia impairs respiratory function in overweight patients. The investigators wanted to compare arterial concentration of sevoflurane and oxygen in overweight patients ventilated with increased tidal volume, or…
- Trial name
- NCT01343017
- Testing
- Ventilatory pattern
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Skane
Respiratory Support
Effects of Nasal High Flow Therapy on Ventilation and Gas Exchange in Healthy Newborns
Nasal High Flow (NHF) and CPAP are established forms of respiratory support in neonates and often produce similar clinical outcomes.
- Trial name
- NCT02632825
- Testing
- Nasal High Flow
- Where
- Armenia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Research Center of Maternal and Child Health Protection, Armenia
Apnea, Ventilation Therapy; Complications
THRIVE Apneic Ventilation With Standardized Airway Management During General Anesthesia.
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) denotes the use of high-flow humidified nasal oxygen system (for example Optiflow®) as an alternative ventilation modality for an anesthetized patient without…
- Conditions
- Apnea, Ventilation Therapy; Complications, Respiratory Acidosis
- Trial name
- NCT03797859
- Testing
- Apneic ventilation
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet