Clinical trials: Gastric (Stomach) Cancer
Gastric Cancer, Gastric (Stomach) Cancer
Gastric Cancer Endoscopic Screening in an Intermediate-risk Country - ROGCAS, a Dual-centre Pilot Program
Endoscopic screening of gastric cancer combined with screening colonoscopy
- Conditions
- Gastric Cancer, Gastric (Stomach) Cancer, Atrophic Gastritis, Intestinal Metaplasia of Gastric Mucosa
- Trial name
- ROGCAS (NCT06316882)
- Testing
- Screening endoscopy
- Where
- Portugal
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Unidade Local De Saúde Do Norte Alentejano
Locally Advanced Gastric Cancer, Gastric Adenocarcinoma
The Safety and Efficacy of Robotic Assisted Surgery Using Vessel Sealer Extend in Locally Advanced Gastric Cancer
Gastric cancer is the fifth most common malignancy and the fourth leading cause of cancer-related deaths. Surgical resection is the primary treatment, with laparoscopic-assisted gastrectomy (LG) being a minimally invasive option.
- Trial name
- STARS-GC09 (NCT06881043)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Hospital of Jilin University
Gastric Cancer, Siewert Type III Adenocarcinoma of Esophagogastric Junction
Postoperative Morbidity and Mortality After Gastric Cancer Surgery
Gastric cancer is still one of the main health care issue and gastrectomy with lymph node dissection is the only chance to be cure.
- Conditions
- Gastric Cancer, Siewert Type III Adenocarcinoma of Esophagogastric Junction, Stomach Cancer
- Trial name
- GASTROSTAT (NCT06277908)
- Testing
- Elective Surgery for gastric cancer
- Where
- 9 sites in Russia
- Volunteers
- 700 people
- Sponsor
- P. Herzen Moscow Oncology Research Institute
HER2-positive Advanced Gastric Cancer
Trastuzumab, Bevacizumab with Paclitaxel for HER2-positive Gastric Cancer in a Second-line Therapy
This is a multicenter, open-label, prospective, phase 2 study of trastuzumab, bevacizumab, and paclitaxel as second-line treatment for patients with HER2-positive advanced gastric cancer who had progressed on first-line…
- Trial name
- TREAZURE (NCT05640830)
- Testing
- trastuzumab, bevacizumab with paclitaxel (triple combination)
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Kangbuk Samsung Hospital
Gastric Cancer, Precancerous Lesion
The Research of Constructing a Risk Assessment Model for Gastric Cancer Based on Machine Learning
Based on the gastric cancer database established earlier, this project explored the PG standard suitable for Chinese people, and further explored the establishment of machine learning model to stratify gastric cancer risk in the…
- Conditions
- Gastric Cancer, Precancerous Lesion, Mechine Learning
- Trial name
- NCT04957407
- Testing
- pepsinogen
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Gastric Cancer
A Study of Trastuzumab Emtansine Versus Taxane in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Gastric Cancer
This multicenter, randomized, adaptive Phase II/III study will evaluate the efficacy and safety of trastuzumab emtansine (T-DM1) compared to standard taxane (docetaxel or paclitaxel) treatment in participants with human epidermal…
- Trial name
- NCT01641939
- Testing
- Taxane, trastuzumab emtansine
- Where
- 148 sites in United States, Argentina and 26 more
- Volunteers
- 415 people
- Sponsor
- Hoffmann-La Roche
Gastric Cancer
Dynamic Circulating Tumor DNA Monitoring to Guide Systemic Therapy in Gastric Cancer
This study aims to evaluate the clinical value of circulating tumor DNA (ctDNA) as a minimally invasive biomarker for monitoring treatment response and guiding systemic therapy in patients with gastric or gastroesophageal…
- Trial name
- NCT07517107
- Testing
- Circulating Tumor DNA (ctDNA) Analysis, Standard Systemic Therapy for Gastric Cancer
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Fudan University
Gastro Intestinal Stromal Tumor
Patterns of Care and Outcomes of Patients With METAstatic Gastrointestinal Stromal Tumors (METAGIST)
Gastro intestinal stromal tumors (GIST) are rare mesenchymal tumors of the gastrointestinal tract characterized by somatic mutations in the gene encoding the KIT or the PDGFR alpha protein1.
- Trial name
- METAGIST (NCT03963544)
- Testing
- oral tyrosine-kinase inhibitors (TKI) of KIT and PDGFR as per recommendations
- Where
- France
- Volunteers
- 492 people
- Sponsor
- Institut Bergonié
Gastrointestinal Cancer
Perioperative Palliative Care Surrounding Cancer Surgery for Patients & Their Family Members
The study goal is to compare surgeon-palliative care team co-management, versus surgeon alone management, of patients and family members preparing for major upper gastrointestinal cancer surgery.
- Trial name
- PERIOP-PC (NCT03611309)
- Testing
- Surgeon-palliative care team co management, Surgeon team alone management
- Where
- 5 sites in United States
- Volunteers
- 379 people
- Sponsor
- Stanford University
Hepatocellular Carcinoma (HCC), Gastro-Entero-Pancreatic Tumors (GEPs)
Evaluating the roLe of Multiplexed PET Imaging in the Detection and Staging of hepatocellulaR Carcinoma and gAstro-entero-pancreatic Tumors
Precision medicine is a major goal in oncology. It aims to tailor treatments to the specific characteristics of each patient's tumor.
- Trial name
- ELMIRA (NCT07178587)
- Testing
- Single tracer PET/CT, Multiplexed PET-CT
- Where
- 3 sites in France
- Volunteers
- 28 people
- Sponsor
- Nantes University Hospital
Gastric Cancer
A Pilot Study of Neoadjuvant Chemotherapy With or Without Camrelizumab for Locally Advanced Gastric Cancer
It is a single-center, open-lable, randomized controlled trial to prospectively investigate the effectiveness and safety of Camrelizumab combined with DOS regimen chemotherapy in neoadjuvant treatment of patients with locally…
- Trial name
- NCT05101616
- Testing
- camrelizumab+chemotherapy, Chemotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Minimally Invasive Surgery Center
Post-Operative Pain
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Post-operative Pain Following Gastrectomy
VVZ-149 is a novel analgesic drug candidate that shows a potential analgesic activity inhibiting GlyT2 and 5HT2A simultaneously.
- Trial name
- NCT02522598
- Testing
- VVZ-149 injections
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Vivozon, Inc.
Gastric Cancer, Gastric Adenocarcinoma
Peritoneal Lavage Liquid Biopsy in Patients With Gastric Cancer
This study investigates the prognostic role of liquid biopsy in patients with locally advanced gastric cancer. Liquid biopsy for the detection of circulating tumor DNA will be performed: In the peritoneal lavage, during staging…
- Trial name
- LIQUID (NCT04943406)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Hereditary Diffuse Gastric Cancer
Liquid Biopsies for the Personalized Management of Patients with Hereditary Diffuse Gastric Cancer
Activating somatic mutations and methylation profiles identified by liquid biopsies could identify CDH1 and CTNNA1 pathogenic variants carriers with invasive diffuse gastric cancer undetectable by upper G-I endoscopy.
- Trial name
- LISA-HDGC (NCT04253106)
- Testing
- Liquid biopsies (blood, gastric fluid).
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastric Cancer
Robotic and Laparoscopic Total Gastrectomy With D2 Lymphadenectomy for Locally Advanced Gastric Cancer
This study is a prospective, single-center, non-randomized, controlled, non-blind, and non-inferiority observation trial comparing robotic-assisted total gastrectomy with D2 lymph nodal dissection for locally advanced gastric…
- Trial name
- NCT03500471
- Testing
- Robotic-assisted Total Gastrectomy, Laparoscopic-assisted Total Gastrectomy
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Southwest Hospital, China
Early Gastric Cancer, Colon Neoplasia
Magnetic Guided Counetrtraction During Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) is a technique that allows curative treatment of early gastrointestinal neoplasia with organ preservation. However, it is a technically demanding procedure.
- Trial name
- NCT06962293
- Testing
- MAG-ESD assisted ESD
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Esophageal Cancer, Gastric Cancer
Cetuximab, Cisplatin, and Irinotecan in Treating Patients With Metastatic Esophageal Cancer, Gastroesophageal Junction Cancer, or Gastric Cancer That Did Not Respond to Previous Irinotecan and Cisplatin
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00397904
- Testing
- cetuximab, cisplatin, irinotecan hydrochloride
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stomach Neoplasm
Vactosertib and Durvalumab in Gastric Cancer
This trial will test the efficacy and safety of durvalumab in combination with vactosertib in patients with metastatic gastric cancers who failed ≥ 2 lines of chemotherapy
- Trial name
- NCT04893252
- Testing
- durvalumab and vactosertib
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Hark Kyun Kim
Metastatic Gastric Adenocarcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma
Docetaxel, Oxaliplatin and 5-FU for Gastric Cancer With Inoperable Malignant Bowel Obstruction
This is a multi-center, non-randomized, 3-cohort, phase II trial, evaluating a triplet combination of docetaxel, oxaliplatin and fluorouracil for gastric cancer with peritoneal carcinomatosis and inoperable malignant bowel…
- Conditions
- Metastatic Gastric Adenocarcinoma, Metastatic Gastroesophageal Junction Adenocarcinoma, Peritoneal Carcinomatosis
- Trial name
- NCT04840264
- Testing
- Docetaxel, Oxaliplatin, Fluorouracil
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Gastric Cancer Stage II, Gastric Cancer Stage III
A Multicenter, RCT Study of the Clinical Efficacy of Robotic and Laparoscopic Gastrectomy in Neoadjuvant Gastric Cancer
To evaluate the clinical efficacy of robot radical Gastrectomy and laparoscopic radical Gastrectomy, patients with gastric adenocarcinoma (cT2N+M0 or cT3-4a/N+M0, phase II and III) undergoing neoadjuvant treatment were selected…
- Trial name
- CLASS14 (NCT06042998)
- Testing
- Robotic radical gastrectomy
- Where
- China
- Volunteers
- 588 people
- Sponsor
- The Affiliated Hospital of Qingdao University
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