Clinical trials: Gastric (Stomach) Cancer
Gastric Neoplasms, Gastrointestinal Stromal Tumors
Endoscopic Full Thickness Resection of Gastric Subepithelial Tumors (FROST)
Prospective observational trial. A full thickness resection of gastric subepithelial tumors is performed after application of full thickness sutures underneath the tumor with the GERDX(TM) device.
- Trial name
- NCT02488746
- Testing
- GERDX(TM)
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Early Gastric Cancer Patients Who Were Scheduled for Endoscopic Submucosal Dissection
A Comparison of Efficacy and Safety During Endoscopic Submucosal Dissection Between Dexmedetomidine-remifentanil and Propofol-remifentanil
Adequate, safe sedation is essential for Endoscopic submucosal dissection. Dexmedetomidine is a potent and selective a2-adrenoceptor agonist used for sedative and analgesic effects, but it is limited to use alone.
- Trial name
- NCT01920113
- Testing
- Dexmedetomidine - remifentanil group, Propofol - remifentanil group
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Gastric Cancer.
Phase I Study of Sorafinib With Folfox4 as First-line Treatment in Advanced/Metastatic Gastric Cancer
To determine the maximum-tolerated dose (MTD) and dose-limiting toxicity (DLT) of sorafenib in combination with FOLFOX4 (oxaliplatin/leucovorin/5-fluorouracil) as first-line treatment for advanced gastric cancer The design of the…
- Trial name
- NCT02209441
- Testing
- Phase I Dose-finding Study of Sorafenib Study
- Sponsor
- Chinese Academy of Medical Sciences
Stomach Neoplasms, Validation Study
Spanish Validation of KOQUSS-40 Questionnaire: Assessing QoL of Gastric Cancer Patients After Gastrectomy: SPQUSS-41
The main objective of this study is the translation, linguistic adaptation into Spanish, and validation of the Korean quality of life questionnaire KOQUSS-40.
- Trial name
- SPQUSS-41 (NCT07504913)
- Testing
- Development Questionnaire and Validation Questionnaire
- Where
- 6 sites in Spain
- Volunteers
- 505 people
- Sponsor
- Parc de Salut Mar
Esophageal Adenocarcinoma, Gastric Cancer
Determining Minimal Residual Disease Using ctDNA Deep Sequencing
Preoperative neoadjuvant chemotherapy is the standard treatment for locally advanced gastrointestinal tumours. However, not all patients respond to preoperative treatment.
- Conditions
- Esophageal Adenocarcinoma, Gastric Cancer, Pancreatic Cancer
- Trial name
- CIT-SEQ (NCT07660627)
- Testing
- NGS sequencing of mutations selected based on sequencing of primary tumors
- Where
- Czechia
- Volunteers
- 34 people
- Sponsor
- Masaryk Memorial Cancer Institute
Adenocarcinoma of the Stomach, Gastroesophageal Junction Expressing Guanylyl Cyclase C
A Study of MLN0264 in Participants With Cancer of the Stomach or Gastroesophageal Junction
The purpose of this study is to assess the efficacy, safety and tolerability of MLN0264 in patients with recurrent or metastatic guanylyl cyclase C (GCC)-positive adenocarcinoma of the stomach or gastroesophageal junction.
- Trial name
- NCT02202759
- Testing
- MLN0264
- Where
- 17 sites in United States, Belgium and 2 more
- Volunteers
- 38 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Dysphagia, Esophageal, Esophageal Cancer
Validation of Instruments Used for Assessment of Dysphagia in Patients With Esophageal Cancer
This study validates 3 well known dysphagia scores for dysphagia due to malignancies of the oesophagus and gastro-oesophageal junction and to the Swedish language.
- Trial name
- NCT03066167
- Testing
- Validation of different dysphagia scores
- Where
- Sweden
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Stomach Neoplasms, Advanced Gastric Cancer
Study Of Axitinib In Combination With Cisplatin And Capecitabine In Patients With Advanced Gastric Cancer
The purpose of this study is to determine the safe and tolerable dose of axitinib given together with cisplatin and capecitabine in patients with advanced gastric cancer who have not received prior chemotherapy for their advanced…
- Trial name
- NCT00842244
- Testing
- axitinib, capecitabine, cisplatin
- Where
- 5 sites in Japan, South Korea
- Volunteers
- 22 people
- Sponsor
- Pfizer
Gastric Cancer, Chemotherapy Effect
Sintilimab Combined With Modified FLOT Regimen in the Treatment of Metastatic Gastric Cancer
This is a prospective, one-arm, single-center phase II study. The objective was to evaluate the efficacy and safety of domestic PD-1 antibody Sintilimab combined with modified FLOT regimen in the treatment of metastatic gastric…
- Conditions
- Gastric Cancer, Chemotherapy Effect, Immune Checkpoint Inhibitor
- Trial name
- NCT05982301
- Testing
- Sintilimab, paclitaxel-albumin, oxaliplatin, 5-FU
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Fudan University
Hypoxia, Gastric Cancer
Nasal Mask Kit in Gastrointestinal Endoscopy
Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol. The nasal mask oxygen kit has good sealing to ensure an adequate oxygen supply and is convenient and economical.The aim of this…
- Conditions
- Hypoxia, Gastric Cancer, Gastric Polyp, Colon Polyp
- Trial name
- NASO (NCT05405530)
- Testing
- nasal mask oxygen kit, regular nasal cannula
- Where
- 3 sites in China
- Volunteers
- 1,204 people
- Sponsor
- RenJi Hospital
Gastric Cancer
Sequential Chemotherapy With Xelox Follows by TX to Treat Gastric Cancer
The purpose of this study is to determine whether sequential chemotherapy with capecitabine plus oxaliplatin (Xelox) followed by docetaxel plus capecitabine (TX)in unresectable gastric cancer.
- Trial name
- NCT01331928
- Testing
- Capecitabine (Xeloda, Roche), Oxaliplatin (Sanofi-Aventis), Docetaxel (Sanofi-Aventis)
- Where
- Taiwan
- Volunteers
- 51 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastric Cancer, Gastric Precancerous Lesions
Diagnosis of Gastric Precancerous Lesions by a Blood Test GastroPanel in Patients With Increased Gastric Cancer Risk
Despite the declining incidence, gastric cancer (GC) remains the second leading cause of cancer death worldwide. In France, it is the second digestive cancer with 7,000 new cases per year.
- Trial name
- GASTRO-PRA (NCT02624271)
- Testing
- blood samples analysis
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Nantes University Hospital
Gastric Neoplasms, Gastroesophageal Junction Adenocarcinoma
Camrelizumab Plus Pyrotinib Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
This study is designed to evaluate the efficacy and safety of Camrelizumab plus pyrotinib in combination with chemotherapy in patients with HER2-positive gastric cancer.
- Trial name
- NCT05111444
- Testing
- Camrelizumab, Pyrotinib, Capecitabine
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Fudan University
Gastric Dysplasia, Gastric Cancer in Situ
Endoscopic Closure of Gastric ESD Defect
This is a pilot study to investigate the usefulness of closure of mucosal defect after gastric endoscopic submucosal dissection (ESD) in patients that are at high risk of post-procedural haemorrhage.
- Trial name
- NCT04282707
- Testing
- Endoscopic closure of ESD defect, Gastric ESD without closure of ESD defect
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Gastro Intestinal Stromal Tumor
Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib
The objective is to compare efficacy and safety of masitinib at 12 mg/kg/day to sunitinib at 50 mg/day in treatment of patients with gastro-intestinal stromal tumor resistant to imatinib.
- Trial name
- NCT01506336
- Testing
- masitinib, sunitinib
- Where
- France
- Volunteers
- 44 people
- Sponsor
- AB Science
Gastric Cancer
Proteiomic Fingerprints of Gastric Juice
No accurate, inexpensive and non-invasive test for gastric cancer screening is currently available. The investigators' recent study identified a1-antitrypsin and other proteins as potential biomarkers of gastric cancer in gastric…
- Trial name
- NCT00834236
- Testing
- normal subject, gastric cancer
- Where
- 2 sites in Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
Gastric Cancer, Colon Cancer
Resilience and Equity in Aging, Cancer, and Health (REACH)
The purpose of this multi-phase research study is to understand how consultation of cancer care with a geriatrician can best improve outcomes for older adults with gastrointestinal malignancies.
- Conditions
- Gastric Cancer, Colon Cancer, Esophageal Cancer, Rectal Cancer
- Trial name
- REACH (NCT04674267)
- Testing
- Phase 2 Intervention - Geriatric Co-Management
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Dana-Farber Cancer Institute
Gastric (Stomach) Cancer
Fecal DNA Methylation and Helicobacter Pylori SNPs Tests for Gastric Cancer
Based on the detection technology of methylation sites in feces, combined or not combined with Helicobacter pylori gastric cancer susceptibility gene detection, an early diagnosis and detection system for gastric cancer is…
- Trial name
- NCT07312500
- Testing
- Diagnostic Test: fecal methylation site-based testing and fecal Helicobacter pylori gastric cancer susceptibility gene-based testing
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fudan University
Gastric Cancer After D2 Lymph Node Dissection
Application of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node Dissection
Gastric cancer radical surgery related complications are common.Somatostatin is a conventional medical therapy for bleeding.This study explore the effect of Somatostatin for Advanced Gastric Cancer After D2 Lymph Node dissection.
- Trial name
- NCT01914692
- Testing
- Somatostatin
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Gastric Cancer
SOX Combined With Tislelizumab and LDRT for Neoadjuvant Treatment of Locally Advanced Gastric Cancer
Neoadjuvant chemotherapy or chemoradiotherapy has become the standard neoadjuvant regimen for locally advanced G/GEJ cancer and has been recommended by a series of treatment guidelines.
- Trial name
- NCT06266871
- Testing
- SOX+Tislelizumab+LDRT
- Volunteers
- 64 people
- Sponsor
- West China Hospital
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