Clinical trials: Gastric Bypass
Gastric Bypass Surgery, Obesity
Mechanisms of Diabetes Control After Weight Loss Surgery
Obesity and type 2 diabetes (T2DM) are increasing in the US. One third of patients seeking bariatric surgery have T2DM. Although all surgeries result in significant weight loss and often 'cure' the T2DM, the rapid onset and the…
- Trial name
- NCT00571220
- Testing
- gastric bypass surgery, Diet induced weight loss
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Insulin Resistance
Ghrelin Changes After Roux-en-Y Gastric Bypass
The purpose of this study is to determine whether gastric division (via Roux-en-Y gastric bypass) with resultant fundic isolation will alter the pattern(s) of Ghrelin secretion in the early post-operative period following feeding…
- Trial name
- NCT00765596
- Testing
- Liquid diet for 3 days
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Vanderbilt University
Sleep Apnea, Hypertension
Tri Staple Technology Stapler Used in Gastric Bypass
The objectives of this clinical trial are to assess in a pilot setting the overall performance and safety of the Endo GIA™ Stapler with Endo GIA™ SULU with Tri-Staple™ Technology when used in a gastric bypass procedure.
- Conditions
- Sleep Apnea, Hypertension, Hyperlipidemia, Coronary Artery Disease
- Trial name
- NCT01026103
- Testing
- Tri Staple Technology stapler
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Morbid Obesity
Sleeve Gastrectomy Versus Gastric Bypass for Private Pay Patients Seeking Obesity Surgery
The purpose of this study is to determine laparoscopic sleeve gastrectomy is a safer surgery than the gastric bypass, gives similar weight losses and that the safety of gastric in private pay patients versus insurance patients…
- Trial name
- NCT01063959
- Testing
- Laparoscopic Sleeve Gastrectomy, Laparoscopic Gastric Bypass
- Where
- United States
- Sponsor
- Pennington Biomedical Research Center
Hypoglycemia Non-Diabetic, Gastric Bypass Surgery
Glucose Monitoring in Treatment of Postprandial Hypoglycemia After Gastric Bypass Surgery
The goal of this clinical trial is to learn if continuous glucose monitoring works to treat postprandial hypoglycaemia in patients who have undergone gastric bypass surgery.
- Trial name
- HypoSurge (NCT06468865)
- Testing
- Continuous glucose monitor (Dexcom® G7)
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sykehuset i Vestfold HF
Gastric Bypass
Mechanistic Investigation Of Intestinal Cytochrome p450 3A4 Following Roux-en-Y Surgery And Its Effect on Plasma Concentrations of Buspirone
This study is to compare intestinal Cytochrome P450 3A4 (CYP3A4) activity in 9-18 month post weight loss surgery Roux-en-Y Gastric Bypass (RYGB) versus control subjects who have not had a weight loss surgery and are of similar…
- Trial name
- NCT02483598
- Testing
- Buspirone, Buspirone and Grapefruit Juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Roux en Y Gastric Bypass Surgery
Pharmacokinetic Properties of Sertraline Before and After Gastric Bypass Surgery
This study is being conducted to evaluate how the body absorbs and processes the medication sertraline (Zoloft®) before compared to how it is absorbed at two time points after gastric bypass surgery.
- Trial name
- NCT01214382
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- North Dakota State University
NASH - Nonalcoholic Steatohepatitis, Bariatric Surgery Candidate
Gut Permeability and Bariatric-metabolic Surgery
Increased intestinal permeability and dysbiosis have been causally associated with NAFLD and NASH progression. However, to date, there are no systematic studies, on the effect of bariatric-metabolic surgery on intestinal…
- Conditions
- NASH - Nonalcoholic Steatohepatitis, Bariatric Surgery Candidate, Intestinal Permeability
- Trial name
- NCT05257200
- Where
- Austria
- Volunteers
- 125 people
- Sponsor
- Medical University of Vienna
Obesity, Morbid
Clinical Outcomes of Single Stage Versus Two-stage Treatment of Severe Obesity
Laparoscopic Roux-en-Y gastric bypass (LRYGB) in super obese patients (BMI≥50kg/m2) is a challenging operation. Weight reduction with intragastric balloon (IGB) prior to LRYGB may improve operative outcomes and improves weight…
- Trial name
- NCT05146011
- Testing
- Gatsric balloon insertion
- Volunteers
- 155 people
- Sponsor
- Imperial College London
Ulcer Disease After Gastric Bypass, Marginal Ulcer
Perforated Marginal Ulcer After Gastric Bypass
A common late complication after gastric bypass surgery is marginal ulceration that is defined as ulcers at the margins of the gastrojejunostomy, mostly on the jejunal side.
- Conditions
- Ulcer Disease After Gastric Bypass, Marginal Ulcer, Perforated Marginal Ulcer, Acutely Perforated Marginal Ulcer
- Trial name
- PerforatedMU (NCT01041196)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Obesity
Gut Hormone Response, Appetite and Intestinal Transit Time in Good and Poor Weight Responders After Gastric Bypass
The aim of the study is to describe differences in meal-stimulated gut hormone response, appetite and intestinal transit time between good and poor responders 1-2 years after Gastric Bypass surgery for obesity.
- Trial name
- RnonR (NCT00908973)
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Hypoglycemia, Gastric Outlet Obstruction
Endoscopic Ultrasound-guided Large Diameter Lumen-apposing Metal Stent Gastro-gastrostomy for Bypass Reversal in Patients With Roux-en-y Gastric Bypass
The primary objective of this open-label pilot study is to investigate whether an endoscopically placed lumen apposing metal stent is an effective alternative to surgery in patients that have a clear indication for reversal of…
- Conditions
- Hypoglycemia, Gastric Outlet Obstruction, Steatohepatitis, Parenteral Support
- Trial name
- LABOR (NCT05640947)
- Testing
- The Hot AXIOS™ Stent and Electrocautery-Enhanced Delivery System
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Insulin Resistance, Obesity
Metabolism and Bariatric Surgery Study
The purpose of this study is to determine if diet-induced weight loss causes different changes in hormones that control appetite and glucose control than surgery-induced weight loss.
- Trial name
- NCT03371368
- Testing
- Roux-en-Y Gastric Bypass (RYGBP), Sleeve Gastrectomy (SG), Very Low Calorie Diet (VLCD)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Columbia University
Type 2 Diabetes
Roux-en-Y-Gastric Bypass vs. Lifestyle Modification and Medical Therapy in the Treatment of Type 2 Diabetes
The study is aimed to compare: Laparoscopic Roux-en-Y-Gastric Bypass (RYGB) + optimal medical therapy versus Intensive lifestyle modification and optimal medical therapy in the treatment of type 2 diabetes in…
- Trial name
- NCT01231308
- Testing
- Roux-en-Y-Gastric Bypass, Intensive lifestyle modification and Optimal medical Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Post-bariatric Hypoglycaemia, Roux-en-Y Gastric Bypass
Forecasting and Preventing Post-Bariatric Hypoglycaemia WP 2
The overall aim of this study is to develop a sustainable hypoglycemia correction strategy.
- Trial name
- PBH Forecast (NCT05250271)
- Testing
- 15 g dextrose, 5 g dextrose, Protein bar
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Lia Bally
Obesity
Randomized Trial Comparing Laparoscopic Roux-en-y Gastric Bypass to Micro-laparoscopic Roux-en-y Gastric Bypass
Background Laparoscopy is the preferred surgical approach for a number of different diseases as it allows for diagnosis and treatment in the setting of a safe and feasible method offering enhanced cosmesis.
- Trial name
- NCT01183273
- Testing
- Microlaparoscopic gastric bypass, Laparoscopic Surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Suzanne J. Rose
Diabetes Mellitus Type 2 in Obese
Efficacy of SASI Bypass for Type-2 Diabetic Obese Patients
the investigator modified the Sanator's operation by performing a loop rather than Roux-en-Y bipartition reconstruction and the investigator are reporting the first clinical results of the outcomes of SASI bypass as a mode of…
- Trial name
- SASI (NCT02680873)
- Testing
- SASI bypass
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Obesity
Bariatric Surgeries and Glucose Homeostasis During a Mixed Meal Test
Bariatric surgery can lead to improvement or even resolution of type 2 diabetes Mellitus (T2DM) with the spectrum of responses depending also on operation procedures.
- Trial name
- BASMEAL (NCT01767441)
- Testing
- Roux-en-Y-gastric bypass, laparoscopic adjustable gastric banding, laparoscopic sleeve gastrectomy
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Nutritional Deficiency in Pregnancy (Disorder), Bariatric Surgery
Nutritional Status During Pregnancy After Bariatric Surgery
Background: There is a lack of evidence on whether maternal nutritional deficiencies after Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) affect fetal development.
- Trial name
- PREGNUTRIBAR (NCT03469635)
- Testing
- Nutritional deficiencies in pregnant women after bariatric surgery
- Volunteers
- 111 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Morbid Obesity
Comparison of Laparoscopic Sleeve Gastrectomy and Roux-Y-gastric Bypass in the Treatment of Morbid Obesity
The laparoscopic sleeve-gastrectomy (SG) compared to laparoscopic proximal Roux-Y-gastric bypass (PGB) is as successful in the treatment of morbid obesity in the majority of patients.
- Trial name
- NCT00356213
- Testing
- sleeve gastrectomy, Roux-Y-gastric bypass
- Volunteers
- 217 people
- Sponsor
- University Hospital, Basel, Switzerland