Clinical trials: Gastric Acid
GERD, Gastroesophageal Reflux
Compassionate Use of Domperidone for Refractory Gastroparesis
The purpose of this program is to allow the use of domperidone in children from 12 to 21 years of age with symptoms related to motility disorders and Gastroesophageal reflux disease (GERD) who have failed all the standard…
- Conditions
- GERD, Gastroesophageal Reflux, Gastroparesis
- Trial name
- NCT04699591
- Testing
- Domperidone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jose Cocjin
Gastro Esophageal Reflux Disease, Dyspepsia
Spirulina Platensis for PPI Withdrawal
Background: Rebound acid hypersecretion after proton pump inhibitors (PPIs) discontinuation may be accompanied by dyspepsia. Aim: To assess whether Spirulina platensis, by its anti-inflammatory properties, could minimize rebound…
- Conditions
- Gastro Esophageal Reflux Disease, Dyspepsia, Rebound Acid Hypersecretion
- Trial name
- SpAReDPPI (NCT04988347)
- Testing
- Spirulina platensis
- Volunteers
- 45 people
- Sponsor
- Universidade de Passo Fundo
Stomach Neoplasms
Enhanced Magnifying Endoscopy for Diagnosis of Early Gastric Cancer
When performing screening endoscopy, small focal gastric lesions are frequently encountered. Novel techniques in endoscopy, such as magnifying endoscopy (ME) with narrow-band imaging (NBI) and chromoendoscopy with acetic…
- Trial name
- NCT01617876
- Where
- China
- Volunteers
- 282 people
- Sponsor
- Peking Union Medical College Hospital
Gastroesophageal Reflux, Obesity
Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux
Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is considered the weight loss procedure of choice for patients suffering of gastro-esophageal reflux (GER).
- Trial name
- NCT02618044
- Volunteers
- 86 people
- Sponsor
- University of Turin, Italy
Gastric or Duodenal Ulcers Caused by Low-dose Aspirin
Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study)
The primary objective of this study to evaluate the effect of preventing recurrence of gastric or duodenal ulcers by administering E3810 5 mg or 10 mg tablets once daily or Teprenone 150 mg/day (50 mg three times daily) as a…
- Trial name
- NCT01397448
- Testing
- E3810, Teprenone
- Where
- 49 sites in Japan
- Volunteers
- 472 people
- Sponsor
- Eisai Co., Ltd.
Gastro-oesophageal Reflux
Influence of Airway Clearance Techniques on GOR in Infants
The purpose of this study is to determine whether Assisted Autogenic Drainage (AAD) or bouncing combined with Assisted Autogenic Drainage (BAAD), induces or aggravates acid and non-acid gastro-oesophageal reflux in infants under…
- Trial name
- NCT03346174
- Testing
- AAD, BAAD
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- Vrije Universiteit Brussel
Stomach Neoplasms
Oxaliplatin in Gastric Cancer
To determine the objective response to oxaliplatin/5FU/leucovorin combination chemotherapy in patients with advanced unresectable or metastatic gastric cancer.
- Trial name
- NCT00263354
- Testing
- Oxaliplatin
- Volunteers
- 20 people
- Sponsor
- Sanofi
Esophagitis, Reflux Esophagitis
The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.
- Conditions
- Esophagitis, Reflux Esophagitis, Gastroesophageal Reflux Disease
- Trial name
- NCT01733810
- Testing
- Cessation of Acid Suppressing Medications
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dallas VA Medical Center
Advanced Solid Tumours
Pantoprazole With Doxorubicin for Advanced Cancer Patients With Extension Cohort of Patients With Solid Tumours
This is a single-centre, open label, dose finding, phase I study to determine the recommended phase II dose (RP2D) for the combination of doxorubicin and pantoprazole in patients with advanced tumours and no standard treatment…
- Trial name
- NCT01163903
- Testing
- pantoprazole sodium for injection, doxorubicin hydrochloride injection
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Severe Obesity
Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass
The purpose of this study is to examine the effects of bile acids on GLP-1 secretion after Roux-en-Y gastric bypass.
- Trial name
- NCT02340247
- Testing
- Water, Ursodeoxycholic Acid, Chenodeoxycholic Acid
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- Hvidovre University Hospital
Bile Reflux, Gastric Cancer
Associations Among Serum and Gastric Juice Bile Acid Profile, Bile Acid-microbiota Cross-talk in Stomach and the Development of Gastric Cancer
To explore the associations among bile acid profile, bile acid-microbiota cross-talk and the development of gastric cancer, so as to better prevent the occurrence and development of gastric cancer
- Conditions
- Bile Reflux, Gastric Cancer, Precancerous Lesion
- Trial name
- NCT04660058
- Where
- China
- Volunteers
- 73 people
- Sponsor
- Xijing Hospital of Digestive Diseases
SARS-CoV-2
EPA-FFA to Treat Hospitalised Patients With COVID-19 (SARS-CoV-2)
This is an double-blind, randomized, placebo controlled phase III study in hospitalized subjects with confirmed SARS-CoV-2.
- Trial name
- NCT04335032
- Testing
- Eicosapentaenoic acid gastro-resistant capsules
- Where
- 5 sites in Spain, United Kingdom
- Volunteers
- 284 people
- Sponsor
- S.L.A. Pharma AG
Gastrointestinal Cancer, Colorectal Cancer
Fish Oil Supplementation in Gastrointestinal Cancer
Double-blind, randomized clinical trial to assess the effects of 1,55 g/day of n-3 fatty acids from fish oil concomitant chemotherapy in gastrointestinal cancer.
- Conditions
- Gastrointestinal Cancer, Colorectal Cancer, Stomach Cancer
- Trial name
- NCT02699047
- Testing
- Encapsuled fish oil, Encapsulated Olive oil
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Universidade Federal de Santa Catarina
Gastric Acid, Human Experimentation
A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (CL2007-17 )(P07813)(COMPLETED)
Open-label randomized crossover design studies. 60 participants will be evaluated on Day 1 to compare effects on stomach acid; 30 participants will continue treatment for 7 days and will have repeat evaluations at Day 7.
- Trial name
- NCT00674115
- Testing
- Omeprazole/sodium bicarbonate, omeprazole magnesium, sodium bicarbonate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bayer
Chronic Use of Acid Suppressive Medication, GORD
On-Demand Use of Pantoprazole: Determinants for Chronic Use of Acid Suppressive Medication
The purpose of this study is to investigate several aspects of chronic use of acid suppressing medication: dependence on maintenance therapy, the possibilities for on-demand use, and predictors (patient characteristics) for daily…
- Conditions
- Chronic Use of Acid Suppressive Medication, GORD, GERD, Reflux
- Trial name
- NCT00161096
- Testing
- pantoprazole 20 mg (drug)
- Volunteers
- 276 people
- Sponsor
- UMC Utrecht
Heartburn, Acid-dependent Diseases of the Gastrointestinal Tract
Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg/10 ml Oral Suspension and Riopan 800 mg Chewable Tablets in Healthy Volunteers
Comparative study of the pharmacodynamic parameters and pharmacodynamic equivalence (bioequivalence) of drug Antareit 800 mg/10 ml oral suspension and drug Riopan 800 mg chewable tablets in healthy volunteers.
- Conditions
- Heartburn, Acid-dependent Diseases of the Gastrointestinal Tract, Symptomatic Treatment of Gastric and Duodenal Ulcers
- Trial name
- NCT06098742
- Testing
- Antareit
- Where
- 2 sites in Russia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Bariatric Surgery Candidate
Pilot Study for Zoledronic Acid to Prevent Bone Loss After Bariatric Surgery
This study evaluates whether zoledronic acid can prevent the high bone turnover that occurs after Roux-en-Y Gastric Bypass (RYGB) and sleeve gastrectomy (SG) surgery.
- Trial name
- NCT03424239
- Testing
- Zoledronic Acid, Calcium citrate + vitamin D, Vitamin D3
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Achlorhydria
Study to Evaluate Effects of Food or Proton Pump Inhibitor on the Pharmacokinetics of Itraconazole in Healthy Volunteers
The aim of this study is to evaluate the effects of food or proton pump inhibitor on the pharmacokinetics of itraconazole in healthy volunteers.
- Trial name
- NCT04942652
- Testing
- Itraconazole 200 mg, Esomeprazole 40 mg
- Where
- South Korea
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy Participants
Comparing the Extent to Which Three Different Formulations of LY4100511 (DC-853) Are Made Available in the Body, Alone and in the Presence of a Drug That Reduces Stomach Acid
The main purpose of this study is to compare the bioavailability of 3 different formulations of LY4100511 and if the use of a proton pump inhibitor (PPI) alters the bioavailability of the 3 different formulations.
- Trial name
- NCT06916143
- Testing
- LY4100511, Rabeprazole
- Where
- 2 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
Bioavailability Study of Long Chain Omega-3 Fatty Acids From a Gastric Stable Emulsion
The purpose of this study is to compare the short term absorption of EPA and DHA from triglycerides (TG) released from normal soft gel capsules and from the new patent pending vehicle providing a gastric stable emulsion.
- Trial name
- NCT01061554
- Testing
- Omega-3 oils from tri-glycerides, Omega-3 oils from marine phospholipids
- Where
- Norway
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Ayanda AS