Clinical trials: Gastric Bypass
Gastric Outlet Obstruction
Randomized Trial of EUS-guided Gastrojejunostomy and Surgical Gastrojejunostomy in Gastric Outlet Obstruction
Malignant gastric outlet obstruction (GOO) results from the mechanical obstruction of the duodenum or distal stomach from an underlying cancer.
- Trial name
- NCT05548114
- Testing
- EUS-guided gastrojejunostomy, Surgical gastrojejunostomy
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Orlando Health, Inc.
Overweight
Trial of Leptin Administration After Roux-en-Y Gastric Bypass
This is a pilot and feasibility study to examine a novel intervention using leptin in weight-reduced individuals who have undergone bariatric surgery but still remain obese.
- Trial name
- NCT00710814
- Testing
- Leptin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Columbia University
Morbid Obesity
Omega-3 Fatty Acids in Bariatric Gastric Bypass Surgery: Effect on Liver Volume, Immune Response and Erythrocyte Function
Gastric bypass surgery is the gold standard in bariatric surgery and is a successful method to reduce weight in morbidly obese subjects.
- Trial name
- OLIVIER (NCT02206256)
- Testing
- Omega-3 fatty acid capsules, Low calorie diet
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Medical Center Alkmaar
Diabetes, Gestational, Gastric Bypass Status for Obesity Complicating Pregnancy, Childbirth, or the Puerperium
Gestational Diabetes After Gastric Bypass Surgery
The goal of this trial is to compare different means of glucose monitoring in women with gestational diabetes and a history of gastric bypass surgery.
- Conditions
- Diabetes, Gestational, Gastric Bypass Status for Obesity Complicating Pregnancy, Childbirth, or the Puerperium, Pregnancy in Diabetic, Blood Glucose Self Monitoring
- Trial name
- NCT06291766
- Testing
- FreeStyle Libre 2, continous glucose monitoring
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Skane
Weight Regain, Weight Loss
Randomized Study on Transoral Outlet Reduction and Lifestyle Changes for Weight Regain After Gastric Bypass
The goal of this clinical trial is to evaluate weight loss with TORe and moderate to intensive lifestyle modification versus moderate to intensive lifestyle modification alone in subjects who have regained weight following a…
- Trial name
- REIGNITE (NCT07015424)
- Testing
- TORe with OverStitch, Intensive lifestyle modification
- Where
- 12 sites in United States
- Volunteers
- 108 people
- Sponsor
- Boston Scientific Corporation
Obesity (BMI>30), Obesity (BMI > 35)
FABP4 Response After Roux-en-Y Gastric Bypass
This retrospective observational cohort study examined serum fatty acid-binding protein 4 (FABP4) dynamics in 28 adults who underwent Roux-en-Y gastric bypass (RYGB), followed at baseline, 3 months, and 6 months.
- Conditions
- Obesity (BMI>30), Obesity (BMI > 35), Insulin Resistance, Bariatric Surgery
- Trial name
- FABP4-RYGB (NCT07774208)
- Volunteers
- 28 people
- Sponsor
- Istanbul University
Obesity, Morbid, Weight Gain
DIStal gastriC Bypass OUtcome in Revision SurgEry After Roux-en-y Gastric Bypass
This study is designed as a prospective multicenter randomized controlled clinical trial comparing two surgical techniques of distal gastric bypass (DGB) in revisional surgery following failed Roux-en-Y gastric bypass.
- Trial name
- DISCOURSE (NCT04894838)
- Testing
- Distal gastric bypass
- Where
- 8 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Post-bariatric Hypoglycemia
An Expanded Access Protocol to Provide Avexitide in Patients With Post-Bariatric Hypoglycemia
The Expanded Access Program will provide access to avexitide for people with post-bariatric hypoglycemia (PBH) following Roux-en-Y gastric bypass (RYGB) who meet the eligibility criteria for this program.
- Trial name
- NCT07582874
- Testing
- Avexitide
- Where
- 4 sites in United States
- Sponsor
- Amylyx Pharmaceuticals Inc.
Type 2 Diabetes Mellitus, Obesity
Surgery or Lifestyle With Intensive Medical Management in the Treatment of Type 2 Diabetes
There is substantial clinical evidence regarding the safety and efficacy of currently practiced bariatric surgical techniques to improve metabolic control and/or resolve type 2 diabetes (T2DM) in clinically severe obese patients…
- Trial name
- SLIMM-T2D (NCT01073020)
- Testing
- Allergan Adjustable Gastric Band Surgery, Intensive Medical Diabetes & Weight Management (Why WAIT) - Band Group, Roux-en-Y Gastric Bypass (RYGB) Surgery
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Joslin Diabetes Center
Morbid Obesity
Effect of Bariatric Surgery on Bile Acid Homeostasis
The purpose of this study is to evaluate the effect of bariatric surgery in bile acid homeostasis and its interrelationship with the metabolic changes induced by the surgery.
- Trial name
- NCT02366624
- Where
- Chile
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Obesity and Obesity-related Medical Conditions, Weight Regain
The Application of Gastric Bypass Stents in Patients with Weight Regain After Laparoscopic Sleeve Gastrectomy：a Feasibility Study
This study is based on the National Center for Integrated Traditional Chinese and Western Medicine, utilizing the centralized advantages of our department and integrating multiple disciplines (general surgery, endocrinology…
- Trial name
- DJBL for LSG (NCT06801496)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Obesity
Bariatric Surgery Versus Diet Alone in the Bile Acid Pathway and Weight Loss
It is unknown whether the bile acid pathway reacts differently to weight loss resulting from Roux-En-Y Gastric Bypass (RYGB) surgery than weight loss resulting from caloric restriction alone.
- Trial name
- NCT03238794
- Testing
- Roux-En-Y Gastric Bypass, Low-calorie Diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Non Insulin Dependent Diabetes Mellitus
Prospective Observatonal Study for Effect of Duodenojejunal Bypass and Gastric Bypass on T2DM Patients
Surgical treatment for type 2 diabetes has been taken note especially in less obese or non obese patients. In Asian, the nuber of less obses or non obese patients with T2DM is greater than that of the obese.
- Trial name
- T2DM (NCT01735253)
- Testing
- laparoscopic roux en Y gastric bypass / open duodenojejunal bypass
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Inha University Hospital
Type 2 Diabetes, Cardiovascular Disease
DSS: Diabetes Surgery Study - Intensive Medical Management of Type 2 Diabetes, With and Without Gastric Bypass Surgery
The present study is the first stage of a research program whose ultimate goal is to conduct a randomized clinical trial involving type 2 diabetics with BMI from 30.0 to 39.9 kg/m2.
- Trial name
- DSS (NCT00641251)
- Testing
- intensive medical management, RYGB & IMM
- Where
- 5 sites in United States, Taiwan
- Volunteers
- 120 people
- Sponsor
- Medtronic - MITG
Anemia, Iron Deficiency
Iron Supplement to Improve Iron Status Following Bariatric Surgery
There is a high prevalence of iron deficiency in patients who undergo bariatric surgery and effective therapies are lacking. Thus, there is a critical need for an effective, non-invasive, and inexpensive form of iron…
- Trial name
- NCT02404012
- Testing
- Oral iron supplementation
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Indiana University
Overweight
Carbohydrates and Gut Hormones After Gastric Bypass Surgery
To investigate the secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1), after ingestion of glucose and fructose as separate monosaccharides or combined in the disaccharides sucrose and isomaltulose and the…
- Trial name
- NCT02879955
- Testing
- Glucose + Fructose, Sucrose, Isomaltulose
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Surgery, Bariatric Surgery Candidate
Magnetic System in Bariatric and General Surgery
Magnetic devices have been successfully used in bariatric surgery. To the date the only reported use of the magnet was for liver retraction.
- Trial name
- NCT04944810
- Testing
- Magnetic Gastric Bypass, Magnetic Sleeve Gastrectomy, Revisional Bariatric Surgery
- Where
- Venezuela
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Unidad Internacional de Cirugia Bariatrica y Metabolica
Obesity, Diabetes Mellitus, Type 2
Longitudinal Phenotyping of Bariatric Surgery Patients
Recent studies have shown that bacteria within the gut play an important role in diabetes improvement after bariatric (weight-loss) surgery.
- Trial name
- NCT02421055
- Testing
- Laparoscopic Roux-en-Y Gastric Bypass, Laparoscopic Sleeve Gastrectomy
- Where
- United Kingdom
- Volunteers
- 158 people
- Sponsor
- Imperial College London
Bariatric Surgery Candidate, Bile Acid, Elevated Serum
Metabolic Effects of Endogenous Bile Acids After Gastric Bypass Surgery
Non-randomized, open-label, parallel-group clinical study evaluating the effects of endogenous bile acids on changes in plasma fibroblast growth factor-19 (FGF-19) and glucose metabolism by extended depletion of circulating bile…
- Conditions
- Bariatric Surgery Candidate, Bile Acid, Elevated Serum, Glucose Metabolism Disorders
- Trial name
- Bile-bar (NCT06925997)
- Testing
- Colesevelam
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Impaired Renal Function
Effects of Obesity Surgery on Renal Function
Increasing risk of impaired renal function as a result of obesity is well known. Early data has postulated that weight loss might improve kidney function, but the evidence is rather limited due to the difficulties in measuring…
- Trial name
- NCT01507350
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Imperial College London