Clinical trials: Gastric Bypass
Gastric Bypass
Mechanistic Investigation Of Intestinal Cytochrome p450 3A4 Following Roux-en-Y Surgery And Its Effect on Plasma Concentrations of Buspirone
This study is to compare intestinal Cytochrome P450 3A4 (CYP3A4) activity in 9-18 month post weight loss surgery Roux-en-Y Gastric Bypass (RYGB) versus control subjects who have not had a weight loss surgery and are of similar…
- Trial name
- NCT02483598
- Testing
- Buspirone, Buspirone and Grapefruit Juice
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Morbid Obesity
Glucose Homeostasis Pre and Post Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the clinical trial.
- Trial name
- RB (NCT00981500)
- Testing
- gastric bypass, gastric banding, sleeve gastrectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Gastroesophageal Reflux, Obesity
Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux
Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is considered the weight loss procedure of choice for patients suffering of gastro-esophageal reflux (GER).
- Trial name
- NCT02618044
- Volunteers
- 86 people
- Sponsor
- University of Turin, Italy
Obesity
Effect of Caloric Restriction and Gastric Bypass on Resting Metabolic Rate
Studies in overweight and obese subjects show a decline in resting metabolic rate (RMR) even after moderate caloric restriction. Yet the onset and course of such a metabolic adaption is still unclear.
- Trial name
- NCT01595945
- Testing
- Gastric bypass, Caloric restriction
- Where
- 2 sites in Austria
- Volunteers
- 75 people
- Sponsor
- KiloCoach e.U.
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Obesity, Bariatric Surgery Candidate
Diet-induced Thermogenesis in Patients With Postoperative Roux-in-Y Gastric Bypass (RYGBP) Weight Regain
Introduction: According to the National Health and Nutrition Examination Survey 2009-2010, 78 million American adults are obese.
- Conditions
- Obesity, Bariatric Surgery Candidate, Protein-energy; Imbalance
- Trial name
- RYGBP (NCT02422212)
- Testing
- patients eat a mixed solid meal
- Where
- 3 sites in Brazil
- Volunteers
- 45 people
- Sponsor
- Silvia Leite Faria
Type 2 Diabetes
Roux-en-Y-Gastric Bypass vs. Lifestyle Modification and Medical Therapy in the Treatment of Type 2 Diabetes
The study is aimed to compare: Laparoscopic Roux-en-Y-Gastric Bypass (RYGB) + optimal medical therapy versus Intensive lifestyle modification and optimal medical therapy in the treatment of type 2 diabetes in…
- Trial name
- NCT01231308
- Testing
- Roux-en-Y-Gastric Bypass, Intensive lifestyle modification and Optimal medical Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Obesity
Effect of Gastric Bypass Surgery on Pancreatic Islet and Incretin Function - Follow-up Study
To examine pancreatic islet function and incretin function during intravenous and oral stimulation >2 years after gastric bypass surgery in patients with normal glucose tolerance.
- Trial name
- NCT02161666
- Where
- Denmark
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Gastric Emptying, Roux-en-Y Gastric Bypass
Bariatric Procedures and Changes Gastric Passage
Gastric emptying measured with scintigraphy in patients after standard Roux-en-Y Gastric Bypass (S-RYGB), Banded-RYGB (B-RYGB) or Extended pouch-RYGB (E-RYGB).
- Conditions
- Gastric Emptying, Roux-en-Y Gastric Bypass, Bariatric Surgery
- Trial name
- BIP (NCT04972357)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Rijnstate Hospital
Obesity
Postprandial Nutrient Homeostasis Before and After Weight Loss Induced by Low-calorie Diet or RYGB
The purpose of this study is to compare the metabolic responses to low-carbohydrate and standard-carbohydrate meals in African Americans and non-Hispanic White adults with obesity and the effect of weight loss induced by…
- Trial name
- FGB (NCT03091725)
- Testing
- Roux-en-Y gastric bypass surgery, Low-calorie diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Evaluation of Expected Bone Loss After Bariatric Surgery, Possible Prevention of Bone Loss After Surgery by Calcium and Vitamin D Supplementation
Bone Metabolism After Laparoscopic Gastric Bypass Surgery (BABS)
Bariatric surgery leads to rapid weight loss in female and male patients. Less data are available about its impact on bone metabolism.
- Trial name
- BABS (NCT01739855)
- Testing
- Calciferol, calcium carbonate
- Where
- Austria
- Volunteers
- 160 people
- Sponsor
- Medical University of Vienna
Obesity, Morbid Obesity
Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery
This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response
- Trial name
- NCT03283644
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Gastric Bypass Surgery
Energy Expenditure and Gastric Bypass Surgery
The aim of this study is to assess whether activity thermogenesis increases in patients undergoing bariatric surgery post-operatively compared to pre-operatively.
- Trial name
- NCT00863993
- Sponsor
- Mayo Clinic
Bypass, Gastric, Roux-en-Y Gastric Bypass
To Define the Role of GLP-1 for Improving Glucose Homeostasis in Humans Following Gastric Bypass Surgery
There is a marked and long-lasting improvement in glucose homeostasis that follows Roux-en-y gastric bypass surgery (RYGB) in humans.
- Conditions
- Bypass, Gastric, Roux-en-Y Gastric Bypass, Vertical Sleeve Gastrectomy, Gastric Banding
- Trial name
- NCT02204813
- Testing
- Lo-Xenin, Hi-Xenin, Extra Hi-Xenin
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Morbid Obesity, Anastomotic Leak
Stratafix vs. Vicryl OAGB / MGB Suture Study
To compare shorttime (6 months) results of two competitive suture materials with regard to time demanded to perform the concerned surgical step and secondary to study anastomotic site safety and complications like leakage and…
- Conditions
- Morbid Obesity, Anastomotic Leak, Anastomotic Stenosis, Hemorrhage Postoperative
- Trial name
- NCT04613635
- Testing
- Stratafix, Vicryl
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- St. Franziskus Hospital
Sugammadex
Quantitative Neuromuscular Monitoring and Gastric Bypass Surgery
This is a single site, prospective, non-blinded, non-randomized, before/after study. This study is designed to evaluate the impact of monitoring and reversal guidelines for neuromuscular blocking drugs on the post-operative…
- Trial name
- NCT05886218
- Testing
- Quantitative Neuromuscular Function Monitoring
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of California, Davis
Obesity
Endostapler Gastric Bypass Study
The goal of this prospective, post-market study is to evaluate safety and efficacy of the AEON™ Endostapler when used in laparoscopic Roux-en-Y gastric bypass surgery.
- Trial name
- NCT04712526
- Testing
- AEON Endostapler
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lexington Medical Inc.
Statin Pharmacokinetics Pre and Post Gastric Bypass Surgery
Rosuvastatin Interethnic PK Study
Statins are the first-line and most commonly prescribed drugs for the prevention of cardiovascular diseases and stroke in the world.
- Trial name
- RST (NCT02215174)
- Testing
- Rosuvastatin
- Where
- 2 sites in United States, Taiwan
- Volunteers
- 21 people
- Sponsor
- University of California, San Francisco
Obesity, GERD
One Anastomosis Gastric Bypass With Excluded Stomach Fundoplication: FundoRing vs Nissen vs OAGB Without Fundoplication
Background and study aims: Currently, one anastomosis Gastric Bypass (OAGB) is a common bariatric procedure. Obesity and gastroesophageal reflux disease (GERD) are steadily increasing world weight and antireflux surgery must be…
- Trial name
- FundoRing (NCT04828733)
- Testing
- laparoscopic one anastomosis gastric bypass with excluded stomach fundoplication: FundoRingOAGB and suture cruroplasty, laparoscopic one anastomosis gastric bypass with excluded stomach Nissen fundoplication and suture cruroplasty, Standard laparoscopic one anastomosis gastric bypass with cruroplasty. Not used fundoplication.
- Where
- Kazakhstan
- Volunteers
- 150 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Post-bariatric Surgery
The Effect of Supervised Exercise on Physical Fitness and Energy Expenditure in Post Bariatric Surgery Patients
It is hypothesized that the patients in the EXDA group will be able to complete a structured exercise program at a level sufficient to accumulate at least 2000 kcal per week, and that the structured endurance activity will…
- Trial name
- NCT00793832
- Testing
- supervised exercise, Diet advice
- Volunteers
- 33 people
- Sponsor
- University of Texas Southwestern Medical Center