Clinical trials: Gastrectomy, open to volunteers
Morbid Obesity
Bougie Sleeve Trial
Staple-line leak is the most frequent and incapacitating complication after laparoscopic sleeve gastrectomy (LSG). The aim of this prospective randomized trial is to compare the staple-line leak rate after LSG according to the…
- Trial name
- BOUST (NCT02937649)
- Testing
- Laparoscopic sleeve gastrectomy using 48-Fr bougie, Laparoscopic sleeve gastrectomy using standard care bougie
- Where
- 12 sites in France
- Volunteers
- 1,658 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adenocarcinoma, Stomach Neoplasm
Radiotherapy + Chemoimmunotherapy Followed by Surgery in Patients With Limited Metastatic Gastric or GEJ Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of radiotherapy combined with chemotherapy and anti-PD-1 immunotherapy followed by surgery for the primary and metastatic lesions in patients with limited…
- Conditions
- Adenocarcinoma, Stomach Neoplasm, Gastroesophageal-junction Cancer, Oligometastatic Disease
- Trial name
- Miracle-G (NCT06121700)
- Testing
- Radiotherapy targeted to the primary lesion, Radiotherapy targeted to the metastatic lesions, Anti-PD-1 monoclonal antibody
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Fudan University
Pain, Acute Post-Operative, Nausea and Vomiting, Postoperative
Catheter Redosing of Autonomic Neural Blockade After Sleeve Gastrectomy
Postoperative visceral pain and autonomic symptoms after laparoscopic sleeve gastrectomy may reappear earlier in selected high-risk patients despite standard intraoperative autonomic neural blockade (ANB).
- Trial name
- NCT07655908
- Testing
- Bupivacaine 0.5% and Dexamethasone via Temporary Catheter
- Volunteers
- 30 people
- Sponsor
- Universidad Simón Bolívar
Morbid Obesity
Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass
The goal of this observational study is to learn whether routine stool tests can detect changes in gut function 6 months after two common types of weight loss surgery: sleeve gastrectomy and gastric bypass (including mini gastric…
- Trial name
- NCT07461610
- Testing
- Laparoscopic Sleeve Gastrectomy, Mini Gastric Bypass, Roux-en-Y Gastric Bypass
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Gastric Cancer, Adenocarcinoma of Esophagogastric Junction
A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique
This is a single-center, open-label, Phase Ib/II study aiming to assess the perioperative safety and postoperative outcomes of a novel surgical technique in treating primary adenocarcinoma located in the upper 1/3 of the stomach…
- Trial name
- NCT06300879
- Testing
- Performing totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huashan Hospital
Obesity, Obesity, Morbid
Management of Sleeve Gastrectomy Failure Using Single-anastomosis Metabolic Surgery
Sleeve gastrectomy (SG) has become the most commonly performed weight loss surgery, accounting for 60% of all bariatric operations worldwide.
- Trial name
- NCT05242835
- Testing
- Standard duodenal switch, Single-anastomosis duodenal switch
- Where
- Canada
- Volunteers
- 151 people
- Sponsor
- Laval University
Postoperative Pain
External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Radical Gastrectomy
Postoperative pain is highly prevalent following laparoscopic radical gastrectomy. Although Transversus abdominis plane block combined with rectus sheath block(TAP+RSB） can effectively alleviate this pain, it still has many…
- Trial name
- NCT07496086
- Testing
- EOIB, TAP+RSB
- Where
- China
- Volunteers
- 100 people
- Sponsor
- General Hospital of Ningxia Medical University
Obesity, Bariatric Surgery
Modified Thoracoabdominal Nerve Plane Block In Laparoscopic Sleeve Gastrectomy
Ultrasound-guided Modified Thoracoabdominal Nerve Plane Block (M-TAPA) is performed into the costochondral aspect at the 9th-10th costal level by injecting local anesthetics deep into the chondrium.
- Conditions
- Obesity, Bariatric Surgery, Laparoscopic Sleeve Gastrectomy, Acute Post Operative Pain
- Trial name
- NCT06515691
- Testing
- M-TAPA block, Postoperative pain management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital
Gastric Carcinoma
Exploration of Lymph Node Metastasis and Tumor Deposit in the Posterior Gastric Mesentery for Distal Gastric Cancer
This study aims to evaluate lymph node metastasis and tumor deposit in the posterior gastric mesentery following distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision (CME) in gastric cancer.
- Trial name
- zydgc001 (NCT06736847)
- Testing
- distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision (CME) in gastric cancer
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jichao Qin
Gastroesophageal Junction (GEJ) Cancer, Gastric Cancer
The Effect of Different Digestive Tract Reconstruction Methods on Postoperative Quality of Life After Proximal Gastrectomy
Gastric cancer ranks as the fifth most common malignancy worldwide and the fourth leading cause of cancer-related deaths. In China, its incidence and mortality rank third among all cancers.
- Trial name
- STARS-GC10 (NCT06929949)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Hospital of Jilin University
Stomach Neoplasm
Laparoscopic vs. Open Distal Gastrectomy After Neoadjuvant Chemotherapy
The study was designed as single-country, multi-center, open-labelled, randomized (1:1), phase II trial. 238 patients with medically and technically operable advanced gastric adenocarcinoma in middle or distal 1/3 of stomach are…
- Trial name
- NCT04658589
- Testing
- Laparoscopic versus open distal gastrectomy
- Volunteers
- 238 people
- Sponsor
- Chonnam National University Hospital
Obesity (Disorder), Metabolic Disorders
Hormonal and Microbiota Modulation After Endoscopic Sleeve Gastroplasty
Obesity is a chronic disease with a rapidly increasing prevalence, expected to affect up to 25% of the French population by 2030, and is associated with significant morbidity, mortality, and healthcare burden.
- Trial name
- HOVIGAMI-ESG (NCT07576777)
- Testing
- Laparoscopic sleeve gastrectomy, Endoscopic sleeve gastroplasty
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Morbid
Low Impact Laparoscopy In Bariatric Surgery
The goal of this clinical trial is to learn if low pressure pneumoperitoneum and small incisions (low impact laparoscopy, LIL) works to reduce pain and improve pulmonary function in patients underwent to bariatric surgery.
- Trial name
- LILYBET (NCT07119437)
- Testing
- low pneumoperitoneum laparoscopy with microsurgery, standard laparoscopy
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Gastric Cancer
Preventive Use of PIPAC in Locally Advanced Gastric Cancer.
Gastric cancer is the fifth most common cancer worldwide and the third leading cause of cancer-related mortality. In patients with locally advanced gastric cancer, multimodal treatment strategies, including perioperative…
- Trial name
- NCT06784765
- Testing
- Intervention Group, Control Group
- Where
- Kazakhstan
- Volunteers
- 160 people
- Sponsor
- National Research Oncology and Transplantology Center, Kazakhstan
Gastrectomy for Gastric Cancer, Gastric Cancer
AI-assisted Decision-making of Reoperation for Postoperative Bleeding of Gastric Cancer
The goal of this observational study is to develop and validate a deep learning model to dynamically assess postoperative bleeding risk and assist in decision-making for re-operation in adult patients (≥18 years) diagnosed with…
- Trial name
- NCT07525765
- Where
- China
- Volunteers
- 7,000 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Gastric Cancer (GC), Gastrectomy
Feasibility and Safety of Laparoscopic Purse-string Suture Clamp and Multi-functional Seal Cap for Totally Laparoscopic Radical Total Gastrectomy
Currently, there are three main methods for endoscopic esophagojejunostomy: circular, linear, and hand-sewn anastomosis, but no universally accepted optimal approach has been established.
- Conditions
- Gastric Cancer (GC), Gastrectomy, Anastomosis, Roux-en-Y, Laparoscopic
- Trial name
- NCT07117812
- Testing
- Laparoscopic purse-string forceps and multifunctional sealing ring
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Gastrectomy
The Pancreatic Enzymes After Gastrectomy Trial
This trial evaluates the effects (e.g. on quality of life, weight) of NORTASE® compared to standard care of patients who have undergone gastrectomy.
- Trial name
- NCT06058442
- Testing
- NORTASE®
- Where
- 12 sites in Germany
- Volunteers
- 188 people
- Sponsor
- University of Leipzig
Surgical Procedures, Operative
A Study Comparing ETHICON™ 4000 Stapler System With Standard of Care Stapling Devices in Adults Undergoing Gastric and Thoracic Procedures
The purpose of this study is to compare how well the ETHICON™ 4000 Stapler works as compared to the standard stapling devices by assessing how often air leaks and bleeding along the staple line occur during lung and stomach…
- Trial name
- NCT07744568
- Testing
- ETHICON™ 4000 Stapler System, Standard of Care Stapler and Reloads
- Volunteers
- 300 people
- Sponsor
- Ethicon Endo-Surgery
Gastric Adenocarcinoma, Stomach Neoplasms
Conversion Therapy Plus Surgery and Radiotherapy for Retroperitoneal Nodal Metastases in Gastric Cancer
This is a randomized, controlled, multicenter phase II clinical trial evaluating the efficacy and safety of conversion therapy combined with radical gastrectomy and adjuvant radiotherapy targeting para-aortic (station 16) lymph…
- Trial name
- NCT07007182
- Testing
- SOX regimen, CAPEOX regimen, PD-1 inhibitor
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Jinbo Yue
Gastroesophageal Reflux, Sleeve Gastrectomy
Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction
Researchers are trying to identify predictors for gastroesophageal reflux disease after sleeve gastrectomy.
- Conditions
- Gastroesophageal Reflux, Sleeve Gastrectomy, Bariatric Surgery Complication
- Trial name
- NCT04411823
- Testing
- EndoFLIP measurement
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic