Clinical trials: Gastric Bypass Surgery
Obesity, Morbid, Diabetes Mellitus, Type 2
Different Limb Lengths in Gastric Bypass Surgery
Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of…
- Conditions
- Obesity, Morbid, Diabetes Mellitus, Type 2, Hypertension, Dyslipidemias
- Trial name
- SLIM (NCT04219787)
- Testing
- Long BPL LRYGB, Short BPL LRYGB
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- Clarunis - Universitäres Bauchzentrum Basel
Diabetes, Surgery
Tailored Bilio-Pancreatic Limb and HbA1c 10 Years Post Mini-Gastric Bypass
Diabetes is now or soon will be a worldwide epidemic. Diabetes has impact on both healthcare costs in addition to the costs in human lives, suffering and disability. Treatment that lowers Hemoglobin A1c (HbA1c) improved outcomes.
- Trial name
- BPLLvHbA1c (NCT04442698)
- Testing
- Mini-Gastric Bypass Original Technique
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kular Hospital
Obesity, Fatty Liver
Impact of Bariatric Surgery on the Evolution of Nonalcoholic Fatty Liver Disease: a Comparative Clinical Trial Between Sleeve Gastrectomy and Gastric Bypass
Aim: To compare prospectively two bariatric surgery techniques: sleeve gastrectomy (SG) vs gastric bypass (GB) in the evolution of nonalcoholic fatty liver disease (NAFLD) measured by the transient elastography in the first year.
- Trial name
- NCT02394353
- Testing
- Transient hepatic elastography
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Brazil
Overweight
Trial of Leptin Administration After Roux-en-Y Gastric Bypass
This is a pilot and feasibility study to examine a novel intervention using leptin in weight-reduced individuals who have undergone bariatric surgery but still remain obese.
- Trial name
- NCT00710814
- Testing
- Leptin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Columbia University
Obesity
Effect of Acute Exercise on Food Intake and Energy Expenditure Following a Gastric Bypass
This pilot study will use a crossover design to explore the effects of acute exercise following bariatric surgery on food intake, energy expenditure, appetite, food reward, appetite hormones, and inflammatory response.
- Trial name
- ExoABari (NCT04348617)
- Testing
- Moderate exercise, Rest
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
Obesity
Cerebrospinal Fluid Biomarkers in Bariatric Surgery
The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms.
- Trial name
- NCT04350892
- Testing
- Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Very Low Calorie Diet (VLCD)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obesity, Morbid, Postoperative Pain
Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting
The purpose of this research study is to evaluate the drug gabapentin (Neurontin®) for its ability to reduce postoperative pain, the need for morphine-like pain medication, and the severity and frequency of postoperative nausea…
- Conditions
- Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
- Trial name
- NCT00886236
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
Obesity
Roux-en-Y Gastric Bypass: Clinical Trial
The present study aims to describe the results of a modified gastric bypass surgery to ensure endoscopic access to the excluded remaining stomach, as well as to monitor the clinical conditions of comorbidities and the patient's…
- Trial name
- ERAPT (NCT04649619)
- Testing
- GASTRIC BYPASS MODIFIED IN ROUX-EN-Y AS A THERAPEUTIC OPTION IN PATIENTS WITH INDICATION OF BARIATRIC AND / OR METABOLIC SURGERY
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Paulo Reis Esselin de Melo
Bariatric Surgery
Incretin Hormone Antagonism After Bariatric Surgery
Using the glucagon-like peptide-1 (GLP-1) antagonist exendin(9-39) and the glucose-dependent insulinotropic peptide (GIP) antagonist GIP(3-30), the purpose of this study is to clarify the importance of endogenous GLP-1 and GIP…
- Trial name
- INCA-BAR (NCT03950245)
- Testing
- GLP-1 antagonism, GIP antagonism, GLP-1 and GIP antagonism
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Type 2 Diabetes Mellitus
Metabolic Surgery Versus Medical Management for Resolution of Type II Diabetes
Best medical management and gastric bypass surgery is a way to treat diabetes as part of regular medical care (standard of care).
- Trial name
- NCT01044602
- Testing
- Laboratory evaluations, sleep study, Best Medical Management, Roux-en-Y gastric bypass surgery
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- David Bradley MD
Diabetes, Stress
Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus
General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Explore the effect of three kinds of anesthesia,that is the total intravenous anesthesia, inhalation anesthesia and inhalation and…
- Conditions
- Diabetes, Stress, Anesthesia
- Trial name
- NCT01963546
- Testing
- different types of anesthesia, Dexmedetomidine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Obesity, Diabetes
Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Biliopancreatic Diversion (BPD)- Duodenal Switch for Superobesity
The purpose of this study is to compare the outcome in a broad perspective after laparoscopic Roux-en-Y gastric bypass and laparoscopic BPD-duodenal switch in the treatment of superobesity (body mass index [BMI] > 50 kg/m2).
- Conditions
- Obesity, Diabetes, Hypertension
- Trial name
- ASGARD (NCT00327912)
- Testing
- Laparoscopic Biliopancreatic diversion with Duodenal switch, Laparoscopic Roux-en-Y Gastric Bypass
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Complications After Gastric Bypass Operation
Complications After Bariatric Surgery Based, a Questionnaire Survey
The number of obese is increasing rapidly. Bariatric surgery is used to a greater and greater extent as treatment of obesity to obtain a greater and more permanent weight loss.
- Trial name
- NCT01930851
- Testing
- Gastric bypass operation
- Where
- Denmark
- Volunteers
- 1,429 people
- Sponsor
- University of Aarhus
Obesity, Morbid, Metabolic Syndrome
Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach
Variable outcomes after weight loss surgery are likely attributable to complex, poorly understood mechanisms. Due to the significant impact that morbid obesity has on a patient's health, successful management of obesity and its…
- Conditions
- Obesity, Morbid, Metabolic Syndrome, NASH - Nonalcoholic Steatohepatitis
- Trial name
- NCT04841057
- Testing
- 50 cm BP limb length, 100 cm BP limb length, 150 cm BP limb length
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Bariatric Surgery
30-Days Post-Operative Complications in Bariatric Surgery
comparison of 30-days post-operative outcomes of laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB)
- Trial name
- Bariatric (NCT04779723)
- Testing
- Comparison of two Techniques of bariatric surgery
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Multan Medical And Dental College
Morbid Obesity
Comparison of Gastric Bypass and Sleeve Gastrectomy in Metabolic and Cardiovascular Indices
Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery.
- Trial name
- NCT03851874
- Testing
- Bariatric surgery
- Volunteers
- 28 people
- Sponsor
- National and Kapodistrian University of Athens
Hypoglycemia, Roux-en-Y Gastric Bypass
The Effect of Physical Activity in Individuals With Post-bariatric Hypoglycemia
The goal of this pilot study is to evaluate the magnitude of changes in glucose and hormone levels in response to structured exercise in the fasting state in individuals with post-bariatric hypoglycemia (PBH).
- Conditions
- Hypoglycemia, Roux-en-Y Gastric Bypass, Post-bariatric Hypoglycemia, Physical Activity
- Trial name
- NCT05560789
- Testing
- Physical activity (cycling on a stationary bicycle ergometer or walking on a treadmill)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Joslin Diabetes Center
Pain, Postoperative Depression
Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy
This is a randomized, double-blind, placebo-controlled, two-arm parallel, single-center study. One hundred subjects (50 in each arm) will be enrolled.
- Trial name
- NCT02452060
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- NYU Langone Health
Obesity
Effect of Weight Loss on Myocardial Metabolism and Cardiac Relaxation in Obese Adults
Obesity adversely affects myocardial (muscular heart tissue) metabolism, efficiency, and diastolic function. The objective of this study was to determine if weight loss could improve obesity-related myocardial metabolism and…
- Trial name
- NCT00572624
- Testing
- Diet, Gastric bypass surgery
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine