Clinical trials: Gastric Bypass
Roux-en-Y Gastric Bypass, Postprandial Hypoglycemia
Effect of Postprandial Hyperinsulinaemic Hypoglycaemia on Driving Performance.
The primary objective of this study is to assess the effect of the natural course of postprandial hypoglycemia vs. a postprandial euglycaemic condition on driving performance in individuals with confirmed postprandial…
- Conditions
- Roux-en-Y Gastric Bypass, Postprandial Hypoglycemia, Driving Impaired
- Trial name
- DEEP1C (NCT04330196)
- Testing
- Oral glucose tolerance test
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Lia Bally
Morbid Obesity, Metabolic Disease
Study Evaluating Metabolic Syndrome in Subjects Undergoing Gastric Bypass Bariatric Syndrome
Metabolic syndrome is rapidly emerging as an epidemic of global proportions and its definition is still evolving. Patients with this syndrome are at increased risk for cardiovascular disease, and at increased risk of mortality…
- Trial name
- NCT00283374
- Testing
- Laparoscopic Roux-en-Y Gastric Bypass
- Where
- 17 sites in United States, Italy and 1 more
- Volunteers
- 120 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Sugammadex
Quantitative Neuromuscular Monitoring and Gastric Bypass Surgery
This is a single site, prospective, non-blinded, non-randomized, before/after study. This study is designed to evaluate the impact of monitoring and reversal guidelines for neuromuscular blocking drugs on the post-operative…
- Trial name
- NCT05886218
- Testing
- Quantitative Neuromuscular Function Monitoring
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of California, Davis
Type 2 Diabetes, Obesity
Changes in Incretins Response and Glycemic Control After Gastric Bypass Surgery in Type 2 Diabetic Patients Versus Healthy
The purpose of this study is to determine the early changes in gut hormonal, and other metabolites with known relations to the glycemic homeostasis.
- Trial name
- NCT01820273
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lund University
Severe Obesity, Renal Failure
Obesity Surgery and Kidney Transplant for Patients With Obesity and Renal Failure
Gastric Bypass followed by renal transplantation is superior to medical management followed by renal transplant for patients with severe obesity and renal failure.
- Trial name
- NCT02128802
- Testing
- Gastric Bypass, Weight Loss Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Gastric Outlet Obstruction
Clinical Trial of EPASS With Hot AXIOS System
A prospective, multi-center, single-arm study for unresectable malignant gastric outlet obstruction with EUS-guided double-balloon-occluded gastrojejunostomy bypass (EPASS)
- Trial name
- PASSAGE (NCT05644951)
- Testing
- Hot AXIOS system used for EPASS
- Where
- 6 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Boston Scientific Corporation
Obesity
Bariatric Surgery Versus Diet Alone in the Bile Acid Pathway and Weight Loss
It is unknown whether the bile acid pathway reacts differently to weight loss resulting from Roux-En-Y Gastric Bypass (RYGB) surgery than weight loss resulting from caloric restriction alone.
- Trial name
- NCT03238794
- Testing
- Roux-En-Y Gastric Bypass, Low-calorie Diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Obesity
Effect of Gastric Bypass Surgery on Pancreatic Islet and Incretin Function - Follow-up Study
To examine pancreatic islet function and incretin function during intravenous and oral stimulation >2 years after gastric bypass surgery in patients with normal glucose tolerance.
- Trial name
- NCT02161666
- Where
- Denmark
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Diabetes Mellitus, Type II
Mechanisms of Glycemic Improvement After Gastrointestinal Surgery
This study is designed as a prospective clinical trial aimed at investigating the mechanisms behind observed improvements in type 2 diabetes mellitus (T2DM) following bariatric surgery.
- Trial name
- NCT01025999
- Testing
- No intervention
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Washington
Iron Deficiency Anemia Associated With Non-Dialysis Dependent Chronic Kidney Disease, Iron Deficiency Anaemia Due to Dietary Causes
The Role of Ferric Carboxymaltose in the Treatment of Pediatric Iron Deficiency Anemia in the Emergency Department
The goal of this project is to assess the feasibility, clinical effectiveness, and cost-effectiveness of IV iron therapy using ferric carboxymaltose (FCM) as a treatment for pediatric patients with iron deficiency anemia (IDA) in…
- Conditions
- Iron Deficiency Anemia Associated With Non-Dialysis Dependent Chronic Kidney Disease, Iron Deficiency Anaemia Due to Dietary Causes, Iron Deficiency Anemia Treatment, Iron Deficiency Anemia Secondary to IBD or Gastric Bypass
- Trial name
- ED-Heme FCM (NCT07414199)
- Testing
- Ferric Carboxymaltose (FCM), Ferrous Sulfate
- Volunteers
- 150 people
- Sponsor
- Children's Hospital of Orange County
Obesity
Influence of Obesity and Gastric Bypass on Medication Absorption
Patients who have scheduled a gastric bypass (RYGB) in UZ Leuven, will be questioned preoperatively and one, three, six and twelve months after gastric bypass surgery.
- Trial name
- INOGMA (NCT01571180)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Healthy Volunteers, Enteric Hyperoxaluria
Safety, Tolerability, and Pharmacodynamics of NOV-001 in Adult Subjects
The first stage of this study is a prospective, adaptive, Phase 1, first-in-human, randomized, controlled study evaluating safety, tolerability, and pharmacodynamics of NOV-001 in adult healthy volunteers.
- Trial name
- NCT04909723
- Testing
- NOV-001, NB1000S, NB2000P
- Where
- 20 sites in United States, Canada
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Novome Biotechnologies Inc
Obesity, Diabetes Mellitus, Type 2
Bariatric Surgery and Male Reproductive Function
Obesity is a global public health problem. According to literature reports, as of 2016, China's obese population has reached more than 90 million and type 2 diabetes mellitus has reached more than 100 million, which has brought a…
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Bariatric Surgery Candidate, Roux en Y Gastric Bypass
- Trial name
- NCT04237311
- Testing
- Sleeve gastrectomy, Roux-en-Y gastric bypass
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Gastric Bypass Status
Rivaroxaban Effects in Subjects Who Have Undergone Gastric Bypass Surgery
The investigators are attempting to compare the anticoagulant (blood thinning) effects of a recently FDA approved medication, Rivaroxaban, in people who have undergone gastric bypass surgery to people who have not had this…
- Trial name
- NCT02058199
- Testing
- rivaroxaban
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Bariatric Surgery
Bariatric Surgery and LDL Cholesterol
Background: Observational studies have shown that gastric bypass is superior to sleeve gastrectomy in terms of LDL cholesterol improvement.
- Trial name
- BASALTO (NCT03975478)
- Testing
- Gastric bypass, Sleeve gastrectomy
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Parc de Salut Mar
Obesity
A Preliminary Comparison of the Blood Levels of Medications in Obese Subjects Compared to Post-Gastric Bypass Subjects
The purpose of this study is to determine the difference, if any, in the area under the sertraline plasma level time curve (AUC) between patients who are nine to fifteen months post Roux-en-Y Bariatric Surgery and control…
- Trial name
- NCT01015976
- Testing
- bariatric surgery, control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Neuropsychiatric Research Institute, Fargo, North Dakota
Obesity, Type 2 Diabetes
Gut Hormones and Roux en Y Gastric Bypass
The purpose of this study is to assess whether the changes in gut hormones seen following Roux en Y Gastric Bypass surgery are responsible for some of the beneficial effects seen post-operatively.
- Trial name
- NCT01945840
- Testing
- Roux en Y Gastric Bypass Surgery, Gut hormone infusion, Very low calorie diet
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity, Gastric Bypass
Impact of a Specific Micronutrient-probiotic-supplement on Fatty Liver of Patients After Mini-Gastric Bypass Surgery
Aim of this prospective randomized intervention study is to evaluate the effect of a dietary intervention with a specific micronutrient-probiotic-combination for 12 weeks on fatty liver and cardiometabolic status in obese…
- Conditions
- Obesity, Gastric Bypass, NAFLD
- Trial name
- FMG-01 (NCT03585413)
- Testing
- Micronutrient-probiotic-combination
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Bonn Education Association for Dietetics r.A., Cologne, Germany
Hypoglycemia, Reactive
Pasireotide in the Treatment of Hypoglycemia Following Gastric Bypass Surgery
Postprandial hyperinsulinemic hypoglycemia is a well-known and potentially severe complication of Roux-en-Y gastric bypass (RYGB), and the treatment options are limited.
- Trial name
- NCT03514576
- Testing
- Pasireotide 0.3 MG/ML, Meal tolerance test (MTT)
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Zealand University Hospital
Post Operative Analgesia, Bariatric Surgery
Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients
Adult patients with morbid obesity who have had Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (LSG) surgery have impaired drug metabolism.
- Conditions
- Post Operative Analgesia, Bariatric Surgery, Bariatric Surgery (Gastric Bypass), Bariatric Surgery Patients
- Trial name
- NCT06658574
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rutgers, The State University of New Jersey